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公开(公告)号:US20090311256A1
公开(公告)日:2009-12-17
申请号:US12264040
申请日:2008-11-03
申请人: Jian Ni , Paul E. Young , Joseph J. Kenny , Henrik S. Olsen , Paul A. Moore , Ying-Fei Wei , John M. Greene , Steven M. Ruben , Ding Liu , Paul R. Crocker
发明人: Jian Ni , Paul E. Young , Joseph J. Kenny , Henrik S. Olsen , Paul A. Moore , Ying-Fei Wei , John M. Greene , Steven M. Ruben , Ding Liu , Paul R. Crocker
IPC分类号: A61K39/395 , C07H21/04 , C12N15/63 , C12N5/10 , C07K14/00 , C07K16/00 , C12P21/02 , A61K31/7088 , A61K38/16 , C12Q1/68 , G01N33/53 , A61P9/00 , A61P3/00
CPC分类号: C12Q1/6883 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C07K14/70546 , C12N9/6424 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要: The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译: 本发明涉及12种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号:US06548063B1
公开(公告)日:2003-04-15
申请号:US09604073
申请日:2000-06-27
IPC分类号: A61K39395
CPC分类号: C07K14/555 , A61K38/00 , C07K2319/00
摘要: The present invention relates to a novel Synferon protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a synthetic interferon polypeptide, called “Synferon”. Synferon polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Synferon activity. Also provided are therapeutic methods for treating immune system-related disorders.
摘要翻译: 本发明涉及作为干扰素家族成员的新型Synferon蛋白。 特别地,提供了分离的核酸分子,其编码称为“Synferon”的合成干扰素多肽。 还提供了Synferon多肽,载体,宿主细胞以及用于制备它的重组方法。 本发明还涉及用于鉴定Synferon活性的激动剂和拮抗剂的筛选方法。 还提供了治疗免疫系统相关疾病的治疗方法。
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公开(公告)号:US6143498A
公开(公告)日:2000-11-07
申请号:US78670
申请日:1998-05-14
申请人: Henrik S. Olsen , Steven M. Ruben
发明人: Henrik S. Olsen , Steven M. Ruben
IPC分类号: C12N15/09 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12Q1/68 , C07H21/02
CPC分类号: C07K14/4723
摘要: The present invention relates to a novel human antimicrobial peptide which is a member of the defensin superfamily. In particular, isolated nucleic acid molecules are provided encoding the human antimicrobial peptide. Antimicrobial peptide are also provided as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for detecting disorders related to the immune system and therapeutic methods for such disorders.
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公开(公告)号:US6114145A
公开(公告)日:2000-09-05
申请号:US205264
申请日:1998-12-02
IPC分类号: A61K38/00 , C07K14/555 , C12N15/20 , A61K38/21
CPC分类号: C07K14/555 , A61K38/00 , C07K2319/00
摘要: The present invention relates to a novel Synferon protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a synthetic interferon polypeptide, called "Synferon". Synferon polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Synferon activity. Also provided are therapeutic methods for treating immune system-related disorders.
摘要翻译: 本发明涉及作为干扰素家族成员的新型Synferon蛋白。 特别地,提供了分离的核酸分子,其编码称为“Synferon”的合成干扰素多肽。 还提供了Synferon多肽,载体,宿主细胞以及用于制备它的重组方法。 本发明还涉及用于鉴定Synferon活性的激动剂和拮抗剂的筛选方法。 还提供了治疗免疫系统相关疾病的治疗方法。
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公开(公告)号:US6028169A
公开(公告)日:2000-02-22
申请号:US995156
申请日:1997-12-19
IPC分类号: C12N15/09 , A61K38/00 , A61K48/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P29/00 , A61P31/00 , A61P37/08 , C07K14/52 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/19 , C07K14/435
CPC分类号: C07K14/523 , A61K38/00 , A61K48/00 , C12N2799/026
摘要: Human chemokine .beta.-6 agonist and antagonist polypeptides and DNA encoding such polypeptides and procedure for producing such polypeptides by recombinant technique are disclosed. The chemokine .beta.-6 antagonists of the present invention may be employed to treat rheumatoid arthritis, lung inflammation, allergy, asmtha, infectious diseases and to prevent inflammation and atherosclerosis. The chemokine .beta.-6 agonists may be employed to myeloprotect patients undergoing chemotherapy.
摘要翻译: 公开了人类趋化因子β-6激动剂和拮抗剂多肽以及编码这些多肽的DNA,以及通过重组技术产生此类多肽的方法。 本发明的趋化因子β-6拮抗剂可用于治疗类风湿性关节炎,肺部炎症,变态反应,甲状腺炎,感染性疾病和预防炎症和动脉粥样硬化。 趋化因子β-6激动剂可用于对进行化疗的患者进行骨髓保护。
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公开(公告)号:US5994301A
公开(公告)日:1999-11-30
申请号:US431117
申请日:1995-04-28
申请人: Henrik S. Olsen , Mark D. Adams
发明人: Henrik S. Olsen , Mark D. Adams
IPC分类号: C12N15/09 , A61K35/12 , A61K35/76 , A61K38/00 , A61K39/395 , A61K48/00 , A61P3/00 , A61P3/02 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/56 , C07K14/575 , C07K16/18 , C07K16/26 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/99 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , A61K38/17 , A61K38/04 , C07K14/435
CPC分类号: C07H21/04 , C07K14/575 , C07K16/26 , A61K38/00 , C07K2317/24 , C07K2317/55 , Y10S530/835
摘要: The present invention relates to human Corpuscles of Stannius polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antagonists against such polypeptides. Also provided are methods of using the polypeptide therapeutically for treating renal, bone and heart diseases and for using the antagonists for treating hypocalcemia and osteoporosis. Also provided is a diagnostic assay to detect mutations in the nucleic acid sequence encoding the polypeptide and for altered concentrations of the polypeptide in a sample derived from a host.
