公开(公告)号：US08685980B2

公开(公告)日：2014-04-01

申请号：US13060154

申请日：2009-08-20

申请人： Gilbert Ebai Besong ,  Christopher Thomas Brain ,  Clinton Alan Brooks ,  Miles Stuart Congreve ,  Claudio Dagostin ,  Guo He ,  Ying Hou ,  Steven Howard ,  Yue Li ,  Yipin Lu ,  Paul Neil Mortenson ,  Troy D. Smith ,  Moo Je Sung ,  Steven John Woodhead ,  Wojciech Wrona ,  Bharat Lagu

发明人： Gilbert Ebai Besong ,  Christopher Thomas Brain ,  Clinton Alan Brooks ,  Miles Stuart Congreve ,  Claudio Dagostin ,  Guo He ,  Ying Hou ,  Steven Howard ,  Yue Li ,  Yipin Lu ,  Paul Neil Mortenson ,  Troy D. Smith ,  Moo Je Sung ,  Steven John Woodhead ,  Wojciech Wrona ,  Bharat Lagu

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D487/04 ,  A61K31/519 ,  C07D487/08

摘要： The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

摘要翻译： 所公开的化合物涉及蛋白激酶相关病症的治疗和疗法。 还需要可用于治疗或预防或改善癌症，移植排斥和自身免疫性疾病的一种或多种症状的化合物。 此外，需要使用本文提供的化合物调节蛋白激酶如CDK1，CDK2，CDK4，CDK5，CDK6，CDK7，CDK8和CDK9的活性的方法。

公开(公告)号：US08665887B2

公开(公告)日：2014-03-04

申请号：US13059934

申请日：2009-07-29

申请人： Shu Ge ,  Jinxia Sun ,  Meng You ,  Wei Li ,  Wei Li ,  Yutian Nie ,  Yue Li ,  Lihong Wei ,  Sitao Lin

发明人： Shu Ge ,  Jinxia Sun ,  Meng You ,  Wei Li ,  Wei Li ,  Yutian Nie ,  Yue Li ,  Lihong Wei ,  Sitao Lin

IPC分类号： H04L12/28

CPC分类号： H04L45/04 ,  H04L45/50 ,  H04L45/52 ,  H04L45/741

摘要： A number automatic routing method, an updating method, a withdrawing method, a router and a device is provided wherein the number automatic routing method includes: converting to-be-distributed number into number routing information to add to dynamic routing protocol; generating a dynamic routing protocol message according to the number routing information; transmitting the dynamic routing protocol message through an Internet Protocol (IP) network and distributing the number through the dynamic routing protocol message and the IP network. The method supports automatic routing of numbers such as E.164 and E.214 and SP through expanding current Multi-Protocol Border Gateway Protocol (MP-BGP) that optimizes network structure and improves efficiency.

摘要翻译： 提供了一种数字自动路由方法，更新方法，撤销方法，路由器和设备，其中号码自动路由方法包括：将分配的号码转换为号码路由信息以添加到动态路由协议; 根据号码路由信息生成动态路由协议消息; 通过互联网协议（IP）网络传输动态路由协议消息，并通过动态路由协议消息和IP网络分配号码。 该方法通过扩展当前的优化网络结构并提高效率的多协议边界网关协议（MP-BGP）来支持自动路由数字，如E.164和E.214和SP。

公开(公告)号：US08621990B2

公开(公告)日：2014-01-07

申请号：US13112509

申请日：2011-05-20

申请人： Chuan Hui Fang ,  Li Sheng Liu ,  Yue Li ,  Liang Guan

发明人： Chuan Hui Fang ,  Li Sheng Liu ,  Yue Li ,  Liang Guan

IPC分类号： A23B5/00

CPC分类号： H02K5/1282 ,  A47J43/044 ,  A47J43/046 ,  A47J43/0465 ,  H02K21/14 ,  H02K21/22 ,  H02K21/24

摘要： A household appliance has a container for receiving working material and a housing that is isolated from the container by a wall. A rotatable working tool disposed inside the container. A motor for driving the working tool has a stator and a rotor. The stator is disposed within the housing so as to be isolated from the working material of the container. The rotor is disposed within the container and the working tool is preferably fixed to a shaft of the rotor.

