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公开(公告)号：US5811124A
公开(公告)日：1998-09-22
申请号：US389157
申请日：1995-02-15
IPC分类号： A61K9/127 , A61K9/16 , A61K9/51 , G01N33/543 , G01N33/58
CPC分类号： B82Y5/00 , A61K9/127 , A61K9/1664 , A61K9/5176 , G01N33/54313 , G01N33/586 , Y10S977/906 , Y10S977/915
摘要： An microparticle composition and its method of use in drug delivery and diagnostic applications are disclosed. Also disclosed are methods of storing and administering drug compounds at high concentration in condensed-phase microparticles.
摘要翻译： 公开了一种微粒组合物及其在药物递送和诊断应用中的应用。 还公开了在冷凝相微粒中以高浓度存储和施用药物化合物的方法。
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公开(公告)号：US5499971A
公开(公告)日：1996-03-19
申请号：US166737
申请日：1993-12-14
CPC分类号： A61M25/104 , A61M16/0481 , A61M37/0092 , A61N1/05 , A61N1/306 , A61N1/325 , A61M2025/0057 , A61M2025/105 , A61N2001/0585
摘要： A drug delivery apparatus and method for iontophoretically delivering a drug locally to internal body tissue. The iontophoretic delivery apparatus and method include a current source producing a net flow of current in a desired direction with high frequency waveforms which enhance delivery and minimize side effects typically associated with iontophoresis.The invention contemplates positioning a drug delivery device in a body passageway or within body tissue and then selectively introducing a selected drug so that it is iontophoretically transported across a drug transport wall of the device for direct contact with the passageway wall or body tissue. A further aspect of the present invention involves treating a dilated vessel in the area of a stenotic lesion with a fixative or other drug to render the vessel biologically inert and to form a biological stent or prevent restenosis using specifically selected drugs. A still further aspect of the present invention involves treating a tumor or local or regional tissue mass with antitumor sensitizing agents, biological modifiers, antibiotics or other types of drugs by iontophoretic delivery of the drug to the tumor or tissue area directly or through the passageway wall.
摘要翻译： 一种药物输送装置和方法，用于将药物局部地离子电渗输送到内部身体组织。 离子电渗传递装置和方法包括电流源，其以期望方向产生电流净流量，其中高频波形增强了输送并最小化通常与离子电渗疗法相关的副作用。 本发明考虑将药物递送装置定位在身体通道或身体组织内，然后选择性地引入所选择的药物，使得其被离子电渗转运穿过装置的药物输送壁，以直接与通道壁或身体组织接触。 本发明的另一方面涉及用固定剂或其它药物在狭窄病变区域中处理扩张的血管，使血管生物学惰性并形成生物支架，或使用特定选择的药物预防再狭窄。 本发明的又一个方面涉及用抗肿瘤敏化剂，生物改良剂，抗生素或其它类型的药物通过离子电渗疗法直接地或通过通道壁将药物离子电渗输送到肿瘤或组织区域来治疗肿瘤或局部或区域组织块 。
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公开(公告)号：US5282785A
公开(公告)日：1994-02-01
申请号：US956789
申请日：1992-10-05
CPC分类号： A61M25/104 , A61M16/0481 , A61M29/02 , A61M37/0092 , A61N1/05 , A61N1/306 , A61N1/325 , A61M2025/0057 , A61M2025/105 , A61N2001/0585
摘要： A drug delivery apparatus and method for delivering a drug locally to internal body tissue. The invention contemplates positioning a drug delivery device in a body passageway or within body tissue and then selectively introducing a selected drug so that it is transported across a drug transport wall of the device for direct contact with the passageway wall or body tissue. A further aspect of the present invention involves treating a dilated vessel in the area of a stenotic lesion with a fixative or other drug to render the vessel biologically inert and to form a biological stent or prevent restenosis using specifically selected drugs. A still further aspect of the present invention involves treating a tumor or local or regional tissue mass with antitumor sensitizing agents, biological modifiers, antibiotics or other types of drugs by delivery of the drug to the tumor or tissue area directly or through the passageway wall.
