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81 条记录 (耗时 0.046 秒)

    Lint roller/brush assembly
    41.
    发明申请
    Lint roller/brush assembly 失效

    公开(公告)号：US20050188485A1

    公开(公告)日：2005-09-01

    申请号：US11116899

    申请日：2005-04-28

    申请人： William McKay

    发明人： William McKay

    IPC分类号： A01K13/00 ,  A46B11/02 ,  A47L13/12 ,  A47L25/00 ,  B05B11/00 ,  A47L25/08

    CPC分类号： A47L25/005 ,  A01K13/002 ,  A47L13/12 ,  B05B11/30

    摘要： A lint/pet hair roller assembly includes a body supporting a tubular adhesive lint remover roller and/or a stationary directional lint brush fabric. The assembly includes a handle section and a roller support section. The support section has an outer diameter less than the diameter of the adhesive lint roll or a directional fabric wrapped about the support section. The elongated handle section receives a separate rubber cushion and an optional decorative top including a hanger. Alternately, an arm projects from the body and receives an additional cleaning element. Alternately, a dispenser is carried on the handle for dispensing fluid from a storage chamber carried in the handle. Alternately, a squeegee is alternately carried in the support.

    Methods of inducing or increasing the expression of proteoglycans such as aggrecan in cells
    42.
    发明申请
    Methods of inducing or increasing the expression of proteoglycans such as aggrecan in cells 审中-公开
    在细胞中诱导或增加蛋白聚糖如聚集蛋白聚糖的表达的方法

    公开(公告)号：US20090304649A9

    公开(公告)日：2009-12-10

    申请号：US11602805

    申请日：2006-11-21

    申请人： William McKay ,  Scott Boden ,  Sangwook Yoon

    发明人： William McKay ,  Scott Boden ,  Sangwook Yoon

    IPC分类号： A61K48/00

    CPC分类号： A61K38/1841 ,  A61K38/1875 ,  A61K48/005 ,  A61K48/0075 ,  C07K14/51

    摘要： Methods of inducing the expression of a proteoglycan such as aggrecan in a cell are described. A method is described which includes transfecting a cell with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein operably linked to a promoter. The LIM mineralization protein can be rLMP, hLMP-1, hLMP-1s, or hLMP-3. Transfection maybe accomplished ex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid. The method can be used to induce proteoglycan synthesis in osseous cells or to stimulate proteoglycan and/or collagen production in cells capable of producing proteoglycan and/or collagen (e.g., intervertebral disc cells including cells of the nucleus pulposus and annulus fibrosus).

    摘要翻译： 描述了在细胞中诱导蛋白聚糖如聚集蛋白聚糖表达的方法。 描述了一种方法，其包括用分离的核酸转染细胞，所述分离的核酸包含可操作地连接于启动子的编码LIM矿化蛋白的核苷酸序列。 LIM矿化蛋白可以是rLMP，hLMP-1，hLMP-1或hLMP-3。 转染可以通过直接注射病毒或裸DNA或通过非病毒载体如质粒在体内或体内完成。 该方法可用于在骨细胞中诱导蛋白聚糖合成或刺激能够产生蛋白聚糖和/或胶原的细胞（例如包括髓核细胞和纤维环的椎间盘细胞）中的蛋白聚糖和/或胶原产生。

    Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use
    44.
    发明申请
    Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use 有权
    包含用于治疗神经元损伤的生物膜密封剂的组合物和使用方法

    公开(公告)号：US20070259044A1

    公开(公告)日：2007-11-08

    申请号：US11418152

    申请日：2006-05-03

    申请人： Josee Roy ,  William McKay ,  Jeffrey Marx

    发明人： Josee Roy ,  William McKay ,  Jeffrey Marx

    IPC分类号： A61K38/20 ,  A61K38/18 ,  A61K38/11 ,  A61K38/05 ,  A61K31/65 ,  A61K31/56 ,  A61K9/14

    CPC分类号： A61K33/06 ,  A61K9/0019 ,  A61K31/56 ,  A61K31/65 ,  A61K31/765 ,  A61K47/10

    摘要： The invention provides compositions, kits, and methods for treatment of neuronal injury. In one embodiment, the composition comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.

