公开(公告)号：US07714300B1

公开(公告)日：2010-05-11

申请号：US11711552

申请日：2007-02-26

申请人： Mark A. McCord ,  Tom G. Miller ,  David L. Brown

发明人： Mark A. McCord ,  Tom G. Miller ,  David L. Brown

IPC分类号： G01T1/00

CPC分类号： H01J37/244 ,  H01J37/28 ,  H01J2237/2441 ,  H01J2237/2444

摘要： One embodiment relates to a solid-state charged-particle detector. The detector includes a PIN diode and a conductive coating on the front-side of the PIN diode, wherein the front-side receives incident charged particles to be detected. In addition, the detector includes a metal layer on the backside of the PIN diode and electrical connections to the metal layer and to the conductive coating. Other embodiment are also disclosed.

摘要翻译： 一个实施方案涉及固态带电粒子检测器。 检测器包括PIN二极管和PIN二极管前侧的导电涂层，其中前侧接收待检测的入射带电粒子。 此外，检测器包括在PIN二极管背面的金属层和与金属层和导电涂层的电连接。 还公开了其他实施例。

公开(公告)号：US20080150678A1

公开(公告)日：2008-06-26

申请号：US11939427

申请日：2007-11-13

申请人： John J. Giobbi ,  Bryan Kelly ,  David L. Brown ,  Fred S. Hirt

发明人： John J. Giobbi ,  Bryan Kelly ,  David L. Brown ,  Fred S. Hirt

IPC分类号： G05B19/00

CPC分类号： G08C17/02 ,  G07C9/00182 ,  G07C2009/00261 ,  G07F17/32 ,  G07F17/3218 ,  G07F17/3239

摘要： A system and method provides efficient and highly reliable customer and asset tracking. A Personal Digital Key (PDK) is associated with and carried by a user or fixed to an asset. The PDK wirelessly communicates with a receiver/decoder circuit (RDC) that can be coupled to a variety of electronic devices. The RDC authenticates the PDK based on received data and stores information to track customers and provide improved service. The RDC can be coupled to or integrated with a variety of electronic devices. The operation of the electronic device is determined based on an identification code of the detected PDK and an identification code of the RDC. The electronic device, the PDK or both can be configured with a personalized user interface and execute specific functions based on stored state information associated with the PDK and RDC identification codes.

摘要翻译： 系统和方法提供高效可靠的客户和资产跟踪。 个人数字密钥（PDK）与用户相关联并由用户承载或固定资产。 PDK与可以耦合到各种电子设备的接收机/解码器电路（RDC）无线通信。 RDC根据接收到的数据对PDK进行认证，并存储信息以跟踪客户并提供改进的服务。 RDC可以耦合到或与各种电子设备集成。 基于检测到的PDK的识别码和RDC的识别码来确定电子设备的操作。 电子设备，PDK或两者可以配置有个性化用户界面，并且基于与PDK和RDC识别码相关联的存储状态信息执行特定功能。

公开(公告)号：US07338965B2

公开(公告)日：2008-03-04

申请号：US10299746

申请日：2002-11-19

申请人： Joseph B. Moon ,  Shon R. Pulley ,  Daniel H. Rich ,  David L. Brown ,  Barbara Jagodzinska ,  Varghese John ,  John Jacobs

发明人： Joseph B. Moon ,  Shon R. Pulley ,  Daniel H. Rich ,  David L. Brown ,  Barbara Jagodzinska ,  Varghese John ,  John Jacobs

IPC分类号： A61K31/445 ,  C07D211/42

CPC分类号： C07D401/04 ,  C07D211/40 ,  C07D211/42 ,  C07D401/12 ,  C07D405/04 ,  C07D409/12 ,  C07D409/14

摘要： The invention relates to substituted piperidine, piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers. One embodiment of the invention relates to compounds having the structure: where Z is CR or N, and R1, R2 and R3 are as described in the specification.

