利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

128 条记录 (耗时 0.03 秒)

    Method of delivering a lipid-coated condensed-phase microparticle composition
    3.
    发明授权
    Method of delivering a lipid-coated condensed-phase microparticle composition 失效
    递送脂质包被的凝聚相微粒组合物的方法

    公开(公告)号：US5820879A

    公开(公告)日：1998-10-13

    申请号：US444244

    申请日：1995-05-18

    申请人： Julio M. Fernandez ,  Mark B. Knudson

    发明人： Julio M. Fernandez ,  Mark B. Knudson

    IPC分类号： A61K9/127 ,  A61K9/16 ,  A61K9/51 ,  G01N33/543 ,  G01N33/58

    CPC分类号： A61K9/5176 ,  A61K9/127 ,  A61K9/1664 ,  G01N33/54313 ,  G01N33/586

    摘要： A method of delivering a therapeutic compound to an in vivo target site having a selected pH, temperature, ligand concentration or binding-molecule characteristic. The method includes entrapping the therapeutic compound in an encapsulated microparticle composition that, when exposed to a selected target stimulus related to pH, temperature, radiation, or the presence of a selected ligand or ion-channel activator, decondenses to release compound into the target site. The encapsulated microparticle composition consists of a condensed-phase particle matrix containing the compound to be delivered in entrapped form, and a stimulus-responsive lipid bilayer membrane formed around the matrix. Localized perturbation of the lipid membrane, and influx of monovalent counterions into the polymer matrix, in response to the selected target stimulus, causes matrix swelling and compound release from the particles.

    摘要翻译： 将治疗化合物递送到具有选定的pH，温度，配体浓度或结合分子特征的体内靶位点的方法。 该方法包括将封闭的微粒组合物包埋在治疗性化合物中，所述微粒组合物当暴露于与pH，温度，辐射或选定的配体或离子通道活化剂的存在相关的选定靶刺激物时，将化合物释放到靶位点 。 包封的微粒组合物由含有以截留形式递送的化合物的冷凝相颗粒基质和围绕该基质形成的刺激响应脂质双层膜组成。 响应于所选择的靶刺激，脂质膜的局部扰动和单价抗衡离子流入聚合物基质中导致基质溶胀和化合物从颗粒中释放。

    Lipid-coated condensed-phase microparticle composition
    4.
    发明授权
    Lipid-coated condensed-phase microparticle composition 失效
    脂质包被的凝聚相微粒组合物

    公开(公告)号：US5753261A

    公开(公告)日：1998-05-19

    申请号：US443402

    申请日：1995-05-17

    申请人： Julio M. Fernandez ,  Mark B. Knudson

    发明人： Julio M. Fernandez ,  Mark B. Knudson

    IPC分类号： A61K8/14 ,  A61K8/64 ,  A61K9/127 ,  A61K9/16 ,  A61K9/51 ,  A61Q7/00 ,  G01N33/58

    CPC分类号： A61K9/0009 ,  A61K8/14 ,  A61K8/64 ,  A61K9/127 ,  A61K9/51 ,  A61Q7/00 ,  G01N33/586

    摘要： A microparticle composition for use in compound delivery, when the composition is exposed to a selected target stimulus related to pH, temperature, radiation, or the presence of a selected ligand or ion-channel activator, is disclosed. The composition includes a condensed-phase particle matrix containing the compound to be delivered in entrapped form, and a stimulus-responsive lipid bilayer membrane formed around the matrix. Localized perturbation of the lipid membrane, and influx of monovalent counterions into the polymer matrix, in response to the selected target stimulus, causes matrix swelling and compound release from the particles.

