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    Multi-channel pipettor with variably repositionable tips
    41.
    发明授权
    Multi-channel pipettor with variably repositionable tips 有权
    多通道移液器，具有可变位置的尖端

    公开(公告)号：US08518345B2

    公开(公告)日：2013-08-27

    申请号：US13411675

    申请日：2012-03-05

    Applicant: David E. Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

    Inventor： David E. Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

    IPC: B01L3/00 ,  B01L3/02 ,  G01N1/14

    CPC classification number: B01L3/0237 ,  B01L3/0217 ,  B01L3/0227 ,  B01L2200/022

    Abstract: A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

    Abstract translation: 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

    Locking pipette tip and mounting shaft
    42.
    发明授权
    Locking pipette tip and mounting shaft 有权
    锁定吸头和安装轴

    公开(公告)号：US07662343B2

    公开(公告)日：2010-02-16

    申请号：US11552384

    申请日：2006-10-24

    Applicant: Gregory Mathus ,  Terrence Kelly ,  Richard Cote

    Inventor： Gregory Mathus ,  Terrence Kelly ,  Richard Cote

    IPC: B01L3/02

    CPC classification number: B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/087

    Abstract: The invention relates to a pipette tip mounting shaft configuration and a disposable pipette tip having a matching configuration. The mounting shaft includes a locking section located above a lower sealing section. The locking section has outwardly extending locking lobes circumferentially spaced around the mounting shaft and located above a stop member that separates the lower sealing section from the upper locking section. When the mounting shaft is fully inserted into the collar of the mating disposable pipette tip, the tip locks onto the mounting shaft. The bore of the pipette tip includes a circumferential shelf separating its upper collar from the tip sealing area which is located below the circumferential shelf. The locking lobes gently flexes and distorts the pipette tip collar out of round as the mounting shaft is inserted in the pipette tip, rather than stretching the tip collar. The circumferential shelf on the pipette tip between the tip collar and the barrel isolates the sealing area at the upper end of the barrel from distortion, thus facilitating reliable sealing engagement.

    Abstract translation: 本发明涉及移液器吸头安装轴构造和具有匹配构型的一次性吸头。 安装轴包括位于下密封部分上方的锁定部分。 锁定部分具有沿安装轴周向间隔开的向外延伸的锁定凸角，并且位于将下部密封部分与上部锁定部分分离的止挡部件上方。 当安装轴完全插入到匹配的一次性移液管尖端的轴环中时，尖端锁定在安装轴上。 移液管尖端的孔包括将其上部套环与位于周向架下方的尖端密封区域分开的周向架。 当安装轴插入移液管尖端时，锁定凸耳轻轻地弯曲和扭曲移液管尖端套环，而不是拉伸尖端套环。 吸头尖端在圆顶架和圆筒之间的圆周架子隔开了筒体上端的密封区域，使其不会变形，从而有利于可靠的密封接合。

    Multi-well assembly for growing cultures in-vitro
    46.
    发明授权
    Multi-well assembly for growing cultures in-vitro 失效
    用于体外培养培养物的多孔组装

    公开(公告)号：US06943009B2

    公开(公告)日：2005-09-13

    申请号：US10146831

    申请日：2002-05-15

    Applicant: William J. Lacey ,  Gregory Mathus ,  David M. Root ,  John A. Ryan

    Inventor： William J. Lacey ,  Gregory Mathus ,  David M. Root ,  John A. Ryan

    IPC: B01L3/00 ,  B29C33/00 ,  B29C33/44 ,  B29C33/76 ,  C12M1/32 ,  C12M1/12

    CPC classification number: B01L3/50853 ,  B01L2200/026 ,  B01L2300/046 ,  B01L2300/0829 ,  B29C33/0033 ,  B29C33/44 ,  B29C33/76 ,  C12M21/06 ,  C12M23/12 ,  C12M23/24

    Abstract: A high-throughput cell or tissue culture apparatus, which is configurable to an industry-standard well plate format, is provided. The apparatus comprises a number of vessels, which may be suspended in wells of a plate. Each vessel has at least one sidewall defining a first opening and a second opening, each of predetermined cross-sectional area. The second opening has an inner cross-sectional area greater than either the inner cross-sectional area of the first opening or a cross-sectional area in a horizontal plane between the first and second openings. A relatively large substrate area is provided in each vessel for supporting tissue cultures in a fluid medium.

