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公开(公告)号：US07468356B2
公开(公告)日：2008-12-23
申请号：US10545354
申请日：2004-02-11
CPC分类号： C07H21/04 , A61K38/00 , C07H21/00 , C07H21/02 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , Y10T436/143333 , C12N2310/3525
摘要： The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory conditions.
摘要翻译： 本发明提供调节生长因子基因表达的组合物和方法。 特别地，本发明涉及化合物，特别是寡核苷酸化合物，其在优选的实施方案中与编码胰岛素样生长因子I受体（IGF-1受体或IGF-1R），特别是人IGF-1R的核酸分子杂交。 这些化合物在本文中示例以调节与治疗增殖性和炎症性皮肤病症和癌症有关的增殖。 然而，应当理解，所述化合物可用于涉及IGF-1R的任何其它病症，包括炎性病症。
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公开(公告)号：US06436909B1
公开(公告)日：2002-08-20
申请号：US09661753
申请日：2000-09-14
申请人： Nicholas M. Dean , Susan F. Murray
发明人： Nicholas M. Dean , Susan F. Murray
IPC分类号： A61K4800
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods are provided for modulating the expression of TGF-&bgr;. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TGF-&bgr; are preferred. Methods of using these compounds for modulation of TGF-&bgr; expression and for treatment of diseases associated with expression of TGF-&bgr; are also provided. Methods of sensitizing cells to apoptotic stimuli are also provided.
摘要翻译： 提供了用于调节TGF-β的表达的组合物和方法。 优选靶向编码TGF-β的核酸的反义化合物，特别是反义寡核苷酸。 还提供了使用这些化合物调节TGF-β表达和治疗与TGF-β表达相关的疾病的方法。 还提供了使细胞对凋亡刺激敏感的方法。
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公开(公告)号：US06300320B1
公开(公告)日：2001-10-09
申请号：US09225749
申请日：1999-01-05
申请人： Nicholas M. Dean , Robert McKay
发明人： Nicholas M. Dean , Robert McKay
IPC分类号： A61K3170
CPC分类号： C12N15/1137 , A61K38/00 , C07H21/00 , C07K14/82 , C12N9/1205 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/11013 , C12N2310/3527 , C12N2310/3521 , C12N2310/3525
摘要： Methods and compositions are provided for modulating c-jun expression using inhibitors of PKC-&agr;. In preferred embodiments, the specific inhibitors are antisense oligonucleotides hybridizable to PKC-&agr;. In preferred embodiments, the oligonucleotides contain one or more chemical modifications. Methods of modulating c-jun expression and of treating animals suffering from disease amenable to therapeutic intervention by modulating c-jun expression are disclosed
摘要翻译： 提供使用PKC-α抑制剂调节c-jun表达的方法和组合物。 在优选的实施方案中，特异性抑制剂是可与PKC-α杂交的反义寡核苷酸。 在优选的实施方案中，寡核苷酸含有一种或多种化学修饰。 公开了调节c-jun表达和通过调节c-jun表达治疗适于治疗干预的疾病的方法
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公开(公告)号：US06180353B2
公开(公告)日：2001-01-30
申请号：US09490692
申请日：2000-01-24
申请人： Nicholas M. Dean , Lex M. Cowsert
发明人： Nicholas M. Dean , Lex M. Cowsert
IPC分类号： C07H2104
CPC分类号： C12N15/113 , C07B2200/11 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of daxx. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding daxx. Methods of using these compounds for modulation of daxx expression and for treatment of diseases associated with expression of daxx are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节daxx的表达。 组合物包含靶向编码daxx的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节daxx表达和治疗与daxx表达有关的疾病的方法。
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公开(公告)号：US6001992A
公开(公告)日：1999-12-14
申请号：US226568
申请日：1999-01-07
IPC分类号： C12N15/09 , A61K31/7105 , A61K31/711 , A61K31/712 , A61K31/7125 , A61K33/24 , A61K45/00 , A61K48/00 , A61P35/00 , C12N5/10 , C12N15/113 , C07H21/04 , C07H21/02 , C12N15/63 , C12Q1/68
CPC分类号： C12N15/1135 , C12N15/113 , C12N2310/315 , C12N2310/318 , C12N2310/3181 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , Y02P20/582
摘要： Compositions and methods are provided for modulating the expression of novel anti-apoptotic bcl-2-related proteins. Antisense oligonucleotides targeted to nucleic acids encoding the human novel anti-apoptotic bcl-2-related proteins A1 and mcl-1 are preferred. Methods of using these compounds for modulation of novel anti-apoptotic bcl-2-related protein expression and for treatment of diseases associated with expression of novel anti-apoptotic bcl-2-related proteins are also provided. Also provided are methods of using these compounds for promoting apoptosis and for treatment of diseases for which promotion of apoptosis is desired.
