公开(公告)号：US07549983B2

公开(公告)日：2009-06-23

申请号：US10997804

申请日：2004-11-24

Applicant: Chad C. Roue ,  Andrew G. C. Frazier ,  Michael D. Lesh ,  Erik J. van der Burg

Inventor： Chad C. Roue ,  Andrew G. C. Frazier ,  Michael D. Lesh ,  Erik J. van der Burg

IPC: A61M31/00

CPC classification number: A61B17/0057 ,  A61B17/00234 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/0644 ,  A61B17/12122 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00632 ,  A61B2017/00668 ,  A61B2017/0409 ,  A61B2017/0412 ,  A61B2017/0414 ,  A61B2017/0417 ,  A61B2017/042 ,  A61B2017/0437 ,  A61B2017/0445 ,  A61B2017/0454 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0472 ,  A61B2017/0477 ,  A61B2017/048 ,  A61B2017/0488 ,  A61B2017/0645 ,  A61B2017/0647 ,  A61F2/24 ,  A61F2/2427 ,  A61F2/2487 ,  Y10S606/907

Abstract: Disclosed is a closure catheter, for closing a tissue opening such as an atrial septal defect, patent foreman ovale, or the left atrial appendage of the heart. The closure catheter carries a plurality of tissue anchors, which may be deployed into tissue surrounding the opening, and used to draw the opening closed. Methods are also disclosed.

Abstract translation: 公开了一种封闭导管，用于封闭组织开口，例如房间隔缺损，专利前额卵巢或心脏的左心耳。 闭合导管携带多个组织锚，其可以部署在围绕开口的组织中，并用于将开口拉开。 还公开了方法。

公开(公告)号：US06758830B1

公开(公告)日：2004-07-06

申请号：US09569734

申请日：2000-05-11

Applicant: Alan K. Schaer ,  Michael D. Lesh

Inventor： Alan K. Schaer ,  Michael D. Lesh

IPC: A61M3500

CPC classification number: A61M25/0668 ,  A61B17/22012 ,  A61B18/1492 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2017/22038 ,  A61B2018/00214 ,  A61B2018/00285 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61M2210/125 ,  A61N7/02 ,  C08L2201/12

Abstract: The present invention relates to a system adapted to position an ablation catheter at a location where a pulmonary vein extends from an atrium. The system includes a deflection device and a sheath and optionally uses a guidewire. An ablation catheter is disclosed for use with the positioning system, wherein the deflection device and the sheath cooperate so as to facilitate positioning of the catheter at the location.

Abstract translation: 本发明涉及一种适于将消融导管定位在肺静脉从心房延伸的位置处的系统。 该系统包括偏转装置和护套，并且可选地使用导丝。 公开了与定位系统一起使用的消融导管，其中偏转装置和护套配合以便于将导管定位在该位置。

公开(公告)号：US06746472B2

公开(公告)日：2004-06-08

申请号：US09903970

申请日：2001-07-11

Applicant: Andrew G. C. Frazier ,  Michael D. Lesh ,  Chad C. Roue ,  Erik J. van der Burg

Inventor： Andrew G. C. Frazier ,  Michael D. Lesh ,  Chad C. Roue ,  Erik J. van der Burg

IPC: A61B1704

CPC classification number: A61B17/0057 ,  A61B17/00234 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/0644 ,  A61B17/12122 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00632 ,  A61B2017/00668 ,  A61B2017/0409 ,  A61B2017/0412 ,  A61B2017/0414 ,  A61B2017/0417 ,  A61B2017/042 ,  A61B2017/0437 ,  A61B2017/0445 ,  A61B2017/0454 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0472 ,  A61B2017/0477 ,  A61B2017/048 ,  A61B2017/0488 ,  A61B2017/0645 ,  A61B2017/0647 ,  A61F2/24 ,  A61F2/2427 ,  A61F2/2487 ,  Y10S606/907

Abstract: Disclosed is an anastomosis catheter, for achieving a tissue to tissue or synthetic graft to tissue attachment. The catheter includes a plurality of deployable tissue anchors, which may be laterally deployed into surrounding tissue. The anchors may be used to achieve end to end or end to side anastomoses. Methods are also disclosed.

