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公开(公告)号：US07151086B2
公开(公告)日：2006-12-19
申请号：US10228808
申请日：2002-08-26
申请人： Anthony J. Celeste , Beth L. Murray
发明人： Anthony J. Celeste , Beth L. Murray
IPC分类号： A61K38/18
摘要： Purified BMP-17 and BMP-18 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-17 and BMP-18 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, epithelium, brain, spleen, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
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公开(公告)号：US06613744B2
公开(公告)日：2003-09-02
申请号：US09816299
申请日：2001-03-23
IPC分类号： A61K3818
CPC分类号： C12N15/85 , A61K38/00 , A61L24/043 , A61L27/227 , C07K14/51 , Y10S530/84 , C08L89/00
摘要： Purified BMP-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
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公开(公告)号：US06610513B2
公开(公告)日：2003-08-26
申请号：US09874628
申请日：2001-06-05
IPC分类号： C12P2106
摘要： Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding these proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to these BMP receptor proteins.
摘要翻译： 公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质，以及编码这些蛋白质的DNA分子和使用受体蛋白质的方法。 进一步公开的是截短的BMP受体蛋白质和作为这些BMP受体蛋白质的配体的分子。
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公开(公告)号：US6034229A
公开(公告)日：2000-03-07
申请号：US982987
申请日：1997-12-02
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61L27/22 , A61L27/36 , A61P43/00 , C07K14/51 , C07K16/22 , C07K19/00 , C12N5/10 , C12N15/12 , C12P21/02 , C07H21/04
CPC分类号： C07K14/51 , A61L27/227 , A61K38/00 , C07K2319/00
摘要： Purified BMP-15-related proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-15-related proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage and/or other connective tissue defects and in wound healing and related tissue repair.
摘要翻译： 公开了纯化的BMP-15相关蛋白质及其生产方法。 还公开了编码BMP-15相关蛋白的DNA分子。 蛋白质可用于治疗骨和软骨和/或其他结缔组织缺陷以及伤口愈合和相关组织修复。
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公开(公告)号：US5849880A
公开(公告)日：1998-12-15
申请号：US469936
申请日：1995-06-06
IPC分类号： A61K38/00 , A61L24/04 , A61L27/22 , C07K14/51 , C12N15/85 , C07K14/46 , A61K38/18 , C07H21/04 , C12P21/00
CPC分类号： C12N15/85 , A61L24/043 , A61L27/227 , C07K14/51 , A61K38/00 , Y10S530/84
摘要： Purified bone morphogenetic protein (BMP)-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译： 公开了纯化的骨形态发生蛋白（BMP）-6蛋白及其生产方法。 蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号：US5639638A
公开(公告)日：1997-06-17
申请号：US247907
申请日：1994-05-20
申请人： John M. Wozney , Anthony J. Celeste
发明人： John M. Wozney , Anthony J. Celeste
IPC分类号： C12N15/09 , A61K38/00 , A61K38/18 , A61P7/00 , A61P13/02 , A61P15/00 , A61P15/18 , A61P19/00 , A61P25/00 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/495 , C07K14/51 , C07K14/575 , C12N5/0793 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91 , C12N15/16 , C12N15/85
CPC分类号： A61K38/1875 , C07K14/51 , C07K14/575 , C12N5/0619 , C07K2319/00 , C12N2501/155 , Y10S930/12
摘要： Purified Bone Morphogenetic Protein-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception, and for the induction of bone, cartilage and/or other connective tissue.
摘要翻译： 公开了纯化骨形态发生蛋白-11蛋白及其生产方法。 还公开了编码BMP-11蛋白的重组DNA分子。 蛋白质可用于调节促卵泡激素，例如用于避孕，以及用于诱导骨，软骨和/或其它结缔组织。
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公开(公告)号：US5635372A
公开(公告)日：1997-06-03
申请号：US446924
申请日：1995-05-18
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61L27/22 , A61L27/36 , A61P43/00 , C07K14/51 , C07K16/22 , C07K19/00 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/06 , C07H21/04 , C12N5/00 , C12N15/00
CPC分类号： C07K14/51 , A61L27/227 , A61K38/00 , C07K2319/00
摘要： Purified BMP-15-related proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-15-related proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage and/or other connective tissue defects and in wound healing and related tissue repair.
摘要翻译： 公开了纯化的BMP-15相关蛋白质及其生产方法。 还公开了编码BMP-15相关蛋白的DNA分子。 蛋白质可用于治疗骨和软骨和/或其他结缔组织缺陷以及伤口愈合和相关组织修复。
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公开(公告)号：US5459047A
公开(公告)日：1995-10-17
申请号：US251069
申请日：1994-05-27
IPC分类号： A61K38/00 , A61L24/04 , A61L27/22 , C07K14/51 , C12N15/85 , C12P21/02 , A01N37/18 , C07H15/12 , C07K1/00 , C12N1/21 , C12N5/00 , C12N7/00 , C12N15/00
CPC分类号： C12N15/85 , A61L24/043 , A61L27/227 , C07K14/51 , A61K38/00 , Y10S530/84
摘要： Purified BMP-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
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公开(公告)号：US07091007B2
公开(公告)日：2006-08-15
申请号：US10600645
申请日：2003-06-23
摘要： Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding the BMP receptor proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to the BMP receptor proteins.
摘要翻译： 公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质，以及编码BMP受体蛋白质的DNA分子和使用受体蛋白质的方法。 还公开了截短的BMP受体蛋白质和作为BMP受体蛋白质的配体的分子。
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公开(公告)号：US6027919A
公开(公告)日：2000-02-22
申请号：US333576
申请日：1994-11-02
申请人： Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
发明人： Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K38/27 , A61L27/22 , A61L27/36 , A61P1/02 , A61P5/00 , A61P19/04 , A61P43/00 , C07H21/04 , C07K14/51 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91 , C07K14/475
CPC分类号： A61L27/227 , A61L27/38 , C07K14/51 , A61K38/00 , C07K2319/02
摘要： The present invention relates to a novel family of purified proteins, and compositions containing such proteins, which compositions are useful for the induction of tendon/ligament-like tissue formation, wound healing and ligament and other tissue repair. The present invention further relates to DNA molecules, vectors and host cells useful for production of such proteins.
摘要翻译： 本发明涉及一种纯化蛋白质的新家族，以及含有这些蛋白质的组合物，该组合物可用于诱导腱/类韧带组织形成，伤口愈合和韧带以及其它组织修复。 本发明还涉及可用于生产这种蛋白质的DNA分子，载体和宿主细胞。
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