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公开(公告)号：US08274643B2
公开(公告)日：2012-09-25
申请号：US10546522
申请日：2004-03-05
IPC分类号： G01N1/00
CPC分类号： A61K47/02 , A61K9/0097 , A61K31/436 , A61K31/573 , C25F3/14 , G01N33/5438 , G01N33/552 , G01N2021/7773 , G01N2021/7776
摘要： A method for simultaneously detecting and separating a target analyte such as a protein or other macromolecule that includes providing a porous silicon matrix on the silicon substrate, exposing the porous silicon matrix to an environment suspect of containing the target analyte, observing optical reflectivity of the porous silicon matrix; and correlating the changes in the silicon substrate to the target analyte.
摘要翻译： 一种用于同时检测和分离诸如蛋白质或其它高分子的目标分析物的方法，其包括在硅衬底上提供多孔硅基质，将多孔硅基质暴露于怀疑含有目标分析物的环境，观察多孔硅的光学反射率 硅基体; 并将硅衬底中的变化与目标分析物相关联。
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公开(公告)号：US07942989B2
公开(公告)日：2011-05-17
申请号：US10731220
申请日：2003-12-09
IPC分类号： C06B25/00 , C06B25/04 , C06B25/32 , C06B31/00 , C06B31/02 , C06B31/12 , C06B31/16 , C06B31/28 , C06B35/00 , C06B45/00 , C06B45/04
摘要： An initiator explosive for detonating a second explosive that includes nanocrystalline silicon containing a plurality of pores and a solid state oxidant disposed within said pores.
摘要翻译： 一种引爆炸药，用于引爆第二种炸药，其中包括含有多个孔的纳米晶硅和置于所述孔内的固态氧化剂。
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43.发明授权Porous photonic crystal with light scattering domains and methods of synthesis and use thereof 有权具有光散射域的多孔光子晶体及其合成和使用方法公开(公告)号：US07903239B2
公开(公告)日：2011-03-08
申请号：US11665613
申请日：2005-10-19
申请人： Michael J. Sailor , Michael P. Schwartz , Sara Alvarez , Sangeeta Bhatia , Austin Derfus , Benjamin Migliori , Lin Chao , Yang Yang Li , Rebecca Campbell , Jason Dorvee , Ulla Camilla Rang
发明人： Michael J. Sailor , Michael P. Schwartz , Sara Alvarez , Sangeeta Bhatia , Austin Derfus , Benjamin Migliori , Lin Chao , Yang Yang Li , Rebecca Campbell , Jason Dorvee , Ulla Camilla Rang
IPC分类号： G01N1/00
CPC分类号： G01N21/4738 , G01N33/5005 , G01N33/54373
摘要： The invention includes sensors and sensing methods for determining cell morphology and/or chemical composition of an analyte. A porous substrate exhibiting a first optical signal is exposed to a target analyte and subsequently monitored for changes in the optical signal. More specifically, a photonic or porous substrate having a well-defined and highly tunable reflectivity or transmission spectrum, such as porous silicon (Si), porous alumina, porous Ge, porous GaAs, porous SiO2 and porous polymer, is used for example. A porous or photonic substrate is exposed to an analyte, such as a cell or other macromolecule, and changes in the scattered light are observed over time to determine cell morphology and/or chemical composition of the analyte using the substrate.
摘要翻译： 本发明包括用于确定分析物的细胞形态和/或化学组成的传感器和感测方法。 表现出第一光信号的多孔基材暴露于目标分析物，随后监测光信号的变化。 更具体地，例如使用具有明确且高度可调谐的反射率或透射光谱的光子或多孔基底，例如多孔硅（Si），多孔氧化铝，多孔Ge，多孔GaAs，多孔SiO 2和多孔聚合物。 将多孔或光子底物暴露于分析物，例如细胞或其他大分子，并随时间观察散射光的变化，以确定使用底物的分析物的细胞形态和/或化学组成。
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公开(公告)号：US07889954B2
公开(公告)日：2011-02-15
申请号：US12218330
申请日：2008-07-14
申请人： Michael J. Sailor , Brian H King , Anne M Ruminski , Jay L Snyder
发明人： Michael J. Sailor , Brian H King , Anne M Ruminski , Jay L Snyder
IPC分类号： G02B6/00
CPC分类号： G01N21/7703 , G01N2021/772 , G01N2021/773 , G01N2021/7773 , G02B2006/12138
摘要： An embodiment of the invention is a remote sensor that has an optical fiber terminating in a tip. A thin film porous particle having a characteristic optical response that changes in the presence of an analyte is optically coupled and physically attached to the tip of the optical fiber. The optical response of the particle changes in the presence of analyte, and the particle also serves to concentrate analyte. The thin film porous particle can be functionalized toward sensitivity for a predetermined analyte or analytes. A method of remote sensing exposes the remote sensor to an environment to be monitored for analyte. The thin film porous particle is probed with a beam of light. Reflected light is monitored through the optical fiber for a shift in frequency or intensity.
