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41.发明授权公开(公告)号：US06562334B1
公开(公告)日：2003-05-13
申请号：US09390729
申请日：1999-09-07
IPC分类号： A61K3819
CPC分类号： C07K14/5434 , A61K38/00 , C12N2799/026 , Y10S514/885
摘要： Canine interleukin 12 and a method for producing it by genetic engineering are disclosed. The canine interleukin 12 includes a protein having an amino acid sequence substantially the same as SEQ ID NO:1 or SEQ ID NO:11 or corresponds to part of either of SEQ ID NOS: 1 and 11, and a protein having an amino acid sequence substantially the same as SEQ ID NO:2 or SEQ ID NO:12 or corresponds to part of either of SEQ ID NOS:2 and 12, and relates to a production method thereof. There is also an immune disease remedy and preventive agent for dogs and cats containing canine interleukin 12, and a method of treating immune disease and a preventive method for dogs and cats using the immune disease remedy or preventive agent.
摘要翻译： 公开了犬白细胞介素12及其遗传工程方法。 犬白细胞介素12包括具有与SEQ ID NO：1或SEQ ID NO：11基本相同的氨基酸序列或对应于SEQ ID NO：1和11中的任一个的氨基酸序列的蛋白质，以及具有氨基酸序列 基本上与SEQ ID NO：2或SEQ ID NO：12相同或对应于SEQ ID NO：2和12中的任一个的一部分，并且涉及其制备方法。 还有一种针对含有犬白介素12的狗和猫的免疫疾病补救和预防剂，以及使用免疫疾病治疗或预防剂治疗免疫疾病的方法和狗和猫的预防方法。
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公开(公告)号：US06197292B1
公开(公告)日：2001-03-06
申请号：US09240004
申请日：1999-01-29
IPC分类号： A61K3821
摘要： The present invention relates to a therapeutic agent, composed of canine interferon-&ggr;, for canine intractable dermatitis and a treatment for canine intractable dermatitis using the agent.
摘要翻译： 本发明涉及一种由犬干扰素-γ组成的治疗剂，用于犬难治性皮炎，以及使用该药物治疗犬顽固性皮炎。
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43.发明授权Use of canine interferon-.gamma.(IFN-.gamma.) to treat non-atopic dermatitis 失效使用犬干扰素-γ（IFN-γ）治疗非特应性皮炎
公开(公告)号：US5955069A
公开(公告)日：1999-09-21
申请号：US1944
申请日：1997-12-31
摘要： Methods for treating intractable dermatitis in dogs are described. The methods involve the administration by injection of formulations comprising canine interferon-.gamma. and, optionally, other agents. The canine IFN-.gamma. may be produced in recombinant expression systems such as E. coli or B. mori.
摘要翻译： 描述了狗治疗难治性皮炎的方法。 所述方法包括通过注射包含犬干扰素-γ和任选的其它试剂的制剂进行给药。 犬IFN-γ可以在重组表达系统如大肠杆菌或禾谷镰孢中产生。
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公开(公告)号：US20120294860A1
公开(公告)日：2012-11-22
申请号：US13576950
申请日：2011-02-04
申请人： Takayoshi Ido , Fumiyoshi Okano , Yoshinori Narita
发明人： Takayoshi Ido , Fumiyoshi Okano , Yoshinori Narita
IPC分类号： A61K39/395 , A61P35/02 , A61P35/00
CPC分类号： A61K39/39558 , A61K2300/00
摘要： This invention relates to a medicament for treating and/or preventing a cancer, comprising a combination of an antibody against a cancer antigen CAPRIN-1 protein that is specifically expressed on the surface of the cancer cell, and an antitumor agent, wherein the antibody and the antitumor agent are combined together or separately, and to a use of the medicament.
摘要翻译： 本发明涉及用于治疗和/或预防癌症的药物，其包含抗癌细胞表面上特异性表达的癌抗原CAPRIN-1蛋白的抗体与抗肿瘤剂的组合，其中抗体和 将抗肿瘤药物组合在一起或分开，以及药物的用途。
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公开(公告)号：US09180187B2
公开(公告)日：2015-11-10
申请号：US13576950
申请日：2011-02-04
申请人： Takayoshi Ido , Fumiyoshi Okano , Yoshinori Narita
发明人： Takayoshi Ido , Fumiyoshi Okano , Yoshinori Narita
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , A61K2300/00
摘要： This invention relates to a medicament for treating and/or preventing a cancer, comprising a combination of an antibody against a cancer antigen CAPRIN-1 protein that is specifically expressed on the surface of the cancer cell, and an antitumor agent, wherein the antibody and the antitumor agent are combined together or separately, and to a use of the medicament.
