公开(公告)号：US06828468B2

公开(公告)日：2004-12-07

申请号：US10138338

申请日：2002-05-06

申请人： Andreas Ansmann ,  Jochem Henkelmann ,  Alois Kindler ,  Heinz Etzrodt ,  Carsten Oost ,  Susanne Stutz ,  Christian Tragut ,  Bernhard Bockstiegel ,  Klaus Reimer ,  Manfred Stroezel ,  Walter Dobler

发明人： Andreas Ansmann ,  Jochem Henkelmann ,  Alois Kindler ,  Heinz Etzrodt ,  Carsten Oost ,  Susanne Stutz ,  Christian Tragut ,  Bernhard Bockstiegel ,  Klaus Reimer ,  Manfred Stroezel ,  Walter Dobler

IPC分类号： C07C3304

CPC分类号： C07C49/203 ,  B01J23/44 ,  B01J23/50 ,  B01J35/04 ,  B01J35/06 ,  B01J37/0225 ,  C07C29/17 ,  C07C29/42 ,  C07C45/62 ,  C07C45/676 ,  C07C33/02 ,  C07C33/048 ,  C07C49/04

摘要： Higher &agr;,&bgr;-unsaturated alcohols are prepared by monoethynylation of a ketone by the NH3/KOH method, if desired hydrogenation of the acetylene alcohol in the presence of hydrogen over a Pd-containing thin layer catalyst, purifying distillation of the hydrogenation product, preferably in a dividing wall column with recirculation of the unreacted ketone to the ethynylation step, and, if desired, preparation of higher alcohols having in each case 5 more carbon atoms in the chain by reacting the alcohols prepared by monoethynylation and, if desired, partial hydrogenation with alkyl acetoacetates diketene in a Carroll reaction to form ketones and using these as starting materials for the steps ethynylation, optional hydrogenation and fractional distillation.

摘要翻译： 如果需要在氢气存在下在含Pd的薄层催化剂上氢化乙炔醇，纯化氢化产物的蒸馏，优选的是通过NH 3 / KOH方法将酮单异构化制备较高级的α，β-不饱和醇 在具有未反应酮再循环至乙炔化步骤的分隔壁塔中，并且如果需要，通过使通过单异丁烯基化制备的醇和如果需要的话进行部分氢化制备在各种情况下在链中多出5个碳原子的高级醇 在Carroll反应中使用烷基乙酰乙酸酯双烯酮形成酮，并将其用作步骤乙炔化，任选的氢化和分馏的起始原料。

公开(公告)号：US5919414A

公开(公告)日：1999-07-06

申请号：US765137

申请日：1997-03-10

申请人： Walter Dobler

发明人： Walter Dobler

IPC分类号： B29C31/00 ,  B29C37/00 ,  B29C45/14 ,  B29C45/32 ,  B29C45/42 ,  B29C51/16

CPC分类号： B29C37/0007 ,  B29C45/14008 ,  B29C51/165 ,  B29C2045/1404 ,  B29C2045/14918 ,  B29C2045/425 ,  B29C31/00 ,  B29C45/32 ,  B29C45/42

摘要： The present invention relates to a method for providing at least one insertion label on a tool of a machine, the insertion label being insertable into a mold half of a tool of a plastics processing machine, in particular injection molding machine or deep-drawing machine. In this method insertion labels are punched out of label web material by means of a punching device consisting essentially of a punching plate and a cutting tool. The insertion labels are transferred by a carrier, which belongs to the punching device, to the tool of the machine and are discharged for insertion thereinto. So far a great problem has consisted in performing such a transfer in such a manner that the insertion label is positioned in a sufficiently precise manner without creases. This problem is overcome in that after the punching operation the insertion labels are held by the punching plate which is movable substantially in a direction transverse to the punching direction and formed as a carrier, and are transferred to the tool of the machine. Furthermore, the present invention relates to an apparatus for performing the method.