摘要翻译： 本发明的实施例是一种远程传感器，其具有端接在尖端中的光纤。 具有在分析物存在下发生变化的特征光学响应的薄膜多孔颗粒被光学耦合并且物理地附着到光纤的末端。 颗粒的光学响应在分析物的存在下发生变化，并且颗粒也用于浓缩分析物。 薄膜多孔颗粒可以针对预定的分析物或分析物的灵敏度进行功能化。 遥感方法将远程传感器暴露在待分析物监测的环境中。 用光束探测薄膜多孔颗粒。 通过光纤监测反射光的频率或强度偏移。
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公开(公告)号：US20100008619A1
公开(公告)日：2010-01-14
申请号：US12218330
申请日：2008-07-14
申请人： Michael J. Sailor
发明人： Michael J. Sailor
IPC分类号： G02B6/00
CPC分类号： G01N21/7703 , G01N2021/772 , G01N2021/773 , G01N2021/7773 , G02B2006/12138
摘要： An embodiment of the invention is a remote sensor that has an optical fiber terminating in a tip. A thin film porous particle having a characteristic optical response that changes in the presence of an analyte is optically coupled and physically attached to the tip of the optical fiber. The optical response of the particle changes in the presence of analyte, and the particle also serves to concentrate analyte. The thin film porous particle can be functionalized toward sensitivity for a predetermined analyte or analytes. A method of remote sensing exposes the remote sensor to an environment to be monitored for analyte. The thin film porous particle is probed with a beam of light. Reflected light is monitored through the optical fiber for a shift in frequency or intensity.
摘要翻译： 本发明的实施例是一种远程传感器，其具有端接在尖端中的光纤。 具有在分析物存在下发生变化的特征光学响应的薄膜多孔颗粒被光学耦合并且物理地附着到光纤的末端。 颗粒的光学响应在分析物的存在下发生变化，并且颗粒也用于浓缩分析物。 薄膜多孔颗粒可以针对预定的分析物或分析物的灵敏度进行功能化。 遥感方法将远程传感器暴露在待分析物监测的环境中。 用光束探测薄膜多孔颗粒。 通过光纤监测反射光的频率或强度偏移。
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公开(公告)号：US07482168B2
公开(公告)日：2009-01-27
申请号：US10244053
申请日：2002-09-14
CPC分类号： G01N21/643 , G01N21/6408 , G01N31/22 , G01N33/0057 , G01N2021/6432 , Y10T436/17
摘要： A method to develop inexpensive inorganic polymeric sensors that can provide a sensitivity and selectivity for explosive nitroaromatic compounds. Selectivity is provided by the arrays of 12 different reactive fluorescent sensors to mimic the human olfactory system. The sensors are based on photoluminescence quenching of polymers containing metalloid-metalloid backbones such as Si—Si, Si—Ge, or Ge—Ge. The sensor employs a thin film of photoluminescent copolymers, which is stable in air, water, acids, common organic solvents, and even seawater containing bioorganisms. The detection method involves measurement of the quenching of photoluminescence of the polysilole by the analyte.
摘要翻译： 开发便宜的无机聚合物传感器的方法，可以为爆炸性硝基芳族化合物提供灵敏度和选择性。 选择性由12个不同反应荧光传感器的阵列提供，以模拟人类嗅觉系统。 这些传感器基于含有类金属 - 准金属主链如Si-Si，Si-Ge或Ge-Ge的聚合物的光致发光淬灭。 该传感器采用光致发光共聚物的薄膜，其在空气，水，酸，常见的有机溶剂，甚至包含生物有机物的海水中是稳定的。 检测方法包括通过分析物测定聚硅氧烷的光致发光的淬灭。
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公开(公告)号：US20080296255A1
公开(公告)日：2008-12-04
申请号：US11632914
申请日：2005-07-18
申请人： Michael J. Sailor , Yang Yang Li , Nathan Trujillo , Jason Dorvee
发明人： Michael J. Sailor , Yang Yang Li , Nathan Trujillo , Jason Dorvee
IPC分类号： H01L21/311 , B32B5/18
CPC分类号： G01N21/31 , B22F1/0003 , B22F1/025 , B22F2998/10 , B82Y20/00 , G02B6/1225 , G02B26/004 , G02F1/09 , H01F1/0063 , Y10S977/838 , Y10S977/96 , Y10S977/962 , Y10T428/29 , Y10T428/2982 , Y10T428/2991 , Y10T428/31 , Y10T428/32 , B22F3/114 , B22F9/04
摘要： The invention provides porous particles that produce a predetermined optical response and that may be manipulated magnetically. A preferred particle of the invention has a porous structure that produces a predetermined optical response and magnetic material adhered to the particle. Another preferred particle is amphiphilic. The optical response provided by a particle of the invention enables particles of the invention to be used in sensing, labeling, signaling, display and many other applications. The magnetic nature of the present magnetic particles permits the particles themselves to be manipulated, e.g., vibrated, moved and re-oriented. The porous particles can also be used to control, move, and/or deliver small volumes of liquids and solids associated with the particles.