摘要翻译： 本发明涉及可用于治疗阿尔茨海默病的取代的哌啶，哌嗪，吗啉和硫代吗啉化合物，更具体地涉及能够抑制β-分泌酶的化合物，其是切割淀粉样蛋白前体蛋白以产生淀粉状蛋白β肽（A-β ）是阿尔茨海默病患者大脑中发现的淀粉样斑块的主要成分。 本发明的一个实施方案涉及具有以下结构的化合物：其中Z为CR或N，且R 1，R 2和R 3为 如说明书中所述。

公开(公告)号：US07260984B2

公开(公告)日：2007-08-28

申请号：US11245485

申请日：2005-10-05

申请人： Shad Roundy ,  Janusz Bryzek ,  Curtis Ray ,  Michael Malaga ,  David L. Brown

发明人： Shad Roundy ,  Janusz Bryzek ,  Curtis Ray ,  Michael Malaga ,  David L. Brown

IPC分类号： B60C23/02

CPC分类号： B60C23/0411

摘要： A method of powering one or more electronic devices in a tire monitoring system using a tire pressure based energy scavenger is provided. With this method, a tire is rotated on a surface to generate pressure changes within the tire. These pressure changes are then converted into electrical energy with a transducer and the energy is stored. The electrical energy or stored electrical energy can then be used to power one or more electronic devices in a tire monitoring system, such as a tire pressure sensor, temperature sensor, acceleration profile sensor, and/or a tire wear monitor. A tire monitoring system with a tire pressure based energy scavenger is also provided.

摘要翻译： 提供一种使用轮胎压力能量清除剂在轮胎监测系统中为一个或多个电子设备供电的方法。 利用该方法，轮胎在表面上旋转以在轮胎内产生压力变化。 然后，这些压力变化用换能器转换成电能并储存能量。 然后可以使用电能或存储的电能来为轮胎监测系统中的一个或多个电子设备供电，例如轮胎压力传感器，温度传感器，加速度曲线传感器和/或轮胎磨损监测器。 还提供了一种具有基于轮胎压力的能量清除剂的轮胎监测系统。

公开(公告)号：US07141594B2

公开(公告)日：2006-11-28

申请号：US10715852

申请日：2003-11-19

申请人： Daniel P. Getman ,  Gary A. DeCrescenzo ,  John N. Freskos ,  Michael L. Vazquez ,  James A. Sikorski ,  Balekudru Devadas ,  Srinivasan Nagarajan ,  David L. Brown ,  Joseph J. McDonald

发明人： Daniel P. Getman ,  Gary A. DeCrescenzo ,  John N. Freskos ,  Michael L. Vazquez ,  James A. Sikorski ,  Balekudru Devadas ,  Srinivasan Nagarajan ,  David L. Brown ,  Joseph J. McDonald

IPC分类号： A61K31/428 ,  C07D417/12

CPC分类号： C07K5/021 ,  A61K38/00 ,  C07K5/06139 ,  C07K5/06165

摘要： Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

公开(公告)号：US06677364B2

公开(公告)日：2004-01-13

申请号：US10004960

申请日：2001-12-04

申请人： John J. Talley ,  James A. Sikorski ,  Balekudru Devadas ,  Matthew J. Graneto ,  Jeffery S. Carter ,  Bryan H. Norman ,  Roland S. Rogers ,  Hwang-Fun Lu ,  David L. Brown

发明人： John J. Talley ,  James A. Sikorski ,  Balekudru Devadas ,  Matthew J. Graneto ,  Jeffery S. Carter ,  Bryan H. Norman ,  Roland S. Rogers ,  Hwang-Fun Lu ,  David L. Brown

IPC分类号： A61K314178

CPC分类号： A61K31/44 ,  A61K31/15 ,  A61K31/277 ,  A61K31/4015

摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.

