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公开(公告)号：US06726700B1
公开(公告)日：2004-04-27
申请号：US09643085
申请日：2000-08-21
申请人： Marc-Alan Levine
发明人： Marc-Alan Levine
IPC分类号： A61M2900
CPC分类号： A61M25/0147 , A61M25/10 , A61M2025/0177 , A61M2025/1052
摘要： This is in the general field of surgical instruments and is, specifically, a microballoon-tipped delivery catheter with a flexible, proximally-manipulated hinge or joint region. The catheter may have a shaft of varying flexibility which contains several lumen. The inner, or delivery, lumen generally may be used with a guide wire to access target sites within the body via the flexible, small diameter vessels of the body. The delivery lumen may be also used for placement of occlusive materials, e.g., in an aneurysm. Inflation of the micro-balloon, located near the distal tip of the catheter, is effected using the inflation lumen. The push/pull wire lumen contains a wire, which when manipulated, flexes the catheter's distal tip.
摘要翻译： 这是在外科器械的一般领域中，具体地说，是具有柔性的，近端操作的铰链或关节区域的微气囊输送导管。 该导管可具有包含若干内腔的具有不同柔性的轴。 内部或输送腔通常可以与导丝一起使用，以经由身体的柔性的小直径容器进入体内的目标部位。 输送腔也可以用于放置封闭材料，例如在动脉瘤中。 位于导管远端顶端的微气囊的充气利用充气腔进行。 推/拉线腔包含线，当被操纵时，其弯曲导管的远端。
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公开(公告)号：US6074407A
公开(公告)日：2000-06-13
申请号：US950002
申请日：1997-10-14
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12136 , A61B17/1214 , A61B2017/00557 , A61B90/39 , A61M2025/0079 , A61M2025/1052 , A61M2025/1063
摘要： This is a catheter device for delivering vaso-occlusive materials or devices to a desired site with the body. The catheter is a single lumen valved balloon catheter that enhances the accurate placement of the vaso-occlusive material or device. The balloon may be positioned such that it blocks the opening to a vascular malformation such as an aneurysm. In one embodiment, the balloon is automatically inflated as the vaso-occlusive material or device engages a constrictive feature near the distal end as the device is discharged. The catheter device may also have a lengthened distal section that may be placed within the malformation or aneurysm to improving the filling capability of the device. The catheter device may be constructed to have a number of advantageous radioopaque markers to aid in accurately discharging the vaso-occlusive material or device.
摘要翻译： 这是用于将血管闭塞材料或装置输送到身体所需位置的导管装置。 该导管是单腔管气囊导管，其可增强血管闭塞性材料或装置的精确放置。 气球可以被定位成使得其将开口阻塞到诸如动脉瘤的血管畸形。 在一个实施例中，当装置被排放时，气囊被自动膨胀，因为血管闭塞性材料或装置接近远端附近的收缩特征。 导管装置还可以具有延长的远端部分，其可以放置在畸形或动脉瘤内以改善装置的填充能力。 该导管装置可以被构造成具有许多有利的放射性标记，以帮助精确地排出血管闭塞性材料或装置。
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公开(公告)号：US09700215B2
公开(公告)日：2017-07-11
申请号：US14052721
申请日：2013-10-12
申请人： Marc-Alan Levine
发明人： Marc-Alan Levine
CPC分类号： A61B5/02007 , A61B5/14503 , A61B5/14539 , A61B5/14542 , A61B5/14551 , A61B5/6851 , A61B5/6852 , A61B8/0833 , A61B8/085 , A61B8/0891 , A61B8/12 , A61B8/445 , A61B8/4494 , A61B8/461 , A61B8/467 , A61B8/485 , A61B8/5223
摘要： A system and method for determining a pH level of blood in a vessel of a patient including a flexible elongated member configured and dimensioned for insertion in the vessel of the patient, a sensor positioned at the distal portion of the elongated member, and a connector connecting the elongated member to an indicator. The sensor measures the pH level of blood downstream of the blood clot. A system and method are also provided for determining a density of a blood clot in a vessel of a patient for subsequent selection of a treatment method. The system includes a sensor positioned at the distal portion of the elongated member, and a connector connecting the elongated member to an indicator, wherein the sensor determines the density of the blood clot and the indicator provides an indication of the density of the clot.
