公开(公告)号：US4738523A

公开(公告)日：1988-04-19

申请号：US89056

申请日：1987-08-25

申请人： Masaaki Ito ,  Yutaka Tanaka ,  Nobuo Ueda ,  Takanori Saito ,  Osami Kato

发明人： Masaaki Ito ,  Yutaka Tanaka ,  Nobuo Ueda ,  Takanori Saito ,  Osami Kato

IPC分类号： G03B21/11 ,  G06F17/30 ,  G03B23/12 ,  G03B27/52 ,  G03B27/70

CPC分类号： G03B21/113 ,  G03B21/118

摘要： The present invention relates to a reader printer having a plurality of mode selection keys, ten-keys and a character display which displays a message indicating contents of input manipulations to be executed next with the ten keys in accordance with the mode selected by the mode selection keys whereby operating conditions of the reader printer under the selected mode are set by way of operator-to-machine conversation.

摘要翻译： 本发明涉及一种具有多个模式选择键，十键和字符显示的读取器打印机，该显示器根据由模式选择所选择的模式显示指示使用十个键执行的接下来执行的输入操作的内容的消息 键，从而通过操作者到机器的对话来设置读取器打印机在所选模式下的操作条件。

公开(公告)号：US09416192B2

公开(公告)日：2016-08-16

申请号：US13057709

申请日：2009-08-05

申请人： Fumiyoshi Okano ,  Takayoshi Ido ,  Takanori Saito ,  Shinichi Kobayashi

发明人： Fumiyoshi Okano ,  Takayoshi Ido ,  Takanori Saito ,  Shinichi Kobayashi

IPC分类号： A61K39/395 ,  C07K16/30

CPC分类号： C07K16/3015 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3053 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/734

摘要： The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.

摘要翻译： 本发明涉及用于治疗和/或预防癌症的药物组合物，其包含与包含7个或更多个连续氨基的CAPRIN-1蛋白或其片段具有免疫学反应性的抗体或其片段作为活性成分 酸。

公开(公告)号：US09209057B2

公开(公告)日：2015-12-08

申请号：US13571011

申请日：2012-08-09

申请人： Koji Yoshii ,  Tatsuya Yamaguchi ,  Wenling Wang ,  Takanori Saito

发明人： Koji Yoshii ,  Tatsuya Yamaguchi ,  Wenling Wang ,  Takanori Saito

IPC分类号： H05B1/02 ,  H01L21/677 ,  H01L21/67

CPC分类号： H01L21/67781 ,  H01L21/67248

摘要： Provided is a method of controlling temperatures of objects to be heated in a heating unit by adjusting a heating rate of each of a plurality of heating elements, based on temperature detection values detected at a plurality of temperature detection elements, wherein the plurality of temperature detection elements are positioned at different positions and the plurality of heating elements are positioned at different positions. The method includes estimating a temperature of each of the plurality of temperature detection elements by using a first estimation algorithm when one of the plurality of temperature detection elements is broken, based on the temperature detection values of the temperature detection elements excluding the broken temperature detection element, and controlling the temperatures of the objects to be heated based on the estimated temperatures.

摘要翻译： 提供了一种通过基于在多个温度检测元件检测到的温度检测值来调节多个加热元件的加热速度来控制加热单元中待加热物体的温度的方法，其中多个温度检测 元件位于不同的位置，并且多个加热元件位于不同的位置。 该方法包括：基于除了断开的温度检测元件之外的温度检测元件的温度检测值，通过使用第一估计算法来估计多个温度检测元件中的每一个的温度， 并且基于估计的温度来控制被加热物体的温度。

公开(公告)号：US09181348B2

公开(公告)日：2015-11-10

申请号：US14236665

申请日：2012-08-03

申请人： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

发明人： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC分类号： C07K16/30 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61K47/48 ,  A61K39/00

CPC分类号： C07K16/30 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6861 ,  A61K47/6865 ,  A61K47/6869 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/732

摘要： An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.

摘要翻译： 本发明的目的是制备靶向癌细胞表面特异性表达的CAPRIN-1的抗体，对常规抗体具有优异的抗肿瘤活性，并提供抗体作为癌症治疗和/或预防剂的用途 。 本发明提供了靶向癌细胞表面特异表达的鉴定癌抗原蛋白的抗体作为癌症的治疗和/或预防剂的用途，特别是用于治疗和/或预防癌症的药物组合物，其包括作为 活性成分是与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体或其片段包含包含SEQ ID NO：5,6和7所代表的氨基酸序列的重链可变区和轻链 链可变区，其包含由SEQ ID NO：9,10和11表示的氨基酸序列。

公开(公告)号：US08911740B2

公开(公告)日：2014-12-16

申请号：US13577028

申请日：2011-02-04

申请人： Takanori Saito ,  Fumiyoshi Okano ,  Shinichi Kobayashi

发明人： Takanori Saito ,  Fumiyoshi Okano ,  Shinichi Kobayashi

IPC分类号： A61K39/395 ,  C07K16/30 ,  C07K16/18 ,  A61K39/00

CPC分类号： A61K39/39533 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3053 ,  C07K2317/23 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734

摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity with a partial polypeptide of CAPRIN-1, which is represented by any of even-numbered sequences of SEQ ID NOS: 2 to 30, wherein the polypeptide has the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence represented by SEQ ID NO: 37.

