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    Fluorescent probe
    41.
    发明申请
    Fluorescent probe 有权
    荧光探针

    公开(公告)号：US20060030054A1

    公开(公告)日：2006-02-09

    申请号：US10519682

    申请日：2003-07-07

    申请人： Tetsuo Nagano ,  Yasuteru Urano ,  Suguru Kenmoku ,  Kohjiro Kanda

    发明人： Tetsuo Nagano ,  Yasuteru Urano ,  Suguru Kenmoku ,  Kohjiro Kanda

    IPC分类号： G01N21/75

    CPC分类号： G01N27/44726 ,  C07D311/82 ,  C09B11/06 ,  C09B11/245 ,  G01N31/22

    摘要： A fluorescent probe which is represented by the following formula (I): (wherein, R1 and R2 represent hydrogen atom, or a substituent for trapping proton, a metal ion, or an active oxygen species, or the like; R3 represents a monovalent substituent; R4 and R5 represent hydrogen atom or a halogen atom; R6 represents hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group, provided that a combination of R1, R2, and R3 provides (1) substantially high electron density of the benzene ring to which said groups bind, so that the compound represented by the formula (I) is substantially no fluorescent before the trapping of proton, or the like, and (2) substantially reduced electron density of the benzene ring to which said groups bind, so that a compound after the trapping, which is derived from the compound represented by the formula (I) is substantially highly fluorescent after the trapping of proton or the like). A fluorescent probe having an excellent fluorescence property is provided.

    摘要翻译： 由下式（I）表示的荧光探针：（其中，R 1和R 2表示氢原子或用于捕获质子的取代基，金属离子 ，或活性氧类等; R 3表示一价取代基; R 4和R 5表示氢原子或卤素 原子; R 6表示氢原子，烷基羰基或烷基羰氧基甲基，条件是R 1，R 2和R 2的组合和 R 3提供（1）所述基团结合的苯环的基本上高的电子密度，使得由式（I）表示的化合物在质子捕获之前基本上不发荧光，或 和（2）所述基团结合的苯环的电子密度大大降低，从而得到由式（I）表示的化合物衍生的捕获后的化合物在其后基本上高度荧光 质子等的捕获）。 提供具有优异荧光性能的荧光探针。

    Diaminofluorescein derivatives
    43.
    发明授权
    Diaminofluorescein derivatives 有权

    公开(公告)号：US07618997B2

    公开(公告)日：2009-11-17

    申请号：US11429447

    申请日：2006-05-08

    申请人： Tetsuo Nagano ,  Hirotatsu Kojima

    发明人： Tetsuo Nagano ,  Hirotatsu Kojima

    IPC分类号： A61K31/352

    CPC分类号： C07D493/10 ,  Y10T436/177692

    摘要： A compound represented by the following formula (I): wherein R1 and R2 represent amino groups that substitute at adjacent positions on the phenyl ring, provided that either of R1 and R2 represents a mono(C1-6 alkyl)-substituted amino group and the other represents an unsubstituted amino group; and R3 and R4 independently represent hydrogen atom or an acyl group, and an agent for measurement of nitrogen monoxide which comprises said compound.

    Fluorescent probe for zinc
    44.
    发明申请
    Fluorescent probe for zinc 有权
    锌荧光探针

    公开(公告)号：US20050064308A1

    公开(公告)日：2005-03-24

    申请号：US10994380

    申请日：2004-11-23

    申请人： Tetsuo Nagano ,  Kazuya Kikuchi ,  Tomoya Hirano

    发明人： Tetsuo Nagano ,  Kazuya Kikuchi ,  Tomoya Hirano

    IPC分类号： C07D311/82 ,  C07D493/10 ,  C09B11/24 ,  C09B11/28 ,  G03C5/00

    CPC分类号： C07D493/10 ,  C07D311/82 ,  C09B11/24 ,  C09B11/245 ,  C09B11/28 ,  Y02P20/55

    摘要： A compound represented by general formula (IA) or a salt thereof useful as a fluorescent probe for zinc: wherein R1 and R2 represent a hydrogen atom or a group represented by formula (A), wherein X1, X2, X3, and X4 represent a hydrogen atom, an alkyl group, a 2-pyridylmethyl group, or a protective group for an-amino group, and m and n represent 0 or 1, provided that R1 and R2 do not simultaneously represent hydrogen atoms; R3 and R4 represent a hydrogen atom or a halogen atom; and R5 and R6 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group, and R7 represents a hydrogen atom or an alkyl group.

