公开(公告)号：US08398559B2

公开(公告)日：2013-03-19

申请号：US11483460

申请日：2006-07-10

申请人： Kai Kück ,  Joseph A. Orr ,  Lara Brewer

发明人： Kai Kück ,  Joseph A. Orr ,  Lara Brewer

IPC分类号： A61B5/08

CPC分类号： A61B5/0836 ,  A61B5/029 ,  G01N33/497 ,  G01N2001/2244

摘要： Methods for estimating the volume of the carbon dioxide stores of an individual's respiratory tract include determining a carbon dioxide store volume at which a correlation between corresponding signals of carbon dioxide elimination and an indicator of the content of carbon dioxide in blood of the individual is optimized. The estimate of the volume of carbon dioxide stores, which comprises a model of the respiratory tract, or lungs, of the individual, may be used as a transformation to improve the accuracy of one or both of the carbon dioxide elimination and carbon dioxide content signals. Transformation, or filtering, algorithms are also disclosed, as are systems in which the methods and algorithms may be used. The methods, algorithms, and systems may be used to accurately and noninvasively determine one or both of the pulmonary capillary blood flow and cardiac output of the individual.

摘要翻译： 用于估计个体呼吸道二氧化碳储存体积的方法包括确定二氧化碳储存容积，其中二氧化碳消除的相应信号与个体血液中二氧化碳含量的指标被优化之间的相关性。 包括个人呼吸道或肺的模型的二氧化碳储存量的估算可以用作改善二氧化碳消除和二氧化碳含量信号中的一种或两种的准确性的转化 。 还公开了转换或滤波算法，以及可以使用方法和算法的系统。 方法，算法和系统可用于精确地和非侵入性地确定个体的肺毛细血管血流量和心输出量中的一个或两个。

公开(公告)号：US20080127977A1

公开(公告)日：2008-06-05

申请号：US11948080

申请日：2007-11-30

申请人： Joseph A. Orr ,  Craig T. Flanagan

发明人： Joseph A. Orr ,  Craig T. Flanagan

IPC分类号： A61M16/00

CPC分类号： A61M16/0858 ,  A61B5/0833 ,  A61M16/0051 ,  A61M16/021 ,  A61M16/0816 ,  A61M16/0841 ,  A61M16/1075 ,  A61M16/16 ,  A61M2016/0036 ,  A61M2016/1025 ,  A61M2016/103 ,  A61M2230/432 ,  A61M2230/435

摘要： A mainstream gas monitoring system and method that includes a using a mainstream airway adapter, and a gas sensing assembly associated with the mainstream airway adapter to measure an analyte of a gas flow through the adapter. A gas sensing portion outputs a signal indicative of the analyte in a gas flow in the mainstream airway adapter. A processing portion receives the signal from the gas sensing portion and determines an amount of the analyte in the gas flow based on the signal from the gas sensing portion. The processing portion also compensates for volumetric differences between the gas flow during inspiration and the gas flow during expiration to maximize the accuracy in the measurements made using such a system and method.

摘要翻译： 包括使用主流气道适配器的主流气体监测系统和方法，以及与主流气道适配器相关联的气体感测组件，以测量通过适配器的气流的分析物。 气体传感部分输出指示主流气道适配器中气体流中分析物的信号。 处理部分接收来自气体检测部分的信号，并且基于来自气体感测部分的信号确定气流中的分析物的量。 处理部分还补偿吸气期间的气体流量和呼气期间的气体流量之间的体积差异，以使得使用这种系统和方法进行的测量的精度最大化。

公开(公告)号：US07135001B2

公开(公告)日：2006-11-14

申请号：US09813225

申请日：2001-03-20

申请人： Joseph A. Orr ,  Kai Kuck ,  Lara Brewer

发明人： Joseph A. Orr ,  Kai Kuck ,  Lara Brewer

IPC分类号： A61B5/02 ,  A61B5/08

CPC分类号： A61B5/0836 ,  A61B5/029 ,  A61M16/0045 ,  A61M2016/0036 ,  A61M2230/432 ,  G06F19/00

摘要： A differential Fick technique including a first phase in which baseline breathing parameters may be established and a second phase in which a change in the effective ventilation of a patient is induced. The durations of the first and second phases may be substantially the same and may be abbreviated relative to the durations of comparable phases of previously known differential Fick techniques. The disclosed differential Fick technique also lacks a recovery period in which the respiratory parameters of a patient are permitted to return to “normal” levels.

