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公开(公告)号:US06287816B1
公开(公告)日:2001-09-11
申请号:US08254353
申请日:1994-06-06
IPC分类号: C12P2100
CPC分类号: C07K14/51 , A61K38/1875 , A61K38/30 , A61L27/227 , C07K2319/02 , Y10S530/84 , Y10S930/12 , A61K2300/00
摘要: Purified bone morphogenetic protein-9 (BMP-9) proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的骨形态发生蛋白-9(BMP-9)蛋白及其生产方法。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US07091007B2
公开(公告)日:2006-08-15
申请号:US10600645
申请日:2003-06-23
摘要: Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding the BMP receptor proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to the BMP receptor proteins.
摘要翻译: 公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质,以及编码BMP受体蛋白质的DNA分子和使用受体蛋白质的方法。 还公开了截短的BMP受体蛋白质和作为BMP受体蛋白质的配体的分子。
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公开(公告)号:US06610513B2
公开(公告)日:2003-08-26
申请号:US09874628
申请日:2001-06-05
IPC分类号: C12P2106
摘要: Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding these proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to these BMP receptor proteins.
摘要翻译: 公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质,以及编码这些蛋白质的DNA分子和使用受体蛋白质的方法。 进一步公开的是截短的BMP受体蛋白质和作为这些BMP受体蛋白质的配体的分子。
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公开(公告)号:US06340668B1
公开(公告)日:2002-01-22
申请号:US09414234
申请日:1999-10-07
IPC分类号: A61K3818
CPC分类号: A61K38/1875 , C07K14/51 , C07K14/575 , C07K2319/00 , C12N5/0619 , C12N2501/155 , Y10S930/12
摘要: Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction and/or maintenance of bone, cartilage and/or other connective tissue, and/or neuronal tissue.
摘要翻译: 公开了纯化的BMP-11蛋白质及其生产方法。 还公开了编码BMP-11蛋白的重组DNA分子。 蛋白质可用于调节促卵泡激素,例如用于避孕。 此外,蛋白质可用于诱导和/或维持骨,软骨和/或其它结缔组织和/或神经元组织。
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公开(公告)号:US06291206B1
公开(公告)日:2001-09-18
申请号:US08123934
申请日:1993-09-17
IPC分类号: C12P2106
摘要: Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding said proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to said BMP receptor proteins.
摘要翻译: 公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质,以及编码所述蛋白质的DNA分子和使用受体蛋白质的方法。 还公开了截短的BMP受体蛋白质和作为所述BMP受体蛋白质的配体的分子。
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公开(公告)号:US07365052B2
公开(公告)日:2008-04-29
申请号:US11154826
申请日:2005-06-17
申请人: Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
发明人: Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
CPC分类号: C07K14/51 , A61K38/1875 , A61L27/227 , A61L27/386 , A61L27/54 , C07K2319/02
摘要: Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
摘要翻译: 公开了具有肌腱/类韧带组织诱导活性的蛋白质组成。 该组合物可用于治疗腱炎和腱或韧带缺陷以及相关组织修复。
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公开(公告)号:US06984623B2
公开(公告)日:2006-01-10
申请号:US10779635
申请日:2004-02-18
申请人: Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
发明人: Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
CPC分类号: C07K14/51 , A61K38/1875 , A61L27/227 , A61L27/386 , A61L27/54 , C07K2319/02
摘要: Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
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公开(公告)号:US06437111B1
公开(公告)日:2002-08-20
申请号:US08919850
申请日:1997-08-28
申请人: John M. Wozney , Anthony J. Celeste
发明人: John M. Wozney , Anthony J. Celeste
IPC分类号: C07H2104
CPC分类号: A61K38/1875 , C07K14/51 , C07K14/575 , C07K2319/00 , C12N5/0619 , C12N2501/155 , Y10S930/12
摘要: Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction of bone, cartilage and/or other connective tissue.
摘要翻译: 公开了纯化的BMP-11蛋白质及其生产方法。 还公开了编码BMP-11蛋白的重组DNA分子。 蛋白质可用于调节促卵泡激素,例如用于避孕。 此外,蛋白质可用于诱导骨,软骨和/或其它结缔组织。
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公开(公告)号:US06207813B1
公开(公告)日:2001-03-27
申请号:US09189157
申请日:1998-11-09
IPC分类号: C07H2104
CPC分类号: C12N15/85 , A61K38/00 , A61L24/043 , A61L27/227 , C07K14/51 , Y10S530/84 , C08L89/00
摘要: Purified BMP-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-6蛋白质及其生产方法。 蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US6027919A
公开(公告)日:2000-02-22
申请号:US333576
申请日:1994-11-02
申请人: Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
发明人: Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
IPC分类号: C12N15/09 , A61K38/00 , A61K38/22 , A61K38/27 , A61L27/22 , A61L27/36 , A61P1/02 , A61P5/00 , A61P19/04 , A61P43/00 , C07H21/04 , C07K14/51 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91 , C07K14/475
CPC分类号: A61L27/227 , A61L27/38 , C07K14/51 , A61K38/00 , C07K2319/02
摘要: The present invention relates to a novel family of purified proteins, and compositions containing such proteins, which compositions are useful for the induction of tendon/ligament-like tissue formation, wound healing and ligament and other tissue repair. The present invention further relates to DNA molecules, vectors and host cells useful for production of such proteins.
摘要翻译: 本发明涉及一种纯化蛋白质的新家族,以及含有这些蛋白质的组合物,该组合物可用于诱导腱/类韧带组织形成,伤口愈合和韧带以及其它组织修复。 本发明还涉及可用于生产这种蛋白质的DNA分子,载体和宿主细胞。
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