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公开(公告)号：US10092572B2
公开(公告)日：2018-10-09
申请号：US14435704
申请日：2013-10-15
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , John Emmerson Campbell , Masashi Seki , Syuji Shirotori , Wataru Itano , Wanjun Zheng
IPC: C07D213/64 , A61K31/5377 , C07D405/14 , A61K31/5375 , A61K31/4412 , A61K31/4545 , C07D401/12 , C07D405/12
Abstract: The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US20180105497A1
公开(公告)日：2018-04-19
申请号：US15675341
申请日：2017-08-11
Applicant: Epizyme, Inc.
Inventor： Richard Chesworth , Lorna Helen Mitchell , Gideon Shapiro , Kevin Wayne Kuntz
IPC: C07D231/56 , C07D405/12 , C07D405/04 , C07D403/12 , C07D401/12 , C07D401/04
CPC classification number: C07D231/56 , A61K31/416 , A61K31/4439 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12
Abstract: Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.
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公开(公告)号：US20170355712A1
公开(公告)日：2017-12-14
申请号：US15601888
申请日：2017-05-22
Applicant: Epizyme, Inc.
Inventor： John Emmerson Campbell , Kenneth William Duncan , Megan Alene Foley , Darren Martin Harvey , Kevin Wayne Kuntz , James Edward John Mills , Michael John Munchhof
IPC: C07D498/04 , C07D405/14 , C07D405/12 , C07D215/38 , C07D487/04 , C07D491/044 , C07D401/14 , C07D401/12 , C07D213/74 , C07D473/32 , C07D239/49 , C07D403/14 , C07D239/48 , C07D413/12 , C07D471/04 , C07D413/14 , C07D403/12 , C07D409/14
CPC classification number: C07D498/04 , C07D213/74 , C07D215/38 , C07D231/38 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04 , C07D473/32 , C07D487/04 , C07D491/044
Abstract: The present disclosure relates to amine-substituted aryl or heteroaryl compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., sickle cell anemia) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering an amine-substituted aryl or heteroaryl compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US09765035B2
公开(公告)日：2017-09-19
申请号：US14775246
申请日：2014-03-14
Applicant: Epizyme, Inc.
Inventor： Richard Chesworth , Lorna Helen Mitchell , Gideon Shapiro , Kevin Wayne Kuntz
IPC: C07D231/56 , C07D403/12 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12
CPC classification number: C07D231/56 , A61K31/416 , A61K31/4439 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12
Abstract: Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.
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公开(公告)号：US09549931B2
公开(公告)日：2017-01-24
申请号：US14742481
申请日：2015-06-17
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: C07D213/64 , C07D405/14 , C07D498/08 , A61K31/5377 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及芳基或杂芳基取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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Patent Agency Ranking
公开(公告)号：US09532992B2
公开(公告)日：2017-01-03
申请号：US14742466
申请日：2015-06-17
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , John Emmerson Campbell , Masashi Seki
IPC: A61K31/5375 , A61K31/4545 , A61K31/4412 , C07D405/14 , C07D213/64 , A61K31/5377 , C07D401/12 , C07D405/12
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/4545 , A61K31/5375 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14
Abstract: The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US09522152B2
公开(公告)日：2016-12-20
申请号：US14876658
申请日：2015-10-06
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: A61K31/5377 , C07D498/08 , C07D213/64 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D405/14
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US20160022693A1
公开(公告)日：2016-01-28
申请号：US14876658
申请日：2015-10-06
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: A61K31/5377
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US20150366893A1
公开(公告)日：2015-12-24
申请号：US14752023
申请日：2015-06-26
Applicant: EPIZYME, INC.
Inventor： Edward J. Olhava , Richard Chesworth , Kevin Wayne Kuntz , Victoria M. Richon , Roy M. Pollock , Scott R. Daigle
IPC: A61K31/7076 , A61K31/519 , A61K31/52 , A61K31/7064
CPC classification number: A61K31/7076 , A61K31/519 , A61K31/52 , A61K31/7064 , C07D473/34 , C07D487/04 , C07H19/14 , C07H19/16
Abstract: The present invention relates to substituted purine and 7-deazapurine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
Abstract translation: 本发明涉及取代的嘌呤和7-脱氮嘌呤化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗其中DOT1介导的蛋白质甲基化作用的疾病如癌症和神经障碍的方法。
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公开(公告)号：US09090562B2
公开(公告)日：2015-07-28
申请号：US14275667
申请日：2014-05-12
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: C07D213/64 , C07D405/14 , C07D405/12 , C07D401/00 , C07D281/02 , C07D243/08 , A61K31/00 , A61K31/55 , A61K31/445 , A61K31/44 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及芳基或杂芳基取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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