公开(公告)号：US06255286B1

公开(公告)日：2001-07-03

申请号：US09214002

申请日：1998-12-24

申请人： Makoto Yanai ,  Masashi Suzuki ,  Norio Oshida ,  Koji Kawamura ,  Shigeru Hiramoto ,  Orie Yasuda ,  Nobuhiro Kinoshita ,  Akiko Shingai ,  Masako Takasu

发明人： Makoto Yanai ,  Masashi Suzuki ,  Norio Oshida ,  Koji Kawamura ,  Shigeru Hiramoto ,  Orie Yasuda ,  Nobuhiro Kinoshita ,  Akiko Shingai ,  Masako Takasu

IPC分类号： A61K3800

CPC分类号： C07K5/1021 ,  A61K38/00 ,  C07K5/06043 ,  C07K5/06052 ,  C07K5/06104 ,  C07K5/101 ,  C07K7/06 ,  C07K11/00

摘要： Depsipeptides represented by the formula (1): (wherein: R1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R2 is —A—B, —A—B—W, —A—B—W—D or —A—B—W—D—E, R3 is a hydroxyl group, a lower alkoxy group, a benzyloxy group, —Z, —Z—G or —Z—G—J, the above A, B, D, E, G and J independently each other are a residue of an amino acid selected from alanine, valine, leucine, isoleucine, serine, threonine, lysine, hydroxylysine, arginine, cysteine, methionine, phenylalanine, tyrosine, aspartic acid, asparagine, glutamic acid, glutamine and the like or an N—(C1-C4) alkyl derivative of these amino acid residues; the above W and Z independently each other are a residue of an amino acid selected from aspartic acid, asparagine, glutamic acid, glutamine, alanine, serine or lysine) or pharmacologically acceptable salts thereof. The depsipeptides have an activity of promoting the production of apolipoprotein E and are useful as a therapeutic agent for neurologic damages, especially for dementia, and further as a therapeutic agent for hyperlipemia.

摘要翻译： 由式（1）表示的缩肽：其中：R1是5-20个碳原子的直链或支链烷基或5-15个碳原子的直链或支链烷氧基甲基; R2是-AB，-ABW，-ABWD 或-ABWDE，R3是羟基，低级烷氧基，苄氧基，-Z，-ZG或-ZGJ，上述A，B，D，E，G和J彼此独立地是氨基的残基 选自丙氨酸，缬氨酸，亮氨酸，异亮氨酸，丝氨酸，苏氨酸，赖氨酸，羟赖氨酸，精氨酸，半胱氨酸，甲硫氨酸，苯丙氨酸，酪氨酸，天冬氨酸，天冬酰胺，谷氨酸，谷氨酰胺等的N-酸或N-（C1-C4） 这些氨基酸残基的烷基衍生物;上述W和Z彼此独立地是选自天冬氨酸，天冬酰胺，谷氨酸，谷氨酰胺，丙氨酸，丝氨酸或赖氨酸的氨基酸的残基）或其药理学上可接受的盐。脱脂肽具有 促进载脂蛋白E的产生的活性并且可用作治疗 用于神经损伤的特异剂，特别是对于痴呆，并且作为高脂血症的治疗剂。

公开(公告)号：US6061152A

公开(公告)日：2000-05-09

申请号：US990778

申请日：1997-12-15

申请人： Makoto Nihei ,  Katsumi Masaki ,  Masayuki Takayama ,  Hiroshi Netsu ,  Masashi Takizawa ,  Koji Kawamura

发明人： Makoto Nihei ,  Katsumi Masaki ,  Masayuki Takayama ,  Hiroshi Netsu ,  Masashi Takizawa ,  Koji Kawamura

IPC分类号： G06T11/00 ,  H04N3/14

CPC分类号： G06T11/00

摘要： An image processing method and apparatus which makes possible image processing based on attribute specification contents specified by an attribute specification image by reading an original including an original image and the attribute specification image which specifies the contents of processings to be performed on the original image.A scanner reads a format original containing bar codes indicating data attribute specifications such as character limit range, character color, etc. The read bar code patterns are analyzed and the attribute specification data such as character limit range, character color, etc. is stored in RAM once. Then, the original to be output is read and stored in RAM as image data. Processings (such as color conversion, etc.) corresponding to the aforementioned attribute specification data are performed in relation to this image data. After all of the processings specified by the attribute specification data has been carried out in relation to this image data, the resulting data is printed onto a printer.

