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95 条记录 (耗时 0.07 秒)

    Trialkyl cationic lipids and methods of use thereof
    46.
    发明授权
    Trialkyl cationic lipids and methods of use thereof 有权
    三烷基阳离子脂质及其使用方法

    公开(公告)号：US08466122B2

    公开(公告)日：2013-06-18

    申请号：US13235253

    申请日：2011-09-16

    申请人： James Heyes ,  Mark Wood ,  Alan Martin

    发明人： James Heyes ,  Mark Wood ,  Alan Martin

    IPC分类号： C12N15/11 ,  C07H21/02 ,  A61K9/127

    CPC分类号： A61K47/44 ,  A61K9/1272 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K47/34 ,  C07C229/12 ,  C07C271/20

    摘要： The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

    摘要翻译： 本发明提供了将治疗剂递送至细胞的组合物和方法。 特别地，这些包括提供核酸的有效包封的新型阳离子脂质和核酸 - 脂质颗粒，并将包封的核酸在体内有效递送至细胞。 本发明的组合物是高度有效的，从而允许以相对低的剂量有效击倒特异性靶蛋白。 此外，与本领域已知的组合物和方法相比，本发明的组合物和方法毒性低，并提供更大的治疗指数。

    Biopsy Cap Attachment and Integrated Locking Device
    48.
    发明申请
    Biopsy Cap Attachment and Integrated Locking Device 审中-公开
    活检盖附件和集成锁定装置

    公开(公告)号：US20090287052A1

    公开(公告)日：2009-11-19

    申请号：US12467947

    申请日：2009-05-18

    申请人： Michael Devon Amos ,  Jason Weiner ,  Mark Wood

    发明人： Michael Devon Amos ,  Jason Weiner ,  Mark Wood

    IPC分类号： A61B1/00

    CPC分类号： A61B1/018 ,  A61B1/0008 ,  A61B1/00137 ,  A61B1/2676

    摘要： Endoscope assemblies and methods for making and using the same. An example endoscope assembly may include an endoscope having a channel formed therein and a port that provides access to the channel, a cap disposed on the port, and an attachment assembly coupled to the cap. The attachment assembly may include a base and one or more arms extending from the base. A locking member may be coupled to at least one of the one or more arms.

    摘要翻译： 内镜组件及其使用方法。 示例性内窥镜组件可以包括具有形成在其中的通道的内窥镜和提供对通道的通路的端口，设置在端口上的盖以及联接到盖的附接组件。 附接组件可以包括基部和从基部延伸的一个或多个臂。 锁定构件可以联接到一个或多个臂中的至少一个臂。

    Positioning system for securing a treatment instrument at the end of a medical device
    49.
    发明申请
    Positioning system for securing a treatment instrument at the end of a medical device 有权
    用于固定治疗仪器在医疗器械末端的定位系统

    公开(公告)号：US20090182194A1

    公开(公告)日：2009-07-16

    申请号：US12314500

    申请日：2008-12-11

    申请人： Mark Wood ,  John Hutchins

    发明人： Mark Wood ,  John Hutchins

    IPC分类号： A61B1/018

    CPC分类号： A61B1/018 ,  A61B1/0008 ,  A61B1/00098 ,  A61B1/2736

    摘要： Embodiments of the invention include a medical device for accessing a patient's body portion and used for diagnosis and treatment of medical conditions. Embodiments of the invention may include a particular endoscopic positioning mechanism for placing an endoscope and an additional treatment device within desired body portions in order to assist in diagnosis and treatment of anatomical diseases and disorders. In particular, a medical device according to an embodiment of the invention includes a positioning mechanism configured to maintain the relative position of a treatment instrument with respect to an underlying endoscope during a treatment procedure.

    摘要翻译： 本发明的实施例包括用于访问患者身体部分并用于诊断和治疗医疗状况的医疗装置。 本发明的实施例可以包括特定的内窥镜定位机构，用于将内窥镜和附加治疗装置放置在期望的身体部分内，以帮助诊断和治疗解剖疾病和病症。 具体地，根据本发明的实施例的医疗装置包括定位机构，其构造成在治疗过程期间保持治疗器具相对于下面的内窥镜的相对位置。

    ENDOPROSTHESIS DELIVERY SYSTEM WITH STENT HOLDER
    50.
    发明申请
    ENDOPROSTHESIS DELIVERY SYSTEM WITH STENT HOLDER 审中-公开
    具有支架的ENDOPROSTHESIS交付系统

    公开(公告)号：US20080009934A1

    公开(公告)日：2008-01-10

    申请号：US11762334

    申请日：2007-06-13

    申请人： Eric Schneider ,  Mark Wood ,  Gary J. Leanna ,  Gary Jordan ,  James Weldon ,  Jason Weiner

    发明人： Eric Schneider ,  Mark Wood ,  Gary J. Leanna ,  Gary Jordan ,  James Weldon ,  Jason Weiner

    IPC分类号： A61F2/06

    CPC分类号： A61F2/95 ,  A61F2002/9583

    摘要： A device, such as a catheter, for intraluminally delivering a distensible stent includes a first elongate tubular member having a proximal end and a distal end; a band circumferentially disposed over at least a circumferential portion of the first tubular member at the proximal end, the band having at least one projection for releasably engaging a portion of a radially distensible stent; and a second elongate tubular member slidably disposed over the first tubular member and the band. Desirably, the at least one projection is a low-profile, lobate-projection. shaped projection. The band may include two opposed projections, where the two opposed projections may be circumferentially disposed at about 180° from one and the other. Desirably, the band includes a metal, for example, stainless steel.

    摘要翻译： 用于腔内递送可扩张支架的诸如导管的装置包括具有近端和远端的第一细长管状构件; 在所述近端处沿周向设置在所述第一管状构件的至少周向部分上的带，所述带具有用于可释放地接合径向扩张的支架的一部分的至少一个突起; 以及可滑动地设置在所述第一管状构件和所述带上的第二细长管状构件。 期望地，至少一个突起是低调的叶状突起。 形状投影。 带可以包括两个相对的突起，其中两个相对的突出部可以沿着圆周方向彼此大约180°设置。 期望地，带包括金属，例如不锈钢。