    摘要翻译： 公开了当组合物暴露于与pH，温度，辐射或选定的配体或离子通道活化剂的存在相关的所选靶刺激物时用于化合物递送的微粒组合物。 该组合物包括含有以截留形式递送的化合物的冷凝相颗粒基质，以及形成于该基质周围的刺激响应脂质双层膜。 响应于所选择的靶刺激，脂质膜的局部扰动和单价抗衡离子流入聚合物基质中导致基质溶胀和化合物从颗粒中释放。

    Bulimia treatment
    7.
    发明授权
    Bulimia treatment 有权
    暴食症治疗

    公开(公告)号：US07986995B2

    公开(公告)日：2011-07-26

    申请号：US11656121

    申请日：2007-01-22

    申请人： Mark B. Knudson ,  Richard R. Wilson ,  Katherine S. Tweden ,  Timothy R. Conrad

    发明人： Mark B. Knudson ,  Richard R. Wilson ,  Katherine S. Tweden ,  Timothy R. Conrad

    IPC分类号： A61N1/18

    CPC分类号： A61N1/36053 ,  A61F5/0026 ,  A61N1/05 ,  A61N1/321 ,  A61N1/36007 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/37235

    摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is bulimia. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.

    摘要翻译： 通过包括将电极定位在迷走神经上的方法来治疗至少部分地由支配患者的多个器官中的至少一个的迷走神经活动表征的患者的多种病症中的至少一种。 将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。 在一些实施方案中，该疾病是贪食症。 该信号可以是阻塞或刺激信号。 在一些实施方案中，所述信号被选择为至少部分地下调迷走神经的神经活动。

    Neural electrode treatment
    8.
    发明授权
    Neural electrode treatment 有权
    神经电极治疗

    公开(公告)号：US07672727B2

    公开(公告)日：2010-03-02

    申请号：US11205415

    申请日：2005-08-17

    申请人： Adrianus P. Donders ,  Koen J. Weijand ,  Mark B. Knudson

    发明人： Adrianus P. Donders ,  Koen J. Weijand ,  Mark B. Knudson

    IPC分类号： A61N1/06 ,  A61N1/36

    CPC分类号： A61N1/36146 ,  A61N1/36053 ,  A61N1/36085 ,  A61N1/36114

    摘要： An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.

    摘要翻译： 用于向神经施加信号以用于治疗病症的装置包括第一电极和第二电极。 每个电极适于固定到患者的神经。 信号发生器电连接到第一和第二电极中的每一个。 信号发生器适于产生在第一电极处具有第一波形的信号和在第二电极处的第二波形。 波形具有选择的参数以阻止神经动作电位的传播。 这些波形具有脉冲周期的重复模式，其中延迟周期至少在所选择的脉冲之间。 在一个实施例中，在另一个波形的延迟周期期间，波形中的一个波形的周期是第一和第二波形异相。

    Obesity treatment with electrically induced vagal down regulation
    9.
    发明授权
    Obesity treatment with electrically induced vagal down regulation 有权
    肥胖治疗电诱导迷走神经下调

    公开(公告)号：US07167750B2

    公开(公告)日：2007-01-23

    申请号：US10752944

    申请日：2004-01-06

    申请人： Mark B. Knudson ,  Richard R. Wilson ,  Katherine S. Tweden ,  Timothy R. Conrad

    发明人： Mark B. Knudson ,  Richard R. Wilson ,  Katherine S. Tweden ,  Timothy R. Conrad

    IPC分类号： A61N1/06 ,  A61N1/22

    CPC分类号： A61N1/36053 ,  A61F5/0026 ,  A61N1/05 ,  A61N1/321 ,  A61N1/36007 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/37235

    摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning a neurostimulator carrier around a body organ of the patient where the organ is innervated by at least a vagal trunk. An electrode is disposed on the carrier and positioned at the vagal trunk. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be a blocking or a stimulation signal.

    摘要翻译： 至少部分由至少部分由迷走神经活动支配至少一个患者的多个器官的患者的障碍中的至少一种通过包括将神经刺激器载体定位在患者的身体器官周围的方法来治疗， 器官由至少一个迷走神经树干支配。 电极设置在载体上并位于迷走神经干线处。 将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。 该信号可以是阻塞或刺激信号。