利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

52 条记录 (耗时 0.027 秒)

    Purine derivatives, the preparation thereof and their use as pharmaceutical compositions
    42.
    发明授权
    Purine derivatives, the preparation thereof and their use as pharmaceutical compositions 有权
    嘌呤衍生物，其制备及其作为药物组合物的用途

    公开(公告)号：US07569574B2

    公开(公告)日：2009-08-04

    申请号：US10634047

    申请日：2003-08-04

    申请人： Roland Maier ,  Frank Himmelsbach ,  Matthias Eckhardt ,  Elke Langkopf ,  Michael Mark ,  Ralf R. H. Lotz

    发明人： Roland Maier ,  Frank Himmelsbach ,  Matthias Eckhardt ,  Elke Langkopf ,  Michael Mark ,  Ralf R. H. Lotz

    IPC分类号： C07D473/30 ,  C07D473/18 ,  C07D473/04 ,  C07D473/06 ,  A61K31/522 ,  A61P3/10 ,  A61P3/04

    CPC分类号： C07D473/30

    摘要： The invention relates to new purine derivatives of general formula wherein R1 to R4 are defined as in the claims, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV), the preparation thereof, the use thereof for the prevention or treatment of diseases or conditions associated with an increased DPP-IV activity or capable of being prevented or alleviated by reducing the DPP-IV activity, particularly type I or type II diabetes mellitus, the pharmaceutical compositions containing a compound of general formula (I) or a physiologically acceptable salt thereof as well as processes for the preparation thereof.

    摘要翻译： 本发明涉及通式的新嘌呤衍生物，其中R 1至R 4如权利要求中所定义，互变异构体，立体异构体，混合物，其前药及其盐，特别是其与无机或有机酸的生理学上可接受的盐或 具有有价值的药理学性质的碱基，特别是对二肽基肽酶-IV（DPP-IV）的活性的抑制作用，其制备方法，其用于预防或治疗与增加的DPP-IV活性有关的疾病或病症的用途 或能够通过减少DPP-IV活性（特别是I型或II型糖尿病）来预防或缓解含有通式（I）化合物或其生理学上可接受的盐的药物组合物及其制备方法 。

    Adaptive cartridge for a subcaliber barrel system
    48.
    发明授权
    Adaptive cartridge for a subcaliber barrel system 失效
    适用于子套筒系统的墨盒

    公开(公告)号：US4955300A

    公开(公告)日：1990-09-11

    申请号：US428196

    申请日：1989-10-27

    申请人： Roland Bertiller ,  Roland Maier

    发明人： Roland Bertiller ,  Roland Maier

    IPC分类号： F42B8/10

    CPC分类号： F42B8/10

    摘要： The invention provides an electrical igniter for an adaptive cartridge of a subcaliber barrel system by which the firing pin extension (12) is arranged axially movable by means of a guide (13) made of an electrically non-conductive material. A slide valve (22) grips a safety rod (17) in the guide (13). The safety rod (17) is situated adjacent the breech mechanism (6) only such that the firing pin (12) borders on the percussion cap (29) of the cartridge (11). By an open breech mechanism (6) the safety rod (17), under spring tension, is moved in the direction of the cartridge (11) together with the firing pin (12).

    摘要翻译： 本发明提供一种用于子套筒系统的自适应套筒的电点火器，通过该电子点火器，撞击销延伸部12可通过由不导电材料制成的导向件13轴向移动。 滑阀（22）夹紧导向件（13）中的安全杆（17）。 安全杆（17）仅位于后膛机构（6）附近，使得撞针（12）与盒（11）的冲击盖（29）相接。 通过打开的后膛机构（6），弹簧张力下的安全杆（17）与撞击销（12）一起沿着盒（11）的方向移动。

    Yarn false twisting apparatus
    50.
    发明授权
    Yarn false twisting apparatus 失效
    纱线假捻装置

    公开(公告)号：US4519204A

    公开(公告)日：1985-05-28

    申请号：US429795

    申请日：1982-09-30

    申请人： Peter Dammann ,  Hellmut Lorenz ,  Roland Maier

    发明人： Peter Dammann ,  Hellmut Lorenz ,  Roland Maier

    IPC分类号： D02G1/08

    CPC分类号： D02G1/087

    摘要： A yarn false twisting apparatus is disclosed which comprises a flexible disc mounted for rotation with a cooperating rigid disc to define a twisting zone therebetween. A pressure applying member is positioned adjacent the back face of the flexible disc for biasing the disc toward the rigid disc locally at the twisting zone so as to firmly engage the yarn passing through the twisting zone. The flexible disc comprises a hub portion disposed adjacent the center of the disc, an annular ring disposed concentrically about the hub portion and including a yarn engaging friction surface on one face thereof, and a distinct and highly flexible junction portion joining the hub portion and annular ring. The highly flexible junction portion permits the annular ring to readily flex in the lateral direction, to thereby permit the deflecting force to be minimized, while still permitting the rotating torque to be transmitted to the annular ring without significant circumferential deformation. The annular ring may also be divided into segments by radial or circumferential slots, to further reduce its resistance to the lateral deforming force of the pressure applying member, and to provide a substantially linear contact with the running yarn.

    摘要翻译： 公开了一种纱线假捻设备，其包括安装成与协作的刚性盘一起旋转的柔性盘，以在它们之间限定扭转区域。 压力施加构件邻近柔性盘的后表面定位，用于在扭转区域局部地朝着刚性盘偏压盘，以便牢固地接合通过扭转区域的纱线。 所述柔性盘包括邻近所述盘的中心设置的轮毂部分，围绕所述轮毂部分同心地设置并且在其一个面上包括纱线接合摩擦表面的环形圈和连接所述轮毂部分和环形部分的不同且高度柔性的接合部分 环。 高度柔性的接合部分允许环形环在横向方向上容易地弯曲，从而允许偏转力最小化，同时仍然允许旋转扭矩传递到环形圈而没有显着的周向变形。 环形环也可以通过径向或周向槽分成段，以进一步减小其对压力施加构件的横向变形力的阻力，并提供与运行纱线的基本线性接触。