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    IN VITRO METHOD FOR DIAGNOSING TUMOR DISEASES
    3.
    发明申请
    IN VITRO METHOD FOR DIAGNOSING TUMOR DISEASES 审中-公开
    用于诊断肿瘤疾病的体外方法

    公开(公告)号：US20100247438A1

    公开(公告)日：2010-09-30

    申请号：US12731499

    申请日：2010-03-25

    申请人： Arne Hengerer ,  Andreas Kappel ,  Luis Lasalvia ,  Andrea Lichte ,  Thomas Mertelmeier ,  Sven Meyburg ,  Christoph Petry ,  Marcus Pfister ,  Martin Requardt

    发明人： Arne Hengerer ,  Andreas Kappel ,  Luis Lasalvia ,  Andrea Lichte ,  Thomas Mertelmeier ,  Sven Meyburg ,  Christoph Petry ,  Marcus Pfister ,  Martin Requardt

    IPC分类号： A61K49/00 ,  G01N33/53 ,  G01N33/573 ,  G01N33/48 ,  A61B1/00

    CPC分类号： G01N33/57488 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57473 ,  G01N2333/585 ,  G01N2333/70503 ,  G01N2333/96486

    摘要： An in vitro method is for diagnosing a tumor disease in a patient. In at least one embodiment, the method includes: (i) determining an IVD marker or an IVD marker panel in at least one biological sample of a patient, wherein the IVD marker has a high sensitivity to the tumor disease, (ii) determining the proportion of patients tested positive due to an adapted reference range of the IVD marker/IVD marker panel, wherein the reference range was adapted such that the number of individuals with false negative tests, the number of individuals with false positive tests and the number of individuals ultimately needing to be subjected to imaging diagnostics to clarify false negative and false positive results are balanced in respect of one another such that tumor screening can be carried out, possibly: (iii) deciding to carry out an imaging method specific to the respective tumor disease for clarifying possible false negative and/or false positive IVD results, or (iv) repeating stages (i) and (ii) after a defined time interval, or (v) carrying out an imaging method for imaging the tumor.

    摘要翻译： 体外方法是用于诊断患者的肿瘤疾病。 在至少一个实施方案中，该方法包括：（i）确定患者的至少一个生物样品中的IVD标记或IVD标记物组，其中IVD标记对肿瘤疾病具有高度敏感性，（ii）确定 由于IVD标记/ IVD标记物组的适应参考范围，患者的比例为阳性，其中参考范围被改编为使得具有假阴性测试的个体数量，具有假阳性测试的个体数量和个体数量 最终需要进行成像诊断以澄清假阴性和假阳性结果在彼此之间相互平衡，使得可以进行肿瘤筛选，可能：（iii）决定执行特定于各自肿瘤疾病的成像方法 用于澄清可能的假阴性和/或假阳性IVD结果，或（iv）在限定的时间间隔后重复阶段（i）和（ii），或（v）进行成像 肿瘤成像方法。

    METHOD FOR IMAGING TUMOR TISSUE
    4.
    发明申请
    METHOD FOR IMAGING TUMOR TISSUE 审中-公开
    成像肿瘤组织的方法

    公开(公告)号：US20100329977A1

    公开(公告)日：2010-12-30

    申请号：US12820205

    申请日：2010-06-22

    申请人： Arne Hengerer ,  Andreas Kappel

    发明人： Arne Hengerer ,  Andreas Kappel

    IPC分类号： A61K51/10 ,  A61K51/08 ,  A61K49/00 ,  A61K49/14 ,  G01N33/53 ,  G01N33/573 ,  G01N33/58 ,  C07K14/435

    CPC分类号： A61K49/0043 ,  A61B6/037 ,  A61K49/0047 ,  A61K49/16 ,  A61K51/1045

    摘要： A method is disclosed for imaging a tumor tissue, wherein in at least one embodiment a) the tumor tissue is contacted with a monoclonal antibody, an antigen-binding fragment thereof, a recombinant binding protein, an aptamer, or other molecule, each of which recognizes and binds at least one neoepitope which has been generated by proteolytic cleavage of proteins surrounding the tumor tissue by tumor-specific proteases, and b) the complexes formed from neoepitope and monoclonal antibody, antigen-binding fragment thereof, recombinant binding protein, aptamer, or other molecule are depicted with an imaging method, and also to neoepitopes generated by proteolytic cleavage of surrounding proteins by tumor-specific proteases, and also proteins or peptides for generating neoepitopes by tumor-specific proteases.

    摘要翻译： 公开了一种用于成像肿瘤组织的方法，其中在至少一个实施方案中a）使肿瘤组织与单克隆抗体，其抗原结合片段，重组结合蛋白，适体或其他分子接触，每个分子 识别和结合由肿瘤特异性蛋白酶通过蛋白水解切割肿瘤组织周围的蛋白质产生的至少一种新表皮，和b）由新表皮和单克隆抗体形成的复合物，其抗原结合片段，重组结合蛋白，适体， 或其他分子用成像方法描述，还涉及通过肿瘤特异性蛋白酶对周围蛋白质的蛋白水解切割产生的新表皮，以及用于通过肿瘤特异性蛋白酶产生新表皮的蛋白质或肽。

    Blood coagulation assays
    5.
    发明授权
    Blood coagulation assays 有权
    血液凝固测定

    公开(公告)号：US08304205B2

    公开(公告)日：2012-11-06

    申请号：US12569714

    申请日：2009-09-29

    申请人： Andreas Kappel ,  Andrea Lichte ,  Norbert Zander ,  Stefan Teigelkamp ,  Sabine Teigelkamp, legal representative ,  Carsten Schelp

    发明人： Andreas Kappel ,  Andrea Lichte ,  Norbert Zander ,  Stefan Teigelkamp ,  Carsten Schelp

