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公开(公告)号：US06914131B1
公开(公告)日：2005-07-05
申请号：US09303518
申请日：1999-04-30
摘要： The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译： 本发明提供脑膜炎奈瑟菌（A＆B）菌株和来自淋病奈瑟氏球菌的蛋白质，包括氨基酸序列，相应的核苷酸序列，表达数据和血清学数据。 蛋白质是疫苗，免疫原性组合物和/或诊断的有用的抗原。
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公开(公告)号：US08293251B2
公开(公告)日：2012-10-23
申请号：US12653954
申请日：2009-12-18
IPC分类号： A61K39/095 , C07H21/04 , C12P21/04 , C07K14/00
摘要： The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译： 本发明提供脑膜炎奈瑟菌（A＆B）菌株和来自淋病奈瑟氏球菌的蛋白质，包括氨基酸序列，相应的核苷酸序列，表达数据和血清学数据。 蛋白质是疫苗，免疫原性组合物和/或诊断的有用的抗原。
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公开(公告)号：US20100034822A1
公开(公告)日：2010-02-11
申请号：US11887712
申请日：2006-03-30
申请人： Vega Masignani , Rino Rappuoli , Herve Tettelin
发明人： Vega Masignani , Rino Rappuoli , Herve Tettelin
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , C07H21/00 , A61K38/16 , A61K31/7052 , A61K39/00 , A61P31/12 , A61P31/04
CPC分类号： C07K14/285 , A61K39/00 , A61K39/102 , A61K39/12 , C07K14/005 , C07K16/1242
摘要： Polypeptides comprising various amino acid sequences derived from Haemophilus influenzae type b, including a number of lipoproteins. These can be used in the development of vaccines for preventing and/or treating bacterial meningitis. They may also be useful for diagnostic purposes, and as targets for antibiotics. Antibodies against the polypeptides are also disclosed, as are the coding nucleic acids.
摘要翻译： 包含衍生自b型流感嗜血杆菌的各种氨基酸序列的多肽，包括许多脂蛋白。 这些可用于开发用于预防和/或治疗细菌性脑膜炎的疫苗。 它们也可用于诊断目的，也可用作抗生素的靶标。 编码核酸也公开了抗多肽的抗体。
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公开(公告)号：US06709660B1
公开(公告)日：2004-03-23
申请号：US09302626
申请日：1999-04-30
IPC分类号： A61K39095
摘要： The invention provides proteins from Neisseria meningitidis (strains A & B), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译： 本发明提供来自脑膜炎奈瑟菌（A＆B）菌株的蛋白质，包括氨基酸序列，相应的核苷酸序列，表达数据和血清学数据。 蛋白质是疫苗，免疫原性组合物和/或诊断的有用的抗原。
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公开(公告)号：US08287884B2
公开(公告)日：2012-10-16
申请号：US12573929
申请日：2009-10-06
申请人： Vega Masignani , Marirosa Mora , Maria Scarselli
发明人： Vega Masignani , Marirosa Mora , Maria Scarselli
IPC分类号： A61K39/085 , C07K14/31 , C07H21/04
CPC分类号： A61K39/085 , A61K2039/70 , C07K14/31
摘要： The invention provides proteins from Staphylococcus aureus, including amino acid sequences and corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies, and as targets for antibiotics.
摘要翻译： 本发明提供了来自金黄色葡萄球菌的蛋白质，包括氨基酸序列和相应的核苷酸序列。 这些蛋白质可用于疫苗，免疫原性组合物，诊断，酶学研究和抗生素靶标。
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公开(公告)号：US20120052084A1
公开(公告)日：2012-03-01
申请号：US13292977
申请日：2011-11-09
申请人： Vega Masignani , Marirosa Mora , Maria Scarselli
发明人： Vega Masignani , Marirosa Mora , Maria Scarselli
IPC分类号： A61K39/085 , A61K39/29 , A61K39/145 , A61K39/09 , A61P31/16 , A61K39/095 , A61P31/04 , A61P37/04 , A61P31/14 , A61P31/20 , C07K14/31 , A61K39/02
CPC分类号： A61K39/085 , A61K2039/70 , C07K14/31
摘要： The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics.
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公开(公告)号：US07618636B1
公开(公告)日：2009-11-17
申请号：US10031289
申请日：2000-07-13
CPC分类号： C07K14/22 , A61K39/00 , A61K2039/505 , A61K2039/53 , Y10S530/825
摘要： WO99/36544 discloses a large number of proteins from Neisseria Meningitidis. The present invention relates to fragments of those proteins which comprise at least one antigenic determinant. Homologous sequences and proteins comprising these fragments are also disclosed.
摘要翻译： WO99 / 36544公开了大量来自脑膜炎奈瑟球菌的蛋白质。 本发明涉及包含至少一种抗原决定簇的那些蛋白质的片段。 还公开了包含这些片段的同源序列和蛋白质。
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公开(公告)号：US08753650B2
公开(公告)日：2014-06-17
申请号：US13253018
申请日：2011-10-04
申请人： Vega Masignani , Marirosa Mora , Maria Scarselli
发明人： Vega Masignani , Marirosa Mora , Maria Scarselli
IPC分类号： A61K39/085 , C07K14/31
CPC分类号： A61K39/085 , A61K2039/70 , C07K14/31
摘要： The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics.
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公开(公告)号：US08431139B2
公开(公告)日：2013-04-30
申请号：US11434203
申请日：2006-05-16
申请人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
发明人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
IPC分类号： A61K39/09
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
摘要翻译： 本发明提供来自B族链球菌（无乳链球菌）和A型链球菌（化脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。 给出数据以显示蛋白质是疫苗，免疫原性组合物和/或诊断的有用抗原。 蛋白质也是抗生素的靶标。
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公开(公告)号：US08398996B2
公开(公告)日：2013-03-19
申请号：US12460422
申请日：2009-07-17
申请人： Vega Masignani , Marirosa Mora , Maria Scarselli
发明人： Vega Masignani , Marirosa Mora , Maria Scarselli
IPC分类号： A61K39/085 , C07K14/31
CPC分类号： A61K39/085 , A61K2039/70 , C07K14/31
摘要： The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics.
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