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41.发明申请ATRIAL NATRIURETIC PEPTIDE (ANP) SPLICE VARIANTS AND METHODS OF USING SAME 审中-公开ATRIAL NATRIURETIC PEPTIDE（ANP）SPLICE VARIANTS AND METHODS OF USAME公开(公告)号：US20090035287A1
公开(公告)日：2009-02-05
申请号：US12088132
申请日：2006-09-26
IPC分类号： A61K35/12 , C12N15/11 , C07K14/00 , C12N15/00 , A61K38/00 , A61P9/00 , C12N5/06 , C12P21/04 , A61K31/7088
CPC分类号： C07K14/58
摘要： Novel ANP polypeptides and polynucleotides encoding same are provided. Also provided are methods and pharmaceutical compositions which can be used to treat ANP-related diseases and disorders including cardiovascular disorders using the polypeptides and polynucleotides of the present invention.
摘要翻译： 提供了新的ANP多肽和编码相同的多核苷酸。 还提供了可使用本发明的多肽和多核苷酸治疗ANP相关疾病和病症（包括心血管疾病）的方法和药物组合物。
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公开(公告)号：US09428586B2
公开(公告)日：2016-08-30
申请号：US13512921
申请日：2010-11-30
申请人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
发明人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
IPC分类号： A61K39/395 , C07K16/30 , C07K16/40 , C12N15/113 , C12N9/24
CPC分类号： C07K16/30 , C07K16/40 , C12N9/2402 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Y302/01166
摘要： The present invention, in at least some aspects, is of splice variants of heparanase, as well as diagnostic kits and methods of use, and therapeutic agents and methods of use based thereon, and antibodies specifically binding thereof.
摘要翻译： 在至少一些方面，本发明是肝素酶的剪接变体，以及诊断试剂盒和使用方法，以及基于其的治疗剂和使用方法以及与其特异性结合的抗体。
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公开(公告)号：US20120301475A1
公开(公告)日：2012-11-29
申请号：US13512921
申请日：2010-11-30
申请人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
发明人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
IPC分类号： C07K16/40 , G01N33/573 , G01N33/574 , A61N5/00 , A61K39/395 , A61P35/00 , A61P35/02 , C12N5/20 , C12Q1/70
CPC分类号： C07K16/30 , C07K16/40 , C12N9/2402 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Y302/01166
摘要： The present invention, in at least some aspects, is of splice variants of heparanase, as well as diagnostic kits and methods of use, and therapeutic agents and methods of use based thereon, and antibodies specifically binding thereof.
摘要翻译： 在至少一些方面，本发明是肝素酶的剪接变体，以及诊断试剂盒和使用方法，以及基于其的治疗剂和使用方法以及与其特异性结合的抗体。
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44.发明授权公开(公告)号：US07758862B2
公开(公告)日：2010-07-20
申请号：US12088210
申请日：2006-10-03
申请人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran
发明人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/20 , C07K2319/30
摘要： Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
摘要翻译： 提供了作为c-Met的剪接变体，肝细胞生长因子的受体和编码其的多核苷酸的新型多肽。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。
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公开(公告)号：US20100166733A1
公开(公告)日：2010-07-01
申请号：US12305953
申请日：2006-06-21
申请人： Zurit Levin , Amir Toporik , Michal Ayalon-Soffer , Iris Hecht , Merav Beiman , Dani Eshel , Tali Handelsman
发明人： Zurit Levin , Amir Toporik , Michal Ayalon-Soffer , Iris Hecht , Merav Beiman , Dani Eshel , Tali Handelsman
IPC分类号： A61K39/395 , C07H21/00 , C07K16/00 , C12N15/74 , C12N5/10 , C12P21/00 , A61K31/7088 , A61K45/00 , A61P3/10 , A61P11/06 , A61P11/08 , A61P9/10 , A61P21/00 , A61P37/02
CPC分类号： C07K14/523 , A61K38/00
摘要： Novel MCP-1 splice variant polypeptides and polynucleotides encoding same are provided. Also provided are pharmaceutical compositions comprising the splice variant polypeptides and polynucleotides, vectors and host cells comprising same. The compositions of the present invention are useful to treat various MCP-1 related disorders as well as for diagnosing, determining predisposition and/or prognosis of various disorders.
摘要翻译： 提供了新的MCP-1剪接变体多肽和编码它们的多核苷酸。 还提供了包含剪接变体多肽和多核苷酸，载体和包含其的宿主细胞的药物组合物。 本发明的组合物可用于治疗各种MCP-1相关疾病以及用于诊断，确定各种疾病的倾向和/或预后。
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46.发明申请HEPATOCYTE GROWTH FACTOR RECEPTOR SPLICE VARIANTS AND METHODS OF USING SAME 失效肝细胞生长因子受体拮抗剂变异体及其使用方法公开(公告)号：US20090036374A1
公开(公告)日：2009-02-05
申请号：US12088210
申请日：2006-10-03
申请人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran
发明人： Galit Rotman , Merav Beiman , Michal Ayalon-Soffer , Zurit Levine , Chen Hermesh , Anat Oren , Zohar Tiran
IPC分类号： C07K14/435 , C12N15/62 , C12N15/85 , C12N5/10 , A61K38/17 , A61K31/7088 , A61P35/00 , A61P29/00 , A61P37/00
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/20 , C07K2319/30
摘要： Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
摘要翻译： 提供了作为c-Met的剪接变体，肝细胞生长因子的受体和编码其的多核苷酸的新型多肽。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。
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