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公开(公告)号：US07655129B2
公开(公告)日：2010-02-02
申请号：US10823503
申请日：2004-04-12
申请人： Gary Blackburn , Stephen E. Creager , Scott Fraser , Bruce D. Irvine , Thomas J. Meade , Stephen J. O'Connor , Robert H. Terbrueggen , Jost G. Vielmetter , Thomas W. Welch
发明人： Gary Blackburn , Stephen E. Creager , Scott Fraser , Bruce D. Irvine , Thomas J. Meade , Stephen J. O'Connor , Robert H. Terbrueggen , Jost G. Vielmetter , Thomas W. Welch
IPC分类号： G01N27/327
CPC分类号： B82Y30/00 , B82Y15/00 , C12Q1/6825 , C12Q2565/629
摘要： The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
摘要翻译： 本发明涉及用于加速目标分析物与表面捕获配体结合的组合物和方法。 检测通过直接或间接使用与目标分析物相关的电子转移部分（ETM）进行，以允许电子检测ETM。
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公开(公告)号：US20090053141A1
公开(公告)日：2009-02-26
申请号：US11952691
申请日：2007-12-07
IPC分类号： A61K49/14
CPC分类号： A61K49/14 , A61K49/085 , A61K49/1803
摘要： The present application provides for compositions and methods of creating and applying contrast agents that find use in magnetic resonance imaging (MRI). In particular, contrast agents that comprise monodisperse, protein polymer backbones capable of chelating multiple paramagnetic ions resulting in high relaxivity for use in enhancing MRI signal intensity.
摘要翻译： 本申请提供了产生和应用在磁共振成像（MRI）中使用的造影剂的组合物和方法。 特别地，包含能够螯合多个顺磁离子的单分散蛋白质聚合物主链的造影剂，导致用于增强MRI信号强度的高弛豫度。
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公开(公告)号：US20080173554A1
公开(公告)日：2008-07-24
申请号：US11980203
申请日：2007-10-30
申请人： Thomas J. Meade
发明人： Thomas J. Meade
IPC分类号： G01F1/64
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , G01N33/542 , G01N33/5438
摘要： The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
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公开(公告)号：US07381533B2
公开(公告)日：2008-06-03
申请号：US11295993
申请日：2005-12-06
CPC分类号： C07H21/00 , C12Q1/6825
摘要： The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
摘要翻译： 本发明涉及通过导电低聚物共价偶联到电极上的核酸。 更具体地，本发明涉及具有电子转移部分和电极的核酸的位点选择性修饰以产生新类别的生物材料，以及制备和使用它们的方法。
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公开(公告)号：US06673333B1
公开(公告)日：2004-01-06
申请号：US09715859
申请日：2000-11-17
申请人： Thomas J. Meade , Scott Fraser , Russell Jacobs
发明人： Thomas J. Meade , Scott Fraser , Russell Jacobs
IPC分类号： A61B5055
CPC分类号： A61K49/103 , A61K49/085 , A61K49/106
摘要： The invention relates to novel magnetic resonance imaging contrast agents for imaging cancer.
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公开(公告)号：US06656450B2
公开(公告)日：2003-12-02
申请号：US09908436
申请日：2001-07-17
申请人： Timothy J. Hubin , Thomas J. Meade
发明人： Timothy J. Hubin , Thomas J. Meade
IPC分类号： A61B5055
CPC分类号： C07D487/08 , A61K49/106
摘要： The invention relates to novel magnetic resonance imaging contrast agents.
摘要翻译： 本发明涉及新型磁共振成像造影剂。
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公开(公告)号：US06521209B1
公开(公告)日：2003-02-18
申请号：US09628386
申请日：2000-08-01
IPC分类号： A61B5055
CPC分类号： A61K49/0041 , A61K49/0002 , A61K49/0052 , A61K49/0056 , A61K49/085 , A61K49/10 , A61K49/128 , A61K49/146 , Y10S436/80 , Y10S436/805 , Y10S977/93 , Y10T436/24
摘要： The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker, which may be either a coupling moiety or a polymer.
摘要翻译： 本发明提供了包含与至少一种磁共振图像（MRI）造影剂共价连接的光学染料的双功能检测剂。 这些试剂可以包括可以是偶联部分或聚合物的连接体。
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公开(公告)号：US06444423B1
公开(公告)日：2002-09-03
申请号：US09191785
申请日：1998-11-13
申请人： Thomas J. Meade , Thomas W. Welch
发明人： Thomas J. Meade , Thomas W. Welch
IPC分类号： C12Q168
CPC分类号： C07H19/06 , C07H21/00 , C12Q1/6825
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
摘要翻译： 本发明提供了用氧化还原活性部分如过渡金属配合物选择性共价修饰核酸。 电子供体和电子受体部分在预定位置与核酸的核糖 - 磷酸骨架共价结合。 所得的复合物表示一系列新的衍生物，其是能够以非常快的速率在非常大的距离上转移电子的双分子模板。 这些复合物具有独特的结构特征，可以使用全新的生物传感器和光敏探针。
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公开(公告)号：US06265155B1
公开(公告)日：2001-07-24
申请号：US08808750
申请日：1997-02-28
申请人： Thomas J. Meade , Jon F. Kayyem
发明人： Thomas J. Meade , Jon F. Kayyem
IPC分类号： C12Q168
CPC分类号： C12Q1/6818 , B82Y30/00 , C07H21/00 , C07H23/00 , C12Q1/6825 , C12Q2563/137 , C12Q2563/113 , C12Q2565/607 , C12Q2565/101 , C12Q2565/1015 , C12Q2565/401
摘要： The present invention is directed to solid supports having metallic surfaces comprising blocking moieties and modified nucleic acids, which exhibit excellent characteristics in hybridization assays, in a stable, reproducible, rapid manner. In an additional aspect, the invention provides methods utilizing the solid supports to hybridize probe nucleic acid to target nucleic acid and methods for detecting the hybridization complex.
摘要翻译： 本发明涉及具有金属表面的固体支持物，其包含阻塞部分和经修饰的核酸，其以稳定，可再现，快速的方式在杂交测定中显示出优异的特性。 在另一方面，本发明提供了利用固体支持物将探针核酸与靶核酸杂交的方法和用于检测杂交复合物的方法。
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公开(公告)号：US06200761B1
公开(公告)日：2001-03-13
申请号：US09454497
申请日：1999-12-06
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q1/6825 , Y02A50/52 , C12Q2565/607 , C12Q2565/401 , C12Q2563/137 , C12Q2563/113 , C12Q2565/101 , C12Q2565/1015
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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