    Abstract translation: 提供了可配置为工业标准孔板格式的高通量细胞或组织培养装置。 该装置包括许多容器，其可以悬浮在板的孔中。 每个容器具有限定第一开口和第二开口的至少一个侧壁，每个预定横截面积。 第二开口具有大于第一开口的内截面积或第一和第二开口之间的水平平面中的横截面积的内横截面面积。 在每个容器中提供相对大的衬底面积，用于支持流体介质中的组织培养。

    Method of making microplates with UV permeable bottom wells
    47.
    发明授权
    Method of making microplates with UV permeable bottom wells 有权
    用UV透过性底孔制作微孔板的方法

    公开(公告)号：US6103169A

    公开(公告)日：2000-08-15

    申请号：US153134

    申请日：1998-09-15

    Applicant: Gregory Mathus ,  Paul M. Szlosek ,  William J. Lacey

    Inventor： Gregory Mathus ,  Paul M. Szlosek ,  William J. Lacey

    IPC: G01N1/00 ,  B01L3/00 ,  B29C45/14 ,  B29D99/00 ,  B29K105/32 ,  B29L22/00 ,  B29L31/00 ,  B32B27/30 ,  C08L27/12 ,  C12M1/32 ,  G01N1/10 ,  G01N21/03 ,  G01N21/25 ,  G01N21/33

    CPC classification number: B01L3/5085 ,  B29C45/1418 ,  B29C45/14344 ,  B29C45/14778 ,  G01N21/03 ,  G01N21/25 ,  G01N21/33 ,  B01L2300/0829 ,  B01L2300/12

    Abstract: Microplates and methods for manufacturing microplates. The microplate is designed to allow UV radiation to pass through the bottom wells of the microplate so that the microplate can be used for assaying samples by use of UV absorbance. In one embodiment, the microplate comprises at least first and second wells, each well having a UV permeable bottom. In another embodiment, the microplate comprises a frame having an upper portion and a lower portion contiguous with the upper portion and a sheet disposed between the upper portion and the lower portion and defining the bottom of at least one well of the microplate. One embodiment of the method includes steps of inserting a sheet of UV permeable material into a mold cavity that includes sections shaped to form the sidewalls of the plurality of wells, injecting molten plastic material into the mold cavity, and cooling the plastic material to form the microplate with the plastic material forming the sidewalls of each of the first and second wells and the sheet of UV permeable material forming the bottom of each of the first and second wells. Another embodiment of the method includes providing an upper plate defining sidewalls of at least one well, adhering an intermediate layer to the upper plate and adhering a sheet of UV permeable material to the intermediate layer. A further embodiment of the method includes inserting a sheet of material having at least one hole into a mold cavity, injecting a molten plastic material into the mold cavity and cooling the plastic material to form a microplate.

    Abstract translation: 微孔板和微孔板制造方法。 微孔板被设计成允许紫外线辐射通过微板的底部孔，使得微孔板可以用于通过使用UV吸光度来测定样品。 在一个实施方案中，微板包括至少第一和第二孔，每个孔具有可UV透过的底部。 在另一个实施例中，微孔板包括具有与上部邻接的上部和下部的框架，以及设置在上部和下部之间并限定微板的至少一个孔的底部的框架。 该方法的一个实施例包括以下步骤：将一片UV可渗透材料插入到模腔中，该模腔包括成形为形成多个孔的侧壁的部分，将熔融的塑料材料注入模腔中，并冷却塑料材料以形成 微板与塑料材料形成第一和第二阱中的每一个的侧壁以及形成第一和第二孔中每一个的底部的UV透过材料片。 该方法的另一实施例包括提供限定至少一个阱的侧壁的上板，将中间层粘附到上板并将一片UV可渗透材料粘合到中间层。 该方法的另一实施例包括将具有至少一个孔的材料片插入模腔中，将熔融的塑料材料注入模腔并冷却塑料以形成微板。

    Reversible membrane insert for growing tissue cultures
    48.
    发明授权
    Reversible membrane insert for growing tissue cultures 失效
    用于生长组织培养物的可逆膜插入物

    公开(公告)号：US5759851A

    公开(公告)日：1998-06-02

    申请号：US510852

    申请日：1995-08-03

    Applicant: Gregory Mathus

    Inventor： Gregory Mathus

    IPC: C12M3/06 ,  C12N5/06 ,  C12M3/00

    CPC classification number: C12M25/04 ,  Y10S435/809

    Abstract: A device and method for growing tissue or cells on both sides of a membrane includes a cylindrical body which may be stood on either end in a culture well. A frame is slidably mounted in the body and carries a membrane, on both sides of which tissue or cells are to be grown. A tissue or cell sample is placed on the upper surface of the membrane and media is supplied to the well on the outside of the body. Passages at the bottom of the body allow the media to flow to the membrane and nurture the sample to cause its growth. When the first monolayer is grown, the body is inverted and the frame is pushed to the other end of the body, preferably by a jig supplied for that purpose. A second cell sample is deposited on the other side of the membrane, again on top of the membrane and it is nurtured by media supplied primarily from the reservoir on top and secondarily through the membrane.

