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41.发明授权
公开(公告)号：US5880160A
公开(公告)日：1999-03-09
申请号：US670878
申请日：1996-06-27
申请人： Ezio Bombardelli , Bruno Gabetta
发明人： Ezio Bombardelli , Bruno Gabetta
IPC分类号： A61K31/165 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P19/06 , A61P21/02 , A61P29/00 , A61P35/00 , C07C233/32 , C07C323/41 , C07H15/248 , A61K31/16 , C07C233/05
CPC分类号： C07H15/248 , C07C233/32 , C07C323/41 , C07C2103/34 , Y10S514/886
摘要： The present invention relates to novel colchicine derivatives having antiproliferative, antineoplastic, antiinflammatory and muscle relaxant activities; said derivatives include novel colchine nitrogen amides for use either as such or after derivatization of the hydroxyl at C.sub.3 of the aromatic ring and at C.sub.10 of the tropolone ring. These novel compounds have a cytotoxicity on human tumoral cell lines comparable with colchicine but, in comparison with the latter, they are much more active on cells resistant to the usual antiblastics. The compounds can be included in pharmaceutical formulations useful for the intravenous, oral and topical administrations.
摘要翻译： 本发明涉及具有抗增殖，抗肿瘤，抗炎和肌肉松弛活性的新型秋水仙碱衍生物; 所述衍生物包括用于本发明或在芳环的C 3的羟基衍生化和在氯普罗酮环的C 10之间使用的新型胆碱氮酰胺。 这些新型化合物对与秋水仙素相当的人肿瘤细胞系具有细胞毒性，但与后者相比，它们对通常抗生素耐药性的细胞活性更高。 该化合物可以包含在用于静脉内，口服和局部给药的药物制剂中。
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42.发明授权Derivatives of physostigmine, their use and pharmaceutical formulations containing them 失效毒扁豆碱的衍生物，其使用和含有它们的药物制剂
公开(公告)号：US5314906A
公开(公告)日：1994-05-24
申请号：US2794
申请日：1993-01-11
申请人： Ezio Bombardelli
发明人： Ezio Bombardelli
IPC分类号： A61K9/70 , A61K31/40 , A61K31/66 , A61P25/28 , A61P43/00 , C07D487/04 , C07F9/10 , C07D487/00
CPC分类号： C07D487/04 , A61K9/7053 , C07F9/106
摘要： The therapeutic use of new salts of physostigmine in the treatment of syndromes related to changes in cerebral metabolism in the elderly is described. The new salts of physostigmine, which are based on phosphatidic acid, are highly lipophilic and exhibit excellent bioavailability when administered orally, transcutaneously or transepidermally.
摘要翻译： 描述了毒扁豆碱新盐治疗与老年人脑代谢变化有关的综合征的治疗用途。 基于磷脂酸的毒扁豆碱的新盐是高度亲脂性的，并且在口服，经皮或经皮上施用时表现出优异的生物利用度。
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公开(公告)号：US5264591A
公开(公告)日：1993-11-23
申请号：US881150
申请日：1992-05-11
申请人： Ezio Bombardelli , Bruno Gabetta
发明人： Ezio Bombardelli , Bruno Gabetta
IPC分类号： A61K31/335 , A61K31/337 , A61K31/695 , A61P35/00 , C07D305/14 , C07D493/08 , C07F7/18
CPC分类号： C07D493/08 , C07D305/14
摘要： Isolation of a new taxane having pharmaceutical activity, 1a 14-beta-hydroxy-10-deacetyl-baccatine III and hemisynthesis of some derivatives useful as antitumor agents and intermediates.
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44.发明申请公开(公告)号：US20140228428A1
公开(公告)日：2014-08-14
申请号：US14342593
申请日：2012-09-13
申请人： Ezio Bombardelli
发明人： Ezio Bombardelli
IPC分类号： A61K31/352 , A61K31/365 , A61K36/28 , A61K31/216
CPC分类号： A61K31/352 , A61K31/216 , A61K31/365 , A61K36/28
摘要： The present invention relates to the preparation of Cynara scolymus leaf extracts, which are useful for the prevention and treatment of dyslipidaemia, in particular to increase HDL cholesterol in patients at cardiovascular risk. Said extracts are useful to normalise the lipid and carbohydrate balances and significantly increase the value of HDL cholesterol by favourably changing the LDL/HDL ratio, especially in post-infarction patients with drug-induced dyslipidaemia.
摘要翻译： 本发明涉及可用于预防和治疗血脂障碍的Cynara scolymus叶提取物的制备，特别是在心血管风险患者中增加HDL胆固醇。 所述提取物可用于使脂质和碳水化合物平衡正常化，并通过有利地改变LDL / HDL比例显着增加HDL胆固醇的值，特别是在药物诱导的血脂异常的梗死后患者中。
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45.发明申请公开(公告)号：US20130280355A1
公开(公告)日：2013-10-24
申请号：US13878520
申请日：2011-10-05
CPC分类号： A61K36/00 , A61K36/185 , A61K36/28 , A61K36/45 , A61K2300/00
摘要： The present invention relates to formulations containing extracts of Vaccinium myrtillus or other species rich in anthocyanosides, Punica granatum, Echinacea, and optionally Krameria triandra. Said formulations are useful in the treatment of disorders of the mouth and its adnexa, the throat and respiratory tract, and in the treatment of influenza.