    IPC分类号： C12Q1/56 ,  G01N33/53

    CPC分类号： C12Q1/56 ,  G01N2333/974

    摘要： The invention relates to methods for determining the activity of a proteolytic coagulation factor of the blood coagulation cascade in a body fluid such as whole blood or plasma. A combination is provided in a reaction mixture. The combination comprises the sample and an activation agent for activating a proteolytic coagulation factor of the blood coagulation cascade or for activating the blood coagulation cascade. The effect of the activating on a reagent system comprising a cleavable moiety is evaluated. The cleavable moiety is or becomes bound to a chemiluminescent agent or a sensitizer agent or both. The chemiluminescent agent and the sensitizer agent are related in that, when in close proximity, energization of the sensitizer agent results in energization of the chemiluminescent agent. The effect of the activating is related to the activity of a proteolytic coagulation factor of the blood coagulation cascade wherein the effect is the extent of cleavage of the cleavable moiety.

    摘要翻译： 本发明涉及确定体液如全血或血浆中凝血级联蛋白水解凝血因子的活性的方法。 在反应混合物中提供组合。 该组合包括样品和用于激活凝血级联的蛋白水解凝血因子或用于激活凝血级联的活化剂。 评估活化对包含可切割部分的试剂体系的影响。 可切割部分是化学发光剂或敏化剂或二者结合。 化学发光剂和敏化剂的作用在于，当紧邻时，敏化剂的通电导致化学发光剂的通电。 活化的作用与血液凝固级联的蛋白水解凝血因子的活性有关，其中效应是切割部分的切割程度。

    Blood Coagulation Assays
    6.
    发明申请
    Blood Coagulation Assays 有权
    血液凝固测定

    公开(公告)号：US20100086953A1

    公开(公告)日：2010-04-08

    申请号：US12569714

    申请日：2009-09-29

    申请人： Andreas Kappel ,  Andrea Lichte ,  Norbert Zander ,  Stefan Teigelkamp ,  Sabine Teigelkamp

    发明人： Andreas Kappel ,  Andrea Lichte ,  Norbert Zander ,  Stefan Teigelkamp ,  Sabine Teigelkamp

    IPC分类号： C12Q1/56

    CPC分类号： C12Q1/56 ,  G01N2333/974

    摘要： The invention relates to methods for determining the activity of a proteolytic coagulation factor of the blood coagulation cascade in a body fluid such as whole blood or plasma. A combination is provided in a reaction mixture. The combination comprises the sample and an activation agent for activating a proteolytic coagulation factor of the blood coagulation cascade or for activating the blood coagulation cascade. The effect of the activating on a reagent system comprising a cleavable moiety is evaluated. The cleavable moiety is or becomes bound to a chemiluminescent agent or a sensitizer agent or both. The chemiluminescent agent and the sensitizer agent are related in that, when in close proximity, energization of the sensitizer agent results in energization of the chemiluminescent agent. The effect of the activating is related to the activity of a proteolytic coagulation factor of the blood coagulation cascade wherein the effect is the extent of cleavage of the cleavable moiety.

    摘要翻译： 本发明涉及确定体液如全血或血浆中凝血级联蛋白水解凝血因子的活性的方法。 在反应混合物中提供组合。 该组合包括样品和用于激活凝血级联的蛋白水解凝血因子或用于激活凝血级联的活化剂。 评估活化对包含可切割部分的试剂体系的影响。 可切割部分是化学发光剂或敏化剂或二者结合。 化学发光剂和敏化剂的作用在于，当紧邻时，敏化剂的通电导致化学发光剂的通电。 活化的作用与凝血级联的蛋白水解凝血因子的活性有关，其中效应是切割部分的切割程度。

    Dosing device for fluids, especially a motor vehicle injection valve
    10.
    发明授权
    Dosing device for fluids, especially a motor vehicle injection valve 有权
    液体加药装置，特别是机动车辆注射阀

    公开(公告)号：US07195182B2

    公开(公告)日：2007-03-27

    申请号：US11003265

    申请日：2004-12-03

    申请人： Bernhard Fischer ,  Bernhard Gottlieb ,  Andreas Kappel ,  Enrico Ulivieri

    发明人： Bernhard Fischer ,  Bernhard Gottlieb ,  Andreas Kappel ,  Enrico Ulivieri

    IPC分类号： B05B1/30 ,  B05B1/34 ,  F02M59/00 ,  F02M61/00 ,  F02M47/02

    CPC分类号： F02M61/08 ,  F02M51/0603 ,  F02M61/12 ,  F02M61/16 ,  F02M61/168 ,  F02M2200/16

    摘要： A dosing device comprises a housing (1) provided with an actuator, a dosing opening (8), a guiding shaft (6) which surrounds part of the valve needle (7) and forms a valve chamber (10) with the same, and a fluid chamber module (4) which is welded to the housing (1) in the form of a duct for guiding the valve needle (7) into the housing (9). The fluid chamber module (4) and the housing (1) are assembled along a separation surface (13) which is subjected to pressure by the dosing liquid and is formed almost only by axial cylinder wall surface parts (13) in order to reduce the pressure load on the weld seam (13).

    摘要翻译： 配量装置包括设置有致动器的壳体（1），配量开口（8），围绕阀针（7）的一部分并且形成与其相连的阀室（10）的引导轴（6），以及 流体室模块（4），其以管道形式焊接到壳体（1），用于将阀针（7）引导到壳体（9）中。 流体室模块（4）和壳体（1）沿着分离表面（13）组装，分离表面（13）受到计量液体的压力，几乎仅由轴向气缸壁表面部分（13）形成，以便减少 焊缝上的压力载荷（13）。