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公开(公告)号：US07175997B2
公开(公告)日：2007-02-13
申请号：US10188886
申请日：2002-07-05
申请人： John M. Wozney , Anthony J. Celeste
发明人： John M. Wozney , Anthony J. Celeste
CPC分类号： A61K38/1875 , C07K14/51 , C07K14/575 , C07K2319/00 , C12N5/0619 , C12N2501/155 , Y10S930/12
摘要： Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction of bone, cartilage and/or other connective tissue.
摘要翻译： 公开了纯化的BMP-11蛋白质及其生产方法。 还公开了编码BMP-11蛋白的重组DNA分子。 蛋白质可用于调节促卵泡激素，例如用于避孕。 此外，蛋白质可用于诱导骨，软骨和/或其它结缔组织。
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公开(公告)号：US5932216A
公开(公告)日：1999-08-03
申请号：US926885
申请日：1997-09-10
申请人： Anthony J. Celeste , John M. Wozney
发明人： Anthony J. Celeste , John M. Wozney
CPC分类号： C07K14/51 , A61K38/00 , C07K2319/02 , Y10S930/12
摘要： Purified Bone Morphogenetic Protein-10(BMP-10) proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-10 proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译： 公开了纯化骨形态发生蛋白-10（BMP-10）蛋白及其制备方法。 还公开了编码BMP-10蛋白质的DNA分子。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号：US5637480A
公开(公告)日：1997-06-10
申请号：US247908
申请日：1994-05-20
申请人： Anthony J. Celeste , John M. Wozney
发明人： Anthony J. Celeste , John M. Wozney
CPC分类号： C07K14/51 , A61K38/00 , C07K2319/02 , Y10S930/12
摘要： Purified Bone Morphogenetic Protein-10 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-10 proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译： 公开了纯化骨形态发生蛋白-10蛋白及其制备方法。 还公开了编码BMP-10蛋白的重组DNA分子。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号：US07378392B1
公开(公告)日：2008-05-27
申请号：US08319831
申请日：1994-10-06
IPC分类号： A61K38/18 , C07K14/435 , C07K14/51
摘要： Purified cartilage and/or bone inductive proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译： 公开了纯化的软骨和/或骨诱导蛋白及其制备方法。 蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号：US06340668B1
公开(公告)日：2002-01-22
申请号：US09414234
申请日：1999-10-07
IPC分类号： A61K3818
CPC分类号： A61K38/1875 , C07K14/51 , C07K14/575 , C07K2319/00 , C12N5/0619 , C12N2501/155 , Y10S930/12
摘要： Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction and/or maintenance of bone, cartilage and/or other connective tissue, and/or neuronal tissue.
摘要翻译： 公开了纯化的BMP-11蛋白质及其生产方法。 还公开了编码BMP-11蛋白的重组DNA分子。 蛋白质可用于调节促卵泡激素，例如用于避孕。 此外，蛋白质可用于诱导和/或维持骨，软骨和/或其它结缔组织和/或神经元组织。
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公开(公告)号：US06291206B1
公开(公告)日：2001-09-18
申请号：US08123934
申请日：1993-09-17
IPC分类号： C12P2106
摘要： Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding said proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to said BMP receptor proteins.
摘要翻译： 公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质，以及编码所述蛋白质的DNA分子和使用受体蛋白质的方法。 还公开了截短的BMP受体蛋白质和作为所述BMP受体蛋白质的配体的分子。
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公开(公告)号：US5703043A
公开(公告)日：1997-12-30
申请号：US453942
申请日：1995-05-30
申请人： Anthony J. Celeste , John M. Wozney
发明人： Anthony J. Celeste , John M. Wozney
CPC分类号： C07K14/51 , A61K38/00 , C07K2319/02 , Y10S930/12
摘要： Purified Bone Morphogenetic Protein-10 (BMP-10) proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-10 proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译： 公开了纯化骨形态发生蛋白-10（BMP-10）蛋白及其制备方法。 还公开了编码BMP-10蛋白质的DNA分子。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号：US5700911A
公开(公告)日：1997-12-23
申请号：US452772
申请日：1995-05-30
申请人： John M. Wozney , Anthony J. Celeste
发明人： John M. Wozney , Anthony J. Celeste
IPC分类号： C12N15/09 , A61K38/00 , A61K38/18 , A61P7/00 , A61P13/02 , A61P15/00 , A61P15/18 , A61P19/00 , A61P25/00 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/495 , C07K14/51 , C07K14/575 , C12N5/0793 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91
CPC分类号： A61K38/1875 , C07K14/51 , C07K14/575 , C12N5/0619 , C07K2319/00 , C12N2501/155 , Y10S930/12
摘要： Purified Bone Morphogenetic Protein-11(BMP-11) proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction of bone, cartilage and/or other connective tissue.
摘要翻译： 公开了纯化骨形态发生蛋白-11（BMP-11）蛋白及其制备方法。 还公开了编码BMP-11蛋白的重组DNA分子。 蛋白质可用于调节促卵泡激素，例如用于避孕。 此外，蛋白质可用于诱导骨，软骨和/或其他结缔组织。
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公开(公告)号：US5688678A
公开(公告)日：1997-11-18
申请号：US800364
申请日：1991-11-26
摘要： Purified cartilage and/or bone inductive proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译： 公开了纯化的软骨和/或骨诱导蛋白及其制备方法。 蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。
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