摘要:
The invention relates to a method of treating central nervous system disorders and other disorders by administering an alpha2delta ligand such as, for example, a compound of the formula or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.
摘要:
A locking system (12) for a mold (14) includes a first mold half (20), a second mold half (22), and a lock assembly that is coupled to one of the mold halves (20, 22). The lock assembly includes a wear plate (80), that is disposed between the first mold half (20) and the second mold half (22), and an adjustment element (86), which is disposed between the wear plate (80) and one of the mold halves (20,22). The lock assembly also includes a wear plate locking fastener (84), that locks the position of the wear plate (80), and an adjustment fastener (88), which is separate therefrom and adjusts the position of the wear plate (80).
摘要:
The present invention provides for an improved trim part, e.g. a bolster or trim plate, with integrated appliqué for use in a trim assembly, and to a continuous two-shot molding operation that may be performed utilizing a single mold assembly. In an exemplary embodiment, the trim part, i.e. a bolster, includes a substrate formed by injecting a first material into a first shot mold cavity in a first shot of a molding operation. An appliqué is provided in a second shot mold cavity then a cover is formed between the substrate and appliqué by injecting into a mold chamber a second foamed material in a second shot of the molding operation. The formed cover is integrally molded to at least a portion of the substrate and the appliqué to form a trim part with integrated appliqué.
摘要:
The instant invention relates to a combination, particularly a synergistic combination, of an alpha-2-delta ligand and a dual serotonin-noradrenaline re-uptake inhibitor (DSNRI) or one or both of a selective serotonin re-uptake inhibitor (SSRI) and a selective noradrenaline re-uptake inhibitor (SNRI), and pharmaceutically acceptable salths thereof, pharmaceutical compositions thereof and their use in the treatment of pain, particularly neuropathic pain.
摘要:
A switch node includes arbiter logic configured to gather global information regarding switching requests within the switch node and to control switching of one or more packets through the switch node. The arbiter logic may include a bus snooping interface configured to detect the switching requests within the switch node. The bus snooping interface includes a plurality of switching request destination registers configured to store switching request destination information from the detected switching requests. In addition, the arbiter logic includes a packet switching request array configured to transmit a next switching request within the switch node according to prior switching request destination information stored in the switching request destination registers. The switching of the one or more packets may be through a cross-point switch matrix in the switch node.
摘要:
A method is provided for forming a welt in a single sheet of coverstock by folding and sewing. A second method is provided for forming a welt adjacent a seam formed by sewing two sheets of coverstock together, the method requiring less selvage from one of the sheets.
摘要:
A common access ring (CAR) architecture that supports multiple masters and slaves is provided. One or more masters may make a request on the ring at the same time, such that multiple transactions are simultaneously pending. Moreover, multiple masters may simultaneously make a request to the same slave. However, each master cannot make more than one request at a time, and must wait until a current request is completed before making another request. The ring architecture ensures that no more than one request arrives at a slave at any given time. If a request arrives while a slave is processing a previous request, the arriving request is not serviced, and the master that originated the arriving request is asked to retry the request at a later time. Atomic shadow-write operations are supported by including all shadow registers in a dedicated sub-ring of the CAR architecture.
摘要:
The present invention provides for an improved bolster with a soft feel for use in a trim assembly, and to a continuous two-shot molding operation that may be continuously performed utilizing a single mold assembly. In an exemplary embodiment, the bolster includes a substrate formed by co-injecting a first and second material into a first shot mold cavity in a first shot of a molding operation. In a second shot mold cavity, a cover is formed on at least a portion of the substrate by co-injecting into a mold chamber a third and fourth material in a second shot of the molding operation. The fourth material defines an outer skin surrounding the third material which may include a foamed material to provide a soft, light cellular inner core such that when a force is applied to the cover, the outer skin will deform and compress the inner core, providing a soft feel to the bolster.
摘要:
The invention relates to a method of treating central nervous system disorders and other disorders by administering an alpha2delta ligand such as, for example, a compound of the formula or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.
摘要:
This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs syndrome, premenstrual dysphoric disorder, hot flashes, and fibromyalgia by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; and R2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S,5R)-3-Aminomethyl-5-methyl-octanoic acid.