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    Acylglycerol Acyltransferase-Like Protein Mgat-X1 and Uses Thereof
    1.
    发明申请
    Acylglycerol Acyltransferase-Like Protein Mgat-X1 and Uses Thereof 失效
    酰基甘油酰基转移酶样蛋白Mgat-X1及其用途

    公开(公告)号：US20080311102A1

    公开(公告)日：2008-12-18

    申请号：US10573500

    申请日：2004-09-16

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Bernhard Weingartner ,  Andreas Geerts

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Bernhard Weingartner ,  Andreas Geerts

    IPC分类号： A61K38/43 ,  C12N15/11 ,  C12N9/10 ,  C12N15/00 ,  C12N5/06 ,  C12P21/04 ,  A61P43/00 ,  C12Q1/68 ,  C12Q1/02 ,  G01N33/53 ,  A61K31/7088

    CPC分类号： C07K16/40 ,  C12N9/1029

    摘要： The present invention is directed to a polynucleotide sequence of a novel acylglycerol acyltransferase-like protein MGAT-X1. The invention also provides the human MGAT-X1 associated with the dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases. The invention also provides assays for the identification of compounds useful for the modulation of dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases for treating of such diseases associated with expression of the MGAT-X1. The invention also features compounds which bind to and/or activate or inhibit the activity of MGAT-X1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明涉及新的酰基甘油酰基转移酶样蛋白MGAT-X1的多核苷酸序列。 本发明还提供了与皮肤病，泌尿疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经疾病，代谢疾病，心血管疾病或胃肠疾病有关的人MGAT-X1。 本发明还提供了用于鉴定可用于调节皮肤病，泌尿系统疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经疾病，代谢疾病，心血管疾病或用于治疗这些疾病的胃肠病学疾病的化合物的测定 与MGAT-X1的表达相关。 本发明还涉及结合和/或活化或抑制MGAT-X1的活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and therapeutics for diseases associated with neuropeptide ff receptor 1 (npff1)
    3.
    发明申请
    Diagnostics and therapeutics for diseases associated with neuropeptide ff receptor 1 (npff1) 审中-公开
    与神经肽ff受体1（npff1）相关疾病的诊断和治疗

    公开(公告)号：US20060014218A1

    公开(公告)日：2006-01-19

    申请号：US10508892

    申请日：2003-03-14

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Bernhard Weingartner

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Bernhard Weingartner

    IPC分类号： G01N33/53 ,  G01N33/567

    CPC分类号： G01N33/74 ,  G01N2333/726 ,  G01N2500/00

    摘要： The invention provides a human NPFF1 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD and asthma and genito-urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD and asthma and genito-urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of NPFF1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与血液疾病，心血管疾病，外周和中枢神经系统疾病，呼吸系统疾病如COPD和哮喘以及泌尿系统疾病有关的人NPFF1。 本发明还提供了用于鉴定可用于治疗或预防血液疾病，心血管疾病，外周和中枢神经系统疾病，呼吸系统疾病如COPD和哮喘以及泌尿系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制NPFF1的活性的化合物以及包含这些化合物的药物组合物。

    ACYLGLYCEROL ACYLTRANSFERASE-LIKE PROTEIN MGAT-X1 AND USES THEREOF
    5.
    发明申请
    ACYLGLYCEROL ACYLTRANSFERASE-LIKE PROTEIN MGAT-X1 AND USES THEREOF 审中-公开
    ACYLGLYCEROL ACYLTRANSFERASE-like蛋白MGAT-X1及其用途

