公开(公告)号：US20070196372A1

公开(公告)日：2007-08-23

申请号：US10568762

申请日：2004-08-17

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

IPC分类号： A61K39/395 ,  A61K48/00 ,  A61K38/55 ,  G01N33/53

CPC分类号： C12Q1/37

摘要： The invention provides a human KLK8 which is associated with the cardiovascular diseases, dermatological diseases, neurological diseases, metabolic diseases, cancer disorders, urological diseases, gastroenterological diseases and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, neurological diseases, metabolic diseases, cancer disorders, urological diseases, gastroenterological diseases and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK8 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，皮肤病，神经疾病，代谢疾病，癌症病症，泌尿科疾病，胃肠疾病和繁殖障碍有关的人类KLK8。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，神经疾病，代谢疾病，癌症疾病，泌尿科疾病，胃肠疾病和繁殖障碍的化合物的测定。 本发明还涉及结合和/或活化或抑制KLK8活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070099255A1

公开(公告)日：2007-05-03

申请号：US10575362

申请日：2004-10-12

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

IPC分类号： A61K48/00 ,  C12Q1/37 ,  A61K39/395 ,  A61K38/55

CPC分类号： G01N33/573 ,  C12Q1/37 ,  G01N33/574 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2500/00

摘要： The invention provides a human NAALADASE 2 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, neurologcial diseases, urological diseases, respiratory diseases and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, neurological diseases, urological diseases, respiratory diseases and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of NAALADASE 2 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，皮肤病，胃肠疾病，癌症，血液疾病，神经疾病，泌尿系疾病，呼吸系统疾病和生殖障碍有关的人NAALADASE2。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，胃肠疾病，癌症，血液疾病，神经疾病，泌尿科疾病，呼吸系统疾病和繁殖障碍的化合物的测定。 本发明还涉及结合和/或活化或抑制NAALADASE 2的活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070081997A1

公开(公告)日：2007-04-12

申请号：US10568763

申请日：2004-08-17

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/53 ,  A61K39/395

CPC分类号： C12Q1/37 ,  G01N2500/00

摘要： The invention provides a human KLK9 which is associated with the hematological diseases, cardiovascular diseases, neurological diseases, metabolic diseases, urological diseases, cancer disorders, inflammation disorders, dermatological diseases and gastroenterological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, neurological diseases, metabolic diseases, urological diseases, cancer disorders, inflammation disorders, dermatological diseases and gastroenterological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK9 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了一种与血液疾病，心血管疾病，神经系统疾病，代谢疾病，泌尿系统疾病，癌症疾病，炎症疾病，皮肤病学和胃肠疾病有关的人类KLK9。 本发明还提供了用于鉴定可用于治疗或预防血液疾病，心血管疾病，神经疾病，代谢疾病，泌尿系统疾病，癌症疾病，炎症疾病，皮肤病学和胃肠疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制KLK9活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070059694A1

公开(公告)日：2007-03-15

申请号：US10545629

申请日：2004-02-10

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

IPC分类号： C12Q1/68 ,  G01N33/567 ,  G01N33/53

CPC分类号： G01N33/88 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N2333/72

摘要： The invention provides a human prostaglandin E2 EP1 which is associated with the cardiovascular diseases, respiratory diseases, hematological diseases, urological diseases, gastrointestinal diseases, endocrinological diseases and metabolic diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, respiratory diseases, hematological diseases, urological diseases, gastrointestinal diseases, endocrinological diseases an and metabolic diseases. The invention also features compounds which hind to and/or activate or inhibit the activity of prostaglandin E2 EP1 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，呼吸系统疾病，血液病，泌尿科疾病，胃肠道疾病，内分泌疾病和代谢疾病有关的人前列腺素E2EP1。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，呼吸系统疾病，血液病，泌尿疾病，胃肠道疾病，内分泌疾病和代谢疾病的化合物的测定。 本发明还涉及后代和/或激活或抑制前列腺素E2EP1的活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070031938A1

