公开(公告)号：US20220184375A1

公开(公告)日：2022-06-16

申请号：US17682073

申请日：2022-02-28

Applicant: MAGENTA MEDICAL LTD.

Inventor： Yosi Tuval ,  Yinnon Elisha ,  David Israeli ,  Gad Lubinsky ,  Victor Troshin ,  Shaul Mustacchi ,  Yuval Zipory ,  Avi Rozenfeld ,  Aurelie Benaddi ,  Gilad Moiseyev ,  Yuri Sudin

IPC: A61M60/531 ,  A61M60/13 ,  A61M60/174 ,  A61M60/237 ,  A61M60/419 ,  A61M60/808 ,  A61M60/816 ,  A61M60/818 ,  A61M60/829

Abstract: Apparatus and methods are described including a ventricular assist device that includes a blood pump configured to be placed inside a left ventricle of a subject and to pump blood from the subject's left ventricle to an aorta of the subject. A blood pressure sensor measures aortic pressure of the subject. A computer processor varies a flow rate that is that is generated by the blood pump, and determines a relationship between arterial pulsatility of the subject and the flow rate that is generated by the blood pump, based upon aortic pressure that is measured by the blood pressure sensor as the flow rate that is generated by the blood pump is varied. The computer processor estimates native cardiac output of the subject at least partially based upon the relationship. Other applications are also described.

公开(公告)号：US20220184371A1

公开(公告)日：2022-06-16

申请号：US17678812

申请日：2022-02-23

Applicant: MAGENTA MEDICAL LTD.

Inventor： Yosi Tuval ,  Yinnon Elisha ,  David Israeli ,  Gad Lubinsky ,  Victor Troshin ,  Shaul Mustacchi ,  Yuval Zipory ,  Avi Rozenfeld ,  Aurelie Benaddi ,  Gilad Moiseyev ,  Yuri Sudin

IPC: A61M60/13 ,  A61M60/216 ,  A61M60/825 ,  A61M60/422 ,  A61M60/531 ,  A61M60/546 ,  A61M60/829

Abstract: Apparatus and methods are described including a ventricular assist device configured to assist ventricular functioning of a subject. The ventricular assist device includes an impeller and a frame disposed around the impeller. An axial shaft extends from a proximal end of the frame to a distal end of the frame, the impeller being coupled to the axial shaft. The axial shaft includes a proximal portion and a distal portion, which are coupled to each other via a joint. The proximal portion and the distal portion of the axial shaft are configured to flex with respect to each other via the joint. Other applications are also described.

公开(公告)号：US11291825B2

公开(公告)日：2022-04-05

申请号：US16276965

申请日：2019-02-15

Applicant: Magenta Medical Ltd.

Inventor： Yosi Tuval ,  Daniel Glozman ,  Gad Lubinsky

IPC: A61M60/205 ,  A61M60/50 ,  A61M60/135 ,  A61M60/148 ,  A61M60/414 ,  A61M60/818 ,  A61M60/857

Abstract: Apparatus and methods are described including a tube configured to traverse a subject's aortic valve. A frame is disposed within a portion of the tube, and a plurality of winged projections are coupled to the frame. An impeller is disposed inside the tube, the impeller including at least one helical elongate element, and a film of material supported at least partially by the helical elongate element. The impeller is rotated, such as to pump blood from the subject's left ventricle to the subject's aorta. Blood flow that is generated by the rotation of the impeller is rectified, by using the winged projections to direct blood flow toward a direction of the longitudinal axis of the tube. Other applications are also described.

公开(公告)号：US11285309B2

公开(公告)日：2022-03-29

申请号：US16810086

申请日：2020-03-05

Applicant: Magenta Medical Ltd.

