公开(公告)号：US08072585B2

公开(公告)日：2011-12-06

申请号：US12650692

申请日：2009-12-31

申请人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

发明人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

IPC分类号： G01N21/00 ,  G01N21/64

CPC分类号： G01N21/6452 ,  G01N21/253

摘要： A multi-modal data acquisition system for detecting target material on a biological reaction surface, the system comprising a radiation source for generating an incoming beam that impinges on the biological reaction surface at an oblique incidence angle and produces a reflected beam, an interferometric detector for detecting an interferometric signal from the illuminated surface, the reflected beam being directed to the interferometric detector, a fluorescence detector for detecting a fluorescence signal from the illuminated surface; the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam; and a processing system for receiving the interferometric and fluorescence signals and determining the presence or absence of target material on the biological reaction surface. A reaction surface conditioned for the simultaneous collection of fluorescence, interferometric and other signals. A multi-modal data acquisition system for collecting and processing additional modes, including multiple interferometric, fluorescence and scattering channels.

摘要翻译： 一种多模式数据采集系统，用于检测生物反应表面上的目标材料，所述系统包括用于产生入射光束的辐射源，该入射光束以倾斜入射角度撞击在生物反应表面上并产生反射光束，干涉检测器 检测来自所述照射表面的干涉信号，所述反射光束被引导到所述干涉检测器;荧光检测器，用于检测来自被照射表面的荧光信号; 荧光检测器被定位成基本上最小化反射光束的入射; 以及用于接收干涉测量和荧光信号并确定生物反应表面上目标材料的存在或不存在的处理系统。 用于同时收集荧光，干涉仪和其他信号的反应表面。 一种多模式数据采集系统，用于收集和处理其他模式，包括多个干涉仪，荧光和散射通道。

公开(公告)号：US07981863B2

公开(公告)日：2011-07-19

申请号：US10246091

申请日：2002-09-18

申请人： Kioumars Delfani ,  Ann Marie Janson ,  H. Georg Kuhn ,  Karlheinz Plate ,  Anne Schanzer ,  Frank-Peter Wachs ,  Ming Zhao

发明人： Kioumars Delfani ,  Ann Marie Janson ,  H. Georg Kuhn ,  Karlheinz Plate ,  Anne Schanzer ,  Frank-Peter Wachs ,  Ming Zhao

IPC分类号： A61K38/00 ,  A61K38/18 ,  C12N5/00 ,  C12N5/079 ,  C12N5/0797 ,  C12N5/0793 ,  C07K14/49

CPC分类号： A61K38/1858 ,  A61K35/30 ,  A61K38/179 ,  A61K38/1866 ,  A61K45/06 ,  A61K48/00 ,  G01N33/5008 ,  G01N2333/49 ,  G01N2333/515 ,  A61K2300/00

摘要： The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to a reagent that modulates the proliferation, migration, differentiation and survival of central nervous system cells. These methods are useful for reducing at least one symptom of the disorder.

摘要翻译： 本发明一般涉及影响中枢神经系统细胞以产生可用于治疗CNS病症的后代的方法。 更具体地，本发明包括将患有这种病症的患者暴露于调节中枢神经系统细胞的增殖，迁移，分化和存活的试剂的方法。 这些方法可用于减少至少一种症状。

公开(公告)号：US20110167351A1

公开(公告)日：2011-07-07

申请号：US12790582

申请日：2010-05-28

申请人： Rakesh Kumar Arora ,  Keith William Paterson ,  Ming Zhao ,  Hong Albert Cai Wang ,  Dan Mihai Dumitru

发明人： Rakesh Kumar Arora ,  Keith William Paterson ,  Ming Zhao ,  Hong Albert Cai Wang ,  Dan Mihai Dumitru

IPC分类号： G06F3/01 ,  G06F15/16 ,  G06F3/048

CPC分类号： G06F17/211 ,  H04M1/72533 ,  H04M2250/02

摘要： A system and method are set forth for remotely controlling a presentation in a loop mode to allow the presentation to continue in the absence of a communication channel between the portable electronic device and remote presentation device. In particular, the portable electronic device can issue a command to the remote presentation device to present the presentation in loop mode so that a user of the portable electronic device can leave the vicinity of the remote presentation device (e.g. out of communication range) while the presentation plays in loop mode.