Abstract translation: 公开了一种用于实现组织到组织或合成移植物到组织附着的吻合导管。 导管包括多个可展开的组织锚，其可以横向地布置到周围组织中。 锚可以用于实现端对端或端到端吻合。 还公开了方法。

公开(公告)号：US06716196B2

公开(公告)日：2004-04-06

申请号：US09797483

申请日：2001-02-28

Applicant: Michael D. Lesh ,  Thomas F. Kordis ,  Stuart D. Edwards

Inventor： Michael D. Lesh ,  Thomas F. Kordis ,  Stuart D. Edwards

IPC: A61M5178

CPC classification number: A61M25/0136 ,  A61B17/22 ,  A61B2017/00243 ,  A61B2017/22082 ,  A61B2017/3488 ,  A61B2018/00273 ,  A61B2018/00815 ,  A61B2018/1425 ,  A61B2018/1435 ,  A61B2090/3784 ,  A61M25/0084 ,  A61M25/0133 ,  A61M25/0147 ,  A61N7/02

Abstract: This is a method and an apparatus for the introduction of therapeutic compounds into tissue, particularly cardiac tissue. The apparatus includes a catheter having an elongated flexible body and a tissue infusion apparatus including a hollow infusion needle configured to secure the needle into the tissue when the needle is at least partially inserted into the tissue to help prevent inadvertent removal of the needle from the tissue. This permits the selected therapeutic compound to be delivered to a specific site. The catheter may also include a visualization assembly including a transducer at the distal end of the body.

Abstract translation: 这是用于将治疗化合物引入组织，特别是心脏组织的方法和装置。 所述装置包括具有细长柔性体的导管和包括中空输液针的组织浸液装置，所述中空灌注针构造成当针至少部分插入组织中时将针固定到组织中，以帮助防止针头从组织中无意中移除 。 这允许将所选择的治疗化合物递送到特定部位。 导管还可以包括可视化组件，其包括在身体的远端处的换能器。

公开(公告)号：US06650923B1

公开(公告)日：2003-11-18

申请号：US09549218

申请日：2000-04-13

Applicant: Michael D. Lesh ,  Alex K. Khairkahan ,  Erik J. van der Burg

Inventor： Michael D. Lesh ,  Alex K. Khairkahan ,  Erik J. van der Burg

IPC: A61B500

CPC classification number: A61B17/32075 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B17/320016 ,  A61B17/320725 ,  A61B17/3478 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00783 ,  A61B2018/00392

Abstract: Disclosed is an access catheter for identifying and providing access through a tissue structure such as the fossa ovalis on the intraatrial septum. The access catheter comprises an elongate flexible tubular body having a proximal and a distal end, and a retractable piercing structure such as a needle carried by the distal end. A detector such as a red, green, and blue light detector is associated with the access catheter, such that placement of the distal end of the catheter against the fossa ovalis can be detected. The piercing structure is thereafter advanceable to provide access to the left atrium through the fossa ovalis.

Abstract translation: 公开了一种进入导管，用于识别和提供通过诸如卵巢上的组织结构（例如卵巢上的卵巢）的通路。 进入导管包括具有近端和远端的细长柔性管状体，以及可伸缩穿刺结构，例如由远端承载的针。 诸如红色，绿色和蓝色光检测器的检测器与进入导管相关联，使得能够检测导管远端放置在卵圆窝上。 穿刺结构此后可以提前进入以通过卵圆窝进入左心房。

公开(公告)号：US06547788B1

公开(公告)日：2003-04-15

申请号：US09517614

申请日：2000-03-02

Applicant: Mark A. Maguire ,  Martin F. O'Sullivan ,  Edward L. Carcamo ,  Michael D. Lesh ,  Alan K. Schaer ,  Kevin J. Taylor ,  Guillermo P. Picazo