摘要翻译： 一种差分Fick技术，包括其中可以建立基线呼吸参数的第一阶段和诱导患者有效通气变化的第二阶段。 第一和第二阶段的持续时间可以基本上相同并且可以相对于先前已知的差分Fick技术的相似阶段的持续时间来缩写。 所公开的差分Fick技术还缺乏允许患者的呼吸参数恢复到“正常”水平的恢复期。

公开(公告)号：US06475158B1

公开(公告)日：2002-11-05

申请号：US09694954

申请日：2000-10-24

申请人： Joseph A. Orr ,  Scott A. Kofoed ,  Kevin Durst

发明人： Joseph A. Orr ,  Scott A. Kofoed ,  Kevin Durst

IPC分类号： A61B508

CPC分类号： A61B5/024 ,  A61B5/0002 ,  A61B5/0833 ,  A61B5/087

摘要： A calorimeter configured to determine a metabolic rate of an individual based on measurements of the individual's respiration. The calorimeter includes an inlet, a flow sensor, a mixing chamber, a gas sensor, and a calibrator. Each of these elements is located along a flow path through the calorimeter. The calibrator of the calorimeter includes a fan that is configured to force calibration gases, such as room air, through or past the gas sensor. A cardiac rate monitor is associated with a processor of the calorimeter. The processor is configured to substantially simultaneously determine and establish a relationship between the cardiac rate of the individual and the measured respiratory parameters or the metabolic rate of the individual. Data representative of this relationship may be communicated to a processor or memory of a portable calorimeter to be subsequently used by the individual. The portable calorimeter, which can be worn by the individual, includes a cardiac rate monitor that measures the cardiac rate of the individual and communicates data representative of the individual's cardiac rate to the processor, which then determines the metabolic rate of the individual based on relationship data obtained from the respiratory-based calorimeter. Methods of calibrating and using the calorimeters are also disclosed.

摘要翻译： 配置成基于个体呼吸的测量来确定个体的代谢率的量热计。 量热计包括入口，流量传感器，混合室，气体传感器和校准器。 这些元件中的每一个沿着通过热量计的流动路径定位。 量热计的校准器包括被配置为迫使校准气体（例如室内空气）通过或经过气体传感器的风扇。 心率监测器与量热计的处理器相关联。 处理器被配置为基本上同时确定和建立个体的心率和测量的呼吸参数或个体的代谢率之间的关系。 表示该关系的数据可以传送到随后由个人使用的便携式量热计的处理器或存储器。 便携式量热计可以由个人佩戴，包括心率监测器，其测量个体的心率，并将表示个体心率的数据传达给处理器，然后处理器基于关系确定个体的代谢率 从呼吸型量热仪获得的数据。 还公开了校准和使用热量计的方法。

公开(公告)号：US06238351B1

公开(公告)日：2001-05-29

申请号：US09150136

申请日：1998-09-09

申请人： Joseph A. Orr ,  Michael B. Jaffe ,  Kai Kück ,  Dinesh G. Haryadi

发明人： Joseph A. Orr ,  Michael B. Jaffe ,  Kai Kück ,  Dinesh G. Haryadi

IPC分类号： A61B508

CPC分类号： A61B5/0836 ,  A61B5/029 ,  A61B5/087 ,  G01N33/49 ,  G01N33/497

摘要： A method of compensating for non-metabolic changes in respiratory or blood gas parameters including generating a compensatory signal based on the magnitude of the non-metabolic change and the amount of time elapsed since the onset of the non-metabolic change. The method of the present invention is useful for compensating for non-metabolic changes in non-invasive carbon dioxide elimination measurements and, particularly, when carbon dioxide elimination is employed to determine cardiac output on a non-invasive, continuous basis.

摘要翻译： 补偿呼吸或血液气体参数中的非代谢变化的方法，包括基于非代谢变化的大小和自非代谢变化开始以来经过的时间量产生补偿信号。 本发明的方法可用于补偿非侵入性二氧化碳消除测量中的非代谢变化，特别是当采用二氧化碳消除来确定非侵入性连续的心输出量时。

公开(公告)号：US06210342B1

公开(公告)日：2001-04-03

申请号：US09391165

申请日：1999-09-08

申请人： Kai Kück ,  Joseph A. Orr

发明人： Kai Kück ,  Joseph A. Orr

IPC分类号： A61B502

CPC分类号： A61B5/0836 ,  A61B5/029

摘要： A re-breathing method for determining pulmonary capillary blood flow that accounts for changes in the cardiac output or in the carbon dioxide content of the venous blood of a patient. The carbon dioxide elimination and partial pressure of end tidal carbon dioxide of the patient are non-invasively measured prior to re-breathing, during re-breathing, and after re-breathing. The carbon dioxide elimination and the carbon dioxide content of the alveolar blood of the patient at each of the before, during, and after re-breathing phases are then used to calculate the pulmonary capillary blood flow of the patient. A rate of change of carbon dioxide content of the venous blood of the patient may also be calculated and employed in calculating the pulmonary capillary blood flow of the patient.