    摘要翻译： 用作锌荧光探针的通式（IA）表示的化合物或其盐：其中R 1和R 2表示氢原子或由式（A）表示的基团，其中X 1， X 2，X 3和X 4表示氢原子，烷基，2-吡啶基甲基或氨基的保护基，m和n表示0或1， 条件是R 1和R 2不同时代表氢原子; R 3和R 4代表氢原子或卤素原子; R 5和R 6表示氢原子，烷基羰基或烷基羰氧基甲基，R 7表示氢原子或烷基。

    Ip3 receptor ligands
    45.
    发明授权
    Ip3 receptor ligands 失效
    Ip3受体配体

    公开(公告)号：US06656927B1

    公开(公告)日：2003-12-02

    申请号：US09926664

    申请日：2001-11-30

    申请人： Tetsuo Nagano ,  Kazuya Kikuchi ,  Takanari Inoue ,  Masamitsu Iino ,  Kenzo Hirose

    发明人： Tetsuo Nagano ,  Kazuya Kikuchi ,  Takanari Inoue ,  Masamitsu Iino ,  Kenzo Hirose

    IPC分类号： A61K3800

    CPC分类号： C07F9/6561 ,  C07F9/117 ,  C07F9/65522

    摘要： A compound represented by the general formula (I) or a salt thereof, wherein R represents a group represented by the following formula (A), (B) or (C) wherein R1 and R2 independently represent a C1-6 alkyl group, R3 represents an amino group, a mono(C1-6 alkyl)amino group, a di(C1-6 alkyl)amino group or a C1-6 alkoxy group and X-represents an anion, and n represents an integer of 2 to 5. The compound or a salt is useful as a ligand of inositol-1,4,5-trisphosphate (IP3) receptor.

    摘要翻译： 由通式（I）表示的化合物或其盐，其中R表示由下式（A），（B）或（C）表示的基团，其中R 1和R 2独立地表示C1 -6烷基，R 3表示氨基，单（C 1-6烷基）氨基，二（C 1-6烷基）氨基或C 1-6烷氧基，X代表阴离子，和 n表示2〜5的整数。化合物或其盐可用作肌醇-1,4,5-三磷酸（IP3）受体的配体。

    Diaminofluorescein derivatives
    46.
    发明授权
    Diaminofluorescein derivatives 有权
    二氨基荧光素衍生物

    公开(公告)号：US06569892B2

    公开(公告)日：2003-05-27

    申请号：US10140059

    申请日：2002-05-08

    申请人： Tetsuo Nagano ,  Hirotatsu Kojima

    发明人： Tetsuo Nagano ,  Hirotatsu Kojima

    IPC分类号： A61K31353

    CPC分类号： C07D493/10 ,  Y10T436/177692

    摘要： A compound represented by the following formula: wherein R1 and R2 represent amino groups that substitute at adjacent positions on the phenyl ring, provided that either of R1 and R2 represents a mono(C1-6 alkyl)-substituted amino group and the other represents an unsubstituted amino group, and wherein R3 represents hydrogen atom or an alkyl group and R4 represents hydrogen atom or an acyl group, and an agent for measurement of nitrogen monoxide which comprises said compound.

    摘要翻译： 由下式表示的化合物：其中R 1和R 2表示在苯环的相邻位置取代的氨基，条件是R 1和R 2中的任一个表示单（C 1-6烷基）取代的氨基，另一个表示 未取代的氨基，其中R3表示氢原子或烷基，R4表示氢原子或酰基，以及含有所述化合物的一氧化氮测定剂。

    Fluorescent probe for zinc
    48.
    发明授权
    Fluorescent probe for zinc 失效
    锌荧光探针

    公开(公告)号：US07696245B2

    公开(公告)日：2010-04-13

    申请号：US10767334

    申请日：2004-01-30

    申请人： Kensuke Komatsu ,  Tomoya Hirano ,  Kazuya Kikuchi ,  Tetsuo Nagano

    发明人： Kensuke Komatsu ,  Tomoya Hirano ,  Kazuya Kikuchi ,  Tetsuo Nagano

    IPC分类号： A61K31/353 ,  C07D311/80

    CPC分类号： C07D405/12 ,  C07D405/14 ,  C07D493/10 ,  G01N33/582 ,  G01N33/84

    摘要： A compound represented by the following general formula (IA) or (IB) or a salt thereof which specifically traps a zinc ion and emits fluorescence, and is useful as a fluorescent probe for zinc: wherein R1 and R2 represent a hydrogen atom or a group represented by the following formula (A): wherein X1 to X4 represent a hydrogen atom, a 2-pyridylmethyl group, a 2-pyridylethyl group, a 2-methyl-6-pyridylmethyl group, or a 2-methyl-6-pyridylethyl group, provided that at least one is the group except a 2-pyridylmethyl group, and m and n represent 0 or 1, provided that they are not simultaneously 0; provided that R1 and R2 are not simultaneously hydrogen atoms; R3 and R4 represent a hydrogen atom or a halogen atom; R5 and R6 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group; and R7 represents a hydrogen atom or an alkyl group.