Inventor： Yosi Tuval ,  Zev Sohn ,  Ehud Schwammenthal ,  Gad Lubinsky ,  Victor Troshin ,  Shaul Mustacchi ,  Yinnon Elisha ,  Yuri Sudin ,  Hagit Zemer Harel ,  Avi Rozenfeld

IPC: A61M1/12 ,  A61M1/10 ,  A61M60/148 ,  A61M60/419 ,  A61M60/422 ,  A61M60/818 ,  A61M60/829 ,  A61M60/857 ,  A61M60/896 ,  A61M60/414 ,  A61M60/135 ,  F04D29/52 ,  F04D29/54 ,  F04D29/38 ,  A61M60/205 ,  A61M60/122

Abstract: Apparatus and methods are described including a left-ventricular assist device that includes a tube configured to traverse a subject's aortic valve, with a distal portion of the tube within the subject's left ventricle. A frame disposed within the distal portion of the tube defines cells, and a width of each of the cells within a cylindrical portion of the frame is less than 2 mm. An inner lining lines at least some of the cylindrical portion of the frame. An impeller is disposed inside the frame such that a gap between an outer edge of the impeller and the inner lining is less than 1 mm. The impeller is stabilized with respect to the frame, such that, during rotation of the impeller, the gap between the outer edge of the impeller and the inner lining is maintained and is substantially constant. Other applications are also described.

公开(公告)号：US11185679B2

公开(公告)日：2021-11-30

申请号：US16279352

申请日：2019-02-19

Applicant: Magenta Medical Ltd.

Inventor： Yosi Tuval ,  Zev Sohn ,  Ehud Schwammenthal ,  Gad Lubinsky

IPC: A61M1/12 ,  A61M1/10 ,  A61M60/422 ,  A61B5/0215 ,  F04D3/02 ,  F04D15/00 ,  F04D29/041 ,  F04D29/042 ,  F04D25/02 ,  F04D29/18 ,  F04D29/24 ,  F04D7/00 ,  A61B5/283 ,  A61M60/40 ,  A61M60/50 ,  A61M60/135 ,  A61M60/148 ,  A61M60/205 ,  A61M60/414 ,  A61M60/419 ,  A61M60/818 ,  A61M60/824 ,  A61M60/829 ,  A61M60/833 ,  A61M60/857 ,  A61M60/896

Abstract: Apparatus and methods are described including placing, into a subject's body, a blood-pump tube, with a blood pump disposed within the blood-pump tube. At least one blood-pressure-measurement tube, which defines an opening at a distal end thereof, extends to at least an outer surface of the blood-pump tube, such that the opening at the distal end of the blood-pressure-measurement tube is in direct fluid communication with a bloodstream of the subject outside the blood-pump tube. Blood is pumped through the blood-pump tube, using the blood pump. Pressure of the bloodstream of the subject outside the blood-pump tube is measured by measuring pressure of blood within the blood-pressure-measurement tube. Other applications are also described.

公开(公告)号：US20210162199A1

公开(公告)日：2021-06-03

申请号：US17176344

申请日：2021-02-16

Applicant: Magenta Medical Ltd.

Inventor： Yosi Tuval ,  Daniel Glozman ,  Gad Lubinsky

IPC: A61M60/205 ,  A61M60/148 ,  A61M60/414 ,  A61M60/818 ,  A61M60/50 ,  A61M60/135 ,  A61M60/857

Abstract: Apparatus and methods are described including an elongate tube configured to traverse an aortic valve of a subject, such that a proximal end of the tube is disposed within an aorta of the subject and a distal end of the tube is disposed within a left ventricle of the subject, the elongate tube comprising a blood-impermeable material, and a radially-expandable frame disposed within at least a portion of the tube. An impeller is disposed inside the radially-expandable frame, the impeller being configured to rotate such as to pump blood from the left ventricle to the aorta. A protective structure is disposed around the impeller, in addition to the radially-expandable frame of the elongate tube. Other applications are also described.

公开(公告)号：US20210038794A1

公开(公告)日：2021-02-11

申请号：US17078472

申请日：2020-10-23

Applicant: Magenta Medical Ltd.