摘要翻译： PCT No.PCT / EP95 / 02505 Sec。 371日期1997年3月10日 102（e）1997年3月10日PCT PCT。1995年6月27日PCT公布。 公开号WO96 / 02378 日期1996年2月1日本发明涉及一种在机器的工具上提供至少一个插入标签的方法，该插入标签可插入到塑料加工机器的工具的半模中，特别是注塑机或 深拉机。 在这种方法中，插入标签通过基本上由冲压板和切割工具组成的冲压装置从标签网材料上冲出。 插入标签由属于冲孔装置的承载件传送到机器的工具，并被排出以插入其中。 到目前为止，一个很大的问题在于进行这种转移，使得插入标签以足够精确的方式定位而没有折痕。 克服了这个问题，因为在冲压操作之后，插入标签被冲压板保持，该冲压板可以基本上沿与冲切方向横切的方向移动并且形成为载体，并且被传送到机器的工具。 此外，本发明涉及一种用于执行该方法的装置。

公开(公告)号：US5773635A

公开(公告)日：1998-06-30

申请号：US498840

申请日：1995-07-06

申请人： Walter Dobler ,  Wolfgang Krause ,  Joachim Paust ,  Otto Worz ,  Udo Rheude ,  Wolfram Burst ,  Gunter Dauwel ,  Armin Bertram ,  Bernhard Schulz ,  Gunter Wegner ,  Peter Munster ,  Hansgeorg Ernst ,  Arno Kochner ,  Heinz Etzrodt

发明人： Walter Dobler ,  Wolfgang Krause ,  Joachim Paust ,  Otto Worz ,  Udo Rheude ,  Wolfram Burst ,  Gunter Dauwel ,  Armin Bertram ,  Bernhard Schulz ,  Gunter Wegner ,  Peter Munster ,  Hansgeorg Ernst ,  Arno Kochner ,  Heinz Etzrodt

IPC分类号： C07C51/16 ,  C07C403/00 ,  C07C403/20

CPC分类号： C07C403/20 ,  C07C403/16 ,  C07B2200/09 ,  C07C2101/16

摘要： A process for preparing polyenecarbonyl compounds having a high all-E content and their acetals or ketals by aldol condensation or Horner-Emmons reaction comprises carrying out the reaction, for the purposes of the preferred formation of a double bond of E configuration and in order to maintain the E configuration of the double bonds in the stating compounds as completely as possible, in the presence of oxygen or an oxygen-inert gas mixture or nitric oxide or a nitric oxide-inert gas mixture and/or in the presence of specific stable radicals and/or in the presence of quinones or quinone derivatives.

摘要翻译： 通过醛醇缩合或霍纳 - 埃蒙斯反应制备具有高全E含量的多元羰基化合物及其缩醛或缩酮的方法包括进行反应，为了优选形成E构型的双键，为了 在氧气或氧惰性气体混合物或一氧化氮或一氧化氮惰性气体混合物的存在下和/或在特定的稳定基团的存在下，尽可能地完全地保持化合物中双键的E构型 和/或在醌或醌衍生物的存在下。

公开(公告)号：US5654444A

公开(公告)日：1997-08-05

申请号：US621035

申请日：1996-03-22

申请人： Michael John ,  Walter Dobler ,  Joachim Paust

发明人： Michael John ,  Walter Dobler ,  Joachim Paust

IPC分类号： C07D307/60

CPC分类号： C07D307/60

摘要： 5-Hydroxy-4-methyl-2(5H)-furanone is prepared by cyclization of alkyl .beta.-formylcrotonates by heating with dilute aqueous hydrochloric acid or, advantageously, in the presence of dilute aqueous hydrochloric acid and catalytic amounts of methanol as solubilizer, subsequent workup of the reaction mixture by distillation and, where appropriate, isomerization of the 5-methoxy- or 5-ethoxy-4-methyl-2(5H)-furanone, which is formed as byproduct, by heating with dilute hydrochloric acid.

