公开(公告)号：US20070191937A1

公开(公告)日：2007-08-16

申请号：US11784882

申请日：2007-04-09

Applicant: Syed Hossainy

Inventor： Syed Hossainy

IPC: A61F2/06

CPC classification number: A61F2/915 ,  A61F2/91 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2250/0001 ,  A61F2250/0068

Abstract: The invention is directed to an implantable device, such as a stent, for delivering a therapeutic substance. The device includes a reservoir containing a therapeutic substance and an energy converter to cause the release of the substance.

公开(公告)号：US20070123689A1

公开(公告)日：2007-05-31

申请号：US11643330

申请日：2006-12-20

Applicant: Syed Hossainy ,  Stephen Pacetti

Inventor： Syed Hossainy ,  Stephen Pacetti

IPC: C08G63/02

CPC classification number: A61L31/06 ,  A61L27/18 ,  C08G63/20 ,  C08G63/668 ,  C08G63/6854 ,  C08G63/6886 ,  C08L67/02 ,  C08L67/025 ,  C08L67/04 ,  C08L69/00 ,  C08L73/02 ,  C08L2666/20 ,  C08L2666/18

Abstract: This disclosure covers polymers, some of which are useful in medical device applications. Some of these medical devices are implantable within a mammalian body, such as in a body lumen. The copolymers comprise at least one alcoholic moiety derived from a diol, triol, or polyol. Additionally, the copolymers comprise an acidic moiety, derived from a polycarboxylic acid, and a biobeneficial moiety. Some of these copolymers are biodegradable or bioerodable. Medical devices comprising these polymers and methods of making these polymers are within the scope of this disclosure.

公开(公告)号：US20070116856A1

公开(公告)日：2007-05-24

申请号：US11641236

申请日：2006-12-18

Applicant: Syed Hossainy ,  Orlando Padilla ,  Daryush Mirzaee

Inventor： Syed Hossainy ,  Orlando Padilla ,  Daryush Mirzaee

IPC: A61L33/00

CPC classification number: A61F2/915 ,  A61F2/91 ,  A61F2002/075 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0013 ,  A61F2230/0076 ,  A61F2250/0018 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  Y10S623/916

Abstract: A composite stent and a method for making the same are provided.

公开(公告)号：US20070055364A1

公开(公告)日：2007-03-08

申请号：US11210344

申请日：2005-08-23

Applicant: Syed Hossainy ,  David Gale ,  Florian Ludwig

Inventor： Syed Hossainy ,  David Gale ,  Florian Ludwig

IPC: A61F2/06

CPC classification number: A61F2/82 ,  A61F2/91 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/604 ,  A61L2300/622

Abstract: Implantable medical devices for treating bodily disorders local and distally to a region of implantation are disclosed.

Abstract translation: 公开了用于治疗局部和远端到植入区域的身体障碍的可植入医疗装置。

公开(公告)号：US20070032853A1

公开(公告)日：2007-02-08

申请号：US10108004

申请日：2002-03-27

Applicant: Syed Hossainy ,  Gordon Stewart ,  Mark Williams ,  Jeff Royal ,  Paul Consigny ,  Dorie Happ ,  Kurt Scheinpflug ,  Ty Hu

Inventor： Syed Hossainy ,  Gordon Stewart ,  Mark Williams ,  Jeff Royal ,  Paul Consigny ,  Dorie Happ ,  Kurt Scheinpflug ,  Ty Hu

IPC: A61F2/06

CPC classification number: A61F2/844 ,  A61F2250/0067 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606

Abstract: A method and coating for reducing the release rate of an active agent from an implantable device, such as a stent, is disclosed.

公开(公告)号：US20070032634A1

公开(公告)日：2007-02-08

申请号：US11195974

申请日：2005-08-02

Applicant: David Gale ,  Syed Hossainy ,  Bin Huang ,  Klaus Kleine

Inventor： David Gale ,  Syed Hossainy ,  Bin Huang ,  Klaus Kleine

IPC: C08F6/00

CPC classification number: C08J3/005 ,  A61L31/06 ,  A61L31/148 ,  C08J2367/04 ,  C08L67/04 ,  C08L2666/02

Abstract: This invention relates to a method of extending the shelf-life of constructs, in particular bioabsorbable stents, comprising semi-crystalline polymers by increasing the crystallinity of the polymers.