Inventor： Yosi Tuval ,  Zev Sohn ,  Ehud Schwammenthal ,  Gad Lubinsky ,  Victor Troshin ,  Shaul Mustacchi ,  Yinnon Elisha ,  Yuri Sudin ,  Hagit Zemer Harel ,  Avi Rozenfeld

IPC: A61M1/12 ,  A61M1/10

Abstract: Apparatus and methods are described including a ventricular assist device that includes a tube. A proximal portion of the tube traverses a subject's aortic valve, and a distal portion of the tube is disposed within the subject's left ventricle. A blood pump is disposed within the distal portion of the tube and pumps blood through the tube from the subject's left ventricle to the subject's aorta, by pumping the blood into the tube via one or more blood inlet openings that are defined by the tube and that are configured to be disposed within the subject's left ventricle, and by pumping blood out of the tube via one or more blood outlet openings that are defined by the tube and that are configured to be disposed within the subject's aorta. The one or more blood outlet openings have teardrop shapes. Other applications are also described.

公开(公告)号：US20210023287A1

公开(公告)日：2021-01-28

申请号：US17070323

申请日：2020-10-14

Applicant: Magenta Medical Ltd.

Inventor： Yosi Tuval ,  Zev Sohn ,  Ehud Schwammenthal ,  Gad Lubinsky

IPC: A61M1/10 ,  A61B5/0215 ,  A61M1/12 ,  F04D3/02 ,  F04D15/00 ,  F04D29/041 ,  F04D29/042 ,  F04D25/02 ,  A61B5/042 ,  F04D29/18 ,  F04D29/24 ,  F04D7/00

Abstract: Apparatus and methods are described including a blood pump that includes an impeller, and a motor configured to drive the impeller to pump blood by rotating the impeller. The impeller is configured to undergo axial motion, in response to changes in a pressure against which the impeller is pumping. A sensor detects the axial motion of the impeller, and generates a sensor signal in response thereto. A computer processor receives the sensor signal and generates an output in response thereto. Other applications are also described.

公开(公告)号：US20200237984A1

公开(公告)日：2020-07-30

申请号：US16810121

申请日：2020-03-05

Applicant: Magenta Medical Ltd.

Inventor： Yosi Tuval ,  Zev Sohn ,  Ehud Schwammenthal ,  Gad Lubinsky ,  Victor Troshin ,  Shaul Mustacchi ,  Yinnon Elisha ,  Yuri Sudin ,  Hagit Zemer Harel ,  Avi Rozenfeld

IPC: A61M1/12 ,  A61M1/10

Abstract: Apparatus and methods are described including a blood pump that includes an impeller configured to pump blood through a subject's body, and a frame disposed around the impeller. The frame defines struts having a structure that is such that, as the frame transitions from a proximal end of the frame toward a center of the frame, the struts pass through junctions, at which the two struts branch from a single strut, in a Y-shape. The structure of the struts of the frame is configured such that, in response to a distal end of a delivery catheter and the frame being moved into overlapping positions with respect to each other, the frame assumes a radially-constrained configuration by becoming axially elongated, and the frame causes the impeller to assume a radially-constrained configuration by becoming axially elongated. Other applications are also described.

公开(公告)号：US20200237983A1

公开(公告)日：2020-07-30

申请号：US16810116

申请日：2020-03-05

Applicant: Magenta Medical Ltd.

Inventor： Yosi Tuval ,  Zev Sohn ,  Ehud Schwammenthal ,  Gad Lubinsky ,  Victor Troshin ,  Shaul Mustacchi ,  Yinnon Elisha ,  Yuri Sudin ,  Hagit Zemer Harel ,  Avi Rozenfeld

IPC: A61M1/12 ,  A61M1/10

Abstract: Apparatus and methods are described including manufacturing an impeller by forming a structure having first and second bushings at proximal and distal ends that are connected to one another by at least one elongate element. The elongate element is made to radially expand and form a helical elongate element. An elastomeric material is coupled to the helical elongate element, such that the helical elongate element with the elastomeric material coupled thereto defines a blade of the impeller. The coupling is performed such that a layer of the material disposed around a radially outer edge of the helical elongate element forms the effective edge of the impeller blade. A step is performed to enhance bonding of the elastomeric material to the helical elongate element in a manner that does not cause a protrusion from the effective edge of the impeller blade. Other applications are also described.