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    Tracking of bone marrow cells for metastasis screening
    2.
    发明授权
    Tracking of bone marrow cells for metastasis screening 失效
    跟踪骨髓细胞进行转移筛选

    公开(公告)号：US08747839B2

    公开(公告)日：2014-06-10

    申请号：US12974214

    申请日：2010-12-21

    申请人： Christian Geppert ,  Arne Hengerer ,  Sven Meyburg ,  Sebastian Schmidt ,  Susanne Schmolke ,  Ralph Markus Wirtz

    发明人： Christian Geppert ,  Arne Hengerer ,  Sven Meyburg ,  Sebastian Schmidt ,  Susanne Schmolke ,  Ralph Markus Wirtz

    IPC分类号： A01N63/02 ,  A61K35/32 ,  A61K51/02 ,  A61B5/055

    CPC分类号： G01N33/574 ,  A61K49/1896 ,  A61K51/1203 ,  C12N5/0669 ,  C12N2503/00

    摘要： At least one embodiment of the invention relates to bone marrow precursor cells or bone marrow cells of a patient, the cells labeled with at least one contrast agent suitable for an imaging method, for use in an imaging method for diagnosing a metastasizing cancer, wherein the local accumulation of the labeled precursor cells or bone marrow cells indicates the presence of a metastasizing tumor growth. At least one embodiment also relates to a method for imaging a metastasizing tumor tissue in a patient, wherein a) bone marrow precursor cells or bone marrow cells are extracted from a patient, b) these precursor cells or bone marrow cells are labeled with at least one contrast agent suitable for an imaging method, c) the precursor cells or bone marrow cells thus labeled are retransplanted or reinjected into the patient, and d) the presence of metastasizing tumor cells is depicted with an imaging method. At least one embodiment also relates a method for imaging a metastasizing tumor tissue, wherein a suitable imaging method is used to image bone marrow precursor cells and/or bone marrow cells that are accumulated in a metastasizing tumor tissue and labeled with at least one contrast agent suitable for an imaging method.

    摘要翻译： 本发明的至少一个实施方案涉及患者的骨髓前体细胞或骨髓细胞，所述细胞用适于成像方法的至少一种造影剂标记，用于诊断转移性癌症的成像方法，其中 标记的前体细胞或骨髓细胞的局部积累表明存在转移性肿瘤生长。 至少一个实施方案还涉及用于对患者的转移性肿瘤组织进行成像的方法，其中a）从患者中提取骨髓前体细胞或骨髓细胞，b）至少标记这些前体细胞或骨髓细胞 一种适用于成像方法的造影剂，c）将如此标记的前体细胞或骨髓细胞重新移植或重新注入患者体内，d）用成像方法描绘转移肿瘤细胞的存在。 至少一个实施方案还涉及用于成像转移肿瘤组织的方法，其中使用合适的成像方法来成像骨髓前体细胞和/或骨髓细胞，所述骨髓前体细胞和/或骨髓细胞积聚在转移肿瘤组织中并用至少一种造影剂 适合成像方法。

    Contrast Agents For Detecting Protease Activity By Means Of Hyperpolarization And For Stratifying Patients
    3.
    发明申请
    Contrast Agents For Detecting Protease Activity By Means Of Hyperpolarization And For Stratifying Patients 审中-公开
    用于通过超极化和分层患者检测蛋白酶活性的对比剂

    公开(公告)号：US20110229414A1

    公开(公告)日：2011-09-22

    申请号：US13013127

    申请日：2011-01-25

    申请人： Christian Geppert ,  Arne Hengerer ,  Sven Meyburg ,  Sebastian Schmidt ,  Susanne Schmolke ,  Ralph Markus Wirtz

    发明人： Christian Geppert ,  Arne Hengerer ,  Sven Meyburg ,  Sebastian Schmidt ,  Susanne Schmolke ,  Ralph Markus Wirtz