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公开(公告)号：US06547779B2
公开(公告)日：2003-04-15
申请号：US09328514
申请日：1999-06-09
申请人： Marc-Alan Levine , Eduardo U. Sucgang , Stephen J. Hebert , Estela D. Gatchalian , Quang Q. Tran , Victor C. Esch
发明人： Marc-Alan Levine , Eduardo U. Sucgang , Stephen J. Hebert , Estela D. Gatchalian , Quang Q. Tran , Victor C. Esch
IPC分类号： A61B1818
CPC分类号： A61B18/26 , A61B18/245 , A61B2017/00176 , A61B2018/2211
摘要： Methods and apparatus for creating fluid flow from one location to another are disclosed. The fluid flow is created via the absorption of repetitive pulses of radiation in a fluid to generate bubbles that expand and collapse repetitively. This fluid mechanism, or pumping phenomenon, can be used to aid removal of a total or partial occlusion in a body passage by disrupting a surface of the occlusion with acoustic shock and pressure waves and/or by causing mechanical disruption of the occlusive material. Appropriate selection of materials and particular constructions improve apparatus flexibility.
摘要翻译： 公开了从一个位置到另一个位置产生流体流动的方法和装置。 通过在流体中吸收重复的辐射脉冲来产生流体流动，以产生重复膨胀和折叠的气泡。 这种流体机制或泵送现象可以用于通过用声波冲击和压力波破坏闭塞表面和/或通过引起封闭材料的机械破坏来去除身体通道中的全部或部分闭塞。 适当选择材料和特定结构可提高设备的灵活性。
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公开(公告)号：US6139543A
公开(公告)日：2000-10-31
申请号：US120598
申请日：1998-07-22
申请人： Victor C. Esch , Quang Q. Tran , R. Rox Anderson , Stephen J. Hebert , Marc-Alan Levine , Eduardo U. Sucgang
发明人： Victor C. Esch , Quang Q. Tran , R. Rox Anderson , Stephen J. Hebert , Marc-Alan Levine , Eduardo U. Sucgang
CPC分类号： A61B18/26 , A61B18/245 , A61B2017/00176 , A61B2018/2211
摘要： The invention encompasses methods and apparatus for pumping fluid from one location to another through the repetitive expansion and collapse of bubbles generated as a result of the absorption of repetitive pulses of radiation in a fluid. This pumping phenomenon can be used to aid removal of a total or partial occlusion in a body passage by emulsifying the occlusion with acoustic shock and pressure waves or by mechanically disrupting the occlusive material.
摘要翻译： 本发明包括用于通过由于在流体中吸收重复的辐射脉冲而产生的气泡的重复膨胀和塌缩来将流体从一个位置泵送到另一个位置的方法和装置。 这种泵送现象可以用于通过用声波冲击和压力波来乳化闭塞或通过机械地破坏封闭材料来帮助去除身体通道中的全部或部分闭塞。
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公开(公告)号：US20120116429A1
公开(公告)日：2012-05-10
申请号：US13303339
申请日：2011-11-23
申请人： Marc-Alan Levine , Michael Leedle
发明人： Marc-Alan Levine , Michael Leedle
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B2017/00778 , A61B2017/22038 , A61B2017/22094 , A61B2017/320008 , A61B2017/320733 , A61B2017/320766 , A61M25/0097 , A61M2025/0681
摘要： A rotational thrombectomy wire for breaking up vascular thrombus or other obstructive material having a core having a proximal region and a distal region and being rotatable by a motor. The distal region has a smaller diameter than the proximal region. A cable is coupled to the distal region of the core and extends distally thereof. A torque tube is positioned over the cable and a coil is positioned over a distal portion of the cable. A distal portion of the cable has a non-linear configuration. A first covering material is positioned over the coil.
摘要翻译： 一种用于分解血管血栓或其它梗阻性材料的旋转血栓切除线，其具有具有近端区域和远侧区域并且可由马达旋转的芯。 远侧区域具有比近侧区域更小的直径。 电缆连接到芯的远侧区域并向远端延伸。 扭矩管位于电缆上方，线圈位于电缆的远端部分上方。 电缆的远端部分具有非线性配置。 第一覆盖材料位于线圈上方。
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公开(公告)号：US06322576B1
公开(公告)日：2001-11-27
申请号：US09018278
申请日：1998-02-04
申请人： Michael P. Wallace , Marc-Alan Levine , Delilah Yin Hui , Mary M. Chen , Liem Ho
发明人： Michael P. Wallace , Marc-Alan Levine , Delilah Yin Hui , Mary M. Chen , Liem Ho
IPC分类号： A61B1700
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/00526 , A61B2017/00862 , A61B2017/00867
摘要： This is an implantable vaso-occlusive device. The device has a complex, three-dimensional structure in a relaxed configuration that may be used in the approximate shape of an anatomical cavity. It may be deployed in the approximate shape of a sphere, an ovoid, a clover, a box-like structure or other distorted spherical shape. The loops forming the relaxed configuration may pass through the interior of the structure. The device is a self-forming shape made from a pre-formed linear vaso-occlusion member. Fibers may be introduced onto the device and affixed to the pre-formed linear member. The constituent member may be also be covered with a fibrous braid. The device is typically introduced through a catheter. The device is passed axially through the catheter sheath and assumes its form upon exiting the catheter without further action. The invention also includes methods of winding the anatomically shaped vaso-occlusive device into appropriately shaped forms and annealing them to form various devices.
