公开(公告)号：US09518020B2

公开(公告)日：2016-12-13

申请号：US15026694

申请日：2014-09-29

Applicant: Hetero Research Foundation

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Thungathurthy Srinivasa Rao ,  Bandi Vamsi Krishna

IPC: C07D213/68 ,  C07D213/81

CPC classification number: C07D213/81 ,  C07B2200/13

Abstract: The present invention provides processes for the preparation of i) Regorafenib (4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, BAY 73-4506, Stivarga®) and its pharmaceutically acceptable salt thereof; ii) a crystalline solid of Regorafenib tosylate; iii) Regorafenib Polymorph I from Regorafenib tosylate, and iv) a pure 4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide from 4-amino-3-fluorophenol and 4-chloro-N-methylpicolinamide in the presence of potassium tert-butoxide.

Abstract translation: 本发明提供了制备i）雷卡非尼（4- [4 - （{[4-氯-3-（三氟甲基）苯基]氨基甲酰基}氨基）-3-氟苯氧基] -N-甲基吡啶-2-甲酰胺的方法， BAY 73-4506，Stivarga？）及其药学上可接受的盐; ii）瑞波非尼甲苯磺酸盐的结晶固体; iii）从罗非拉布甲苯磺酸盐获得的瑞考非非多晶型I，和iv）在钾存在下，由4-氨基-3-氟苯酚和4-氯-N-甲基吡啶酰胺制得纯的4-（4-氨基-3-氟苯氧基）-N-甲基吡啶酰胺 叔丁醇盐。

公开(公告)号：US09345712B2

公开(公告)日：2016-05-24

申请号：US14436284

申请日：2013-10-23

Applicant: HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Podili Khadgapathi ,  Goli Kamalakar Reddy

IPC: A61K31/55 ,  A61K9/20 ,  A61K9/10

CPC classification number: A61K31/55 ,  A61K9/10 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2072 ,  A61K9/2095

Abstract: The present invention relates to solid dispersion compositions of tolvaptan and process for the preparation of oral dosage forms.

Abstract translation: 本发明涉及托伐普坦的固体分散体组合物和制备口服剂型的方法。

公开(公告)号：US20150290199A1

公开(公告)日：2015-10-15

申请号：US14589495

申请日：2013-07-08

Applicant: Bandi PARTHASARADHI ,  Kura RATHNAKAR REDDY ,  Dasari MURALIDHARA REDDY ,  Kesireddy SUBASH CHANDER REDDY ,  Bandi VAMSI KRISHNA ,  HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Kesireddy Subash Chander Redd ,  Bandi Vamsi Krishna

IPC: A61K31/522 ,  A61K9/14

CPC classification number: A61K31/522 ,  A61K9/146

Abstract: The present invention provides a novel amorphous solid dispersion of linagliptin in combination with a pharmaceutically acceptable carrier, process for its preparation and pharmaceutical compositions comprising it.

Abstract translation: 本发明提供了一种与药学上可接受的载体组合的利拉格列汀的新型无定形固体分散体，其制备方法和包含其的药物组合物。

公开(公告)号：US20150246053A1

公开(公告)日：2015-09-03

申请号：US14436284

申请日：2013-10-23

Applicant: HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Podili Khadgapathi ,  Goli Kamalakar Reddy

IPC: A61K31/55 ,  A61K9/20 ,  A61K9/10

CPC classification number: A61K31/55 ,  A61K9/10 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2072 ,  A61K9/2095

Abstract: The present invention relates to solid dispersion compositions of tolvaptan and process for the preparation of oral dosage forms.

Abstract translation: 本发明涉及托伐普坦的固体分散体组合物和制备口服剂型的方法。

公开(公告)号：US20150183751A1

公开(公告)日：2015-07-02

申请号：US14589622

申请日：2013-07-08

Applicant: HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Adulla Venkat Narsimha Reddy ,  Bandi Vamsi Krishna

IPC: C07D239/48 ,  C07D239/42

CPC classification number: C07D239/48 ,  C07D239/42

Abstract: The present invention provides a commercially viable process for preparing rilpivirine and its pharmaceutically acceptable acid addition salts thereof in high yields using novel intermediate.

Abstract translation: 本发明提供了使用新型中间体以高产率制备利比利林及其药学上可接受的酸加成盐的商业上可行的方法。

公开(公告)号：US20150182458A1

公开(公告)日：2015-07-02

申请号：US14590432

申请日：2013-07-18

Applicant: HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

IPC: A61K9/10 ,  A61K47/10 ,  A61K47/32 ,  A61K31/4192 ,  A61K47/38

CPC classification number: A61K9/10 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/1694 ,  A61K31/4192 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38

Abstract: The present invention provides a solid dispersion of rufinamide in combination with a pharmaceutically acceptable carrier, process for its preparation and pharmaceutical compositions comprising it.

Abstract translation: 本发明提供了与药学上可接受的载体，其制备方法和包含它的药物组合物的rufinamide的固体分散体。

公开(公告)号：US20150119373A1

公开(公告)日：2015-04-30

申请号：US14395668

申请日：2013-04-19

Applicant: HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Vedula Manohar Sharma ,  Kura Rathnakar Reddy ,  Mamnoor Prem Kumar ,  Kasireddy Bhaskar Reddy ,  Mogili Narsingam ,  Mukkera Venkati ,  Lanka VL Subrahmanyam ,  Ravi Mallikarjun Reddy

IPC: C07J53/00

CPC classification number: C07J53/002 ,  C07J63/008

Abstract: The invention relates to novel betulinic acid derivatives and related compounds, and pharmaceutical compositions useful for therapeutic treatment of viral diseases and particularly HIV mediated diseases.

Abstract translation: 本发明涉及新颖的桦木酸衍生物和相关化合物，以及可用于治疗性治疗病毒性疾病，特别是HIV介导的疾病的药物组合物。