公开(公告)号：US20100247438A1

公开(公告)日：2010-09-30

申请号：US12731499

申请日：2010-03-25

申请人： Arne Hengerer ,  Andreas Kappel ,  Luis Lasalvia ,  Andrea Lichte ,  Thomas Mertelmeier ,  Sven Meyburg ,  Christoph Petry ,  Marcus Pfister ,  Martin Requardt

发明人： Arne Hengerer ,  Andreas Kappel ,  Luis Lasalvia ,  Andrea Lichte ,  Thomas Mertelmeier ,  Sven Meyburg ,  Christoph Petry ,  Marcus Pfister ,  Martin Requardt

IPC分类号： A61K49/00 ,  G01N33/53 ,  G01N33/573 ,  G01N33/48 ,  A61B1/00

CPC分类号： G01N33/57488 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57473 ,  G01N2333/585 ,  G01N2333/70503 ,  G01N2333/96486

摘要： An in vitro method is for diagnosing a tumor disease in a patient. In at least one embodiment, the method includes: (i) determining an IVD marker or an IVD marker panel in at least one biological sample of a patient, wherein the IVD marker has a high sensitivity to the tumor disease, (ii) determining the proportion of patients tested positive due to an adapted reference range of the IVD marker/IVD marker panel, wherein the reference range was adapted such that the number of individuals with false negative tests, the number of individuals with false positive tests and the number of individuals ultimately needing to be subjected to imaging diagnostics to clarify false negative and false positive results are balanced in respect of one another such that tumor screening can be carried out, possibly: (iii) deciding to carry out an imaging method specific to the respective tumor disease for clarifying possible false negative and/or false positive IVD results, or (iv) repeating stages (i) and (ii) after a defined time interval, or (v) carrying out an imaging method for imaging the tumor.

摘要翻译： 体外方法是用于诊断患者的肿瘤疾病。 在至少一个实施方案中，该方法包括：（i）确定患者的至少一个生物样品中的IVD标记或IVD标记物组，其中IVD标记对肿瘤疾病具有高度敏感性，（ii）确定 由于IVD标记/ IVD标记物组的适应参考范围，患者的比例为阳性，其中参考范围被改编为使得具有假阴性测试的个体数量，具有假阳性测试的个体数量和个体数量 最终需要进行成像诊断以澄清假阴性和假阳性结果在彼此之间相互平衡，使得可以进行肿瘤筛选，可能：（iii）决定执行特定于各自肿瘤疾病的成像方法 用于澄清可能的假阴性和/或假阳性IVD结果，或（iv）在限定的时间间隔后重复阶段（i）和（ii），或（v）进行成像 肿瘤成像方法。

公开(公告)号：US20090252688A1

公开(公告)日：2009-10-08

申请号：US12010135

申请日：2008-01-22

申请人： Arne Hengerer

发明人： Arne Hengerer

IPC分类号： A61K51/10 ,  C07K14/00 ,  C07H21/04

CPC分类号： C07K14/22 ,  A61K49/14 ,  A61K49/186 ,  A61K49/1863 ,  A61K49/1866 ,  B82Y5/00 ,  C07K14/285 ,  C07K2319/01

摘要： An inventive principle of at least one embodiment is based on linking an iron-binding functionality in the form of a bacterial iron-binding protein to a binding element which specifically recognizes a biological structure, in order to increase a local detectable increase in the concentration of the contrast medium. In at least one embodiment of the invention, a magnetic resonance contrast medium is provided which is capable of binding by way of a binding element to a biological structure in the body of a mammal, the binding element including an isolated polypeptide. The polypeptide includes a first amino acid sequence of a bacterial iron-binding protein or a derivative thereof, wherein the bacterial iron-binding protein or said derivative thereof has an iron-binding activity. In at least one embodiment, the binding element can bind a protein. In at least one embodiment, the binding element can have a ligand for a cellular membrane protein, a ligand for a cellular glycoprotein, an antibody or an antigen-binding fragment of an antibody and/or can bind a tumor antigen.

摘要翻译： 至少一个实施方案的发明原理基于将细菌铁结合蛋白形式的铁结合官能团与特异性识别生物结构的结合元件连接，以增加局部可检测的浓度增加 造影剂。 在本发明的至少一个实施方案中，提供了能够通过结合元件与哺乳动物身体中的生物结构结合的磁共振造影剂，所述结合元件包括分离的多肽。 多肽包括细菌铁结合蛋白或其衍生物的第一氨基酸序列，其中细菌铁结合蛋白或其衍生物具有铁结合活性。 在至少一个实施方案中，结合元件可以结合蛋白质。 在至少一个实施方案中，结合元件可以具有细胞膜蛋白的配体，细胞糖蛋白的配体，抗体或抗体的抗原结合片段和/或可以结合肿瘤抗原。

公开(公告)号：US20080153710A1

公开(公告)日：2008-06-26

申请号：US11797428

申请日：2007-05-03

申请人： Arne Hengerer ,  Rainer Kuth

发明人： Arne Hengerer ,  Rainer Kuth

IPC分类号： C40B20/08 ,  C40B60/10 ,  G06G7/48

CPC分类号： G01N29/022 ,  G01N29/036 ,  G01N2291/0222 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/106

摘要： A biosensor includes an analysis unit and a reader device for detecting an analyte. In at least one embodiment, the analysis unit includes a quartz oscillator on whose surface capture molecules, which bind specifically to the analyte, are immobilized; as well as a transponder to transmit information, regarding whether and/or how many analyte molecules have bound to the capture molecules, to the reader device.