Inventor： Mark A. Maguire ,  Martin F. O'Sullivan ,  Edward L. Carcamo ,  Michael D. Lesh ,  Alan K. Schaer ,  Kevin J. Taylor ,  Guillermo P. Picazo

IPC: A61B1818

CPC classification number: A61B18/00 ,  A61B18/1492 ,  A61B2017/00243 ,  A61B2018/00083 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61M25/1002 ,  A61M2210/125 ,  A61N7/02 ,  A61N7/022

Abstract: A tissue ablation catheter for forming a lesion along a substantially circumferential region of tissue is described. The catheter includes one or more sensors for monitoring the temperature of the tissue being ablated. The temperature sensors are mounted on the interior or exterior of an expandable member that is affixed to a shaft of the catheter.

Abstract translation: 描述了用于沿着组织的基本圆周区域形成病变的组织消融导管。 该导管包括一个或多个传感器，用于监测被消融的组织的温度。 温度传感器安装在固定到导管的轴上的可扩张构件的内部或外部。

公开(公告)号：US06527769B2

公开(公告)日：2003-03-04

申请号：US10083317

申请日：2002-02-25

Applicant: Jonathan J. Langberg ,  James C. Peacock, III ,  Michael D. Lesh

Inventor： Jonathan J. Langberg ,  James C. Peacock, III ,  Michael D. Lesh

IPC: A61B1818

CPC classification number: A61B18/1492 ,  A61B2018/00279 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/1407

Abstract: The present invention relates to a tissue ablation device assembly which is adapted to form a conduction block along a length of tissue between two predetermined locations along the left atrial wall. The assembly comprises an ablation element on an elongated ablation member that is coupled to each of two delivery members, wherein the delivery members are adapted to controllably position and secure the ablation element along the length of tissue between the predetermined locations. A linear lesion in the tissue between the predetermined locations is then formed by actuation of the ablation element. The invention further provides that the ablation member may slideably engage one or two delivery members such that an adjustable length of the ablation element along the ablation member may be extended externally from the engaged delivery member and along a length of tissue.

公开(公告)号：US06502576B1

公开(公告)日：2003-01-07

申请号：US09642251

申请日：2000-08-17

Applicant: Michael D. Lesh

Inventor： Michael D. Lesh

IPC: A61B1900

CPC classification number: A61B18/10 ,  A61B18/08 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2017/00243 ,  A61B2017/22038 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00011 ,  A61B2018/00083 ,  A61B2018/00107 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00369 ,  A61B2018/00375 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00898 ,  A61B2018/00994 ,  A61B2018/1407 ,  A61B2218/002 ,  A61M25/1002 ,  A61M2025/1075 ,  A61M2210/125 ,  A61N7/022

Abstract: This invention is a method for treating a patient diagnosed with atrial arrhythmia by forming a circumferential conduction block along a circumferential path of tissue in a pulmonary vein wall that circumscribes the pulmonary vein lumen and transects the electrical conductivity of the pulmonary vein such that conduction is blocked along the longitudinal axis of the vein wall and into the left atrial wall. The method is performed to treat a patient with a focal arrythmogenic origin along the pulmonary vein wall by either ablating the focal origin or by isolating the focal origin from the atrial wall with the circumferential conduction block. The circumferential conduction block is also formed in a pulmonary vein in order to bridge the adjacent ends of two linear lesions, wherein each linear lesion is formed to extend between the pulmonary vein and another adjacent pulmonary vein in a less-invasive “maze”-type procedure. A circumferential ablation element in a circumferential ablation device assembly is used in a percutaneous translumenal catheter technique in order to form the circumferential conduction block in the pulmonary vein wall.