摘要翻译： 5-羟基-4-甲基-2（5H） - 呋喃酮是通过用稀盐酸水溶液加热或有利地在稀盐酸水溶液和催化量的甲醇作为增溶剂的存在下，通过环化β-甲酰基巴豆酸烷基酯来制备的， 随后通过蒸馏和通过用稀盐酸加热作为副产物形成的5-甲氧基 - 或5-乙氧基-4-甲基-2（5H） - 呋喃酮的异构化反应混合物进行后处理。

公开(公告)号：US5625099A

公开(公告)日：1997-04-29

申请号：US471314

申请日：1995-05-23

申请人： Hansgeorg Ernst ,  Walter Dobler ,  Joachim Paust ,  Udo Rheude

发明人： Hansgeorg Ernst ,  Walter Dobler ,  Joachim Paust ,  Udo Rheude

IPC分类号： C07C41/18 ,  C07C45/45 ,  C07C49/303 ,  C07C403/24 ,  C07D317/46 ,  C07D317/50 ,  C07D317/54 ,  C07D407/06 ,  C07D407/12 ,  C07F9/54 ,  C09B23/10

CPC分类号： C07C403/24 ,  C07C403/04 ,  C07C403/08 ,  C07C403/10 ,  C07D317/46 ,  C07F9/5435 ,  C07F9/5442 ,  C07C2101/16 ,  Y02P20/55

摘要： Abstract of the Disclosure: Compounds of the formula I ##STR1## where R.sup.1 is H or C.sub.1 -C.sub.4 -alkyl, R.sup.2 is C.sub.1 -C.sub.4 -alkyl and R.sup.3 is an ether, silyl ether or acetal protective group which can be converted into a hydroxyl group by hydrolysis, in particular one of the radicals ##STR2## and a process for preparing these compounds by reacting an alkenyne of the formula II ##STR3## in an inert solvent in the presence of lithium amide with a cyclohexenone of the formula III ##STR4## and the use of the compounds of the formula I for preparing astaxanthin, are described.

摘要翻译： 本发明摘要：式Ⅰ化合物其中R 1为H或C 1 -C 4烷基，R 2为C 1 -C 4烷基，R 3为醚，可转化的甲硅烷基醚或缩醛保护基 通过水解形成羟基，特别是一个基团，以及通过在惰性溶剂中在酰胺与环己烯酮的存在下使式II的烯键（II）反应来制备这些化合物的方法 描述了式III（III）化合物和式I化合物用于制备虾青素的用途。

公开(公告)号：US5380920A

公开(公告)日：1995-01-10

申请号：US113089

申请日：1993-08-30

申请人： Joachim Paust ,  Peter Eckes ,  Wolfgang Siegel ,  Friedhelm Balkenhohl ,  Walter Dobler ,  Michael Hullmann

发明人： Joachim Paust ,  Peter Eckes ,  Wolfgang Siegel ,  Friedhelm Balkenhohl ,  Walter Dobler ,  Michael Hullmann

IPC分类号： C07C69/708 ,  C07C319/08 ,  C07C323/52 ,  C07D313/04 ,  C07D339/04 ,  C07C53/126 ,  C07C53/02 ,  C07C67/36

CPC分类号： C07C69/708 ,  C07C319/08 ,  C07D313/04 ,  C07D339/04

摘要： A process for preparing R/S-.gamma.-lipoic acid of the formula I or R/S-.alpha.-lipoic acid of the formula II ##STR1## is disclosed.

摘要翻译： 公开了制备式I的R /S-γ-硫辛酸或式II的R / S-α-硫辛酸的方法（I）图像（II）。

公开(公告)号：US5015296A

公开(公告)日：1991-05-14

申请号：US184805

申请日：1988-04-22

申请人： Walter Dobler ,  Joachim Paust

发明人： Walter Dobler ,  Joachim Paust

IPC分类号： C07B61/00 ,  C07H3/02

CPC分类号： C07H3/02

摘要： Pentoses and hexoses are continuously epimerized by heating a sugar in solution in a solvent in the presence of a basic anion exchanger charged with a molybedenum(VI) compound by preparing a D- or L-sugar having cis-disposed OH groups in the 2- and 3-positions of the sugar by continuously passing a homogeneous solution of the corresponding sugar having transdisposed OH groups in the 2- and 3-positions of the sugar in a mixture of water and methanol or ethanol at from 70.degree. to 100.degree. C., preferably at from 73.degree. and 80.degree. C., through a reaction tube which contains the basic anion exchanger charged with the molybdenum(VI) compound, this method being suitable in particular for epimerizing D-arabinose to prepare D-ribose required for the production of riboflavin.