摘要翻译： 一种用于将药物局部递送到内部身体组织的药物递送装置和方法。 本发明考虑将药物递送装置定位在身体通道或身体组织内，然后选择性地引入所选择的药物，使得其被输送穿过装置的药物输送壁，以与通道壁或身体组织直接接触。 本发明的另一方面涉及用固定剂或其它药物在狭窄病变区域中处理扩张的血管，使血管生物学惰性并形成生物支架，或使用特定选择的药物预防再狭窄。 本发明的另一方面涉及通过将药物直接或通过通道壁递送到肿瘤或组织区域，用抗肿瘤敏化剂，生物改良剂，抗生素或其它类型的药物来治疗肿瘤或局部或区域组织块。
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公开(公告)号：USD288478S
公开(公告)日：1987-02-24
申请号：US622983
申请日：1984-06-21
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45.发明授权Treatment of excess weight by neural downregulation in combination with compositions 有权通过神经下调与组合物组合治疗过量体重公开(公告)号：US09186502B2
公开(公告)日：2015-11-17
申请号：US12370984
申请日：2009-02-13
CPC分类号： A61N1/36007 , A61M5/14276 , A61M2205/3515 , A61M2205/3523 , A61M2205/353 , A61M2210/105 , A61M2210/1053 , A61N1/36053 , A61N1/36114 , A61N1/37223 , A61N1/37264
摘要： A method and system for designing a therapy or for treating a condition associated with excess weight in a subject comprising applying a neural conduction block to the vagus nerve at a blocking site with the neural conduction block selected to at least partially block nerve impulses on the vagus nerve at the blocking site and administering a composition comprising an effective amount of an agent that alters the energy balance of the subject.
摘要翻译： 一种用于设计治疗或用于治疗与受试者中超重相关的病症的方法和系统，其包括将神经传导阻滞在阻塞位点处的迷走神经中，所述神经传导阻滞被选择为至少部分阻断迷走神经脉冲上的神经传导阻滞 并且施用包含改变受试者的能量平衡的有效量的药剂的组合物。
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46.发明授权公开(公告)号：US08538542B2
公开(公告)日：2013-09-17
申请号：US13188293
申请日：2011-07-21
CPC分类号： A61N1/36007 , A61N1/05 , A61N1/0551 , A61N1/321 , A61N1/36053 , A61N1/3606 , A61N1/36071
摘要： Systems and methods of using a system for treating a gastrointestinal disorder characterized by dysmotility of a gastrointestinal organ. A system comprises a first electrode adapted for placement on the vagus nerve at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ, a second electrode adapted for placement on the vagus nerve at a site proximal to the stimulation site, a third electrode adapted for placement on the vagus nerve at a distal blocking site distal to the stimulation site, an implantable controller comprising at least one circuit for generating a neural conduction blocking signal connected to the second and third electrode, at least one circuit for generating a neural conduction stimulating signal connected to the first electrode; and an external programmer configured to communicate at least one parameter for the neural conduction blocking signal to the implantable controller; and an external coil adapted to be worn by the patient, wherein the external coil is connected to the external programmer, and is adapted to inductively couple to the implantable controller.
摘要翻译： 使用系统治疗以胃肠器官发育不良为特征的胃肠道疾病的系统和方法。 系统包括适于放置在迷走神经附近的刺激部位的第一电极，所述刺激部位接近胃肠器官的迷走神经支配的至少一个部位，适于放置在靠近刺激部位的部位的迷走神经上的第二电极， 适于放置在远离刺激部位的远端阻塞位置处的迷走神经上的第三电极，可植入控制器，包括用于产生连接到第二和第三电极的神经传导阻断信号的至少一个电路，至少一个用于产生 连接到第一电极的神经传导刺激信号; 以及外部编程器，被配置为将至少一个神经传导阻断信号的参数传送到所述可植入控制器; 以及适于由患者佩戴的外部线圈，其中所述外部线圈连接到所述外部编程器，并且适于感应地耦合到所述可植入控制器。
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公开(公告)号：US08483830B2
公开(公告)日：2013-07-09
申请号：US12417918
申请日：2009-04-03
申请人： Katherine S. Tweden , Mark B. Knudson , Richard R. Wilson , Arnold W. Thornton , Dennis Dong-won Kim
发明人： Katherine S. Tweden , Mark B. Knudson , Richard R. Wilson , Arnold W. Thornton , Dennis Dong-won Kim
IPC分类号： A61N1/05
CPC分类号： A61N1/36053 , A61M5/00 , A61N1/0551 , A61N1/36007 , A61N1/36167 , A61N1/37211 , A61N1/37235
摘要： Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus and its branches, and the splanchnic is used to modify the production of GLP-1 and GIP, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to modify the production of GLP-1 and GIP, to treat impaired glucose regulation.
