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1.发明授权CXCL13 antagonists and their use for the treatment of inflammatory diseases 有权CXCL13拮抗剂及其用于治疗炎性疾病的用途公开(公告)号：US08277809B2
公开(公告)日：2012-10-02
申请号：US11738019
申请日：2007-04-20
申请人： Peter Bugelski , Anuk Das , Donald E. Griswold , Bailin Liang , Li Li , Robert T. Sarisky , Xiaozhou Shang
发明人： Peter Bugelski , Anuk Das , Donald E. Griswold , Bailin Liang , Li Li , Robert T. Sarisky , Xiaozhou Shang
IPC分类号： A61K39/395
CPC分类号： C07K16/241 , A61K2039/507 , C07K16/24 , C07K2317/76
摘要： Methods of treating disorders related to CXCL13 activity utilize CXCL13 antagonists and, optionally, TNFα antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, siRNA, shRNA, ribozymes, and DNAzymes. Disorders related to CXCL13 activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD, and systemic lupus erythematosus.
摘要翻译： 治疗与CXCL13活性相关的疾病的方法利用CXCL13拮抗剂和任选的TNFα拮抗剂，例如包括特定部分或变体，多肽，多核苷酸，siRNA，shRNA，核酶和DNA酶的抗体。 与CXCL13活性相关的疾病包括炎症性疾病，例如肺部疾病，例如哮喘，肺气肿和COPD，以及系统性红斑狼疮。
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2.发明申请CXCL13 Antagonists and Their Use for the Treatment of Inflammatory Diseases 有权CXCL13拮抗剂及其用于治疗炎症疾病的用途公开(公告)号：US20080014201A1
公开(公告)日：2008-01-17
申请号：US11738019
申请日：2007-04-20
申请人： Peter Bugelski , Anuk Das , Donald Griswold , Bailin Liang , Li Li , Robert Sarisky , Xiaozhou Shang
发明人： Peter Bugelski , Anuk Das , Donald Griswold , Bailin Liang , Li Li , Robert Sarisky , Xiaozhou Shang
IPC分类号： A61K39/395 , A61K31/7052 , A61P11/00 , A61P29/00 , A61K38/02
CPC分类号： C07K16/241 , A61K2039/507 , C07K16/24 , C07K2317/76
摘要： Methods of treating disorders related to CXCL13 activity utilize CXCL13 antagonists and, optionally, TNFα antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, siRNA, shRNA, ribozymes, and DNAzymes. Disorders related to CXCL13 activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD, and systemic lupus erythematosus.
摘要翻译： 治疗与CXCL13活性相关的疾病的方法利用CXCL13拮抗剂和任选的TNFα拮抗剂，例如包括特定部分或变体，多肽，多核苷酸，siRNA，shRNA，核酶和DNA酶的抗体。 与CXCL13活性相关的疾病包括炎症性疾病，例如肺部疾病，例如哮喘，肺气肿和COPD，以及系统性红斑狼疮。
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3.发明申请Toll Like Receptor 3 Antagonists, Methods and Uses 审中-公开Toll Like Receptor 3 Antagonists，Methods and Uses公开(公告)号：US20120189643A1
公开(公告)日：2012-07-26
申请号：US13412259
申请日：2012-03-05
申请人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
发明人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , C12N1/21 , A61P3/10 , C12P21/00 , C12N5/16 , A61P29/00 , A61P1/00 , A61P11/00 , C07K16/28 , C12N5/10
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/74 , C07K2317/76
摘要： Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译： Toll样受体3（TLR3）拮抗剂，编码TLR3拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。
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公开(公告)号：US08153583B2
公开(公告)日：2012-04-10
申请号：US11291140
申请日：2005-11-30
申请人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
发明人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists, and methods of making and using the foregoing are disclosed.
摘要翻译： 公开了Toll样受体3（TLR3）拮抗剂，编码TLR3拮抗剂的多核苷酸，以及制备和使用前述物质的方法。
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公开(公告)号：US20100254992A1
公开(公告)日：2010-10-07
申请号：US12602164
申请日：2008-06-30
申请人： Anuk Das , Raymond Sweet , Ping Tsui , Deidra Bethea , Sheng-Jiun Wu , James Kang , Audrey Baker
发明人： Anuk Das , Raymond Sweet , Ping Tsui , Deidra Bethea , Sheng-Jiun Wu , James Kang , Audrey Baker
IPC分类号： A61K39/395 , C07K16/18 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00 , A61P11/00 , A61P25/00 , A61P37/00 , A61P27/02 , A61P27/16 , A61P9/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The present invention relates to at least one novel anti-MCP-1 antibody having specific epitopes, including isolated nucleic acids that encode at least one anti-MCP-1 antibody, MCP-1, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译： 本发明涉及至少一种具有特异性表位的抗MCP-1抗体，其包括编码至少一种抗MCP-1抗体，MCP-1，载体，宿主细胞，转基因动物或植物的分离核酸，以及 制备和使用它们的方法，包括治疗组合物，方法和装置。
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6.发明申请TOLL LIKE RECEPTOR 3 ANTAGONISTS, METHODS AND USES 审中-公开TOLL LIKE RECEPTOR 3 ANTAGONISTS，METHODS AND USES公开(公告)号：US20140255388A1
公开(公告)日：2014-09-11
申请号：US13799476
申请日：2013-03-13
申请人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill Giles-Komar , Theresa Goletz , David Knight , Roberta Lamb , Lamine Mbow , Gopalan Raghunathan , Lani San Mateo , Robert Sarisky , Nicole Stowell , Raymond Sweet , Shanrong Zhao
发明人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill Giles-Komar , Theresa Goletz , David Knight , Roberta Lamb , Lamine Mbow , Gopalan Raghunathan , Lani San Mateo , Robert Sarisky , Nicole Stowell , Raymond Sweet , Shanrong Zhao
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/74 , C07K2317/76
摘要： Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists or fragments, and methods of making and using the foregoing are disclosed.