摘要翻译： 用于确定肺毛细血管血流的再呼吸方法，其考虑了心输出量或患者静脉血二氧化碳含量的变化。 患者的二氧化碳消除和部分潮气二氧化碳的分压在呼吸前，再呼吸期间和再次呼吸之后都是非侵入性的。 然后使用在再呼吸阶段之前，期间和之后患者的二氧化碳消除和患者肺泡血液中的二氧化碳含量来计算患者的肺毛细血管血流量。 也可以计算患者的静脉血二氧化碳含量的变化率，并用于计算患者的肺毛细血管血流量。

公开(公告)号：USD423101S

公开(公告)日：2000-04-18

申请号：US102863

申请日：1999-04-02

申请人： Kevin Durst ,  Scott A. Kofoed ,  Joseph A. Orr

设计人： Kevin Durst ,  Scott A. Kofoed ,  Joseph A. Orr

公开(公告)号：US5789660A

公开(公告)日：1998-08-04

申请号：US680492

申请日：1996-07-15

申请人： Scott A. Kofoed ,  Joseph A. Orr ,  David R. Rich

发明人： Scott A. Kofoed ,  Joseph A. Orr ,  David R. Rich

IPC分类号： A61B5/083 ,  G01F1/40 ,  G01F1/42 ,  G01N21/05 ,  G01N33/497 ,  G01N7/00

CPC分类号： G01N21/05 ,  A61B5/083 ,  G01F1/40 ,  G01F1/42

摘要： An integrated airway adapter capable of monitoring CO.sub.2 concentration in real time, breath by breath using infrared absorption techniques and monitoring respiratory flow with differential pressure flowmeters under diverse inlet conditions through improved sensor configurations which minimize phase lag and dead space within the airway adapter.

摘要翻译： 一种集成气道适配器，能够实时监测二氧化碳浓度，使用红外吸收技术进行呼吸呼吸，并通过改进的传感器配置在不同入口条件下通过差压流量计监测呼吸流量，从而最大限度地减少气道适配器内的相位滞后和死区。

公开(公告)号：US08166971B2

公开(公告)日：2012-05-01

申请号：US12046808

申请日：2008-03-12

申请人： Michael B. Jaffe ,  Joseph A. Orr

发明人： Michael B. Jaffe ,  Joseph A. Orr

IPC分类号： A61M11/00

CPC分类号： A61B5/0836 ,  A61B5/087 ,  A61M16/026 ,  A61M16/161 ,  A61M2016/0027 ,  A61M2016/0036 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2202/0241 ,  A61M2202/0275 ,  A61M2202/0283 ,  A61M2205/502 ,  A61M2230/432 ,  A61M2230/435 ,  A61M2230/437

摘要： An apparatus and method of indicating the reliability of an end-tidal gas value that includes measuring a plurality of gas concentration values, measuring a plurality of ventilation values, determining an end-tidal gas value from the gas concentration values, determining the degree of ventilatory stability from the ventilation values, and providing an estimate of reliability of the end-tidal gas values using the degree of ventilatory stability.

摘要翻译： 一种指示终端气体价值的可靠性的装置和方法，包括测量多个气体浓度值，测量多个通风值，根据气体浓度值确定终端气体值，确定通气程度 通风值的稳定性，并使用通气稳定度提供最终潮气值的可靠性估计值。

公开(公告)号：US07621272B2

公开(公告)日：2009-11-24

申请号：US11123887

申请日：2005-05-06

申请人： Joseph A. Orr

发明人： Joseph A. Orr

IPC分类号： A61M11/00

CPC分类号： A61M16/009 ,  A61M16/0045 ,  A61M16/0093 ,  A61M16/0833 ,  A61M16/085 ,  A61M16/1055 ,  A61M16/106 ,  A61M2230/432 ,  A61M2230/435

摘要： An apparatus for reversing inhaled anesthesia includes a filter for removing one or more anesthetic agents from gases passing therethrough, as well as a component for elevating CO2 levels in gases that are to be inhaled by a subject. The CO2 level-elevating component facilitates an increase in the ventilation of the subject without resulting in a significant decrease in the subject's PaCO2 level and, thus, a decrease in the rate at which blood flows through the subject's brain. A method of reversing the effects of inhaled anesthesia includes increasing the rate of ventilation of an anesthetized subject while causing the subject to inhale gases with elevated amounts of CO2 and while filtering anesthetic agents from such gases.

摘要翻译： 用于逆转吸入麻醉的装置包括用于从通过其中的气体中除去一种或多种麻醉剂的过滤器，以及用于提高待被受试者吸入的气体中的CO 2水平的组分。 CO 2水平升高组分有助于受试者的通气量的增加，而不会导致受试者的PaCO 2水平的显着降低，并且因此导致血液流过受试者的大脑的速度的降低。 一种逆转吸入麻醉效果的方法包括增加麻醉受试者的通气率，同时使受试者以较高量的CO 2吸入气体，同时从这些气体中过滤麻醉剂。