摘要翻译： 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体地说，本发明提供了一种用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为与CAPRIN-1的部分多肽具有免疫反应性的活性成分， SEQ ID NO：2至30的编号序列，其中所述多肽具有由SEQ ID NO：37表示的氨基酸序列或与SEQ ID NO：37所示氨基酸序列具有80％或更多序列同一性的氨基酸序列 。

公开(公告)号：US20140308283A1

公开(公告)日：2014-10-16

申请号：US14236818

申请日：2012-08-03

申请人： Yoshitaka Minamida ,  Fumiyoshi Okano ,  Takanori Saito

发明人： Yoshitaka Minamida ,  Fumiyoshi Okano ,  Takanori Saito

IPC分类号： C07K16/30 ,  A61K39/395

CPC分类号： C07K16/303 ,  A61K39/0011 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/5258 ,  C07K14/4738 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/10 ,  C07K2317/23 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732

摘要： This invention relates to a pharmaceutical composition for treatment and/or prevention of pancreatic cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 to 12 or more consecutive amino acid residues.

摘要翻译： 本发明涉及一种用于治疗和/或预防胰腺癌的药物组合物，其包含与CAPRIN-1蛋白或其片段具有免疫反应性的抗体或其片段作为活性成分，其包含7至12个或更多个连续氨基 酸残留。

公开(公告)号：US08835811B2

公开(公告)日：2014-09-16

申请号：US13408223

申请日：2012-02-29

申请人： Koji Yoshii ,  Tatsuya Yamaguchi ,  Wenling Wang ,  Takanori Saito

发明人： Koji Yoshii ,  Tatsuya Yamaguchi ,  Wenling Wang ,  Takanori Saito

IPC分类号： F27B5/14 ,  H01L21/67 ,  F27D19/00 ,  F27D21/00 ,  F27B17/00

CPC分类号： H01L21/67115 ,  F27B17/0025 ,  F27D19/00 ,  F27D21/0014 ,  H01L21/67109 ,  H01L21/67248

摘要： A control unit can select a large-number control zone model in which the number of control zones, which are independently controlled, is large, and a small-number control zone model in which the number of control zones, which are independently controlled, is small. When a temperature is increased or decreased, the control unit can select the small-number control zone model so as to control, based on signals from temperature sensors of the respective control zones C1 . . . C5 whose number is small, heaters located on the respective control zones C1 . . . C5. When a temperature is stabilized, the control unit can select the large-number control zone model so as to control, based on signals from the temperature sensors of the respective control zones C1 . . . C10 whose number is large, the heaters located on the respective control zones C1 . . . C10.

摘要翻译： 控制单元可以选择其中独立控制的控制区域的数量大的大量控制区域模型，以及独立控制的控制区域的数量为少数的控制区域模型 小。 当温度升高或降低时，控制单元可以根据来自相应控制区C1的温度传感器的信号，选择小数控制区模型，以便控制。 。 。 数量少的加热器位于相应控制区C1上。 。 。 C5。 当温度稳定时，控制单元可以根据来自相应控制区C1的温度传感器的信号来选择大数量的控制区域模型。 。 。 C10，其数量大，位于各个控制区C1上的加热器。 。 。 C10。

公开(公告)号：US20140186359A1

公开(公告)日：2014-07-03

申请号：US14236793

申请日：2012-08-03

申请人： Fumiyoshi Okano ,  Shinichi Kobayashi ,  Yoshitaka Minamida ,  Takanori Saito

发明人： Fumiyoshi Okano ,  Shinichi Kobayashi ,  Yoshitaka Minamida ,  Takanori Saito

IPC分类号： C07K16/18 ,  A61K45/06 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/732

摘要： This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. More specifically, the present invention provides an antibody, or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence shown by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer comprising the same as an active ingredient.

摘要翻译： 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。 更具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列或具有80％以上序列同一性的氨基酸序列组成的部分CAPRIN-1多肽具有免疫学反应性的抗体或其片段 和用于治疗和/或预防癌症的药物组合物，其包含其作为活性成分。

公开(公告)号：US20130071398A1

公开(公告)日：2013-03-21

申请号：US13577028

申请日：2011-02-04

申请人： Takanori Saito ,  Fumiyoshi Okano ,  Shinichi Kobayashi

发明人： Takanori Saito ,  Fumiyoshi Okano ,  Shinichi Kobayashi

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/30

CPC分类号： A61K39/39533 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3053 ,  C07K2317/23 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734

摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity with a partial polypeptide of CAPRIN-1, which is represented by any of even-numbered sequences of SEQ ID NOS: 2 to 30, wherein the polypeptide has the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence represented by SEQ ID NO: 37.

摘要翻译： 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体地说，本发明提供了一种用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为与CAPRIN-1的部分多肽具有免疫反应性的活性成分， SEQ ID NO：2至30的编号序列，其中所述多肽具有由SEQ ID NO：37表示的氨基酸序列或与SEQ ID NO：37所示氨基酸序列具有80％或更多序列同一性的氨基酸序列 。

公开(公告)号：US20120321641A1

公开(公告)日：2012-12-20

申请号：US13576955

申请日：2011-02-04

申请人： Fumiyoshi Okano ,  Takanori Saito

发明人： Fumiyoshi Okano ,  Takanori Saito

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/22

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/3015 ,  C07K16/3053 ,  C07K2317/23 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734

摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody comprising a heavy chain variable region that comprises SEQ ID NOS: 39, 40, and 41 and a light chain variable region that comprises SEQ ID NOS: 43, 44, and 45 or a fragment thereof as an active ingredient and having immunological reactivity with a CAPRIN-1 protein.

摘要翻译： 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体而言，本发明提供了用于治疗和/或预防癌症的药物组合物，其包含含有包含SEQ ID NO：39,40和41的重链可变区的抗体和包含SEQ ID NO：39,40和41的轻链可变区， NOS：43,44和45或其片段作为活性成分，并与CAPRIN-1蛋白具有免疫反应性。