摘要翻译： Toll样受体3（TLR3）拮抗剂，编码TLR3拮抗剂或片段的多核苷酸，以及制备和使用前述物质的方法。
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公开(公告)号：US08114964B2
公开(公告)日：2012-02-14
申请号：US11942126
申请日：2007-11-19
申请人： Anuk Das , Raymond Sweet , Ping Tsui , Michael Bardroff
发明人： Anuk Das , Raymond Sweet , Ping Tsui , Michael Bardroff
CPC分类号： C07K16/24 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to at least one novel anti-MCP-1 antibody, including isolated nucleic acids that encode at least one anti-MCP-1 antibody, MCP-1, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译： 本发明涉及至少一种新的抗MCP-1抗体，包括编码至少一种抗MCP-1抗体，MCP-1，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 包括治疗组合物，方法和装置。
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8.发明申请COMPOSITIONS AND METHODS FOR REGULATING COLLAGEN AND SMOOTH MUSCLE ACTIN EXPRESSION BY SERPINE2 审中-公开SERPINE2调节胶原和丝氨酸肌酸激酶表达的组合物和方法公开(公告)号：US20100183620A1
公开(公告)日：2010-07-22
申请号：US12626534
申请日：2009-11-25
申请人： KAUMUDI BHAWE , Elizabeth Bosch , Kathleen Boyle , Arthur Brace , Anuk Das , Francis Farrell , Pitchumani Sivakumar , Jeffrey Finer , Kristen Pierce , Kathleen M. Sullivan , Brian Wong
发明人： KAUMUDI BHAWE , Elizabeth Bosch , Kathleen Boyle , Arthur Brace , Anuk Das , Francis Farrell , Pitchumani Sivakumar , Jeffrey Finer , Kristen Pierce , Kathleen M. Sullivan , Brian Wong
IPC分类号： A61K39/395 , A61K31/7088 , A61K38/02 , A61K38/16 , A61P21/00 , C12Q1/68
CPC分类号： C07K14/811 , A61K38/57 , C07K16/38 , C07K2317/76
摘要： The invention encompasses methods and compositions for increasing or decreasing collagen 1A1 expression and/or α-smooth muscle actin expression in lung fibroblasts using SERPINE2 and antagonists of SERPINE2. The invention also encompasses methods and compositions for increasing or decreasing the formation of myofibroblasts. The invention further provides methods and compositions for treatment of lung diseases, such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease.
摘要翻译： 本发明包括使用SERPINE2和SERPINE2拮抗剂增加或减少肺成纤维细胞中胶原1A1表达和/或α-平滑肌肌动蛋白表达的方法和组合物。 本发明还包括用于增加或减少肌成纤维细胞形成的方法和组合物。 本发明进一步提供了治疗肺部疾病如特发性肺纤维化和慢性阻塞性肺疾病的方法和组合物。
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公开(公告)号：US20100074886A1
公开(公告)日：2010-03-25
申请号：US12442404
申请日：2007-10-05
申请人： Anuk Das , Lynne Murray , Fahrat Syed
发明人： Anuk Das , Lynne Murray , Fahrat Syed
IPC分类号： A61K39/395 , A61K38/16 , A61K31/404 , A61P7/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Anti-MCP-1/CCR2 antagonist therapy is provided for the control or reversal of fibrosis related diseases, including, e.g., but not limited to MCP-1/CCR2 antagonist therapy for the modulation of profibrotic markers associated with fibrotic processes including collagen matrix deposition and alveolar collapse.
摘要翻译： 提供了抗MCP-1 / CCR2拮抗剂治疗用于控制或逆转纤维化相关疾病，包括例如但不限于MCP-1 / CCR2拮抗剂治疗用于调节纤维化过程（包括胶原基质沉积）的纤维化性标记 和肺泡塌陷。
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公开(公告)号：US20050244410A1
公开(公告)日：2005-11-03
申请号：US10835475
申请日：2004-04-29
申请人： Ashlyn Bassiri , Anuk Das , Susan Dillon , Karen Duffy , Jonathan Seideman , M. Mbow , Lars Karlsson , Siquan Sun , Jian Zhu , Mark Cunningham
发明人： Ashlyn Bassiri , Anuk Das , Susan Dillon , Karen Duffy , Jonathan Seideman , M. Mbow , Lars Karlsson , Siquan Sun , Jian Zhu , Mark Cunningham
IPC分类号： A61K39/395 , A61K48/00 , C07K16/28
CPC分类号： C07K16/2896 , C07K2317/34
摘要： Cell surface TLR9 and TLR9 ligand binding agents are disclosed. The binding agents include antibodies and other proteins. The binding agents are useful as therapeutics, diagnostics or research reagents.
摘要翻译： 公开了细胞表面TLR9和TLR9配体结合剂。 结合剂包括抗体和其它蛋白质。 结合剂可用作治疗剂，诊断或研究试剂。
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