    公开(公告)号：US20130089552A1

    公开(公告)日：2013-04-11

    申请号：US13693301

    申请日：2012-12-04

    申请人： Stefan Golz ,  Ulf Brüggemeier ,  Bernhard Weingartner ,  Andreas Geerts

    发明人： Stefan Golz ,  Ulf Brüggemeier ,  Bernhard Weingartner ,  Andreas Geerts

    IPC分类号： C07K16/40

    CPC分类号： C07K16/40 ,  C12N9/1029

    摘要： The present invention is directed to a polynucleotide sequence of a novel acylglycerol acyltransferase-like protein MGAT-X1. The invention also provides the human MGAT-X1 associated with the dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases. The invention also provides assays for the identification of compounds useful for the modulation of dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases for treating of such diseases associated with expression of the MGAT-X1. The invention also features compounds which bind to and/or activate or inhibit the activity of MGAT-X1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明涉及新的酰基甘油酰基转移酶样蛋白MGAT-X1的多核苷酸序列。 本发明还提供了与皮肤病，泌尿疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经疾病，代谢疾病，心血管疾病或胃肠疾病有关的人MGAT-X1。 本发明还提供了用于鉴定可用于调节皮肤病，泌尿系统疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经疾病，代谢疾病，心血管疾病或用于治疗这些疾病的胃肠病学疾病的化合物的测定 与MGAT-X1的表达相关。 本发明还涉及结合和/或活化或抑制MGAT-X1的活性的化合物以及包含这些化合物的药物组合物。

    Acylglycerol acyltransferase-like protein MGAT-X1 and uses thereof
    6.
    发明授权
    Acylglycerol acyltransferase-like protein MGAT-X1 and uses thereof 失效
    酰基甘油酰基转移酶样蛋白MGAT-X1及其用途

    公开(公告)号：US08343745B2

    公开(公告)日：2013-01-01

    申请号：US12854524

    申请日：2010-08-31

    申请人： Stefan Golz ,  Ulf Brüggemeier ,  Bernhard Weingartner ,  Andreas Geerts

    发明人： Stefan Golz ,  Ulf Brüggemeier ,  Bernhard Weingartner ,  Andreas Geerts

    IPC分类号： C12N9/10 ,  A61K38/00 ,  C07H21/04 ,  C07K1/00

    CPC分类号： C07K16/40 ,  C12N9/1029

    摘要： The present invention is directed to a polynucleotide sequence of a novel acylglycerol acyltransferase-like protein MGAT-X1. The invention also provides the human MGAT-X1 associated with the dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases. The invention also provides assays for the identification of compounds useful for the modulation of dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases for treating of such diseases associated with expression of the MGAT-X1. The invention also features compounds which bind to and/or activate or inhibit the activity of MGAT-X1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明涉及新的酰基甘油酰基转移酶样蛋白MGAT-X1的多核苷酸序列。 本发明还提供了与皮肤病，泌尿疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经疾病，代谢疾病，心血管疾病或胃肠疾病有关的人MGAT-X1。 本发明还提供了用于鉴定可用于调节皮肤病，泌尿系统疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经疾病，代谢疾病，心血管疾病或用于治疗这些疾病的胃肠病学疾病的化合物的测定 与MGAT-X1的表达相关。 本发明还涉及结合和/或活化或抑制MGAT-X1的活性的化合物以及包含这些化合物的药物组合物。

    Electrical connector
    8.
    发明授权
    Electrical connector 失效
    电连接器

    公开(公告)号：US4392699A

    公开(公告)日：1983-07-12

    申请号：US243660

    申请日：1981-03-13

    申请人： Bernhard Weingartner

    发明人： Bernhard Weingartner

    IPC分类号： H01R13/502 ,  H01R13/639 ,  H01R13/652

    CPC分类号： H01R13/502 ,  H01R12/724 ,  Y10S439/903

    摘要： An electrical connector assembly particularly adapted for attachment to the chassis of an appliance including a housing defining a generally longitudinal axis and an insertion piece having therein electrical contact elements for effecting desired electrical connection, the insertion piece being received within the housing from one end thereof. A flange on one end of the insertion piece engages the housing to act as a stop member when the insertion piece is placed within the housing and a slotted recess extending transversely to the longitudinal axis defined in the insertion piece a distance from the flange receives a locking lug pivotally mounted within the recess. A bore extending through the insertion piece into cooperative relationship with the locking lug enables a tool to be inserted therein to pivot the locking lug between a locking position to effect locking engagement between the insertion piece and the housing and a nonlocking position releasing this locking engagement. A shoulder defined on the interior of the housing and spaced from the one end thereof an interval corresponding to the distance between the slotted recess and the flange is engaged by the locking lug when it is in the locking position.