摘要翻译： 本发明提供产生预定光学响应且可以磁性操作的多孔颗粒。 本发明的优选颗粒具有产生预定光学响应的多孔结构和附着于颗粒的磁性材料。 另一个优选的颗粒是两亲性的。 由本发明的颗粒提供的光学响应使得本发明的颗粒可用于感测，标记，信号传递，显示和许多其它应用。 本磁性颗粒的磁性使粒子本身受到操纵，例如振动，移动和重新取向。 多孔颗粒也可用于控制，移动和/或传送与颗粒相关的小体积的液体和固体。
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48.发明申请Porous Photonic Crystal with Light Scattering Domains and Methods of Synthesis and Use Thereof 有权具有光散射域的多孔光子晶体及其合成和使用方法公开(公告)号：US20080212068A1
公开(公告)日：2008-09-04
申请号：US11665613
申请日：2005-10-19
申请人： Michael J. Sailor , Michael P. Schwartz , Sara Alvarez , Sangeeta Bhatia , Austin Derfus , Benjamin Migliori , Lin Chao , Yang Yang Li , Rebecca Campbell , Jason Dorvee , Ulla Camilla Rang
发明人： Michael J. Sailor , Michael P. Schwartz , Sara Alvarez , Sangeeta Bhatia , Austin Derfus , Benjamin Migliori , Lin Chao , Yang Yang Li , Rebecca Campbell , Jason Dorvee , Ulla Camilla Rang
IPC分类号： G01N1/00
CPC分类号： G01N21/4738 , G01N33/5005 , G01N33/54373
摘要： The invention includes sensors and sensing methods for determining cell morphology and/or chemical composition of an analyte. A porous substrate exhibiting a first optical signal is exposed to a target analyte and subsequently monitored for changes in the optical signal. More specifically, a photonic or porous substrate having a well-defined and highly tunable reflectivity or transmission spectrum, such as porous silicon (Si), porous alumina, porous Ge, porous GaAs, porous SiO2 and porous polymer, is used for example. A porous or photonic substrate is exposed to an analyte, such as a cell or other macromolecule, and changes in the scattered light are observed over time to determine cell morphology and/or chemical composition of the analyte using the substrate.
摘要翻译： 本发明包括用于确定分析物的细胞形态和/或化学组成的传感器和感测方法。 表现出第一光信号的多孔基材暴露于目标分析物，随后监测光信号的变化。 更具体地，例如使用具有明确且高度可调谐的反射率或透射光谱的光子或多孔基底，例如多孔硅（Si），多孔氧化铝，多孔Ge，多孔GaAs，多孔SiO 2和多孔聚合物。 将多孔或光子底物暴露于分析物，例如细胞或其他大分子，并随时间观察散射光的变化，以确定使用底物的分析物的细胞形态和/或化学组成。
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公开(公告)号：US07042570B2
公开(公告)日：2006-05-09
申请号：US10339163
申请日：2003-01-09
申请人： Michael J. Sailor , Sonia Letant
发明人： Michael J. Sailor , Sonia Letant
CPC分类号： G01N21/55
摘要： A method for analyzing gaseous or liquid samples is provided. Samples are interacted with pores of a porous thin film. A time-varying response of reflectivity is obtained from the surface of the porous thin film during the interaction. One or more analytes forming the sample or a part of the sample are identified based upon the time-varying response.
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公开(公告)号：US06897965B2
公开(公告)日：2005-05-24
申请号：US10801282
申请日：2004-03-16
IPC分类号： G01N33/543 , C08G8/28
CPC分类号： G01N21/45 , G01N33/5438 , G01N2021/458 , Y10S435/808 , Y10S435/973 , Y10S436/805
摘要： The measurement of the wavelength shifts in the reflectometric interference spectra of a porous semiconductor substrate such as silicon, make possible the highly sensitive detection, identification and quantification of small analyte molecules. The sensor of the subject invention is effective in detecting multiple layers of biomolecular interactions, termed “cascade sensing”, including sensitive detection of small molecule recognition events that take place relatively far from the semiconductor surface.
摘要翻译： 多孔半导体衬底（如硅）的反射干涉光谱中波长偏移的测量使得可以对小分析物分子进行高灵敏度的检测，鉴定和定量。 本发明的传感器有效地检测称为“级联感测”的多层生物分子相互作用，包括敏感地检测相对远离半导体表面的小分子识别事件。
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