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    Hypocholesterolemic Compositions Comprising a Statin and an Antiflatulent Agent
    44.
    发明申请
    Hypocholesterolemic Compositions Comprising a Statin and an Antiflatulent Agent 审中-公开
    包含他汀类药物和抗凝剂的低胆固醇血症组合物

    公开(公告)号：US20080206328A1

    公开(公告)日：2008-08-28

    申请号：US10588377

    申请日：2005-02-02

    申请人： Marta Guerrero ,  Anna Orriols ,  Manuel M. Raga ,  Antonio Guglietta

    发明人： Marta Guerrero ,  Anna Orriols ,  Manuel M. Raga ,  Antonio Guglietta

    IPC分类号： A61K9/28 ,  A61K31/40 ,  A61K31/351 ,  A61K33/00

    CPC分类号： A61K31/40 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2054 ,  A61K31/22 ,  A61K31/366 ,  A61K31/695 ,  A61K2300/00

    摘要： The present invention relates to hypocholesterolemic compositions comprising statins plus antiflatulent agents. In particular the compositions of the present invention comprise a statin selected from the group consisting of atorvastatin, cerivastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin, whether in free form or as pharmaceutically acceptable salts and hydrates thereof, plus an antiflatulent agent. selected from the group consisting of simethicone and dimethicone. The combination of statins plus antiflatulent agents is useful in the prevention and management of flatulence caused by statins.

    摘要翻译： 本发明涉及包含他汀类加抗消化剂的降血胆固醇组合物。 特别地，本发明的组合物包含选自阿伐他汀，西立伐他汀，氟伐他汀，洛伐他汀，匹伐他汀，普伐他汀，罗苏伐他汀和辛伐他汀的他汀类，无论是游离形式还是药学上可接受的盐和水合物，以及抗消化剂 。 选自二甲硅油和聚二甲基硅氧烷。 他汀类药物联合消炎药可有效预防和治疗他汀类药物引起的肠胃气胀。

    Growth factor compositions, preparation and use
    47.
    发明授权
    Growth factor compositions, preparation and use 失效
    生长因子组成，制备和用途

    公开(公告)号：US5434135A

    公开(公告)日：1995-07-18

    申请号：US008641

    申请日：1993-01-25

    申请人： Indu Parikh ,  Ronald Nardi ,  Tanchum Amarant ,  Antonio Guglietta

    发明人： Indu Parikh ,  Ronald Nardi ,  Tanchum Amarant ,  Antonio Guglietta

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/22 ,  A61P43/00 ,  C07K1/18 ,  C07K14/37 ,  C07K14/41 ,  C07K14/485 ,  C07K14/52 ,  C12P21/02 ,  C12R1/84

    CPC分类号： C07K14/485 ,  A61K38/00

    摘要： The invention in growth factor compositions includes: a novel compound which is a separate pure nicked or pure non-nicked species of epidermal growth factor EGF1-48 or its hEGF1-47 or hEGF1-49 congener compound, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition in dosage form comprising an effective amount of the novel compound and/or the known hEGF1-53; and use thereof for treating abnormal cell growth conditions including gastrointestinal/duodenal lesions; and methods of making the pure novel hEGF species. This unique therapeutic utility is enhanced by the unexpected and heretofore unappreciated structural stability and resistance of the pure species to enzymatic degradation.

    摘要翻译： 本发明在生长因子组合物中包括：一种新型化合物，其为分离的纯切口或纯非切口的表皮生长因子EGF1-48或其hEGF1-47或hEGF1-49同源化合物或其药学上可接受的盐; 包含有效量的新化合物和/或已知的hEGF1-53的剂型药物组合物; 及其用于治疗包括胃肠/十二指肠损伤的异常细胞生长条件的用途; 以及制作纯新型hEGF物种的方法。 这种独特的治疗效用通过意想不到的和迄今为止尚未被欣赏的结构稳定性和纯物质对酶降解的抗性而增强。