    摘要翻译： 一种电连接器组件，特别适于附接到器具的底座，其包括限定大致纵向轴线的壳体和具有用于实现期望的电连接的电接触元件的插入件，插入件从其一端接收在壳体内。 当插入件放置在壳体内时，插入件的一端上的凸缘接合壳体以用作止动构件，并且横向于限定在插入件中的纵向轴线延伸的开槽凹槽与凸缘接近一定距离 凸耳枢转地安装在凹槽内。 延伸穿过插入件的孔与锁定凸耳的协作关系使得工具能够插入其中以将锁定凸耳枢转在锁定位置之间，以实现插入件与壳体之间的锁定接合，以及释放该锁定接合的非锁定位置。 限定在壳体内部并且与其一端间隔开的肩部当其处于锁定位置时由锁定凸耳接合，该间隔对应于开槽凹部和凸缘之间的距离。

    Level and frequency measuring recorder
    9.
    发明授权
    Level and frequency measuring recorder 失效
    液位和频率测量记录仪

    公开(公告)号：US4228439A

    公开(公告)日：1980-10-14

    申请号：US938638

    申请日：1978-08-31

    申请人： Bernhard Weingartner

    发明人： Bernhard Weingartner

    IPC分类号： G01D3/02 ,  G01D9/38 ,  G01D15/10 ,  G01H3/00

    CPC分类号： G01D15/10 ,  G01D3/02 ,  G01D9/38 ,  G01H3/00

    摘要： An audio-frequency generator applies signals to a unit under test. The output of the tested unit is applied selectively through either an amplifier having a linear or a logarithmic characteristic to a push-pull output stage driving a rotary coil measuring instrument. The latter drives a recording stylus. An electronically controlled paper drive is coupled to the wiper arm of a potentiometer. The voltage picked up by the wiper arm is applied to the audio-frequency generator to control the frequency thereof.

    摘要翻译： 音频发生器将信号应用于被测单元。 所测试的单元的输出通过具有线性或对数特性的放大器选择性地施加到驱动旋转线圈测量仪的推挽输出级。 后者驱动录音笔。 电子控制纸驱动器连接到电位器的刮水器臂。 由刮水臂拾取的电压被施加到音频发生器以控制它的频率。

    Plug-in connection for electrical leads
    10.
    发明授权
    Plug-in connection for electrical leads 失效
    插头连接电线

    公开(公告)号：US5984703A

    公开(公告)日：1999-11-16

    申请号：US018201

    申请日：1998-02-03

    申请人： Bernhard Weingartner

    发明人： Bernhard Weingartner

    IPC分类号： H01R13/44 ,  H01R13/639 ,  H01R13/64 ,  H01R13/53

    CPC分类号： H01R13/6395 ,  H01R24/28 ,  H01R24/76 ,  H01R13/64 ,  H01R2103/00

    摘要： The electrical plug-in connector for electric leads comprises a cable plug and a chassis receptacle. The cable plug and chassis receptacle each have a housing with preferably flat contacts. The contacts of the cable plug are arranged at inner surfaces of legs of a U-shaped or frame-shaped part of the housing, which inner surfaces face one another. A wedge-shaped receiving space is cut out in the chassis receptacle for receiving this U-shaped or frame-shaped part. A nose-shaped projection is provided at one of the converging side surfaces of this receiving space, this nose-shaped projection projecting across from the other side surface. Contacts are arranged at the boundary surfaces of the latter which are disposed at right angles to the opposite side surface. The front side of this nose-shaped projection is arranged at a distance from the adjacent side surface.

    摘要翻译： 用于电引线的电插头连接器包括电缆插头和底座插座。 电缆插头和底座插座各自具有优选地具有平坦触头的壳体。 电缆插头的触点设置在壳体的U形或框状部分的腿的内表面处，该内表面彼此面对。 在底盘插座中切出楔形的接收空间，以容纳该U形或框状部分。 在该容纳空间的会聚侧表面之一处设置有鼻状突起，该鼻形突起从另一侧表面突出。 接触件布置在后者的边界表面处，其与相对的侧表面成直角设置。 该鼻形突起的前侧配置在与相邻侧面一定距离处。