    摘要翻译： 由以下通式（IA）或（IB）表示的化合物或其盐特异性捕获锌离子并发射荧光，并且可用作锌的荧光探针：其中R1和R2表示氢原子或基团 由下式（A）表示：其中X 1至X 4表示氢原子，2-吡啶基甲基，2-吡啶基乙基，2-甲基-6-吡啶基甲基或2-甲基-6-吡啶基乙基 条件是至少一个是除2-吡啶基甲基以外的基团，m和n表示0或1，条件是它们不同时为0; 条件是R1和R2不同时为氢原子; R3和R4表示氢原子或卤素原子; R5和R6表示氢原子，烷基羰基或烷基羰氧基甲基; 并且R 7表示氢原子或烷基。

    Method for measurement by using long-lived excitation fluorescence
    49.
    发明申请
    Method for measurement by using long-lived excitation fluorescence 审中-公开
    使用长寿命激发荧光测定方法

    公开(公告)号：US20060252099A1

    公开(公告)日：2006-11-09

    申请号：US11486035

    申请日：2006-07-14

    申请人： Tetsuo Nagano ,  Kazuya Kikuchi ,  Mitsunori Koresawa ,  Hirotatsu Kojima

    发明人： Tetsuo Nagano ,  Kazuya Kikuchi ,  Mitsunori Koresawa ,  Hirotatsu Kojima

    IPC分类号： C07F5/00 ,  G01N33/53

    CPC分类号： G01N33/542 ,  G01N21/6428 ,  G01N2021/6441

    摘要： A method for measurement of a target substance in a sample by means of fluorescence, which comprises the step of carrying out the measurement in the presence of (1) a specific fluorescent probe which specifically reacts with the target substance to generate fluorescence, and (2) a donor which, per se, has long-lived fluorescence and is capable of inducing fluorescence resonance energy transfer to the specific fluorescent probe that acts as an acceptor, provided that the donor forms no binding to the specific fluorescent probe by means of a chemical bond; and the step of converting fluorescence, wherein said fluorescence is resulted from a reaction between the acceptor and the target substance, into long-lived excitation fluorescence by the fluorescence resonance energy transfer which is induced on the acceptor.

    摘要翻译： 一种通过荧光测定样品中的目标物质的方法，包括在（1）特异性荧光探针存在下进行测定的步骤的步骤，所述荧光探针与目标物质特异性反应以产生荧光，和（2 ）供体本身具有长寿命的荧光，并且能够诱导荧光共振能量转移到用作受体的特定荧光探针，条件是供体通过化学物质不与特定荧光探针结合 键; 以及通过在受体上诱导的荧光共振能量转移，将受体和目标物质之间的反应产生的荧光转化为长寿命激发荧光的步骤。

    Fluorescent probe for the quantitation of zinc
    50.
    发明授权
    Fluorescent probe for the quantitation of zinc 有权
    用于定量锌的荧光探针

    公开(公告)号：US06903226B2

    公开(公告)日：2005-06-07

    申请号：US10203658

    申请日：2001-02-28

    申请人： Tetsuo Nagano ,  Kazuya Kikuchi ,  Tomoya Hirano

    发明人： Tetsuo Nagano ,  Kazuya Kikuchi ,  Tomoya Hirano

    IPC分类号： C07D311/82 ,  C07D493/10 ,  C09B11/24 ,  C09B11/28 ,  C07D311/78

    CPC分类号： C07D493/10 ,  C07D311/82 ,  C09B11/24 ,  C09B11/245 ,  C09B11/28 ,  Y02P20/55

    摘要： A compound represented by general formula (IA) or a salt thereof useful as a fluorescent probe for zinc: wherein R1 and R2 represent a hydrogen atom or a group represented by formula (A), wherein X1, X2, X3, and X4 represent a hydrogen atom, an alkyl group, a 2-pyridylmethyl group, or a protective group for an amino group, and m and n represent 0 or 1 provided that R1 and R2 do not simultaneously represent hydrogen atoms; R3 and R4 represent a hydrogen atom or a halogen atom; and R5 and R6 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group, and R7 represents a hydrogen atom or an alkyl group.

    摘要翻译： 用作锌荧光探针的通式（IA）表示的化合物或其盐：其中R 1和R 2表示氢原子或由 式（A）其中X 1，X 2，X 3和X 4表示氢原子 ，烷基，2-吡啶基甲基或氨基的保护基，m和n表示0或1，条件是R 1和R 2都是 不同时代表氢原子; R 3和R 4代表氢原子或卤素原子; R 5和R 6表示氢原子，烷基羰基或烷基羰氧基甲基，R 7表示氢原子或 烷基。