公开(公告)号：US08338424B2

公开(公告)日：2012-12-25

申请号：US13468200

申请日：2012-05-10

Applicant: YuHua Ji ,  Craig Husfeld ,  YongQi Mu ,  Rick Lee ,  Li Li

Inventor： YuHua Ji ,  Craig Husfeld ,  YongQi Mu ,  Rick Lee ,  Li Li

IPC: A61K31/496

CPC classification number: C07D333/24 ,  C07D209/14 ,  C07D213/38 ,  C07D231/12 ,  C07D277/28 ,  C07D295/13 ,  C07D307/52 ,  C07D307/81 ,  C07D317/58 ,  C07D333/20 ,  C07D333/58

Abstract: The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1-3, R5-7, a, X, Y, Y′, Y″, and Z are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

公开(公告)号：US08277809B2

公开(公告)日：2012-10-02

申请号：US11738019

申请日：2007-04-20

Applicant: Peter Bugelski ,  Anuk Das ,  Donald E. Griswold ,  Bailin Liang ,  Li Li ,  Robert T. Sarisky ,  Xiaozhou Shang

Inventor： Peter Bugelski ,  Anuk Das ,  Donald E. Griswold ,  Bailin Liang ,  Li Li ,  Robert T. Sarisky ,  Xiaozhou Shang

IPC: A61K39/395

CPC classification number: C07K16/241 ,  A61K2039/507 ,  C07K16/24 ,  C07K2317/76

Abstract: Methods of treating disorders related to CXCL13 activity utilize CXCL13 antagonists and, optionally, TNFα antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, siRNA, shRNA, ribozymes, and DNAzymes. Disorders related to CXCL13 activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD, and systemic lupus erythematosus.

Abstract translation: 治疗与CXCL13活性相关的疾病的方法利用CXCL13拮抗剂和任选的TNFα拮抗剂，例如包括特定部分或变体，多肽，多核苷酸，siRNA，shRNA，核酶和DNA酶的抗体。 与CXCL13活性相关的疾病包括炎症性疾病，例如肺部疾病，例如哮喘，肺气肿和COPD，以及系统性红斑狼疮。

公开(公告)号：US20120198200A1

公开(公告)日：2012-08-02

申请号：US13360839

申请日：2012-01-30

Applicant: Li Li ,  Ju Wei Shi ,  Wen Jie Wang ,  Bo Yang

Inventor： Li Li ,  Ju Wei Shi ,  Wen Jie Wang ,  Bo Yang

IPC: G06F12/02

CPC classification number: G06F3/061 ,  G06F3/0647 ,  G06F3/067 ,  G06F11/2094 ,  G06F11/3433

Abstract: A computer-implemented method, system, apparatus, and article of manufacture for memory overload management. The method includes: collecting memory application information of at least one node of a computer system that is implementing the method; predicting a memory overload period and an overload memory size of a first node where memory overload will occur based on the memory application information; and scheduling a memory space according to the memory overload period and the overload memory size.

公开(公告)号：US08230951B2

公开(公告)日：2012-07-31

申请号：US12570464

申请日：2009-09-30

Applicant: Steven R. Radford ,  Khoi Q. Trinh ,  Li Li ,  Mark E. Anderson

Inventor： Steven R. Radford ,  Khoi Q. Trinh ,  Li Li ,  Mark E. Anderson

IPC: E21B10/32

CPC classification number: E21B10/322

Abstract: An expandable apparatus for use in a borehole includes a tubular body having at least one opening extending between a longitudinal bore of the tubular body and an outer surface of the tubular body and at least one member positioned within the at least one opening of the tubular body. The at least one member is configured to move between a retracted position and an extended position. An actuation structure is positioned within the tubular body. The actuation structure is coupled to the at least one member and is configured to move the at least one member from the retracted position to the extended position responsive to a flow rate of drilling fluid passing through the longitudinal bore.