摘要翻译： 戊二酸和己糖通过在带有钼（VI）化合物的碱性阴离子交换剂存在下，在溶剂中加热溶液而连续差向异构化，通过制备在2-位上具有顺式设置的OH基团的D-或L-糖， 和糖的3-位，通过在70至100℃的水和甲醇或乙醇的混合物中连续通过糖的2-位和3-位的具有反式OH基团的相应糖的均匀溶液。 ，优选在73℃和80℃，通过含有装载有（VI）化合物的碱性阴离子交换剂的反应管，该方法特别适合于差向异构化D-阿拉伯糖以制备D-阿拉伯糖所需的D-核糖 生产核黄素。

公开(公告)号：US4987229A

公开(公告)日：1991-01-22

申请号：US323795

申请日：1989-03-15

申请人： Walter Dobler ,  Manfred Eggersdorfer ,  Joachim Paust

发明人： Walter Dobler ,  Manfred Eggersdorfer ,  Joachim Paust

IPC分类号： C07D475/14 ,  C07F9/6561

CPC分类号： C07F9/65618

摘要： Salts of riboflavin 5'-phosphate which are obtained by phosphorylation of riboflavin and reaction of the resulting riboflavin 5'-phosphate (5'-FMN), contaminated with unconverted riboflavin and isomeric riboflavin monophosphates and diphosphates, with an alkali metal hydroxide or a nitrogen base are purified by a process in which(a) a roughly 1-15% strength by weight homogeneous, clear, aqueous 5'-FMN salt solution having a pH of from 4 to 7 is prepared from the crude 5'-FMN obtained in the phosphorylation, water and the alkali metal hydroxide or the nitrogen base, preferably sodium hydroxide solution, if necessary with heating at from 30.degree. to 100.degree. C.,(b) the resulting solution is treated with a suitable polymeric adsorber resin and(c) the 5'-FMN salt substantially freed from unconverted riboflavin is isolated from the resulting solution and, if desired, the solution is fed to a subsequent fine purification.Treatment with the suitable polymeric adsorber resin is advantageously carried out in a column filled with adsorber resin. The subsequent fine purification can be effected by evaporative crystallization or by chromatographing a 5'-FMN solution, containing from 1 to 15% by weight of dry substance, in water or in a mixture of water and a lower aliphatic alcohol, having a pH of from 4 to 7, in a minimum amount of from 5 to 50% of the bed volume of the column over RP silica gel derivatized with alkyl groups, using water, or a mixture of water and a lower aliphatic alcohol, as the eluant. Preparative chromatography of 5'-FMN salts over derivatized RP silica gel using water, or a mixture of water and a lower aliphatic alcohol, as the solvent and eluant is also claimed independently of pretreatment with the suitable adsorber resin.

摘要翻译： 通过核黄素磷酸化获得的核黄素5'-磷酸盐的盐和由未转化的核黄素和异构核黄素单磷酸酯和二磷酸酯污染的所得核黄素5'-磷酸（5'-FMN）与碱金属氢氧化物或氮 碱通过以下方法纯化，其中（a）从所得粗制5'-FMN制备了具有约1-15％重量的均匀，透明的pH5-4的5-FMN盐水溶液， 磷酸化，水和碱金属氢氧化物或氮碱，优选氢氧化钠溶液，如果需要，在30℃至100℃下加热，（b）所得溶液用合适的聚合物吸附树脂处理，（c ）从所得溶液中分离出基本上未转化的核黄素的5'-FMN盐，并且如果需要，将溶液加入到随后的精细纯化中。 用合适的聚合物吸附树脂处理有利地在填充有吸附树脂的柱中进行。 随后的精细纯化可以通过蒸发结晶或通过色谱法将含有1至15重量％干物质的5-FMN溶液在水或水和低级脂族醇的混合物中进行，其pH为 作为洗脱剂，使用水或水和低级脂族醇的混合物，用烷基衍生的RP硅胶的柱体积的最小量为5至50％。 独立于合适的吸附剂树脂的预处理，也要求使用水，或水和低级脂族醇的混合物作为溶剂和洗脱剂的衍生化RP硅胶的5-FMN盐的制备色谱法。