摘要翻译： 一种图像处理方法和装置，其通过读取包括原始图像的原件和指定要对原始图像执行的处理的内容的属性指定图像，基于由属性指定图像指定的属性指定内容进行图像处理。 扫描仪读取包含指示诸如字符限制范围，字符颜色等数据属性规格的条形码的格式原稿。分析读取的条形码图案，并将诸如字符限制范围，字符颜色等的属性指定数据存储在 RAM一次 然后，将要输出的原稿作为图像数据读取并存储在RAM中。 相对于该图像数据执行与上述属性指定数据对应的处理（例如，颜色转换等）。 在通过属性指定数据指定的所有处理已经相对于该图像数据执行之后，所得到的数据被打印到打印机上。

公开(公告)号：US5785502A

公开(公告)日：1998-07-28

申请号：US540556

申请日：1995-10-06

申请人： Masaki Ota ,  Sokichi Hibino ,  Hisakazu Kobayashi ,  Masahiro Kawaguchi ,  Ken Suitou ,  Koji Kawamura ,  Takuya Okuno

发明人： Masaki Ota ,  Sokichi Hibino ,  Hisakazu Kobayashi ,  Masahiro Kawaguchi ,  Ken Suitou ,  Koji Kawamura ,  Takuya Okuno

IPC分类号： F04B49/06 ,  F04B27/08 ,  F04B27/10 ,  F04B27/14 ,  F04B27/18 ,  F04B49/22 ,  F04B1/26

CPC分类号： F04B27/1804 ,  F04B27/1036 ,  F04B49/225 ,  F04B2027/1813 ,  F04B2027/1827 ,  F04B2027/1854 ,  F04B2027/1859 ,  F04B2027/1895

摘要： A swash plate tiltably supported on a drive shaft is controlled by adjusting the pressure in a crank chamber. When an electromagnetic valve is de-excited, the high-pressure refrigerant gas in a discharge chamber is supplied to the crank chamber so that the inclination angle of the swash plate is shifted to its minimum inclination from its maximum inclination. An open/close mechanism located in a suction passage gradually opens or closes the suction passage in accordance with the differential pressure between the pressure in the external refrigeration circuit located upstream the open/close mechanism and the pressure in a suction chamber. When the inclination angle of the swash plate is minimized, the open/close mechanism closes the suction passage. It is therefore possible to prevent frosting while also suppressing rapid changes in load torque.

摘要翻译： 倾斜地支撑在驱动轴上的斜盘通过调节曲柄室中的压力来控制。 当电磁阀被去激励时，排出室中的高压制冷剂气体被供应到曲柄室，使得斜盘的倾斜角度从其最大倾角移动到其最小倾角。 位于吸入通道中的打开/关闭机构根据位于打开/关闭机构上游的外部制冷回路的压力与吸入室中的压力之间的差压逐渐打开或关闭吸入通道。 当斜盘的倾斜角度最小时，打开/关闭机构关闭吸入通道。 因此，能够防止结霜，同时也抑制负载转矩的急剧变化。

公开(公告)号：US08655230B2

公开(公告)日：2014-02-18

申请号：US13542205

申请日：2012-07-05

申请人： Koji Kawamura

发明人： Koji Kawamura

IPC分类号： G03G15/01

CPC分类号： G03G15/0896 ,  G03G15/0121 ,  G03G2221/1657

摘要： An image forming apparatus for forming a color image on a recording material includes mounting means for detachably mounting a plurality of process cartridges each including a photosensitive drum and a developing roller. Movable members are provided that are actable on first and second clutches for switching between an operation state for transmitting the driving force to the developing rollers and a non-operation state not transmitting the driving force thereto. Also provided is a switching member for switching among a first mode for transmitting the driving force to the developing rollers of all of the process cartridges, a second mode for not transmitting the driving force to any one of the developing rollers, and a third mode for transmitting the driving force only to the developing roller of a black process cartridge.