    摘要翻译： 本发明提供用于治疗神经元损伤的组合物，试剂盒和方法。 在一个实施方案中，组合物包含生物膜密封剂，例如PEG，以及生物活性剂，例如镁化合物。 静脉内给药，肌内给药，鞘内给药，皮下给药，硬膜外给药，胃肠外给药，直接施用于病理状况的部位或其附近的生物膜密封剂和/或生物活性剂，以及任何 其组合。 或者，生物膜密封剂和/或生物活性剂可以从泵或植入物递送。

    Malleable implants containing demineralized bone matrix
    45.
    发明申请
    Malleable implants containing demineralized bone matrix 有权
    含有脱钙骨基质的韧性植入物

    公开(公告)号：US20070254042A1

    公开(公告)日：2007-11-01

    申请号：US11415037

    申请日：2006-05-01

    申请人： Susan Drapeau ,  Kathy Chamness ,  William McKay

    发明人： Susan Drapeau ,  Kathy Chamness ,  William McKay

    IPC分类号： A61K35/37

    CPC分类号： A61L27/20 ,  A61F2/28 ,  A61L27/24 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/48

    摘要： Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising a polysaccharide. Also described are methods for making and using such medical compositions.

    摘要翻译： 描述的是可延展的药物组合物，例如包括与液体载体结合的固体的糊剂或油灰。 固体包括颗粒状胶原和颗粒脱矿质骨基质。 液体载体包括含有多糖的水性介质。 还描述了制备和使用这种医药组合物的方法。

    Drug depot implant designs and methods of implantation
    46.
    发明申请
    Drug depot implant designs and methods of implantation 有权
    药物植入物设计和植入方法

    公开(公告)号：US20070243228A1

    公开(公告)日：2007-10-18

    申请号：US11403733

    申请日：2006-04-13

    申请人： William McKay

    发明人： William McKay

    IPC分类号： A61F2/02

    CPC分类号： A61K9/0024 ,  A61K9/0085 ,  A61K9/0097

    摘要： The present invention relates to novel drug depot implant designs for optimal delivery of therapeutic agents to subjects. The invention provides a method for alleviating pain associated with neuromuscular or skeletal injury or inflammation by targeted delivery of one or more therapeutic agents to inhibit the inflammatory response which ultimately causes acute or chronic pain. Controlled and directed delivery can be provided by drug depot implants, comprising therapeutic agents, specifically designed to deliver the therapeutic agent to the desired location by facilitating their implantation, minimizing their migration from the desired tissue location, and without disrupting normal joint and soft tissue movement.

    摘要翻译： 本发明涉及用于将治疗剂最佳递送给受试者的新的药物储库植入物设计。 本发明提供了一种通过靶向递送一种或多种治疗剂来减轻与神经肌肉或骨骼损伤或炎症相关的疼痛以抑制最终引起急性或慢性疼痛的炎症反应的方法。 药物贮库植入物可以由药物贮库植入物提供，包括治疗剂，其特别设计用于通过促进其植入将其转移到期望的位置，使其从所需组织位置的迁移最小化，并且不破坏正常的关节和软组织移动 。

    Cleaning apparatus with flexible connection between head and handle
    48.
    发明申请
    Cleaning apparatus with flexible connection between head and handle 审中-公开

    公开(公告)号：US20070163062A1

    公开(公告)日：2007-07-19

    申请号：US11701161

    申请日：2007-02-01

    申请人： William McKay

    发明人： William McKay

    IPC分类号： A47L25/00

    CPC分类号： A47L25/005 ,  B25G1/02 ,  Y10S16/90 ,  Y10T16/476

    摘要： An improved cleaning tool is provided with a flexible connection between the head or spindle and the handle. The improved tool broadly includes a spindle or head, a handle and a flexible connection between the head and handle to permit relative pivotal movement therebetween and rubber bumpers to protect against scratching furniture. The flexible connection regulates relative movement between the spindle head in such a way that lateral movement is greater than the up and down movement.

    Grooming/cleaning apparatus
    49.
    发明申请
    Grooming/cleaning apparatus 审中-公开
    美容/清洁设备

    公开(公告)号：US20070151052A1

    公开(公告)日：2007-07-05

    申请号：US11651676

    申请日：2007-01-10

    申请人： William McKay

    发明人： William McKay

    IPC分类号： A46B13/02

    CPC分类号： A01K13/003 ,  A01K13/002 ,  A46B13/001

    摘要： A cleaning apparatus includes a handle, a support coupled to the handle and a cleaning element mountable on the support. The support is fixed to the handle or is rotatably coupled to the handle for rotation by a drive motor mounted in the handle. The cleaning element may include bristles extending from a flexible mat fixed about the support of about a core mountable on the support. A cleaning sheet is windable about the support, the core or the cleaning element, including over and through the bristles, for dual cleaning action.

    摘要翻译： 清洁装置包括手柄，联接到手柄的支撑件和可安装在支撑件上的清洁元件。 支撑件固定到手柄上或通过安装在手柄中的驱动马达可旋转地联接到手柄以旋转。 清洁元件可以包括从可安装在支撑件上的芯的围绕支撑件固定的柔性垫延伸的刷毛。 清洁片可围绕支撑件，芯部或清洁元件卷绕，包括刷毛和通过刷毛，用于双重清洁动作。