    IPC分类号： A61K49/08 ,  C07K2/00 ,  A61K49/00 ,  C07K7/06 ,  A61P43/00

    CPC分类号： A61K49/06

    摘要： A contrast agent is disclosed for imaging methods. In at least one embodiment the contrast agent includes a construct including i) at least two copies of a substrate for at least one tumor-specific protease, and ii) at least one linker having at least one recognition site for at least one tumor-specific protease, wherein a hyperpolarization site is located at the N and/or C terminus of the substrate, and wherein the linker is configured such that the hydrophobic ends of the substrate interact and form a central core by means of noncovalent interactions with the lipophilic residues, and the contrast agent together with a parahydrogen metal template for use in an imaging method for diagnosing a tumor. At least one embodiment of the invention further relates to a method for imaging a tumor tissue, wherein the above-described contrast agent accumulated in a tumor tissue is imaged using a suitable imaging method after hyperpolarization by way of contact with a parahydrogen metal template, and also to a method for imaging a tumor tissue in a patient, wherein a) a contrast agent as described above is administered to a patient, b) a parahydrogen metal template is administered to the patient, and c) the presence of a tumor is depicted using an imaging method.

    摘要翻译： 公开了用于成像方法的造影剂。 在至少一个实施方案中，造影剂包括构建体，其包括i）用于至少一种肿瘤特异性蛋白酶的底物的至少两个拷贝，和ii）至少一个具有至少一个肿瘤特异性的识别位点的接头 蛋白酶，其中超极化位点位于底物的N和/或C末端，并且其中接头被配置为使得底物的疏水末端通过与亲脂性残基的非共价相互作用相互作用并形成中心核心， 和造影剂以及用于诊断肿瘤的成像方法中的副氢金属模板。 本发明的至少一个实施方案还涉及一种用于对肿瘤组织进行成像的方法，其中通过与超临界金属模板的接触在超极化之后，使用合适的成像方法将累积在肿瘤组织中的上述造影剂成像，并且 还涉及对患者的肿瘤组织进行成像的方法，其中a）对患者施用如上所述的造影剂，b）向患者施用副氢金属模板，和c）描绘肿瘤的存在 使用成像方法。

    TRACKING OF BONE MARROW CELLS FOR METASTASIS SCREENING
    4.
    发明申请
    TRACKING OF BONE MARROW CELLS FOR METASTASIS SCREENING 失效
    跟踪用于METASTASIS筛选的骨髓细胞

    公开(公告)号：US20110150758A1

    公开(公告)日：2011-06-23

    申请号：US12974214

    申请日：2010-12-21

    申请人： Christian Geppert ,  Arne Hengerer ,  Sven Meyburg ,  Sebastian Schmidt ,  Susanne Schmolke ,  Ralph Markus Wirtz

    发明人： Christian Geppert ,  Arne Hengerer ,  Sven Meyburg ,  Sebastian Schmidt ,  Susanne Schmolke ,  Ralph Markus Wirtz

    IPC分类号： A61K51/02 ,  C12N5/071 ,  A61K49/08 ,  C12Q1/02 ,  B82Y15/00

    CPC分类号： G01N33/574 ,  A61K49/1896 ,  A61K51/1203 ,  C12N5/0669 ,  C12N2503/00

    摘要： At least one embodiment of the invention relates to bone marrow precursor cells or bone marrow cells of a patient, the cells labeled with at least one contrast agent suitable for an imaging method, for use in an imaging method for diagnosing a metastasizing cancer, wherein the local accumulation of the labeled precursor cells or bone marrow cells indicates the presence of a metastasizing tumor growth. At least one embodiment also relates to a method for imaging a metastasizing tumor tissue in a patient, wherein a) bone marrow precursor cells or bone marrow cells are extracted from a patient, b) these precursor cells or bone marrow cells are labeled with at least one contrast agent suitable for an imaging method, c) the precursor cells or bone marrow cells thus labeled are retransplanted or reinjected into the patient, and d) the presence of metastasizing tumor cells is depicted with an imaging method. At least one embodiment also relates a method for imaging a metastasizing tumor tissue, wherein a suitable imaging method is used to image bone marrow precursor cells and/or bone marrow cells that are accumulated in a metastasizing tumor tissue and labeled with at least one contrast agent suitable for an imaging method.