Abstract translation: 一种用于钻孔的可扩张装置包括管状主体，其具有至少一个开口，其在管状主体的纵向孔和管状体的外表面之间延伸，并且至少一个构件定位在管状体的至少一个开口内 。 所述至少一个构件构造成在缩回位置和延伸位置之间移动。 致动结构定位在管状体内。 所述致动结构联接到所述至少一个构件，并且构造成响应于穿过所述纵向孔的钻井液的流量，将所述至少一个构件从所述缩回位置移动到所述延伸位置。

公开(公告)号：US08221642B2

公开(公告)日：2012-07-17

申请号：US12755223

申请日：2010-04-06

Applicant: Li Li ,  Don L. Yates

Inventor： Li Li ,  Don L. Yates

IPC: B44C1/22 ,  H01L21/302

CPC classification number: C03C15/00 ,  C03C17/22 ,  C03C2218/32 ,  C03C2218/33 ,  H01L21/31111 ,  H01L21/32 ,  H01L21/76202

Abstract: A method for removing a plurality of dielectric films from a supporting substrate by providing a substrate with a dielectric layer overlying another dielectric layer, contacting the substrate at a first temperature with an acid solution exhibiting a positive etch selectivity at the first temperature, and then contacting the substrate at a second temperature with an acid solution exhibiting a positive etch selectivity at the second temperature. The dielectric layers exhibit different etch rates when etched at the first and second temperatures. The first and second acid solutions may contain phosphoric acid. The first dielectric layer may be silicon nitride and the second dielectric layer may be silicon oxide. Under these conditions, the first temperature may be about 175° C. and the second temperature may be about 155° C.

Abstract translation: 一种用于通过提供覆盖在另一电介质层上的介电层的衬底来从支撑衬底去除多个电介质膜的方法，在第一温度下使衬底与在第一温度下呈现正蚀刻选择性的酸溶液接触，然后接触 在第二温度下用碱性溶液在第二温度下显示出正的蚀刻选择性。 当在第一和第二温度下进行蚀刻时，介电层表现出不同的蚀刻速率。 第一和第二酸溶液可以含有磷酸。 第一电介质层可以是氮化硅，第二电介质层可以是氧化硅。 在这些条件下，第一温度可以是约175℃，第二温度可以是约155℃。

公开(公告)号：US08198304B2

公开(公告)日：2012-06-12

申请号：US13228782

申请日：2011-09-09

Applicant: YuHua Ji ,  Craig Husfeld ,  YongQi Mu ,  Rick Lee ,  Li Li

Inventor： YuHua Ji ,  Craig Husfeld ,  YongQi Mu ,  Rick Lee ,  Li Li

IPC: A61K31/4525 ,  A61K31/453 ,  A61K31/4535 ,  A61K31/445 ,  C07D213/68 ,  C07D405/12 ,  C07D409/12

CPC classification number: C07D333/24 ,  C07D209/14 ,  C07D213/38 ,  C07D231/12 ,  C07D277/28 ,  C07D295/13 ,  C07D307/52 ,  C07D307/81 ,  C07D317/58 ,  C07D333/20 ,  C07D333/58

Abstract: The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1-3, R5-7, a, X, Y, Y′, Y″, and Z are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，其中R1-3，R5-7，a，X，Y，Y'，Y“和Z如说明书中所定义。 这些化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。

公开(公告)号：US20120137218A1

公开(公告)日：2012-05-31

申请号：US12956941

申请日：2010-11-30

Applicant: Li Li ,  Su Liu ,  Azubuike Victor Onwuta ,  Aruna Yedavilli

Inventor： Li Li ,  Su Liu ,  Azubuike Victor Onwuta ,  Aruna Yedavilli

IPC: G06F17/24

CPC classification number: G06F17/2217

Abstract: A computer implemented method, computer program product, and computer system for viewing content encoded in at least one code set and stored in a file system. A computer identifies a unified code set covering all characters used in the file system. The computer, responsive to a user input to view the content, determines whether the content is wholly encoded in the unified code set. The computer, responsive to determining that the code set is not wholly encoded in the unified code set, converts encoding of the content to the unified code set to form converted content. The computer displays the converted content.