公开(公告)日：2007-02-08

申请号：US10548420

申请日：2004-03-04

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

IPC分类号： C12P21/04 ,  C12Q1/68 ,  C12N15/11

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The present invention is directed to a polynucleotide sequence of a novel organic anion transporting (OAT)-like protein UST3-like1. More particularly, the present invention provides a polynucleotide sequence comprising the nucleic acid sequence SEQ ID NO: 1 or nucleic acid sequences that hybridize to SEQ ID NO: 1 or its complimentary strand. The invention also provides the human UST3-LIKE1 associated with the gastrointestinal and liver diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cardiovascular diseases as a result of relative quantification of the mRNA distribution in different human tissues by expression profiling. The invention also provides assays for the identification of compounds useful for the modulation of said diseases. The methods of the invention involve cell-free and cell-based assays that identify compounds which bind to and/or activate or inhibit the activity of UST3-LIKE1, a organic anion transporting (OAT)-like protein, followed by an in vivo assay of the effect of the compound on said diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of UST3-LIKE1 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明涉及新型有机阴离子转运（OAT）样蛋白质UST3样的多核苷酸序列。 更具体地，本发明提供了包含核酸序列SEQ ID NO：1或与SEQ ID NO：1或其互补链杂交的核酸序列的多核苷酸序列。 本发明还提供了与胃肠和肝脏疾病，代谢疾病，血液学疾病，呼吸系统疾病，神经系统疾病，泌尿系统疾病和心血管疾病相关的人类UST3-LIKE1，其是通过表达相对定量不同人体组织中的mRNA分布的结果 剖析。 本发明还提供用于鉴定可用于调节所述疾病的化合物的测定。 本发明的方法包括无细胞和基于细胞的测定，其鉴定结合和/或活化或抑制UST3-LIKE1（有机阴离子转运（OAT）样蛋白）的活性的化合物，然后进行体内测定 化合物对所述疾病的作用。 本发明还涉及结合和/或活化或抑制UST3-LIKE1的活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20060292155A1

公开(公告)日：2006-12-28

申请号：US10574786

申请日：2004-10-02

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

IPC分类号： A61K48/00 ,  A61K38/17 ,  C12Q1/68 ,  G01N33/574 ,  A61K39/395

CPC分类号： C12Q1/37 ,  G01N33/574 ,  G01N33/6893 ,  G01N33/6896

摘要： The invention provides a human MSP which is associated with the cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases, urological diseases and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases, urological diseases and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of MSP as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，血液疾病，呼吸系统疾病，神经系统疾病，泌尿系统疾病和繁殖障碍有关的人MSP。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，血液疾病，呼吸系统疾病，神经疾病，泌尿系疾病和繁殖障碍的化合物的测定。 本发明还涉及结合和/或活化或抑制MSP活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20060166911A1

公开(公告)日：2006-07-27

申请号：US10528460

申请日：2003-09-18

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

IPC分类号： A61K48/00 ,  G01N33/53 ,  A61K39/395

CPC分类号： G01N33/6896 ,  C12Q1/44 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N2500/00

摘要： The invention provides a human PDE11A which is associated with the disorders of the peripheral and central nervous system, cardiovascular diseases, cancer, liver disease and genito-urinary diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cardiovascular diseases, cancer, liver disease and genito-urinary diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PDE11A as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与外周和中枢神经系统疾病，心血管疾病，癌症，肝脏疾病和生殖泌尿疾病相关的人PDE11A。 本发明还提供了用于鉴定可用于治疗或预防外周和中枢神经系统疾病，心血管疾病，癌症，肝脏疾病和生殖泌尿疾病的化合物的化验。 本发明还涉及结合和/或活化或抑制PDE11A的活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20050043511A1

