Fusion protein of hiv regulatory/accessory proteins
    41.
    发明申请
    Fusion protein of hiv regulatory/accessory proteins 审中-公开
    hiv调节/辅助蛋白的融合蛋白

    公开(公告)号:US20050222388A1

    公开(公告)日:2005-10-06

    申请号:US10514740

    申请日:2003-05-14

    摘要: The invention relates to fusion proteins comprising the amino acid sequence of at least four HIV proteins selected from Vif, Vpr, Vpu, Rev, Tat and Nef or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV proteins having the natural N and C termini. The invention further concerns nucleic acids encoding said proteins, vectors comprising said nucleic acids, and methods for producing said proteins. The fusion protein, nucleic acids and vectors are usable as vaccines for the at least partial prophylaxis against HIV infections.

    摘要翻译: 本发明涉及包含选自Vif,Vpr,Vpu,Rev,Tat和Nef的至少四种HIV蛋白质的氨基酸序列或一种或多种所述蛋白质的氨基酸序列的衍生物的融合蛋白,其中融合蛋白是 没有加工成具有天然N和C末端的单个HIV蛋白质。 本发明还涉及编码所述蛋白质的核酸,包含所述核酸的载体和用于产生所述蛋白质的方法。 融合蛋白,核酸和载体可用作用于至少部分预防HIV感染的疫苗。

    Fusion protein of HIV regulatory/accessory proteins
    46.
    发明授权
    Fusion protein of HIV regulatory/accessory proteins 失效
    HIV调节/辅助蛋白融合蛋白

    公开(公告)号:US08143054B2

    公开(公告)日:2012-03-27

    申请号:US12490424

    申请日:2009-06-24

    摘要: The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV proteins having the natural N and C termini. The invention further concerns nucleic acids encoding said proteins, vectors comprising said nucleic acids, and methods for producing said proteins. The fusion protein, nucleic acids and vectors are usable as vaccines for the at least partial prophylaxis against HIV infections.

    摘要翻译: 本发明涉及包含选自Vif,Vpr,Vpu,Rev和Tat的至少三种HIV蛋白质的氨基酸序列或一种或多种所述蛋白质的氨基酸序列的衍生物的融合蛋白,其中融合蛋白不是 加工成具有天然N和C末端的单独的HIV蛋白质。 本发明还涉及编码所述蛋白质的核酸,包含所述核酸的载体和用于产生所述蛋白质的方法。 融合蛋白,核酸和载体可用作用于至少部分预防HIV感染的疫苗。