公开(公告)号：US20070202567A1

公开(公告)日：2007-08-30

申请号：US10573584

申请日：2004-09-16

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

IPC分类号： C12P21/06

CPC分类号： G01N33/6893 ,  C12N9/48 ,  C12Q1/37 ,  G01N33/6896 ,  G01N2500/00

摘要： The invention provides a human RNPEP which is associated with the cardiovascular diseases, cancer, dermatological diseases, hematological diseases, neurological diseases, urological diseases, respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, dermatological diseases, hematological diseases, neurological diseases, urological diseases, respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of RNPEP as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，癌症，皮肤病，血液疾病，神经系统疾病，泌尿科疾病，呼吸系统疾病有关的人类RNPEP。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，癌症，皮肤病，血液疾病，神经疾病，泌尿科疾病，呼吸系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制RNPEP的活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070191296A1

公开(公告)日：2007-08-16

申请号：US10569438

申请日：2004-08-17

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/574 ,  A61K39/395

CPC分类号： G01N33/6872 ,  G01N2333/96455

摘要： The invention provides a human KLK13 which is associated with the hematological diseases, neurological diseases, metabolic diseases, endocrinological diseases, dermatological diseases, gastroenterological diseases, urological diseases, cancer disorders and inflammation. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, neurological diseases, metabolic diseases, endocrinological diseases, dermatological diseases, gastroenterological diseases, urological diseases, cancer disorders and inflammation. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK13 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与血液疾病，神经疾病，代谢疾病，内分泌疾病，皮肤病，肠胃病，泌尿科疾病，癌症病症和炎症有关的人类KLK13。 本发明还提供了用于鉴定可用于治疗或预防血液疾病，神经疾病，代谢疾病，内分泌疾病，皮肤病学，胃肠疾病，泌尿科疾病，癌症病症和炎症的化合物的测定。 本发明还涉及结合和/或活化或抑制KLK13活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070042423A1

公开(公告)日：2007-02-22

申请号：US10573583

申请日：2004-09-16

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

IPC分类号： G01N33/53 ,  G01N33/574

CPC分类号： G01N33/573 ,  G01N2333/948

摘要： The invention provides a human RNPEP-like which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of RNPEP-like as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，胃肠疾病，炎症，血液疾病，神经疾病和泌尿系疾病相关的人类RNPEP。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，胃肠疾病，炎症，血液疾病，神经疾病和泌尿疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制RNPEP样活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070196372A1

公开(公告)日：2007-08-23

申请号：US10568762

申请日：2004-08-17

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

IPC分类号： A61K39/395 ,  A61K48/00 ,  A61K38/55 ,  G01N33/53

CPC分类号： C12Q1/37

摘要： The invention provides a human KLK8 which is associated with the cardiovascular diseases, dermatological diseases, neurological diseases, metabolic diseases, cancer disorders, urological diseases, gastroenterological diseases and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, neurological diseases, metabolic diseases, cancer disorders, urological diseases, gastroenterological diseases and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK8 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，皮肤病，神经疾病，代谢疾病，癌症病症，泌尿科疾病，胃肠疾病和繁殖障碍有关的人类KLK8。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，神经疾病，代谢疾病，癌症疾病，泌尿科疾病，胃肠疾病和繁殖障碍的化合物的测定。 本发明还涉及结合和/或活化或抑制KLK8活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070099255A1

公开(公告)日：2007-05-03

申请号：US10575362

申请日：2004-10-12

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

IPC分类号： A61K48/00 ,  C12Q1/37 ,  A61K39/395 ,  A61K38/55

CPC分类号： G01N33/573 ,  C12Q1/37 ,  G01N33/574 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2500/00

摘要： The invention provides a human NAALADASE 2 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, neurologcial diseases, urological diseases, respiratory diseases and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, neurological diseases, urological diseases, respiratory diseases and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of NAALADASE 2 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，皮肤病，胃肠疾病，癌症，血液疾病，神经疾病，泌尿系疾病，呼吸系统疾病和生殖障碍有关的人NAALADASE2。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，胃肠疾病，癌症，血液疾病，神经疾病，泌尿科疾病，呼吸系统疾病和繁殖障碍的化合物的测定。 本发明还涉及结合和/或活化或抑制NAALADASE 2的活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070081997A1

公开(公告)日：2007-04-12

申请号：US10568763

申请日：2004-08-17

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/53 ,  A61K39/395

CPC分类号： C12Q1/37 ,  G01N2500/00

摘要： The invention provides a human KLK9 which is associated with the hematological diseases, cardiovascular diseases, neurological diseases, metabolic diseases, urological diseases, cancer disorders, inflammation disorders, dermatological diseases and gastroenterological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, neurological diseases, metabolic diseases, urological diseases, cancer disorders, inflammation disorders, dermatological diseases and gastroenterological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK9 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了一种与血液疾病，心血管疾病，神经系统疾病，代谢疾病，泌尿系统疾病，癌症疾病，炎症疾病，皮肤病学和胃肠疾病有关的人类KLK9。 本发明还提供了用于鉴定可用于治疗或预防血液疾病，心血管疾病，神经疾病，代谢疾病，泌尿系统疾病，癌症疾病，炎症疾病，皮肤病学和胃肠疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制KLK9活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070258974A1