摘要翻译： 用于在记录材料上形成彩色图像的图像形成装置包括用于可拆卸地安装包括感光鼓和显影辊的多个处理盒的安装装置。 提供可移动的构件，其可用于在用于将驱动力传递到显影辊的操作状态和不传递驱动力的非操作状态之间切换的第一和第二离合器上。 还提供了一种切换构件，用于在用于将驱动力传递到所有处理盒的显影辊的第一模式之间切换，用于不将驱动力传递到任何一个显影辊的第二模式，以及用于 仅将驱动力传递到黑色处理盒的显影辊。

公开(公告)号：US20120142932A1

公开(公告)日：2012-06-07

申请号：US13386698

申请日：2010-09-07

申请人： Koji Kawamura ,  Keita Miyoshi ,  Emi Kobayashi

发明人： Koji Kawamura ,  Keita Miyoshi ,  Emi Kobayashi

IPC分类号： C07D401/12

CPC分类号： C07D401/12

摘要： A novel method for manufacturing 5-methyl-2-(piperidin-4-ylamino)pyridine is established. This method can be used as an industrial manufacturing method to produce a 4-(5-methylpyridin-2-ylamino)piperidine-1-carboxylic acid derivative represented by the general formula, (wherein R represents a linear or branched alkyl group having 1 to 6 carbon atoms or an aralkyl group having 7 to 12 carbon atoms) in a reaction solution having an aromatic monocyclic hydrocarbon as a reaction medium, in the presence of sodium triacetoxyborohydride as a reducing agent, or after adding sodium borohydride and acetic acid to the reaction solution in advance.

摘要翻译： 建立了一种制备5-甲基-2-（哌啶-4-基氨基）吡啶的新方法。 该方法可以用作工业制造方法来制备由通式表示的4-（5-甲基吡啶-2-基氨基）哌啶-1-羧酸衍生物（其中R表示具有1〜 6个碳原子或具有7〜12个碳原子的芳烷基）在具有芳香族单环烃作为反应介质的反应溶液中，在三乙酰氧基硼氢化钠作为还原剂的存在下，或在将硼氢化钠和乙酸加入反应中 提前解决。

公开(公告)号：US07826773B2

公开(公告)日：2010-11-02

申请号：US11621780

申请日：2007-01-10

申请人： Koji Kawamura

发明人： Koji Kawamura

IPC分类号： G03G15/01

CPC分类号： G03G15/0896 ,  G03G15/0121 ,  G03G2221/1657

摘要： An image forming apparatus detachably mounts black and non-black cartridges each including a photosensitive drum and a developing roller. The apparatus includes a driving source; first and second clutches for connecting and disconnecting between the driving source and the developing roller of the black and non-black cartridges, respectively; movable first and second members actable on the first and second clutches, respectively, for switching between transmitting the driving force to the developing rollers and not transmitting the driving force; and a switching member, movable by the driving force of the driving source and actable on the first and second members for switching among first, second, and third modes for transmitting the driving force to the developing rollers of all of the cartridges, not transmitting the driving force to any one of the rollers, and transmitting the driving force only to the developing roller of the black cartridge.