Abstract translation: 一种计算机实现的方法，计算机程序产品和用于观看以至少一个代码集编码并存储在文件系统中的内容的计算机系统。 计算机识别覆盖文件系统中使用的所有字符的统一代码集。 计算机响应于用户输入来查看内容，确定内容是否被完全编码在统一代码集中。 计算机响应于确定代码集未被完全编码在统一代码集中，将内容的编码转换为统一代码集以形成转换的内容。 计算机显示已转换的内容。

公开(公告)号：US08189963B2

公开(公告)日：2012-05-29

申请号：US11939269

申请日：2007-11-13

Applicant: Li Li ,  Brian Burdick ,  Sachin Dhawan ,  Ewa Dominowska

Inventor： Li Li ,  Brian Burdick ,  Sachin Dhawan ,  Ewa Dominowska

IPC: G06K9/00 ,  G06K9/54 ,  G06K9/60 ,  H04N1/00 ,  G06F7/00 ,  G06F17/30

CPC classification number: G06Q30/02 ,  G06K9/6217

Abstract: Systems, methods, and computer-readable media for matching a visual media object to an advertisement are provided. Embodiments of the present invention include receiving un-categorized visual media objects, automatically categorizing received visual media objects into subject-matter categories using image recognition technology, and retrieving advertisements assigned to the same subject-matter category for presentation in association therewith.

Abstract translation: 提供了用于将可视媒体对象与广告相匹配的系统，方法和计算机可读介质。 本发明的实施例包括接收未分类的可视媒体对象，使用图像识别技术将接收到的可视媒体对象自动分类为主题类别，以及检索分配给相同主题类别的广告以便与之相关联地呈现。

公开(公告)号：US08178575B2

公开(公告)日：2012-05-15

申请号：US12518259

申请日：2007-10-30

Applicant: Pengcho Tang ,  Zhigang Lin ,  Hejun Lü ,  Fuqiang Zhao ,  Li Li

Inventor： Pengcho Tang ,  Zhigang Lin ,  Hejun Lü ,  Fuqiang Zhao ,  Li Li

IPC: A61K31/40 ,  C07D209/00

CPC classification number: C07D403/12 ,  C07D209/52

Abstract: Derivatives of azabicyclo octane presented by formula (I), the method of making them, and the compositions containing the same and the uses thereof as inhibitors of dipeptidyl peptidase IV (DPP-IV), wherein the substitutes in formula (I) have the same meanings as what is mentioned in the descriptions.

Abstract translation: 由式（I）表示的氮杂二环辛烷衍生物，其制备方法和含有该衍生物的组合物及其作为二肽基肽酶IV（DPP-IV）抑制剂的用途，其中式（I）中的取代基具有相同 意义与描述中提到的相同。

公开(公告)号：US20120108207A1

公开(公告)日：2012-05-03

申请号：US13111801

申请日：2011-05-19

Applicant: Stephan V. Schell ,  Arun G. Mathias ,  Jerrold Von Hauck ,  David T. Haggerty ,  Kevin McLaughlin ,  Ben-Heng Juang ,  Li Li

Inventor： Stephan V. Schell ,  Arun G. Mathias ,  Jerrold Von Hauck ,  David T. Haggerty ,  Kevin McLaughlin ,  Ben-Heng Juang ,  Li Li

IPC: H04W12/06

CPC classification number: H04W12/06 ,  G06F21/45 ,  G06F21/57 ,  H04L63/08 ,  H04L63/0853 ,  H04L63/123 ,  H04L63/20 ,  H04L67/34 ,  H04W4/50 ,  H04W4/60 ,  H04W8/205 ,  H04W12/04 ,  H04W12/08

Abstract: Methods and apparatus enabling programming of electronic identification information of a wireless apparatus. In one embodiment, a previously purchased or deployed wireless apparatus is activated by a cellular network. The wireless apparatus connects to the cellular network using an access module to download operating system components and/or access control client components. The described methods and apparatus enable updates, additions and replacement of various components including Electronic Subscriber Identity Module (eSIM) data, OS components. One exemplary implementation of the invention utilizes a trusted key exchange between the device and the cellular network to maintain security.

Abstract translation: 能够对无线装置的电子识别信息进行编程的方法和装置。 在一个实施例中，先前购买或部署的无线设备由蜂窝网络激活。 无线设备使用访问模块连接到蜂窝网络，以下载操作系统组件和/或访问控制客户端组件。 所描述的方法和装置能够更新，添加和替换各种组件，包括电子订户身份模块（eSIM）数据，OS组件。 本发明的一个示例性实施方式利用设备和蜂窝网络之间的可信密钥交换来维护安全性。