摘要翻译： 本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。

公开(公告)号：US06673818B2

公开(公告)日：2004-01-06

申请号：US10124209

申请日：2002-04-16

申请人： David L. Brown ,  Matthew J. Graneto ,  Cindy L. Ludwig ,  John M. Molyneaux ,  John J. Talley

发明人： David L. Brown ,  Matthew J. Graneto ,  Cindy L. Ludwig ,  John M. Molyneaux ,  John J. Talley

IPC分类号： C07D40102

CPC分类号： C07D231/12 ,  C07D261/08 ,  C07D307/32

摘要： Methods of treating cyclooxygenase-2 mediated disorders comprising administering to a subject a therapeutically effective amount of one or more fluoro-substituted benzenesulfonyl compounds corresponding to Formula I: wherein A, X, n, R1, R2, and R3 are as described in the specification, and novel fluoro-substituted benzenesulfonyl compounds within Formula I.

摘要翻译： 治疗环氧合酶-2介导的病症的方法包括向受试者施用治疗有效量的一种或多种对应于式I的氟取代的苯磺酰基化合物：其中A，X，n，R 1，R 2和R 在说明书中描述的<3>和式I中的新的氟取代的苯磺酰基化合物。

公开(公告)号：US06592660B2

公开(公告)日：2003-07-15

申请号：US10080237

申请日：2002-02-19

申请人： Philip D. Nguyen ,  Ronald J. Crook ,  Johnny A. Barton ,  David L. Brown

发明人： Philip D. Nguyen ,  Ronald J. Crook ,  Johnny A. Barton ,  David L. Brown

IPC分类号： C04B2000

CPC分类号： E21B43/08

摘要： Methods and compositions for forming permeable cement sand screens in well bores are provided. The compositions are basically comprised of a hydraulic cement, a particulate cross-linked gel containing an internal breaker which after time causes the gel to break into a liquid and water present in an amount sufficient to form a slurry.

公开(公告)号：US06390195B1

公开(公告)日：2002-05-21

申请号：US09698315

申请日：2000-10-27

申请人： Philip D. Nguyen ,  Ronald J. Crook ,  Johnny A. Barton ,  David L. Brown

发明人： Philip D. Nguyen ,  Ronald J. Crook ,  Johnny A. Barton ,  David L. Brown

IPC分类号： E21B33138

CPC分类号： E21B43/08

摘要： Methods and compositions for forming permeable cement sand screens in well bores are provided. The compositions are basically comprised of a hydraulic cement, a particulate cross-linked gel containing an internal breaker which after time causes the gel to break into a liquid and water present in an amount sufficient to form a slurry.

摘要翻译： 提供了在井眼中形成渗透性水泥砂筛的方法和组合物。 所述组合物基本上由水硬性水泥，含有内部破碎剂的颗粒状交联凝胶组成，所述内部破裂剂在时间后导致凝胶破裂成液体，并且以足以形成浆料的量存在水。

公开(公告)号：US06202751B1

公开(公告)日：2001-03-20

申请号：US09627264

申请日：2000-07-28

申请人： Jiten Chatterji ,  Roger S. Cromwell ,  Baireddy R. Reddy ,  Bobby J. King ,  Philip D. Nguyen ,  David L. Brown

发明人： Jiten Chatterji ,  Roger S. Cromwell ,  Baireddy R. Reddy ,  Bobby J. King ,  Philip D. Nguyen ,  David L. Brown

IPC分类号： E21B33138

CPC分类号： E21B43/08

摘要： Methods and compositions for forming permeable cement sand screens in well bores are provided. The compositions are basically comprised of a hydraulic cement, an acid soluble particulate solid, a liquid hydrocarbon solvent soluble particulate solid, a particulate cross-linked gel containing an internal breaker which after time causes the gel to break into a liquid, water present in an amount sufficient to form a slurry, a gas present in an amount sufficient to form a foam and a mixture of foaming and foamed stabilizing surfactants.

摘要翻译： 提供了在井眼中形成渗透性水泥砂筛的方法和组合物。 组合物基本上由水硬性水泥，酸溶性颗粒固体，液体烃溶剂可溶性颗粒固体，含有内部破碎剂的颗粒状交联凝胶组成，其在时间使凝胶破裂成液体后，存在于 足以形成浆料，以足以形成泡沫的量存在的气体和发泡和泡沫稳定表面活性剂的混合物。