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    COMPOUNDS AND METHOD FOR TREATING AUTOIMMUNE DISEASES
    42.
    发明申请
    COMPOUNDS AND METHOD FOR TREATING AUTOIMMUNE DISEASES 审中-公开
    化合物和治疗自身免疫性疾病的方法

    公开(公告)号：US20140213555A1

    公开(公告)日：2014-07-31

    申请号：US14163822

    申请日：2014-01-24

    Applicant: Rigel Pharmaceuticals, Inc.

    Inventor： Esteban Masuda ,  Rajinder Singh ,  Vanessa Taylor ,  Donald G. Payan

    IPC: C07D413/12 ,  C07F9/653

    CPC classification number: C07D413/12 ,  A61K31/506 ,  A61K31/675 ,  A61K45/06 ,  C07F9/65324 ,  Y10T436/141111 ,  A61K2300/00

    Abstract: Compounds and embodiments of a method for treating and/or preventing autoimmune diseases are disclosed. The method includes administering to a subject having an autoimmune disease, such as an inflammatory bowel disease, a therapeutically effective amount of a compound according to formula I wherein X and Y independently are O or NR1; each R1 is independently H or C1-C6 alkyl; ring A is aryl; each R2 independently is H, alkyl, alkoxy, amide, cyano, halo, haloalkyl, hydroxyalkyl, heteroalkyl, heterocyclyl, sulfonyl, sulfonamide, or two R2 groups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered ring system; p is 0, 1, 2, 3, or 4; R3 and R4 independently are H or C1-C6 alkyl; and R5 is halo, cyano, or C1-C6 alkyl.

    Abstract translation: 公开了用于治疗和/或预防自身免疫疾病的方法的化合物和实施方案。 该方法包括向具有自身免疫性疾病如炎症性肠病的受试者施用治疗有效量的式I化合物，其中X和Y独立地为O或NR 1; 每个R 1独立地为H或C 1 -C 6烷基; 环A是芳基; 每个R 2独立地是与它们所连接的原子或原子一起形成的H，烷基，烷氧基，酰胺，氰基，卤素，卤代烷基，羟基烷基，杂烷基，杂环基，磺酰基，磺酰胺或两个R 2基团 4-10元环系; p为0,1,2,3或4; R3和R4独立地是H或C1-C6烷基; 且R 5为卤素，氰基或C 1 -C 6烷基。

    Compounds and method for treating autoimmune diseases
    43.
    发明授权
    Compounds and method for treating autoimmune diseases 有权

    公开(公告)号：US11220496B2

    公开(公告)日：2022-01-11

    申请号：US16551431

    申请日：2019-08-26

    Applicant: Rigel Pharmaceuticals, Inc.

    Inventor： Esteban Masuda ,  Rajinder Singh ,  Vanessa Taylor ,  Donald G. Payan

    IPC: C07D413/12 ,  C07F9/653 ,  A61K31/675 ,  A61K45/06 ,  A61K31/506

    Abstract: Compounds and embodiments of a method for treating and/or preventing autoimmune diseases are disclosed. The method includes administering to a subject having an autoimmune disease, such as an inflammatory bowel disease, a therapeutically effective amount of a compound according to formula I wherein X and Y independently are O or NR1; each R1 is independently H or C1-C6 alkyl; ring A is aryl; each R2 independently is H, alkyl, alkoxy, amide, cyano, halo, haloalkyl, hydroxyalkyl, heteroalkyl, heterocyclyl, sulfonyl, sulfonamide, or two R2 groups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered ring system; p is 0, 1, 2, 3, or 4; R3 and R4 independently are H or C1-C6 alkyl; and R5 is halo, cyano, or C1-C6 alkyl.

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