摘要翻译： 家用电器具有用于接收工作材料的容器和通过墙与容器隔离的外壳。 设置在容器内的可旋转工作工具。 用于驱动加工工具的马达具有定子和转子。 定子被布置在壳体内以便与容器的工作材料隔离。 转子设置在容器内，并且加工工具优选地固定到转子的轴上。

公开(公告)号：US08577112B2

公开(公告)日：2013-11-05

申请号：US12489682

申请日：2009-06-23

申请人： Susumu Mori ,  Hangyi Jiang ,  Ming-Chung Chou ,  Yue Li

发明人： Susumu Mori ,  Hangyi Jiang ,  Ming-Chung Chou ,  Yue Li

IPC分类号： G06K9/00

CPC分类号： G01R33/56341 ,  A61B5/055

摘要： Featured is a method for automatically evaluating acquired MRI data, determining the quality of the acquired images and removing the image data when it is determined that an image is corrupted so the imaged data for the corrupted image is removed from the subsequent tensor fitting. In further embodiments, such determining includes judging the quality of the image data to determine if the image data satisfies a quality threshold criteria and if determined not to be satisfied adjudging the image to be corrupted. Such methods include performing said evaluating, determining and removing in real time and in the case where an image is determined to be corrupted, such methods further includes re-acquiring additional image data corresponding to each of the one or more images removed as being corrupted. Also featured are MRI systems embodying such methods.

摘要翻译： 特色是一种自动评估获取的MRI数据，确定所获取的图像的质量并确定图像已损坏时删除图像数据的方法，以便从后续的张量拟合中删除损坏的图像的成像数据。 在另外的实施例中，这种确定包括判断图像数据的质量，以确定图像数据是否满足质量阈值标准，并且如果确定不满足判断被破坏的图像。 这样的方法包括实时地执行所述评估，确定和移除，并且在确定图像被破坏的情况下，这种方法还包括重新获取对应于被删除的一个或多个图像中的每一个被损坏的附加图像数据。 还有体现这种方法的MRI系统。

公开(公告)号：US08516704B2

公开(公告)日：2013-08-27

申请号：US12502375

申请日：2009-07-14

申请人： Guo Ji Zhang ,  Kam Fung Cheng ,  Yue Li ,  Jian Hong Wu ,  Hong Liu ,  Guan Lei Jiang

发明人： Guo Ji Zhang ,  Kam Fung Cheng ,  Yue Li ,  Jian Hong Wu ,  Hong Liu ,  Guan Lei Jiang

IPC分类号： B23P13/00

CPC分类号： G02B26/0833

摘要： A method of manufacturing suspension devices comprising the steps of: a) forming an integral elastic sheet, the elastic sheet having first and second suspension devices, each suspension device being provided with attachment parts configured to be fixed to a movable object, fixing parts configured to be fixed to a base, and elastic parts connected between the attachment parts and the fixing parts respectively and configured to bias the object relative to the base, the elastic parts of the suspension devices being alternately distributed; b) separating the first and second suspension devices from each other before being attached to the object.

摘要翻译： 一种制造悬挂装置的方法，包括以下步骤：a）形成整体弹性片，所述弹性片具有第一和第二悬挂装置，每个悬挂装置设置有被配置为固定到可移动物体的附接部分， 固定到基座上，弹性部分分别连接在附接部分和固定部分之间，并被配置为相对于基座偏压物体，悬挂装置的弹性部分交替分布; b）在附接到物体之前将第一和第二悬挂装置彼此分离。

公开(公告)号：US20130204536A1

公开(公告)日：2013-08-08

申请号：US13805966

申请日：2011-06-30

申请人： Tony Kusalik ,  Yue Li ,  Scott Napper ,  Philip Griebel ,  Ryan Arsenault

发明人： Tony Kusalik ,  Yue Li ,  Scott Napper ,  Philip Griebel ,  Ryan Arsenault

IPC分类号： G06F19/10

CPC分类号： G16B99/00 ,  G16B5/00 ,  G16B25/00 ,  G16B40/00

摘要： Method for analyzing phosphorylation data of a plurality of peptides are provided, the method comprising obtaining one or more datasets, each dataset comprising a phosphorylation signal intensity for each replicate of the plurality of peptides for a sample; transforming the phosphorylation signal intensity of each replicate of the plurality of peptides using a variance stabilizing transformation to provide a variance stabilized signal intensity for each replicate of the plurality of peptides; and identifying one or more peptides of the plurality of peptides that is/are consistently phosphorylated or consistently unphosphorylated.