摘要翻译： 提出了一种用于以循环模式远程控制呈现的系统和方法，以允许呈现在便携式电子设备和远程呈现设备之间没有通信信道的情况下继续。 特别地，便携式电子设备可以向远程呈现设备发出命令以循环模式呈现呈现，使得便携式电子设备的用户可以离开远程呈现设备的附近（例如，不在通信范围内），同时 演示文稿以循环模式播放。

公开(公告)号：US20100145627A1

公开(公告)日：2010-06-10

申请号：US12650692

申请日：2009-12-31

申请人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

发明人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

IPC分类号： G01N33/48 ,  G01N21/00 ,  G06F19/00

CPC分类号： G01N21/6452 ,  G01N21/253

摘要： A multi-modal data acquisition system for detecting target material on a biological reaction surface, the system comprising a radiation source for generating an incoming beam that impinges on the biological reaction surface at an oblique incidence angle and produces a reflected beam, an interferometric detector for detecting an interferometric signal from the illuminated surface, the reflected beam being directed to the interferometric detector, a fluorescence detector for detecting a fluorescence signal from the illuminated surface; the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam; and a processing system for receiving the interferometric and fluorescence signals and determining the presence or absence of target material on the biological reaction surface. A reaction surface conditioned for the simultaneous collection of fluorescence, interferometric and other signals. A multi-modal data acquisition system for collecting and processing additional modes, including multiple interferometric, fluorescence and scattering channels.

摘要翻译： 一种多模式数据采集系统，用于检测生物反应表面上的目标材料，所述系统包括用于产生入射光束的辐射源，该入射光束以倾斜入射角度撞击在生物反应表面上并产生反射光束，干涉检测器 检测来自所述照射表面的干涉信号，所述反射光束被引导到所述干涉检测器;荧光检测器，用于检测来自被照射表面的荧光信号; 荧光检测器被定位成基本上最小化反射光束的入射; 以及用于接收干涉测量和荧光信号并确定生物反应表面上目标材料的存在或不存在的处理系统。 用于同时收集荧光，干涉仪和其他信号的反应表面。 一种多模式数据采集系统，用于收集和处理其他模式，包括多个干涉仪，荧光和散射通道。

公开(公告)号：US07522282B2

公开(公告)日：2009-04-21

申请号：US11744726

申请日：2007-05-04

申请人： David D. Nolte ,  Ming Zhao

发明人： David D. Nolte ,  Ming Zhao

IPC分类号： G01B9/02

CPC分类号： G01N21/45 ,  G01N21/253

摘要： A molecular interferometric imaging system for detecting an analyte in a sample, that includes an illumination source providing a beam of radiation; a pixel array for detecting radiation in an image plane; a biolayer designed to react to the analyte when it comes in contact with the sample; a substrate designed to convert phase modulation into intensity modulation which can be detected and imaged directly by the pixel array, the biolayer being on the substrate; a reference surface; an image switching means for switching between a first position for collecting a sample image of the biolayer, and a second position for collecting a reference image of the reference surface; and a processing means for producing a composite image using the sample image and the reference image for illumination normalization.

摘要翻译： 一种用于检测样品中分析物的分子干涉成像系统，其包括提供辐射束的照明源; 用于检测图像平面中的辐射的像素阵列; 设计成当分析物与样品接触时与分析物反应的生物层; 设计用于将相位调制转换成强度调制的基板，该调制可由像素阵列直接检测和成像，生物层位于基板上; 参考表面 用于在用于收集生物层的样本图像的第一位置和用于收集参考表面的参考图像的第二位置之间切换的图像切换装置; 以及用于使用样本图像和用于照明归一化的参考图像来生成合成图像的处理装置。

公开(公告)号：US20080200211A1

公开(公告)日：2008-08-21

申请号：US12034713

申请日：2008-02-21

申请人： Seong-Taek HWANG ,  Shuangfeng Han ,  Chunhui Zhou ,  Jing Wang ,  Ming Zhao ,  Zheng Xu

发明人： Seong-Taek HWANG ,  Shuangfeng Han ,  Chunhui Zhou ,  Jing Wang ,  Ming Zhao ,  Zheng Xu

IPC分类号： H04M1/00

CPC分类号： H04W16/26 ,  H04W16/32 ,  H04W88/085

摘要： A system and a method for forming a cell by using distributed antennas in a World interoperability for Microwave Access (WiMAX) mobile communication system supporting a broadband wireless access communication system. A virtual cell is formed with a specific Mobile Station (MS) as a central part of the virtual cell by using distributed antennas, which improves the transmission capacity and the performance of an overall network system without changing the structure of a backbone network and the interface of the overall network system. The system includes, multiple MSes; distributed antennas for perform simultaneous communications with at least one MS among the multiple MSes, and for forming one virtual cell by communicating with the multiple MSes; and a Base Station (BS), which is typically connected to the distributed antennas through optical fibers, for communicating with the MSes.