摘要翻译： 图像形成装置可拆卸地安装黑色和非黑色墨盒，每个墨盒包括感光鼓和显影辊。 该装置包括驱动源; 第一和第二离合器，分别用于在黑色和黑色墨盒之间连接和断开驱动源和显影辊; 可移动的第一和第二构件分别作用在第一和第二离合器上，用于在传递驱动力到显影辊之间切换并且不传递驱动力; 以及切换构件，可通过驱动源的驱动力移动并且能够在第一和第二构件上移动，用于在第一，第二和第三模式之间切换，以将驱动力传递到所有墨盒的显影辊，而不传送 驱动力到任何一个辊，并且仅将驱动力传递到黑色暗盒的显影辊。

公开(公告)号：US07763001B2

公开(公告)日：2010-07-27

申请号：US11553114

申请日：2006-10-26

申请人： Koji Kawamura

发明人： Koji Kawamura

IPC分类号： A61F13/15

CPC分类号： A61F13/47218 ,  A61F13/4752

摘要： An absorbent article includes a fluid permeable top sheet, a fluid impermeable back sheet, and an absorbent body disposed therebetween, and in addition is provided with an evagination means extending in a longitudinal direction between the top sheet and the back sheet. The top sheet has a first attachment region attached to the evagination means, second attachment regions attached to the vicinity of both side edges of the absorbent article, and an unattached region positioned between the regions. In the unattached region, many inflected creases, in particular, diagonally directed creases directed from the first attachment region towards both side edges are generated.

摘要翻译： 吸收性物品包括流体可渗透的顶片，流体不可渗透的背片和设置在其间的吸收体，并且还设置有在顶片和背片之间沿纵向延伸的分离装置。 顶片具有附接到分离装置的第一附接区域，附接到吸收制品的两个侧边缘附近的第二附接区域和位于该区域之间的未附着区域。 在未附着区域中，产生许多变形的折痕，特别是产生从第一附接区域朝向两侧边缘引导的对角线引导的折痕。

公开(公告)号：US20050085508A1

公开(公告)日：2005-04-21

申请号：US10492065

申请日：2002-10-08

申请人： Ryuuta Fukutomi ,  Hitoshi Inoue ,  Koji Kawamura ,  Takuya Kishimoto ,  Masashi Suzuki ,  Rie Shibayama ,  Kazuko Kojima ,  Kouichirou Hagihara

发明人： Ryuuta Fukutomi ,  Hitoshi Inoue ,  Koji Kawamura ,  Takuya Kishimoto ,  Masashi Suzuki ,  Rie Shibayama ,  Kazuko Kojima ,  Kouichirou Hagihara

IPC分类号： A61P1/04 ,  A61P1/08 ,  A61P1/10 ,  A61P17/04 ,  A61P43/00 ,  C07D211/58 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  A61K31/445

CPC分类号： C07D401/12 ,  C07D211/58 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14

摘要： There are provided novel 4-(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is CH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III): wherein a, b and c are each an integer of 0-6; Z is CH2 or NH; W is O or S; T is O or N—R15 wherein R15 is H, a C1-C6 alkyl group, a benzyl group or a phenethyl group; and R1 is H, a C1-C6 alkoxycarbonyl group, a benzyloxycarbonyl group, or the like. The 4-(2-furoyl)aminopiperidine derivatives according to this invention possess opioid μ antagonistic activity and are useful for the treatment or prevention of side effects which are caused by μ receptors agonist and which are selected from constipation, nausea/emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.

摘要翻译： 提供由通式（I）表示的新型4-（2-糠酰基）氨基哌啶，其合成中间体，其制备方法和含有它们的药物。 在上式中，X是CH或N，Y是下列通式（II），式（II-a）或式（III）的基团：其中a，b和c各自为0〜 6; Z是CH 2或NH; W为O或S; T是O或N-R 15，其中R 15是H，C 1 -C 6烷基，苄基或苯乙基; R 1是H，C 1 -C 6烷氧基羰基，苄氧基羰基等。 根据本发明的4-（2-糠酰基）氨基哌啶衍生物具有阿片样物质μ拮抗活性，可用于治疗或预防由mu受体激动剂引起的副作用，其选自便秘，恶心/呕吐或瘙痒， 或用于治疗或预防特发性便秘，术后肠梗阻，麻痹性肠梗阻，肠易激综合征或慢性瘙痒。