摘要翻译: 本发明涉及人类Stannius多肽多糖和编码这种多肽的DNA(RNA)。 还提供了通过重组技术和针对这种多肽的拮抗剂生产此类多肽的方法。 还提供了使用该多肽治疗性治疗肾,骨和心脏病以及使用拮抗剂治疗低钙血症和骨质疏松症的方法。 还提供了用于检测编码多肽的核酸序列中的突变和来自宿主的样品中多肽的变化浓度的诊断测定法。
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公开(公告)号:US06955885B2
公开(公告)日:2005-10-18
申请号:US10418226
申请日:2003-04-18
IPC分类号: C07H21/04 , C07K14/56 , C07K14/575 , C12N1/21 , C12N15/12 , C12Q1/68 , C07K16/22 , C12N5/12 , G01N33/53
CPC分类号: C07H21/04 , C07K14/575
摘要: A human stanniocalcin-alpha polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the regulation of electrolyte imbalances which can lead to renal, bone and heart diseases and osteoporosis and Paget's Disease. Antagonists against such polypeptides and their use in the regulation of electrolyte imbalances which can lead to hypocalcemia and osteoporosis are also disclosed. Use of the stanniocalcin-alpha sequence as a diagnostic to detect diseases or the susceptibility to diseases related to a mutated form of stanniocalcin-alpha sequences is also disclosed.
摘要翻译: 公开了一种编码这种多肽的人类猕猴素α多肽和DNA(RNA),以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽来调节可导致肾,骨和心脏病以及骨质疏松症和佩吉特氏病的电解质不平衡的方法。 还公开了抗这些多肽的拮抗剂及其在调节可导致低钙血症和骨质疏松症的电解质不平衡中的用途。 还公开了将斯诺钙钙素α序列用作诊断疾病或与突变形式的锡氨钙素-α序列相关的疾病的易感性的用途。
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公开(公告)号:US06852506B1
公开(公告)日:2005-02-08
申请号:US08839525
申请日:1997-04-11
申请人: Henrik S. Olsen , Haodong Li
发明人: Henrik S. Olsen , Haodong Li
IPC分类号: C07K14/485 , C12N1/21 , C12P21/02 , C12N5/10
CPC分类号: C07K14/485
摘要: The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of DNA synthesis, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
摘要翻译: 本发明公开了细胞外/表皮生长因子多肽和编码这些多肽的多核苷酸。 还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法,其包括诱导DNA合成,刺激伤口愈合,治疗神经障碍,治疗眼部疾病,治疗肾脏和肝脏疾病以及刺激胚胎发生和血管发生。 还公开了抗这种多肽的拮抗剂及其作为治疗瘤形成的治疗剂的用途。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。
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公开(公告)号:US06576445B1
公开(公告)日:2003-06-10
申请号:US09630709
申请日:2000-08-01
申请人: Henrik S. Olsen , Steven M. Ruben , Zhi-Zhen Zeng
发明人: Henrik S. Olsen , Steven M. Ruben , Zhi-Zhen Zeng
IPC分类号: C12P2106
CPC分类号: C07K14/522 , A61K38/00
摘要: The present invention relates to a novel CK&agr;-4 protein which is a member of the CXC chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK&agr;-4 protein. CK&agr;-4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK&agr;-4 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译: 本发明涉及作为CXC趋化因子家族成员的新型CKalpha-4蛋白。 特别地,提供编码人CKalpha-4蛋白的分离的核酸分子。 也提供CKalpha-4多肽,载体,宿主细胞和用于制备它们的重组方法。 本发明还涉及鉴定CKalpha-4活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。
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公开(公告)号:US06379926B1
公开(公告)日:2002-04-30
申请号:US09419281
申请日:1999-10-15
IPC分类号: C12N121
CPC分类号: C07K14/523 , A61K38/00 , A61K48/00 , C12N2799/026 , Y02A50/423
摘要: Human chemokine &bgr;-6 agonist and antagonist polypeptides and DNA encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. The chemokine &bgr;-6 antagonists of the present invention may be employed to treat rheumatoid arthritis, lung inflammation, allergy, asmtha, infectious diseases and to prevent inflammation and atherosclerosis. The chemokine &bgr;-6 agonists may be employed to myeloprotect patients undergoing chemotherapy.
摘要翻译: 公开了人类趋化因子β-6激动剂和拮抗剂多肽以及编码这些多肽的DNA以及通过重组技术产生此类多肽的方法。 本发明的趋化因子β-6拮抗剂可用于治疗类风湿性关节炎,肺部炎症,过敏,甲状腺炎,感染性疾病和预防炎症和动脉粥样硬化。 趋化因子β-6激动剂可用于对进行化学疗法的患者进行骨髓保护。
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