摘要翻译： 一种用于在支持宽带无线接入通信系统的微波接入（WiMAX）移动通信系统的世界互用性中使用分布式天线形成小区的系统和方法。 通过使用分布式天线，以特定的移动台（MS）作为虚拟小区的中心部分形成虚拟小区，这提高了整个网络系统的传输容量和性能，而不改变骨干网络和接口的结构 的整体网络系统。 该系统包括多个MS; 用于与所述多个MS之间的至少一个MS进行同时通信的分布式天线，以及通过与所述多个MS通信来形成一个虚拟小区; 和基站（BS），其通常通过光纤连接到分布式天线，用于与MS通信。

公开(公告)号：US07379269B1

公开(公告)日：2008-05-27

申请号：US10903140

申请日：2004-07-30

申请人： Mohamad T. Krounbi ,  Li He ,  Ming Zhao ,  Yining Hu

发明人： Mohamad T. Krounbi ,  Li He ,  Ming Zhao ,  Yining Hu

IPC分类号： G11B5/147

CPC分类号： G11B5/3133 ,  G11B5/314 ,  G11B5/3163

摘要： A head including a write element for writing data to a magnetic media, and methods for its production are provided. A write element of the invention includes one or more of a recessed first pole, a heat sink layer, and a shortened yoke length. A method of the invention provides forming an anti-reflective layer before forming a mask layer. During photolithography the anti-reflective layer suppresses undesirable reflections off of features, such as vertical sidewalls, that otherwise limit how closely to such features portions of the mask layer can be formed.

摘要翻译： 提供一种包括用于向磁性介质写入数据的写入元件的头，以及用于其生产的方法。 本发明的写入元件包括凹入的第一极，散热层和缩短的磁轭长度中的一个或多个。 本发明的方法提供了在形成掩模层之前形成抗反射层。 在光刻期间，抗反射层抑制了诸如垂直侧壁的特征（例如垂直侧壁）的不期望的反射，否则可以限制与这些特征的接近程度，可以形成掩模层的部分。

公开(公告)号：US20070009435A1

公开(公告)日：2007-01-11

申请号：US11175596

申请日：2005-07-06

申请人： Faisal Syud ,  Nichole Wood ,  Daniel Kramer ,  Mark Baillie ,  Dinko Eduardo Trotter ,  Anup Sood ,  Ming Zhao

发明人： Faisal Syud ,  Nichole Wood ,  Daniel Kramer ,  Mark Baillie ,  Dinko Eduardo Trotter ,  Anup Sood ,  Ming Zhao

IPC分类号： A61K51/00 ,  A61K48/00 ,  C07H21/02 ,  C07F9/6533

CPC分类号： C07F9/65586 ,  A61K49/0002 ,  A61K51/0491 ,  A61K51/0495 ,  C07F9/65616

摘要： A set of compounds that includes an active agent-labeled species and a pretargeting conjugate is disclosed. The active agent-labeled species includes a first oligomeric nucleotide or mimic thereof conjugated to a linker having a first moiety coupled with a diagnostic active agent. The pretargeting conjugate includes a second oligomeric nucleotide or mimic thereof conjugated to a targeting species having a targeting moiety capable of binding to a target or a marker produced by or associated with the target. The second oligomeric nucleotide or mimic thereof has a sequence that is at least partially complementary to a sequence of the first oligomeric nucleotide or mimic thereof. Also disclosed are methods of administering the pretargeting conjugate and active agent-labeled species to a subject for diagnosing a disease condition or assessing the effectiveness of a treatment of the disease condition.

摘要翻译： 公开了一组包含活性剂标记的物质和预靶向缀合物的化合物。 活性剂标记的物质包括与具有与诊断活性剂偶联的第一部分的接头缀合的第一寡聚核苷酸或其模拟物。 预靶向缀合物包括与靶向物质缀合的第二寡聚核苷酸或其模拟物，所述靶向物质具有能够结合靶标的靶向部分或由靶产生或与靶标相关的标记。 第二寡聚核苷酸或其模拟物具有与第一寡核苷酸序列至少部分互补的序列或其模拟物。 还公开了将预靶向缀合物和活性剂标记物质施用于受试者以诊断疾病状况或评估治疗疾病状况的有效性的方法。