摘要翻译： 本发明涉及用于治疗和/或预防癌症的药物，其包含抗癌细胞表面上特异性表达的癌抗原CAPRIN-1蛋白的抗体与抗肿瘤剂的组合，其中抗体和 将抗肿瘤药物组合在一起或分开，以及药物的用途。
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公开(公告)号：US20140179558A1
公开(公告)日：2014-06-26
申请号：US14236807
申请日：2012-08-03
申请人： Takayoshi Ido , Fumiyoshi Okano
发明人： Takayoshi Ido , Fumiyoshi Okano
IPC分类号： G01N33/574 , C07K16/18 , C12Q1/68 , C07K14/47
CPC分类号： C07K16/18 , C07K14/47 , C07K14/4738 , C07K16/30 , C07K16/303 , C07K2317/34 , C07K2317/56 , C12Q1/6886 , C12Q2600/158 , G01N33/57438 , G01N2333/705
摘要： This invention relates to a method for detecting pancreatic cancer using novel tumor markers. Specifically, the invention provides a method for detecting pancreatic cancer comprising measuring the presence or an amount of a polypeptide having an reactivity of binding via an antigen-antibody reaction to an antibody against CAPRIN-1 protein in a sample separated from a subject, and to a reagent or kit for detecting pancreatic cancer comprising a CAPRIN-1 protein or a fragment thereof, an antibody against the same, or a polynucleotide encoding the same.
摘要翻译： 本发明涉及使用新型肿瘤标志物检测胰腺癌的方法。 具体地，本发明提供了一种检测胰腺癌的方法，包括测量在与受试者分离的样品中具有通过抗原 - 抗体反应与抗CAPRIN-1蛋白的抗体的结合反应性的多肽的存在或量，以及 用于检测胰腺癌的试剂或试剂盒，其包含CAPRIN-1蛋白质或其片段，针对其的抗体或编码该蛋白质的多核苷酸。
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公开(公告)号：US20120177673A1
公开(公告)日：2012-07-12
申请号：US13391595
申请日：2010-09-02
申请人： Akira Kurihara , Fumiyoshi Okano
发明人： Akira Kurihara , Fumiyoshi Okano
CPC分类号： A61K39/0011 , A61K35/17 , A61K38/16 , C12N5/0636 , C12N5/0639 , C12Q1/6886 , C12Q2600/158
摘要： An immunity-inducing agent comprising as an effective ingredient(s) a polypeptide(s) selected from the polypeptides: (a) a polypeptide consisting essentially of not less than 7 consecutive amino acids in any one of the amino acid sequences shown in SEQ ID NOs:2, 4, 6, 8, 10, 12 and 44 in SEQUENCE LISTING; (b) a polypeptide having a sequence identity of not less than 90% with the polypeptide (a) and consisting essentially of not less than 7 amino acids; and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof; which polypeptide(s) has/have an immunity-inducing activity/activities, or as an effective ingredient(s) a recombinant vector(s) which comprise(s) a polynucleotide(s) encoding the polypeptide(s) and is/are capable of expressing the polypeptide(s) in vivo, is useful as a therapeutic and/or prophylactic agent for cancer, and/or the like.
摘要翻译： 一种免疫诱导剂，其包含选自以下多肽作为有效成分的多肽：（a）基本上由SEQ ID NO：1所示氨基酸序列中的任一个中不少于7个连续氨基酸组成的多肽 序号：2，4，6，8，10，12和44; （b）与多肽（a）具有不小于90％的序列同一性并且基本上由不少于7个氨基酸组成的多肽; 和（c）包含多肽（a）或（b）作为其部分序列的多肽; 哪些多肽具有/具有免疫诱导活性/活性，或作为有效成分的重组载体，其包含编码多肽的多核苷酸并且是/ 能够在体内表达多肽，可用作癌症的治疗和/或预防剂和/或类似物。
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公开(公告)号：US20110136121A1
公开(公告)日：2011-06-09
申请号：US13057515
申请日：2009-08-05
申请人： Fumiyoshi Okano , Kana Suzuki
发明人： Fumiyoshi Okano , Kana Suzuki
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/112 , G01N33/57407
摘要： The present invention relates to a method for detecting cancer, comprising measuring the expression of a polypeptide having a reactivity of binding to an antibody against a CAPRIN-1 protein having an amino acid sequence shown in any one of the even-numbered SEQ ID NOS: 2-30 in the Sequence Listing via an antigen-antibody reaction in a sample separated from a living organism, and, a reagent for detecting a cancer comprising the CAPRIN-1 protein or a fragment thereof, an antibody against the CAPRIN-1 protein or a fragment thereof, or a polynucleotide encoding the CAPRIN-1 protein or a fragment thereof.