摘要翻译： 生物传感器包括用于检测分析物的分析单元和读取器装置。 在至少一个实施方案中，分析单元包括石英振荡器，其表面捕获分子特异性结合分析物被固定; 以及将读取器装置传送关于是否和/或有多少分析物分子结合到捕获分子的信息的转发器。

公开(公告)号：US20080132777A1

公开(公告)日：2008-06-05

申请号：US11048312

申请日：2005-02-01

申请人： Wilhelm Durr ,  Ralph Gareus ,  Arne Hengerer ,  Ralph Weissleder ,  Bogdan von Rueckmann

发明人： Wilhelm Durr ,  Ralph Gareus ,  Arne Hengerer ,  Ralph Weissleder ,  Bogdan von Rueckmann

IPC分类号： A61B5/055

CPC分类号： G01R33/285 ,  G01R33/24 ,  G01R33/34084

摘要： We present, in exemplary embodiments of the present invention, a system combining anatomical imaging technologies (e.g., MR) with optical technologies. The system can be used for a variety of applications, including, but not limited to, (1) cancer diagnosis and staging; (2) image guidance; and (3) radiation therapy planning. Image guidance may include guiding a biopsy. For example, a prostatectomy potentially has severe side effects, such as impotence and incontinence. Thus, a histologically-confirmed diagnosis, such as one provided from a biopsy, may prevent unnecessary prostatectomy. Image guidance may also include guiding minimal invasive therapy, such as brachytherapy focused ultrasound. The present invention may be used to plan radiation therapy, for example, by detecting, and thus sparing, healthy tissue from radiation exposure.

摘要翻译： 在本发明的示例性实施例中，存在将解剖成像技术（例如，MR）与光学技术相结合的系统。 该系统可用于各种应用，包括但不限于（1）癌症诊断和分期; （2）图像指导; 和（3）放射治疗计划。 图像指导可能包括指导活检。 例如，前列腺切除术可能具有严重的副作用，例如阳ence和失禁。 因此，组织学确诊的诊断，例如从活组织检查提供的诊断可以防止不必要的前列腺切除术。 图像引导还可以包括引导最小侵入性治疗，例如近距离放射治疗聚焦超声。 本发明可以用于计划放射治疗，例如通过从辐射暴露中检测健康组织并因此节省健康组织。

公开(公告)号：US20060100529A1

公开(公告)日：2006-05-11

申请号：US11044239

申请日：2005-01-27

申请人： Bogdan Rueckmann ,  Ralph Gareus ,  Arne Hengerer ,  Ralph Weissleder ,  Wilhelm Durr

发明人： Bogdan Rueckmann ,  Ralph Gareus ,  Arne Hengerer ,  Ralph Weissleder ,  Wilhelm Durr

IPC分类号： A61B6/00

CPC分类号： A61B8/4461 ,  A61B1/0005 ,  A61B1/043 ,  A61B1/0638 ,  A61B5/0035 ,  A61B5/0077 ,  A61B5/415 ,  A61B5/418 ,  A61B8/12 ,  A61B8/5238 ,  G01R33/285

摘要： We present, in exemplary embodiments of the present invention, a system combining optical imaging technologies with anatomical imaging technologies (e.g., MR, ultrasound). The system can be used for a variety of applications, including, but not limited to, (1) cancer diagnosis and staging; (2) image guidance; and (3) radiation therapy planning. Image guidance may include guiding a biopsy. For example, a prostatectomy potentially has severe side effects, such as impotence and incontinence. Thus, a histologically-confirmed diagnosis, such as one provided from a biopsy, may prevent unnecessary prostatectomy. Image guidance may also include guiding minimal invasive therapy, such as brachytherapy focused ultrasound. The present invention may be used to plan radiation therapy, for example, by detecting, and thus sparing, healthy tissue from radiation exposure.

摘要翻译： 在本发明的示例性实施例中，存在将光学成像技术与解剖成像技术（例如，MR，超声波）组合的系统。 该系统可用于各种应用，包括但不限于（1）癌症诊断和分期; （2）图像指导; 和（3）放射治疗计划。 图像指导可能包括指导活检。 例如，前列腺切除术可能具有严重的副作用，例如阳ence和失禁。 因此，组织学确诊的诊断，例如从活组织检查提供的诊断可以防止不必要的前列腺切除术。 图像引导还可以包括引导最小侵入性治疗，例如近距离放射治疗聚焦超声。 本发明可以用于计划放射治疗，例如通过从辐射暴露中检测健康组织并因此节省健康组织。