公开(公告)日：2005-02-24

申请号：US10495392

申请日：2002-11-15

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

IPC分类号： A61K31/7088 ,  A61K31/713 ,  A61K38/17 ,  A61K39/395 ,  A61K48/00 ,  C07K14/705 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C12Q1/68 ,  G01N33/68 ,  C07H21/04

CPC分类号： C07K14/705

摘要： Polynucleotide sequence for novel G-protein coupled receptor LUSTR2 and uses thereof. The present invention is directed to a polynucleotide sequence of a novel G-Protein Coupled Receptor LUSTR2. More particularly, the present invention provides a polynucleotide sequence comprising the nucleic acid sequence SEQ ID NO: 1 or nucleic acid sequences that hybridize to SEQ ID NO: 1 or its complimentary strand having at least 40% sequence identity. Preferably, the hybridizing nucleic acid sequence should hybridize under stringent conditions and in particular have 85% sequence identity, more preferably 90% sequence identity, and most preferably 95% sequence identity. The invention also provides the human LUSTR2 associated with the hemaotological, peripheral and central nervous system, COPD, asthma, genito-urological, metabolic diseases and pancreas and heart disorders as a result of relative quantification of the mRNA distribution in different human tissues by expression profiling. The invention also provides assays for the identification of compounds useful for the modulation of hematological, peripheral and central nervous system, COPD, asthma, genito-urological, metabolic diseases and pancreas and heart disorders for treating or preventing hematological, peripheral and central nervous system, COPD, asthma, genito-urological, metabolic diseases and pancreas and heart disorders associated with expression of the LUSTR2. The methods of the invention involve cell-free and cell-based assays that identify compounds which bind to and/or activate or inhibit the activity of LUSTR2, a G protein coupled receptor, followed by an in vivo assay of the effect of the compound on hematological, peripheral and central nervous system, COPD, asthma, genito-urological, metabolic diseases and pancreas and heart disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of LUSTR2 as well as pharmaceutical compositions comprising such compounds.

公开(公告)号：US20080286260A1

公开(公告)日：2008-11-20

申请号：US10594034

申请日：2005-03-11

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

IPC分类号： G01N33/68 ,  A61K31/7088 ,  A61K38/02 ,  C12Q1/68 ,  A61P9/00 ,  A61P7/00 ,  A61P25/00 ,  A61P11/00 ,  A61P13/00 ,  G01N33/50

CPC分类号： G01N33/6896 ,  G01N33/57407 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/06 ,  G01N2800/12 ,  G01N2800/22 ,  G01N2800/28 ,  G01N2800/32 ,  G01N2800/34

摘要： The invention provides a human PPARA which is associated with the cardiovascular diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PPARA as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，胃肠病，癌症，炎症，血液疾病，呼吸系统疾病，神经系统疾病和泌尿系疾病有关的人类PPARA。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，胃肠疾病，癌症，炎症，血液疾病，呼吸系统疾病，神经疾病和泌尿疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制PPARA活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20080050314A1

公开(公告)日：2008-02-28

申请号：US10590304

申请日：2005-02-12

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Bernhard Weingartner

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Bernhard Weingartner

IPC分类号： A61K48/00 ,  A61K31/7088 ,  A61K31/7105 ,  A61P17/00 ,  A61P29/00 ,  A61P5/00 ,  A61P9/00 ,  G01N33/00 ,  G01N33/68 ,  C12Q1/68 ,  A61P7/00 ,  A61P3/00 ,  A61P25/00 ,  A61P11/00 ,  A61K39/395

CPC分类号： G01N33/573 ,  G01N2333/9121

摘要： The invention provides a human GSK3B which is associated with cardiovascular diseases, cancer, metabolic diseases, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, metabolic diseases, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GSK3B as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，癌症，代谢疾病，血液疾病，炎症，呼吸系统疾病，神经系统疾病和泌尿系疾病有关的人类GSK3B。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，癌症，代谢疾病，血液疾病，炎症，呼吸系统疾病，神经疾病和泌尿疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制GSK3B活性的化合物以及包含这些化合物的药物组合物。