摘要翻译： 本发明涉及一种检测癌症的方法，包括测定具有与抗体相对于抗体的抗体的反应性的多肽的表达，所述CAPRIN-1蛋白质具有偶数序列SEQ ID NO： 2-30在序列表中通过从活体分离的样品中的抗原 - 抗体反应，和用于检测包含CAPRIN-1蛋白或其片段的癌症的试剂，针对CAPRIN-1蛋白的抗体或 或其编码CAPRIN-1蛋白或其片段的多核苷酸。
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公开(公告)号：US07902143B2
公开(公告)日：2011-03-08
申请号：US11792400
申请日：2005-12-06
申请人： Fumiyoshi Okano
发明人： Fumiyoshi Okano
CPC分类号： C07K14/4748 , A61K38/1709
摘要： Novel peptides useful as a therapeutic and/or prophylactic agent of cancers, as well as medical uses thereof, are described. Each of these peptides have a consecutive amino acid sequence within a specific region of YKL-40 antigen expressing on the cell surface of brain tumor cells, that is, within the region aa10-19, aa49-61, aa74-83, aa96-117, aa152-161, aa177-185, aa202-211, aa246-261 or aa326-354, which peptide has an immunity-inducing activity. These peptides are useful for therapy and/or prevention of cancers when administered to a living body, and are useful for inducing T cells which exert cytotoxic activity against cancer cells when used to stimulate the T cells in vitro.
摘要翻译： 描述了可用作癌症的治疗和/或预防剂的新型肽及其医疗用途。 这些肽中的每一个在脑肿瘤细胞的细胞表面上表达的YKL-40抗原的特定区域内具有连续的氨基酸序列，即在aa10-19，aa49-61，aa74-83，aa96-117 ，aa152-161，aa177-185，aa202-211，aa246-261或aa326-354，该肽具有免疫诱导活性。 这些肽在施用于活体时可用于治疗和/或预防癌症，并且可用于诱导当用于在体外刺激T细胞时对癌细胞发挥细胞毒活性的T细胞。
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公开(公告)号：US20090214480A1
公开(公告)日：2009-08-27
申请号：US11792400
申请日：2005-12-06
申请人： Fumiyoshi Okano
发明人： Fumiyoshi Okano
CPC分类号： C07K14/4748 , A61K38/1709
摘要： Novel peptides useful as a therapeutic and/or prophylactic agent of cancers, as well as medical uses thereof, are described. Each of these peptides have a consecutive amino acid sequence within a specific region of YKL-40 antigen expressing on the cell surface of brain tumor cells, that is, within the region aa10-19, aa49-61, aa74-83, aa96-117, aa152-161, aa177-185, aa202-211, aa246-261 or aa326-354, which peptide has an immunity-inducing activity. These peptides are useful for therapy and/or prevention of cancers when administered to a living body, and are useful for inducing T cells which exert cytotoxic activity against cancer cells when used to stimulate the T cells in vitro.
摘要翻译： 描述了可用作癌症的治疗和/或预防剂的新型肽及其医疗用途。 这些肽中的每一个在脑肿瘤细胞的细胞表面上表达的YKL-40抗原的特定区域内具有连续的氨基酸序列，即在aa10-19，aa49-61，aa74-83，aa96-117 ，aa152-161，aa177-185，aa202-211，aa246-261或aa326-354，该肽具有免疫诱导活性。 这些肽在施用于活体时可用于治疗和/或预防癌症，并且可用于诱导当用于在体外刺激T细胞时对癌细胞发挥细胞毒活性的T细胞。
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