公开(公告)号：US06858585B1

公开(公告)日：2005-02-22

申请号：US09147434

申请日：1997-06-25

申请人： Makoto Yanai ,  Masashi Suzuki ,  Norio Oshida ,  Koji Kawamura ,  Shigeru Hiramoto ,  Orie Yasuda ,  Nobuhiro Kinoshita ,  Akiko Shingai ,  Masako Takasu

发明人： Makoto Yanai ,  Masashi Suzuki ,  Norio Oshida ,  Koji Kawamura ,  Shigeru Hiramoto ,  Orie Yasuda ,  Nobuhiro Kinoshita ,  Akiko Shingai ,  Masako Takasu

IPC分类号： A61K38/00 ,  C07K7/06 ,  A61K38/15 ,  C07K7/00

CPC分类号： C07K7/06 ,  A61K38/00

摘要： Cyclic depsipeptides represented by the formula wherein: R is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15-carbon atoms; A, B, D, E and F independently each other are alanine, valine, leucine, isoleucine, phenylalanine, etc.; W and Z independently each other are aspartic acid, asparagine, glutamic acid or glutamine; and m and n independently each other is 0 or 1, or pharmacologically acceptable salts thereof. The present compounds are prepared according to a method conventionally used in peptide synthesis. The present compounds are useful as an agent for promoting the production of apolipoprotein E, a therapeutic agent for neurologic damages, a therapeutic agent for dementia, an agent for inhibiting the production of apolipoprotein B, an agent for promoting the production of apolipoprotein A1 or a therapeutic agent for hyperlipemia.

摘要翻译： 以下式表示的环状缩酚酸酯：R为5-20个碳原子的直链或支链烷基或5-15个碳原子的直链或支链烷氧基甲基; A，B，D，E和F独立地为丙氨酸，缬氨酸，亮氨酸，异亮氨酸，苯丙氨酸等; W和Z独立地是天冬氨酸，天冬酰胺，谷氨酸或谷氨酰胺; m和n彼此独立地为0或1，或其药理学上可接受的盐。 本发明化合物根据肽合成中常规使用的方法制备。 本发明化合物可用作促进载脂蛋白E的产生，神经损伤治疗剂，痴呆治疗剂，抑制载脂蛋白B的制备的试剂，促进载脂蛋白A1的制造的试剂或 高脂血症治疗剂。

公开(公告)号：US06544242B1

公开(公告)日：2003-04-08

申请号：US08882787

申请日：1997-06-26

申请人： Tsutomu Kido ,  Hiroyuki Soga ,  Toshio Inoue ,  Koji Kawamura

发明人： Tsutomu Kido ,  Hiroyuki Soga ,  Toshio Inoue ,  Koji Kawamura

IPC分类号： A61F1315

CPC分类号： A61F13/5512

摘要： A disposable body fluids absorbent article is provided on an outer surface of a backsheet thereof with a tape fastener for fastening the used article in a rolled up condition for disposal. The tape fastener includes a fixed end portion secured to the outer surface of the backsheet, a free end portion longitudinally opposite the fixed end portion, an elastically stretchable portion extending longitudinally between these opposite end portions, and an adhesive portion extending longitudinally between the free end portion and the elastically stretchable portion and releasably bonded to the outer surface of the backsheet.

摘要翻译： 一次性体液吸收性物品在其背面的外表面上设置有带状紧固件，用于将卷绕的物品紧固在待处理中。 带状紧固件包括固定在底片的外表面上的固定端部，与固定端部纵向相对的自由端部，在这两个相对端部之间纵向延伸的弹性伸缩部分，以及在自由端 部分和弹性伸缩部分并且可释放地结合到底片的外表面。