    Abstract translation: 用于在膜的两侧生长组织或细胞的装置和方法包括可以位于培养井中的任一端的圆柱体。 框架可滑动地安装在主体中并且在其组织或细胞将要生长的两侧上承载膜。 将组织或细胞样品放置在膜的上表面上，并将介质提供给身体外部的孔。 身体底部的通道允许介质流到膜上并培养样品以使其生长。 当第一单层生长时，主体被倒置并且框架被推动到主体的另一端，优选地通过为此目的提供的夹具。 第二个细胞样品沉积在膜的另一侧，再次沉积在膜的顶部，并且由主要从储存器供应的介质在上部和第二次通过膜培养。

    Non-screeching laboratory article
    49.
    发明授权
    Non-screeching laboratory article 失效
    非尖锐的实验室文章

    公开(公告)号：US5508005A

    公开(公告)日：1996-04-16

    申请号：US142520

    申请日：1993-10-26

    Applicant: Gregory Mathus

    Inventor： Gregory Mathus

    IPC: B01L3/00 ,  C12M1/20

    CPC classification number: B01L3/5085 ,  C12M23/12

    Abstract: A laboratory article, and in particular a cluster plate is provided including a plurality of wells supported by a structural framework including a peripheral wall. At locations in the structural framework a plurality of protrusions are provided so as to support the cluster plate on a support surface, such as a benchtop, in a point-to-point manner. Such point-to-point support allows the article to be moved across the support surface without the generation of unpleasant audible vibrations. According to a preferred embodiment, a cluster plate having protrusions extending from the lower edge of a peripheral wall is provided.

    Abstract translation: 提供实验室物品，特别是集群板，其包括由包括周壁的结构框架支撑的多个井。 在结构框架中的位置处，设置有多个突起，以便以点对点方式将簇板支撑在诸如台面的支撑表面上。 这种点对点支撑允许物品跨过支撑表面移动，而不会产生不愉快的可听见的振动。 根据优选实施例，提供了具有从周壁的下边缘延伸的突起的簇板。

    Filter for centrifuge tube
    50.
    发明授权
    Filter for centrifuge tube 失效
    过滤离心管

    公开(公告)号：US4683058A

    公开(公告)日：1987-07-28

    申请号：US841583

    申请日：1986-03-20

    Applicant: George F. Lyman ,  Gregory Mathus

    Inventor： George F. Lyman ,  Gregory Mathus

    IPC: B04B5/02 ,  B01D33/15 ,  B01D63/08 ,  B01D63/16 ,  B01L3/14 ,  B04B5/04 ,  B01D33/00

    CPC classification number: B01L3/5021 ,  B01D33/15 ,  B04B5/0414 ,  B01D2201/285

    Abstract: A filter for a centrifuge tube including a pressure filter for separating a mixture under centrifugal force. The filter tube is adapted to fit within the upper portion of a standard plastic centrifuge tube. The filter tube has a pressure filter at its lower end and an opening at its upper end adapted to be sealed by a cap extending from the centrifuge tube to hold the filter tube securely in position within the centrifuge tube. The filter tube is filled with a mixture of permeable and non-permeable materials and when the composite centrifuge tube and filter tube is spun in the centrifuge, the centrifugal force causes the permeable materials to flow through the filter and collect in the bottom of the centrifuge tube while the non-permeable materials are retained in the filter tube.

    Abstract translation: 一种用于离心管的过滤器，包括用于在离心力下分离混合物的压力过滤器。 过滤管适于装配在标准塑料离心管的上部。 过滤管在其下端具有压力过滤器，其上端的开口适于由从离心管延伸的盖密封，以将过滤管牢固地固定在离心管内的适当位置。 过滤管填充有可渗透和不可渗透材料的混合物，当复合离心管和过滤管在离心机中旋转时，离心力使渗透材料流过过滤器并收集在离心机的底部 而不可渗透的材料保留在过滤管中。

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