公开(公告)日：2007-11-08

申请号：US10588104

申请日：2005-01-22

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Ralf Thiele

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Ralf Thiele

IPC分类号： A61K31/7052 ,  A61K31/7105 ,  A61K38/00 ,  A61K39/395 ,  A61P1/00 ,  A61P11/00 ,  A61P19/00 ,  A61P21/00 ,  A61P29/00 ,  A61P3/00 ,  A61P35/00 ,  A61P5/00 ,  A61P9/00 ,  C12Q1/37 ,  C12Q1/68 ,  G01N33/573

CPC分类号： C12Q1/37 ,  G01N33/573

摘要： The invention provides a human NPEPPS which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, muscle-skeleton diseases, neurological diseases, respiratory diseases, inflammation and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, muscle-skeleton diseases, neurological diseases, respiratory diseases, inflammation and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of NPEPPS as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，胃肠疾病，肌肉骨骼疾病，神经系统疾病，呼吸系统疾病，炎症和泌尿系疾病相关的人NPEPPS。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，胃肠疾病，肌肉骨骼疾病，神经系统疾病，呼吸系统疾病，炎症和泌尿疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制NPEPPS的活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20060160083A1

公开(公告)日：2006-07-20

申请号：US10531655

申请日：2003-10-15

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

IPC分类号： C12Q1/68 ,  G01N33/567 ,  G01N33/53

CPC分类号： G01N33/74 ,  G01N2333/726 ,  G01N2500/00

摘要： The invention provides a human GPR14 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, urological diseases, endocrinological diseases and cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, urological diseases, endocrinological diseases and cancer. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR14 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与血液疾病，心血管疾病，外周和中枢神经系统疾病，泌尿系统疾病，内分泌疾病和癌症有关的人GPR14。 本发明还提供了用于鉴定可用于治疗或预防血液疾病，心血管疾病，外周和中枢神经系统疾病，泌尿系统疾病，内分泌疾病和癌症的化合物的测定。 本发明还涉及结合和/或活化或抑制GPR14活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20060057143A1

公开(公告)日：2006-03-16

申请号：US10515604

申请日：2003-05-12

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/567 ,  A61K39/395

CPC分类号： A61K38/195 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/6863 ,  G01N2500/04

摘要： The invention provides a human CCR11 which is associated with the disorders of the peripheral and central nervous system, cardio-vascular diseases, genitourinary diseases, metabolic diseases and hematological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cardio-vascular diseases, genitourinary diseases, metabolic diseases and hematological diseases. he invention also features compounds which bind to and/or activate or inhibit the activity of CCR11 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与周围和中枢神经系统疾病，心血管疾病，泌尿生殖疾病，代谢疾病和血液疾病相关的人类CCR11。 本发明还提供了用于鉴定可用于治疗或预防外周和中枢神经系统疾病，心血管疾病，泌尿生殖疾病，代谢疾病和血液疾病的化合物的测定。 他的发明还具有结合和/或活化或抑制CCR11活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20050164305A1

公开(公告)日：2005-07-28

申请号：US10509715

申请日：2003-03-21

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

IPC分类号： G01N33/50 ,  A61K31/7088 ,  A61K31/7105 ,  A61K38/00 ,  A61K38/46 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P7/00 ,  A61P9/00 ,  A61P11/00 ,  A61P11/06 ,  A61P13/00 ,  A61P15/00 ,  A61P25/02 ,  A61P25/28 ,  A61P29/00 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/566 ,  G01N33/68 ,  G01N33/74 ,  G01N33/53 ,  A61K38/17 ,  G01N33/567

CPC分类号： G01N33/74 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/566 ,  G01N2333/726 ,  G01N2500/00

摘要： The invention provides a human FPRL1 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD, asthma, genito-urological disorders and inflammation diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD, asthma, genito-urological disorders and inflammation diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of FPRL1 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与血液疾病，心血管疾病，外周和中枢神经系统疾病，呼吸系统疾病如COPD，哮喘，泌尿系统疾病和炎症疾病有关的人FPRL1。 本发明还提供了用于鉴定可用于治疗或预防血液疾病，心血管疾病，外周和中枢神经系统疾病，呼吸系统疾病如COPD，哮喘，泌尿系统疾病和炎症疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制FPRL1活性的化合物以及包含这些化合物的药物组合物。