公开(公告)号：US20070009427A1

公开(公告)日：2007-01-11

申请号：US11175595

申请日：2005-07-06

申请人： Faisal Syud ,  Nichole Wood ,  Andrew Torres ,  Mark Baillie ,  Dinko Eduardo Trotter ,  Cristina Hehir ,  Ming Zhao ,  Daniel Kramer

发明人： Faisal Syud ,  Nichole Wood ,  Andrew Torres ,  Mark Baillie ,  Dinko Eduardo Trotter ,  Cristina Hehir ,  Ming Zhao ,  Daniel Kramer

IPC分类号： A61K51/00

CPC分类号： B82Y5/00 ,  A61K47/6899 ,  A61K51/04

摘要： A set of compounds that includes an active-agent labeled species and a pretargeting conjugate is disclosed. The active agent-labeled species includes a ligand coupled to an active agent. The pretargeting conjugate includes a protein conjugated to a targeting species having a targeting moiety capable of binding to an in-vivo target or a biomarker produced by or associated with the target. The protein and the ligand are covalently attached. Also disclosed are methods of administering the pretargeting species and the active-agent labeled species to a subject for diagnosing or treating a disease condition, or assessing the effectiveness of a treatment of the disease condition.

摘要翻译： 公开了一组包含活性剂标记的物质和预靶向缀合物的化合物。 活性剂标记的物质包括与活性剂偶联的配体。 预靶向缀合物包括与靶向物质缀合的蛋白质，其具有能够结合体内靶标的靶向部分或由靶产生或与靶标相关的生物标志物。 蛋白质和配体共价连接。 还公开了将预靶向物种和活性剂标记物种施用于受试者以诊断或治疗疾病状况或评估治疗疾病状况的有效性的方法。

公开(公告)号：US20070003436A1

公开(公告)日：2007-01-04

申请号：US11345462

申请日：2006-02-01

申请人： David Nolte ,  Leilei Peng ,  Fred Regnier ,  Ming Zhao

发明人： David Nolte ,  Leilei Peng ,  Fred Regnier ,  Ming Zhao

IPC分类号： G01N21/00

CPC分类号： G01N21/45 ,  G01B11/2441 ,  G01N21/4788 ,  G01N21/75 ,  G01N2021/757 ,  G01N2021/7779 ,  Y10T436/111666

摘要： A phase contrast quadrature interferometric method for determining the presence or absence of a target analyte in a sample. The method comprises using a laser beam having a wavelength λ and a waist wo to probe at least a portion of a substrate having a reflecting surface that has been exposed to the sample. The reflecting surface includes at least a first region having a layer of recognition molecules specific to the target analyte and a second region that does not include a layer of recognition molecules specific to the target analyte. The method further comprises measuring a time dependent intensity on a photodetector of a substantially only first quadrature at one of a pair of quadrature angles ⊖q of a reflected diffraction signal of the probe beam while probing the first region and the second region. An apparatus for phase-contrast quadrature interferometric detection of the presence or absence of a target molecule on a planar array, comprises a laser source for generating a probe beam. The apparatus includes a platform for receiving the planar array and a first optical train for directing the probe beam at the platform in a substantially surface normal manner. The apparatus also includes an objective lens having a first side and a second side and having a focal length, the objective lens being offset on the first side of the lens from the platform by a first distance approximately equal to the focal length. The apparatus further includes split photodetector means for measuring a first quadrature and a second quadrature in a signal resulting from reflection of the probe laser beam.

摘要翻译： 用于确定样品中目标分析物的存在或不存在的相差正交干涉法。 该方法包括使用具有波长λ和腰围的激光束来探测具有暴露于样品的反射表面的基底的至少一部分。 反射表面至少包括具有对靶分析物特异性的识别分子层的第一区域和不包括对靶分析物特异性的识别分子层的第二区域。 该方法还包括：在探测第一区域时，在探测光束的反射衍射信号的一对正交角度θ1中的一个处测量基本上仅第一正交的光电检测器上的时间依赖强度，以及 第二个地区。 用于在平面阵列上存在或不存在靶分子的相位对比正交干涉测量的装置包括用于产生探针光束的激光源。 该装置包括用于接收平面阵列的平台和用于以基本上正常的方式将探测光束引导到平台处的第一光学列。 该装置还包括具有第一侧和第二侧并具有焦距的物镜，该物镜在透镜的第一侧与平台偏移大约等于焦距的第一距离。 该装置还包括用于测量由探头激光束的反射产生的信号中的第一正交和第二正交的分离光电检测器装置。