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49 条记录 (耗时 0.052 秒)

    TRANSFECTION DEVICE UTILIZING SERICIN
    44.
    发明申请
    TRANSFECTION DEVICE UTILIZING SERICIN 审中-公开
    转染装置利用丝氨酸

    公开(公告)号：US20110165664A1

    公开(公告)日：2011-07-07

    申请号：US12674836

    申请日：2008-08-22

    申请人： Yoshiji Fujita ,  Tomohiro Yoshikawa

    发明人： Yoshiji Fujita ,  Tomohiro Yoshikawa

    IPC分类号： C12M1/00

    CPC分类号： C12N15/87 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/32

    摘要： There is provided a transfection device having a mixture (1) immobilized on a solid-phase support (3), the mixture including: a gene sample; a gene delivery material; and at least one compound selected from the group consisting of sericin, a hydrolysate thereof and a chemically modified product of sericin or a hydrolysate thereof.

    摘要翻译： 提供了具有固定在固相载体（3）上的混合物（1）的转染装置，所述混合物包括：基因样品; 基因递送材料; 和至少一种选自丝胶蛋白，其水解产物和丝胶蛋白的化学修饰产物或其水解产物的化合物。

    COMPOUND PROFILING METHOD
    46.
    发明申请
    COMPOUND PROFILING METHOD 审中-公开
    化合物分析方法

    公开(公告)号：US20100210708A1

    公开(公告)日：2010-08-19

    申请号：US12595604

    申请日：2008-04-07

    申请人： Masato Miyake ,  Yoshiji Fujita

    发明人： Masato Miyake ,  Yoshiji Fujita

    IPC分类号： A61K31/7088 ,  C12Q1/02 ,  C12Q1/68 ,  C40B30/06

    CPC分类号： G01N33/5026 ,  C12Q1/6886 ,  C12Q2600/178 ,  G01N33/5011 ,  G16B5/00

    摘要： The present invention provides a method for deriving an upstream or downstream component of a component necessary for phenotypic alteration of a living organism, the method comprising the steps of: specifying a pathway of interest related to the phenotypic alteration and a reference pathway different from the pathway of interest, and specifying a stimulant of interest and a reference stimulant which respectively stimulate the pathway of interest and the reference pathway; giving the stimulant of interest to the living organism to identify a collection of components of interest necessary for the phenotypic alteration; giving the reference stimulant to the living organism to identify a collection of reference components necessary for the phenotypic alteration; calculating an intersection between the collections of the components of interest and the reference components; and calculating a differential collection by subtracting the intersection from the collection of components of interest.

    摘要翻译： 本发明提供了一种用于衍生生物体表型改变所必需的组分的上游或下游组分的方法，所述方法包括以下步骤：指定与所述表型改变相关的感兴趣途径和不同于所述途径的参考途径 并且指定分别刺激感兴趣途径和参考途径的兴趣兴奋剂和参考刺激物; 给予活体有兴趣的兴奋剂，以确定表型改变所必需的组成部分的集合; 给生物体提供参考刺激物，以确定表型改变所必需的参考组分的集合; 计算感兴趣组件的集合和参考组件之间的交集; 以及通过从所述关注部件的收集中减去所述交叉点来计算差分收集。

    Farnesylacetic acid ester derivatives
    48.
    发明授权
    Farnesylacetic acid ester derivatives 失效
    法呢基乙酸酯衍生物

    公开(公告)号：US4289786A

    公开(公告)日：1981-09-15

    申请号：US96570

    申请日：1979-11-21

    申请人： Susumu Okabe ,  Yoshiaki Omura ,  Yoichi Ninagawa ,  Yoshiji Fujita

    发明人： Susumu Okabe ,  Yoshiaki Omura ,  Yoichi Ninagawa ,  Yoshiji Fujita

    IPC分类号： A61K31/215 ,  A61K31/22 ,  A61K31/445 ,  A61P1/04 ,  C07C67/00 ,  C07C213/00 ,  C07C219/08 ,  C07C219/10 ,  C07D211/22 ,  C07D211/42 ,  C07D211/46 ,  C07D295/088 ,  A61K31/23 ,  C09F5/08

    CPC分类号： C07D295/088 ,  C07D211/22 ,  C07D211/42 ,  C07D211/46 ,  Y10S514/925

    摘要： Novel farnesylacetic acid ester derivatives containing an amine nitrogen in the alcohol residue thereof and represented by the following general formula exhibit high levels of antiulcerogenic activity and very low levels of toxicity: ##STR1## wherein A is an alkylene radical containing at least 2 carbon atoms; R.sup.1 is H, alkyl, cycloalkyl, aryl, aralkyl or alkenyl; R.sup.2 and R.sup.3 are independently H, alkyl, aryl, aralkyl or alkenyl or one of R.sup.2 and R.sup.3 forms, together with A, a piperidine, pyrrolidine, tetrahydropyrimidine or piperazine ring which contains the nitrogen atom lying therebetween or R.sup.2 and R.sup.3 combine to form, together with the adjacent nitrogen atom, a piperazine ring; provided that the total number of carbon atoms contained in A, R.sup.1, R.sup.2 and R.sup.3 is at least 5.

    摘要翻译： 在其醇残基中含有胺氮并由下列通式表示的新型法呢基乙酸酯衍生物具有高水平的抗致癌活性和非常低的毒性水平：其中A是含有至少2个碳原子的亚烷基; R1是H，烷基，环烷基，芳基，芳烷基或烯基; R2和R3独立地是H，烷基，芳基，芳烷基或烯基或R2和R3中的一个与A，哌啶，吡咯烷，四氢嘧啶或哌嗪环一起形成，其中氮原子位于其间或R2和R3结合形成， 与相邻的氮原子一起形成哌嗪环; 条件是A，R1，R2和R3中含有的碳原子总数至少为5。

    Allenic esters, process for preparation thereof and process for rearrangement thereof
    49.
    发明授权
    Allenic esters, process for preparation thereof and process for rearrangement thereof 失效
    烯酸酯，其制备方法及其重排方法

    公开(公告)号：US3978100A

    公开(公告)日：1976-08-31

    申请号：US461977

    申请日：1974-04-18

    申请人： Yoshiji Fujita ,  Yoshiaki Omura ,  Takashi Hishida ,  Kazuo Itoi

    发明人： Yoshiji Fujita ,  Yoshiaki Omura ,  Takashi Hishida ,  Kazuo Itoi

    IPC分类号： C07C69/587 ,  C11C3/02

    CPC分类号： C07C69/587 ,  C07C403/20 ,  C07C2101/16

    摘要： Allenic esters of the formula: ##EQU1## (specific examples of R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are given) and a process for the preparation thereof which comprises reacting propargyl alcohol derivatives with 2-substituted ortho-acetic acid esters in the presence of an acidic catalyst. These allenic esters are rearranged in the presence of an alkali catalyst to form .alpha., .beta., .gamma., .delta.-unsaturated carboxylic acid esters and are useful as intermediates in the synthesis of various perfumes, medicines, agricultural chemicals and the like.

    摘要翻译： 式R 2 R 1 R 4的酰亚胺酯R 3 -C = C = C-CH-COOR（R，R 1，R 2，R 3和R 4的具体实例）及其制备方法，其包括使炔丙醇衍生物 与2-取代的原乙酸酯在酸性催化剂存在下反应。 这些烯酸酯在碱催化剂存在下重排，形成α，β，γ，δ-不饱和羧酸酯，可用作合成各种香料，药物，农药等的中间体。