摘要翻译： 本发明涉及含有牛痘提取物或富含花色素苷的其他物种，扁桃属，松果菊，以及任选的克拉克氏菌（Krameria triandra）的制剂。 所述制剂可用于治疗口腔及其附件，咽喉和呼吸道疾病以及治疗流行性感冒。
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公开(公告)号：US08343554B2
公开(公告)日：2013-01-01
申请号：US10562205
申请日：2004-01-06
申请人： Ezio Bombardelli
发明人： Ezio Bombardelli
CPC分类号： A61K31/19 , A61K31/045 , A61K31/353 , A61K31/7008 , A61K36/185 , A61K36/324 , A61K36/76 , A61K36/82 , A61K36/87 , A61K2300/00
摘要： The present invention relates to formulations comprising combinations of analgesic/anti-inflammatory, immunomodulating and cartilage-reconstructing agents in particular comprising saligenig, boswellic acid, procyanidins, N-acety-glucosamine and either glucoronic acid or glucoronolactone, for the treatment of rheumatoid arthritis and, more generally, of arthritis conditions.
摘要翻译： 本发明涉及包含镇痛/抗炎，免疫调节和软骨重建剂的组合的制剂，特别是包括苦参碱，保乳酸，原花青素，N-乙酰葡糖胺和葡萄糖酸或葡萄糖内酯，用于治疗类风湿性关节炎和 ，更一般地，关节炎状况。
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47.发明申请FORMULATIONS WITH SANGUINARINE, CHELERYTHRINE OR CHELIDONINE FOR THE TREATMENT OF WARTS, VERRUCAS AND PSORIATIC PLAQUES 审中-公开用于治疗战争，威胁和精神病毒药物的配方与香兰素，儿茶素或儿茶素公开(公告)号：US20120263810A1
公开(公告)日：2012-10-18
申请号：US13530721
申请日：2012-06-22
IPC分类号： A61K31/4741 , A61P17/12 , A61K36/758 , A61K36/28 , A61K36/71 , A61K36/87
CPC分类号： A61K36/66 , A61K31/4741 , A61K36/75 , Y10S514/863
摘要： The invention provides formulations containing sanguinarine, chelerythrine or chelidonine or their salts or extracts containing them, mixed with suitable vehicles and/or excipients, for the treatment of common skin warts and verrucas, anal and vulvar warts and psoriatic plaques.
摘要翻译： 本发明提供含有血根碱，螯合物或螯合物或其含有它们的盐或提取物的配方，与合适的载体和/或赋形剂混合，用于治疗常见的皮肤疣和疣状，肛门和外阴疣以及牛皮癣斑块。
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公开(公告)号：US08217053B2
公开(公告)日：2012-07-10
申请号：US12374963
申请日：2007-07-13
申请人： Gabriele Fontana , Ezio Bombardelli , Carla Manzotti , Arturo Battaglia , Maria Grazia Allegri, legal representative , Cristian Samori′
IPC分类号： A61K31/4745 , C07D491/22
CPC分类号： C07D491/22
摘要： Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
摘要翻译： 具有抗肿瘤活性的新型喜树碱衍生物，其制备方法，其作为抗肿瘤药物的用途和含有它们的药物组合物。
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49.发明授权Method of reducing blood cholesterol and triglyceride levels using combinations of vasoprotective agent 有权使用血管保护剂的组合降低血液胆固醇和甘油三酯水平的方法公开(公告)号：US08206759B2
公开(公告)日：2012-06-26
申请号：US13033826
申请日：2011-02-24
申请人： Ezio Bombardelli
发明人： Ezio Bombardelli
IPC分类号： A01N65/00
CPC分类号： A61K31/045 , A23L33/10 , A23L33/105 , A23L33/115 , A61K31/01 , A61K31/20 , A61K31/355 , A61K2300/00
摘要： Combinations of vasoprotective agents useful for the treatment of reducing blood cholesterol and triglyceride levels induced by an excess of plasma lipids. The agents include polycosanols, tocotriends and/or lycopene, procyanidole oligomers and vegetable oil rich in insaturated fatty acids.
摘要翻译： 用于治疗由过量血浆脂质诱导的降低血液胆固醇和甘油三酯水平的血管保护剂的组合。 这些试剂包括聚花生醇，类植物和/或番茄红素，原花青素低聚物和富含不饱和脂肪酸的植物油。
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50.发明申请COMBINATIONS OF VASOACTIVE SUBSTANCES WITH ESTROGENS AND THEIR USE IN THE TREATMENT OF FEMALE SEXUAL DYSFUNCTIONS 失效挥发性物质与雌激素的组合及其在治疗女性性功能障碍中的应用公开(公告)号：US20100183751A1
公开(公告)日：2010-07-22
申请号：US12667392
申请日：2008-06-26
申请人： Ezio Bombardelli
发明人： Ezio Bombardelli
IPC分类号： A61K36/23 , A61K31/352 , A61K31/7048 , A61P15/12
CPC分类号： A61K36/23
摘要： Compositions comprising: vasokinetic natural coumarins or extracts containing them; anti-phosphodiesterase agents selected from 3,7-O-di-(2-hydroxyethyl)icaritin or 7-O-hydroxyethyl-icariside II and/or forskolin or extracts containing them; phytoestrogens selected from ferutinine or ferutinine-containing extracts of Ferula sp. or p-pivaloylferutinine.
摘要翻译： 组合物包含：血管动力学天然香豆素或含有它们的提取物; 选自3,7-O-二 - （2-羟乙基）甲氰菊酯或7-O-羟乙基 - 酰胺二糖和/或毛喉素或含有它们的提取物的抗磷酸二酯酶试剂; 植物雌激素选自含有Ferutinine或Ferutinine的Ferula sp。提取物。 或对新戊酰呋喃蛋白。
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