摘要翻译： 提供了用于分析多个肽的磷酸化数据的方法，所述方法包括获得一个或多个数据集，每个数据集包含用于样品的多个肽的每个重复的磷酸化信号强度; 使用方差稳定转化来转化多个肽的每个重复的磷酸化信号强度，以为多个肽的每个重复提供方差稳定的信号强度; 以及鉴定所述多个肽中一个或多个肽一直被磷酸化或始终未磷酸化的肽。

公开(公告)号：US20120274170A1

公开(公告)日：2012-11-01

申请号：US13458564

申请日：2012-04-27

申请人： Yue Li ,  Li Sheng Liu ,  Yong Qing Qi ,  Hong Jian Zhang

发明人： Yue Li ,  Li Sheng Liu ,  Yong Qing Qi ,  Hong Jian Zhang

IPC分类号： H02K23/00

CPC分类号： H02K25/00 ,  H01R39/04 ,  H02K13/00 ,  H02K13/006 ,  H02K13/04 ,  H02K23/00 ,  H02K23/18 ,  H02K23/20 ,  H02K23/36

摘要： A brush direct current motor has a stator with a plurality of coils that correspond to a number of stator windings, a rotor with a number of poles, and a commutator. The commutator is connected to a first terminal of a direct current power source to convert the power into N phase alternating current. One end of each stator winding is connected to a respective phase of the alternating current via a brush and the other ends of the stator windings are connected to the second terminal of the direct current power source.

摘要翻译： 电刷直流电动机具有定子，该定子具有对应于多个定子绕组的多个线圈，具有多个极的转子和换向器。 换向器连接到直流电源的第一端子以将功率转换成N相交流电。 每个定子绕组的一端通过电刷连接到交流电的相应相位，定子绕组的另一端连接到直流电源的第二端。

公开(公告)号：US08206718B2

公开(公告)日：2012-06-26

申请号：US11475627

申请日：2006-06-27

申请人： Kin-Ming Lo ,  Yue Li ,  Stephen D. Gillies

发明人： Kin-Ming Lo ,  Yue Li ,  Stephen D. Gillies

IPC分类号： A61K39/00 ,  C07K14/00

CPC分类号： A61K38/00 ,  C07K14/515 ,  C07K14/78 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/30 ,  C07K2319/75 ,  C12N9/6435 ,  C12N15/62 ,  C12Y304/21007 ,  Y10S530/81

摘要： A homodimeric protein of the invention has angiogenesis inhibiting activity. The homodimeric protein consists of two identical fusion proteins bound together as a homodimer. Each fusion protein comprises an immunoglobulin Fc region and a first target protein linked to the immunoglobulin Fc region. The first target protein has an angiogenesis inhibiting activity of angiostatin or endostatin, and is selected from the group consisting of a plasminogen fragment and a collagen XVIII fragment. The immunoglobulin Fc region comprises a hinge region, a CH2 region, and a CH3 region.

摘要翻译： 本发明的同二聚体蛋白质具有血管生成抑制活性。 同二聚体蛋白由两个相同的融合蛋白组成，作为同型二聚体结合在一起。 每个融合蛋白包含免疫球蛋白Fc区和与免疫球蛋白Fc区连接的第一靶蛋白。 第一靶蛋白具有血管生成抑制活性的血管抑素或内皮抑素，并且选自纤溶酶原片段和胶原XVIII片段。 免疫球蛋白Fc区包含铰链区，CH2区和CH3区。

公开(公告)号：US20110227439A1

公开(公告)日：2011-09-22

申请号：US13053755

申请日：2011-03-22

申请人： Mao Xiong JIANG ,  Yue Li ,  Jian Zhao ,  Yong Li ,  Yu Hong Guo

发明人： Mao Xiong JIANG ,  Yue Li ,  Jian Zhao ,  Yong Li ,  Yu Hong Guo

IPC分类号： H02K23/04

CPC分类号： H02K23/04

摘要： An electric machine has a stator and a rotor. The stator has a housing and at least one pair of magnetic poles. Each magnetic pole has a primary magnet and two auxiliary magnets disposed on respective sides of the primary magnet. All of the magnets are disposed on an inner surface of the housing. All the magnets of a magnetic pole have the same polarity.

摘要翻译： 电机具有定子和转子。 定子具有壳体和至少一对磁极。 每个磁极具有主磁体和设置在主磁体的相应侧上的两个辅助磁体。 所有磁体均设置在壳体的内表面上。 磁极的所有磁体都具有相同的极性。

公开(公告)号：USD642527S1

公开(公告)日：2011-08-02

申请号：US29380093

申请日：2010-11-30

申请人： Yue Li ,  Jian Zhao ,  Yong Wang ,  Ya Ming Zhang ,  Yan Hong Xue ,  Mao Xiong Jiang

设计人： Yue Li ,  Jian Zhao ,  Yong Wang ,  Ya Ming Zhang ,  Yan Hong Xue ,  Mao Xiong Jiang