摘要翻译： 用于治疗与受试者中的葡萄糖调节受损有关的病症的各种方法和装置包括在一个实施方案中，将神经传导阻滞物施用于至少部分阻断神经脉冲的神经传导阻滞位置处的阻断部位的靶神经。 在另一个实施方案中，下调和/或上调与或不与药剂的组合用于治疗葡萄糖调节受损。 在其他实施方案中，使用诸如迷走神经及其分支以及内脏的各种神经的上调或下调来改变GLP-1和GIP的产生，从而控制葡萄糖水平。 在另外的实施方案中，使用具有或不具有药剂的下调和/或上调的组合来改变GLP-1和GIP的产生，以治疗葡萄糖调节受损。
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公开(公告)号：US08413662B2
公开(公告)日：2013-04-09
申请号：US13276146
申请日：2011-10-18
IPC分类号： A61F5/56
CPC分类号： A61F5/56 , A61F2/04 , A61F2/20 , A61F2002/046 , A61M31/002 , A61M37/00
摘要： A pharyngeal airway having a pharyngeal wall of a patient at least partially surrounding and defining the airway is treated by selecting an implant dimensioned so as to be implanted at or beneath a mucosal layer of the pharyngeal wall and extending transverse to said wall. The implant has mechanical characteristics for the implant, at least in combination with a fibrotic tissue response induced by the implant, to stiffen said pharyngeal wall to resist radial collapse. The implant is implanted into the pharyngeal wall transverse to a longitudinal axis of the airway.
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49.发明申请Device and Method for Treating Cardiac Disorders by Modulating Autonomic Response 有权通过调节自主反应来治疗心脏疾病的装置和方法公开(公告)号：US20130012938A1
公开(公告)日：2013-01-10
申请号：US13515630
申请日：2010-12-03
CPC分类号： A61B18/1492 , A61B5/02 , A61B5/0215 , A61B5/04001 , A61B5/0402 , A61B5/4035 , A61B18/02 , A61B2018/00083 , A61B2018/00214 , A61B2018/0022 , A61B2018/00351 , A61B2018/00434 , A61B2018/00577 , A61B2018/00839 , A61B2018/00994 , A61B2218/002 , A61M25/007 , A61M25/04 , A61M25/10 , A61M2025/105 , A61N1/0587 , A61N1/06 , A61N1/20 , A61N1/36114
摘要： A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
摘要翻译： 用于调节毗邻心包空间以治疗心律不齐的自主神经系统的方法和装置包括：设置成供应治疗介质的治疗源，具有尺寸用于插入心包空间的端部的导管，具有远端的介质递送组件 布置成由导管定位成心包，其中输送组件的远端包括布置成远离导管的远端延伸到心包空间中的输送尖端。 连接器将介质输送组件的输送末端可操作地连接到治疗源，并且介质递送组件的输送末端包括用于在心包空间内的多个治疗区域处递送治疗介质的多个递送点。 该装置在心包内的选定治疗区域进行自主神经系统的调制或消融。
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公开(公告)号：US20110307023A1
公开(公告)日：2011-12-15
申请号：US13154846
申请日：2011-06-07
CPC分类号： A61N1/36007 , A61N1/0509 , A61N1/0551 , A61N1/36053 , A61N1/36085 , A61N1/36117 , A61N1/36171 , A61N1/36178 , A61N1/37235 , A61N1/3787
摘要： A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.
摘要翻译： 一种用于设计用于治疗或治疗与受试者相关的胃肠疾病或与体重过重相关的病症的系统，所述系统包括至少一个被配置成植入患者体内并置于迷走神经的电极，所述电极还被配置为施加 在向电极施加治疗周期时对迷走神经进行治疗; 可植入神经调节器，用于放置在皮肤层下面的患者体内，所述可植入神经调节器被配置为产生治疗周期，其中所述治疗周期包括传递电信号的接通时间，所述电信号包括：a） 以大约150-10,000Hz的第一选定频率施加的一组脉冲，其中脉冲组的每个脉冲具有至少0.01毫秒且小于第一选定频率的周期的脉冲宽度。
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