摘要翻译： 提供组合物和方法用于调节新型抗凋亡性bcl-2相关蛋白的表达。 靶向编码人类新型抗凋亡性bcl-2相关蛋白A1和mcl-1的核酸的反义寡核苷酸是优选的。 还提供了使用这些化合物调节新型抗凋亡性bcl-2相关蛋白表达和治疗与抗细胞凋亡性bcl-2相关蛋白表达相关的疾病的方法。 还提供了使用这些化合物促进细胞凋亡和治疗需要促进细胞凋亡的疾病的方法。
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46.发明授权Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (CTGF) 有权使用针对结缔组织生长因子（CTGF）的反义化合物治疗瘢痕疙瘩或肥厚性瘢痕的方法公开(公告)号：US09173894B2
公开(公告)日：2015-11-03
申请号：US13364547
申请日：2012-02-02
申请人： Nicholas M. Dean , Lincoln Krochmal , Gregory Hardee , J. Gordon Foulkes , Niall O'Donnell , Leroy Young , Mark Jewell
发明人： Nicholas M. Dean , Lincoln Krochmal , Gregory Hardee , J. Gordon Foulkes , Niall O'Donnell , Leroy Young , Mark Jewell
IPC分类号： A61K48/00 , A61K31/7088 , A61K31/712 , A61K45/06
CPC分类号： C12N15/1136 , A61K31/7088 , A61K31/712 , A61K45/06 , C12N2310/11 , C12N2310/14 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2320/30
摘要： This invention provides methods of preventing formation of, or treating, fibrotic lesions, including skin scars such as keloids and hypertrophic scars which comprise administering to the subject by one or more injection a compound which comprises a modified oligonucleotide, such as a modified antisense oligonucleotide, siRNA, or oligodeoxyribonucleotide, which inhibits expression of protein involved in fibrosis. Dosing of the antisense using an intradermal threading technique is also described.
摘要翻译： 本发明提供了防止纤维化病变的形成或治疗，包括皮肤瘢痕如瘢痕疙瘩和肥大性瘢痕的方法，其包括通过一次或多次注射向受试者施用包含修饰寡核苷酸的化合物，例如修饰的反义寡核苷酸， siRNA或寡脱氧核糖核苷酸，其抑制参与纤维化的蛋白质的表达。 还描述了使用皮内螺纹技术给予反义剂。
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公开(公告)号：US08772260B2
公开(公告)日：2014-07-08
申请号：US13584573
申请日：2012-08-13
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
摘要翻译： 本发明提供了包含能够抑制表达结缔组织因子的修饰寡核苷酸和含有其的组合物的化合物，以及治疗过度放射性疾病和纤维化疾病的方法，以及使用这些化合物减少伤口愈合引起的瘢痕形成。
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公开(公告)号：US20130190382A1
公开(公告)日：2013-07-25
申请号：US13584573
申请日：2012-08-13
IPC分类号： C12N15/113
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
摘要翻译： 本发明提供了包含能够抑制表达结缔组织因子的修饰寡核苷酸和含有其的组合物的化合物，以及治疗过度放射性疾病和纤维化疾病的方法，以及使用这些化合物减少伤口愈合引起的瘢痕形成。
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49.发明授权Antisense oligonucleotides directed against connective tissue growth factor and uses thereof 有权针对结缔组织生长因子的反义寡核苷酸及其用途公开(公告)号：US08252762B2
公开(公告)日：2012-08-28
申请号：US12547474
申请日：2009-08-25
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
摘要翻译： 本发明提供了包含能够抑制表达结缔组织因子的修饰寡核苷酸和含有其的组合物的化合物，以及治疗过度放射性疾病和纤维化疾病的方法，以及使用这些化合物减少伤口愈合引起的瘢痕形成。
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公开(公告)号：US08198253B2
公开(公告)日：2012-06-12
申请号：US12374635
申请日：2007-07-18
CPC分类号： C12N15/1135 , C12N2310/11
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of HBXIP in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
摘要翻译： 本文公开了用于调节细胞，组织或动物中HBXIP表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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