摘要翻译： 这是一种植入式血管闭塞装置。 该装置具有可以以解剖腔的近似形状使用的松弛构造中的复杂的三维结构。 它可以以球体，卵球形，三叶草，盒状结构或其它变形球形的大致形状部署。 形成松弛构型的环可以穿过结构的内部。 该装置是由预先形成的线性血管闭塞构件制成的自形成形状。 纤维可以引入到装置上并固定到预成形的线性构件上。 构成部件也可以用纤维编织物覆盖。 该装置通常通过导管引入。 该装置轴向穿过导管护套，并且在离开导管时采取其形式，而无需进一步的动作。 本发明还包括将解剖形状的血管闭塞装置卷绕成适当形状的形状并将其退火以形成各种装置的方法。
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公开(公告)号：US06210400B1
公开(公告)日：2001-04-03
申请号：US09165435
申请日：1998-10-02
IPC分类号： A61B1818
CPC分类号： A61B18/26 , A61B18/245 , A61B2017/00176 , A61B2018/2211
摘要： Apparatus for pumping fluid from one location to another via generation of bubbles in fluid, and expansion and callapse thereof, are described. These apparatus deliver repetitive pulses of radiation to a fluid to form bubbles therein. The expansion and collapse of the bubbles cause fluid motion or pumping. This pumping can be used to facilitate removal of a total or partial occlusion in a body passage by a variety of mechanisms. The apparatus are flexible to facilitate use within a body passage.
摘要翻译： 描述了用于通过在流体中产生气泡将流体从一个位置泵送到另一个位置的装置，以及其膨胀和回收。 这些装置将重复的辐射脉冲输送到流体以在其中形成气泡。 气泡的膨胀和破裂会导致流体运动或泵送。 这种泵送可以用于通过各种机制促进身体通道中的全部或部分闭塞的去除。 该装置是灵活的，以便于在身体通道内使用。
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公开(公告)号：US09480464B2
公开(公告)日：2016-11-01
申请号：US13561722
申请日：2012-07-30
申请人： Jamie P. Levine , Alexes Hazen , Marc-Alan Levine
发明人： Jamie P. Levine , Alexes Hazen , Marc-Alan Levine
IPC分类号： A61B10/02
CPC分类号： A61B10/0283
摘要： The present invention relates to a tissue collection system. The system includes an outer housing, a first cylindrical fenestrated member within and immovable relative to the outer housing, a second cylindrical fenestrated member defining an inner tissue collection chamber and being positioned within and rotatable relative to the first cylindrical fenestrated member, a plunger axially movable within the second fenestrated member, an elongate rod being connected to the plunger, and one or more stop units attached to the outer housing. The present invention also relates to methods for separating components of a tissue sample using a system according to the present invention.
摘要翻译： 本发明涉及组织收集系统。 该系统包括外壳体，相对于外壳体内并且不可移动的第一圆柱形开窗构件，限定内组织收集室并定位在第一圆柱形开窗构件内并可相对于第一圆柱形开窗构件旋转的第二圆柱形开窗构件， 在第二开窗构件内的细长杆连接到柱塞，以及连接到外壳的一个或多个止挡单元。 本发明还涉及使用根据本发明的系统分离组织样品的组分的方法。
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公开(公告)号：US20140148831A1
公开(公告)日：2014-05-29
申请号：US14170577
申请日：2014-02-01
申请人： Marc-Alan Levine , Michael Leedle , John D. Leedle
发明人： Marc-Alan Levine , Michael Leedle , John D. Leedle
IPC分类号： A61B17/3207
CPC分类号： A61B17/320725 , A61B17/32002 , A61B17/320758 , A61B2017/00331 , A61B2017/320733 , A61B2017/320775
摘要： A rotational thrombectomy wire for breaking up vascular thrombus or other obstructive material having a core having a proximal portion and a distal portion. The distal portion has a smaller diameter than the proximal portion. A cable extends distally of the core. The cable has a first covering material positioned external thereof. A first coil is attached to a distal portion of the cable and has a diameter larger than a diameter of the cable and has a second covering material positioned thereover. The wire is rotatable by a motor.
摘要翻译： 一种用于分解血管血栓的旋转性血栓切除线或具有具有近端部分和远端部分的芯的其它阻塞物质。 远侧部分具有比近侧部分更小的直径。 电缆沿芯线向远侧延伸。 电缆具有位于其外部的第一覆盖材料。 第一线圈附接到电缆的远端部分并且具有大于电缆直径的直径，并且具有定位在其上的第二覆盖材料。 电线可通过电机旋转。
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