公开(公告)号：US20060280770A1

公开(公告)日：2006-12-14

申请号：US11506656

申请日：2006-08-17

Applicant: Syed Hossainy ,  Stephen Pacetti ,  Keith Fong ,  Vinayak Bhat ,  Deborra Sanders Millare ,  Judy Guruwaiya ,  Daryush Mirzaee ,  Evgenia Mandrusov

Inventor： Syed Hossainy ,  Stephen Pacetti ,  Keith Fong ,  Vinayak Bhat ,  Deborra Sanders Millare ,  Judy Guruwaiya ,  Daryush Mirzaee ,  Evgenia Mandrusov

IPC: A61K9/22

CPC classification number: A61L27/34 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L33/0011 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/02 ,  A61L2420/08 ,  C08L29/04

Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.

Abstract translation: 提供用于可植入装置或腔内假体（例如支架）的涂层，包括形成涂层的方法。 涂层可用于递送活性成分或活性成分的组合。

公开(公告)号：US20060182782A1

公开(公告)日：2006-08-17

申请号：US11402392

申请日：2006-04-11

Applicant: Stephen Pacetti ,  Syed Hossainy

Inventor： Stephen Pacetti ,  Syed Hossainy

IPC: A61F2/00

CPC classification number: A61L31/10 ,  Y10T428/31504 ,  Y10T428/31786 ,  C08L67/04

Abstract: A polymer coating for medical devices based on polyorthoesters and methods for fabricating the coating are disclosed.

公开(公告)号：US20060142541A1

公开(公告)日：2006-06-29

申请号：US11023837

申请日：2004-12-27

Applicant: Syed Hossainy

Inventor： Syed Hossainy

IPC: C08G63/08

CPC classification number: C08G69/44 ,  A61K47/593 ,  A61K47/595 ,  A61K47/64 ,  A61L27/34 ,  A61L31/10 ,  C08L77/12

Abstract: Provided herein is a copolymer that includes a soft block (A) that contains poly(ester amide) (PEA) and a hard block (B). The copolymer can be any of AB, ABA or BAB type block copolymers. By varying the relative amount of the PEA block and the hard block, one can obtain a copolymer with a Tg for mechanical integrity in drug-delivery stent applications. The copolymer can be used alone or optionally in combination with a biobeneficial material and/or a biocompatible polymer to form an implantable device or a coating on an implantable device. When the copolymer is used in combination with a biobeneficial material, the copolymer and the biobeneficial material can be co-deposited or applied in sequence during the coating process. A coating formed of the copolymer may also include a bioactive agent. The implantable device can be implanted in a patient to treat, prevent, or ameliorate a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, and/or tumor obstruction.

Abstract translation: 本文提供了包含含有聚（酯酰胺）（PEA）和硬嵌段（B）的软嵌段（A）的共聚物。 共聚物可以是AB，ABA或BAB型嵌段共聚物中的任一种。 通过改变PEA嵌段和硬嵌段的相对量，可以获得在药物递送支架应用中机械完整性的具有Tα的共聚物。 共聚物可以单独使用或任选地与生物有益材料和/或生物相容性聚合物组合使用以在可植入装置上形成可植入装置或涂层。 当共聚物与生物有益材料组合使用时，共聚物和生物有益材料可以在涂覆过程中按顺序共沉积或应用。 由共聚物形成的涂层也可以包括生物活性剂。 可植入装置可以植入患者体内以治疗，预防或改善诸如动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉吻合增殖等障碍 人工移植物，胆管阻塞，输尿管梗阻和/或肿瘤阻塞。

公开(公告)号：US20060121089A1

公开(公告)日：2006-06-08

申请号：US11338058

申请日：2006-01-23

Applicant: Eugene Michal ,  Syed Hossainy ,  Ashok Shah

Inventor： Eugene Michal ,  Syed Hossainy ,  Ashok Shah

IPC: A61K31/56 ,  A61K31/4745 ,  A61K31/337 ,  C08F120/02 ,  C08F120/62 ,  A61F2/00

CPC classification number: A61L31/10 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/56 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/43 ,  A61L2300/606 ,  C08F8/00 ,  C08F8/30 ,  C08F8/32 ,  C08F2800/10 ,  C08F2810/50 ,  C08G18/6212 ,  C08G18/711 ,  C09D151/003 ,  C09D151/06 ,  C09D151/08 ,  C09D175/04 ,  C08L2666/02 ,  C08L2666/04 ,  C08L2666/14 ,  C08F216/06 ,  C08F8/34 ,  C08F210/02 ,  C08F8/14

Abstract: The present application teaches a coating having a biologically compatible compound conjugated to, or blended with, a polymer, wherein the polymer includes at least one olefin-derived unit and at least one unit derived from a vinyl alcohol, an allyl alcohol, or derivatives thereof.