    摘要翻译： 本发明的至少一个实施方案涉及患者的骨髓前体细胞或骨髓细胞，所述细胞用适于成像方法的至少一种造影剂标记，用于诊断转移性癌症的成像方法，其中 标记的前体细胞或骨髓细胞的局部积累表明存在转移性肿瘤生长。 至少一个实施方案还涉及用于对患者的转移性肿瘤组织进行成像的方法，其中a）从患者中提取骨髓前体细胞或骨髓细胞，b）至少标记这些前体细胞或骨髓细胞 一种适用于成像方法的造影剂，c）将如此标记的前体细胞或骨髓细胞重新移植或重新注入患者体内，d）用成像方法描绘转移肿瘤细胞的存在。 至少一个实施方案还涉及用于成像转移肿瘤组织的方法，其中使用合适的成像方法来成像骨髓前体细胞和/或骨髓细胞，所述骨髓前体细胞和/或骨髓细胞积聚在转移肿瘤组织中并用至少一种造影剂 适合成像方法。

    IN VITRO METHOD FOR DIAGNOSING TUMOR DISEASES
    7.
    发明申请
    IN VITRO METHOD FOR DIAGNOSING TUMOR DISEASES 审中-公开
    用于诊断肿瘤疾病的体外方法

    公开(公告)号：US20100247438A1

    公开(公告)日：2010-09-30

    申请号：US12731499

    申请日：2010-03-25

    申请人： Arne Hengerer ,  Andreas Kappel ,  Luis Lasalvia ,  Andrea Lichte ,  Thomas Mertelmeier ,  Sven Meyburg ,  Christoph Petry ,  Marcus Pfister ,  Martin Requardt

    发明人： Arne Hengerer ,  Andreas Kappel ,  Luis Lasalvia ,  Andrea Lichte ,  Thomas Mertelmeier ,  Sven Meyburg ,  Christoph Petry ,  Marcus Pfister ,  Martin Requardt

    IPC分类号： A61K49/00 ,  G01N33/53 ,  G01N33/573 ,  G01N33/48 ,  A61B1/00

    CPC分类号： G01N33/57488 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57473 ,  G01N2333/585 ,  G01N2333/70503 ,  G01N2333/96486

    摘要： An in vitro method is for diagnosing a tumor disease in a patient. In at least one embodiment, the method includes: (i) determining an IVD marker or an IVD marker panel in at least one biological sample of a patient, wherein the IVD marker has a high sensitivity to the tumor disease, (ii) determining the proportion of patients tested positive due to an adapted reference range of the IVD marker/IVD marker panel, wherein the reference range was adapted such that the number of individuals with false negative tests, the number of individuals with false positive tests and the number of individuals ultimately needing to be subjected to imaging diagnostics to clarify false negative and false positive results are balanced in respect of one another such that tumor screening can be carried out, possibly: (iii) deciding to carry out an imaging method specific to the respective tumor disease for clarifying possible false negative and/or false positive IVD results, or (iv) repeating stages (i) and (ii) after a defined time interval, or (v) carrying out an imaging method for imaging the tumor.

    摘要翻译： 体外方法是用于诊断患者的肿瘤疾病。 在至少一个实施方案中，该方法包括：（i）确定患者的至少一个生物样品中的IVD标记或IVD标记物组，其中IVD标记对肿瘤疾病具有高度敏感性，（ii）确定 由于IVD标记/ IVD标记物组的适应参考范围，患者的比例为阳性，其中参考范围被改编为使得具有假阴性测试的个体数量，具有假阳性测试的个体数量和个体数量 最终需要进行成像诊断以澄清假阴性和假阳性结果在彼此之间相互平衡，使得可以进行肿瘤筛选，可能：（iii）决定执行特定于各自肿瘤疾病的成像方法 用于澄清可能的假阴性和/或假阳性IVD结果，或（iv）在限定的时间间隔后重复阶段（i）和（ii），或（v）进行成像 肿瘤成像方法。