Abstract translation: 本发明是一种通过沿着肺静脉壁的肺组织周向路径形成圆周传导阻滞来诊断患有心律失常的患者的方法，所述肺静脉壁围绕肺静脉管腔并横切肺静脉的导电性，从而导致阻塞 沿着静脉壁的纵向轴线并进入左心房壁。 执行该方法以通过消融焦点来源或通过用圆周传导阻滞来将心源起点与心房壁一起沿着肺静脉壁治疗具有局灶性原发性起源的患者。 圆周传导阻滞也形成在肺静脉中以便桥接两个线性损伤的相邻端，其中每个线性病变形成为在较小侵入性“迷宫”型的肺静脉和另一相邻的肺静脉之间延伸 程序。 在经皮腔内导管技术中使用周缘消融装置组件中的圆周消融元件，以便在肺静脉壁中形成圆周传导阻滞。

公开(公告)号：US06419669B1

公开(公告)日：2002-07-16

申请号：US09447390

申请日：1999-11-22

Applicant: Andrew G. C. Frazier ,  Michael D. Lesh ,  Chad C. Roue ,  Erik J. van der Burg

Inventor： Andrew G. C. Frazier ,  Michael D. Lesh ,  Chad C. Roue ,  Erik J. van der Burg

IPC: A61M3100

CPC classification number: A61B17/0057 ,  A61B17/00234 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/0644 ,  A61B17/12122 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00632 ,  A61B2017/00668 ,  A61B2017/0409 ,  A61B2017/0412 ,  A61B2017/0414 ,  A61B2017/0417 ,  A61B2017/042 ,  A61B2017/0437 ,  A61B2017/0445 ,  A61B2017/0454 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0472 ,  A61B2017/0477 ,  A61B2017/048 ,  A61B2017/0488 ,  A61B2017/0645 ,  A61B2017/0647 ,  A61F2/24 ,  A61F2/2427 ,  A61F2/2487 ,  Y10S606/907

Abstract: Disclosed is a closure catheter, for patching a tissue opening such as an atrial septal defect, patent foreman ovale, or the left atrial appendage of the heart. The closure catheter carries a deployable patch and a plurality of tissue anchors, which may be deployed to secure the patch to surrounding tissue. Methods are also disclosed.

Abstract translation: 公开了一种封闭导管，用于修补组织开口，例如房间隔缺损，专利前额卵巢或心脏的左心耳。 闭合导管携带可展开的贴片和多个组织锚，其可以被部署以将贴片固定到周围的组织。 还公开了方法。

公开(公告)号：US06328727B1

公开(公告)日：2001-12-11

申请号：US09482986

申请日：2000-01-11

Applicant: Andrew G. C. Frazier ,  Michael D. Lesh ,  Chad C. Roue ,  Erik J. van der Burg

Inventor： Andrew G. C. Frazier ,  Michael D. Lesh ,  Chad C. Roue ,  Erik J. van der Burg

IPC: A61M2900

CPC classification number: A61B17/0057 ,  A61B17/00234 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/0644 ,  A61B17/12122 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00632 ,  A61B2017/00668 ,  A61B2017/0409 ,  A61B2017/0412 ,  A61B2017/0414 ,  A61B2017/0417 ,  A61B2017/042 ,  A61B2017/0437 ,  A61B2017/0445 ,  A61B2017/0454 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0472 ,  A61B2017/0477 ,  A61B2017/048 ,  A61B2017/0488 ,  A61B2017/0645 ,  A61B2017/0647 ,  A61F2/24 ,  A61F2/2427 ,  A61F2/2487 ,  Y10S606/907

Abstract: Disclosed is an anastomosis catheter, for achieving a tissue to tissue or synthetic graft to tissue attachment. The catheter includes a plurality of deployable tissue anchors, which may be laterally deployed into surrounding tissue. The anchors may be used to achieve end to end or end to side anastomoses. Methods are also disclosed.

Abstract translation: 公开了一种用于实现组织到组织或合成移植物到组织附着的吻合导管。 导管包括多个可展开的组织锚，其可以横向地布置到周围组织中。 锚可以用于实现端对端或端到端吻合。 还公开了方法。