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公开(公告)号：US07964181B2
公开(公告)日：2011-06-21
申请号：US11694181
申请日：2007-03-30
申请人： Shubh D. Sharma , Margarita Bastos , Wei Yang , Hui-Zhi Cai
发明人： Shubh D. Sharma , Margarita Bastos , Wei Yang , Hui-Zhi Cai
IPC分类号： A61K31/785 , A61K47/16 , A61K38/02 , A01N43/34
CPC分类号： C07K14/58 , C07D403/04 , C07K7/16
摘要： Ring-constrained amino acid surrogates of formula I: where R1, R2, R3, R4, R5, R6a, R6b, R7, and y are as defined in the specification, methods for synthesizing ring-constrained amino acid surrogates of formula I, methods of use of ring-constrained amino acid surrogates of formula I, including use in linear or cyclic compounds which include a plurality of amino acid residues and one or more ring-constrained amino acid surrogates of formula I and linear or cyclic compounds which include a plurality of amino acid residues and one or more ring-constrained amino acid surrogates of formula I.
摘要翻译： 式I的环受限氨基酸替代物：其中R1，R2，R3，R4，R5，R6a，R6b，R7和y如本说明书中所定义，用于合成式I的环受限氨基酸替代物的方法，方法 包括用于包括多个氨基酸残基和一个或多个式I的环受约束的氨基酸替代物的直链或环状化合物的线形或环状化合物，其包括多个 的氨基酸残基和一个或多个式I的环受限氨基酸替代物。
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公开(公告)号：US07795378B2
公开(公告)日：2010-09-14
申请号：US11031898
申请日：2005-01-07
CPC分类号： C07K5/0827 , A61K38/00 , C07K5/0806 , C07K5/081 , C07K5/1024
摘要： A peptide of the structural formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, m and n are as defined. Further provided are methods for treatment of sexual dysfunction, including erectile dysfunction and female sexual dysfunction, and combination drugs and method of use thereof, including a peptide of the invention and one or more second sexual dysfunction pharmaceutical agents.
摘要翻译： 结构式的肽或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，m和n如上所定义。 还提供了治疗性功能障碍的方法，包括勃起功能障碍和女性性功能障碍，以及联合药物及其使用方法，包括本发明的肽和一种或多种第二性功能障碍药剂。
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公开(公告)号：US20100121027A1
公开(公告)日：2010-05-13
申请号：US12348489
申请日：2009-01-05
申请人： Shubh D. Sharma , Wei Yang
发明人： Shubh D. Sharma , Wei Yang
IPC分类号： C07K7/64
CPC分类号： A61K38/12 , A61K31/519 , A61K31/565 , C07K7/56 , C07K14/665 , C07K14/685 , Y10S436/811 , A61K2300/00
摘要： A cyclic peptide of the structural formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, m and p are as defined. Further provided are compositions for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction, by administration of a cyclic peptide including a C-terminus —OH group. Routes of administration include injection, oral, urethral, vaginal, nasal and mucosal administration.
摘要翻译： 结构式的环状肽或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，m和p如上所定义。 还提供了通过施用包括C末端-OH基团的环肽来治疗哺乳动物的性功能障碍的组合物，包括男性性功能障碍，例如勃起功能障碍和女性性功能障碍。 给药途径包括注射，口服，尿道，阴道，鼻和粘膜给药。
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公开(公告)号：US07473760B2
公开(公告)日：2009-01-06
申请号：US11269271
申请日：2005-11-09
申请人： Shubh D. Sharma , Wei Yang
发明人： Shubh D. Sharma , Wei Yang
CPC分类号： A61K38/12 , A61K31/519 , A61K31/565 , C07K7/56 , C07K14/665 , C07K14/685 , Y10S436/811 , A61K2300/00
摘要： A cyclic peptide of the structural formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, R6, m, n and p are as defined. Further provided are compositions for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction, by administration of a cyclic peptide including a C-terminus —OH group. Routes of administration include injection, oral, urethral, vaginal, nasal and mucosal administration.
摘要翻译： 结构式的环状肽或其药学上可接受的盐，其中R 1，R 2，R 3，R 5，R 6，m，n和p如上所定义。 还提供了通过施用包括C末端-OH基团的环肽来治疗哺乳动物的性功能障碍的组合物，包括男性性功能障碍，例如勃起功能障碍和女性性功能障碍。 给药途径包括注射，口服，尿道，阴道，鼻和粘膜给药。
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45.发明授权Melanocortin metallopeptide constructs, combinatorial libraries and applications 有权黑皮质素金属肽构建体，组合文库和应用公开(公告)号：US07049398B1
公开(公告)日：2006-05-23
申请号：US10049718
申请日：2000-06-15
申请人： Shubh D. Sharma , Yiqun Shi , Wei Yang , Hui-Zhi Cai
发明人： Shubh D. Sharma , Yiqun Shi , Wei Yang , Hui-Zhi Cai
CPC分类号： C07K5/1016 , A61K38/00 , A61K51/086 , A61K51/088 , C07K5/1008 , C07K5/1024 , C07K14/665
摘要： Metallopeptides and metallopeptide combinatorial libraries specific for melanocortin receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, in which the peptide, peptidomimetic or construct is conformationally fixed on complexation of a metal ion-binding portion thereof with a metal ion.
摘要翻译： 提供了特异于黑皮质素受体的金属肽和金属肽组合文库，用于生物，药物和相关应用。 金属肽和组合文库由肽，肽模拟物和肽样构建体制成，其中肽，拟肽或构建体在金属离子结合部分与金属离子的络合上被构象地固定。
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公开(公告)号：US20170326259A1
公开(公告)日：2017-11-16
申请号：US15603817
申请日：2017-05-24
申请人： Kaushik J. Dave , Shubh D. Sharma
发明人： Kaushik J. Dave , Shubh D. Sharma
摘要： Compositions and methods are described for stabilizing a radio-iodinated monoclonal IgG antibody for up to 17 days against radiolytic decomposition. The stabilized radiolabeled murine antibody binding the CD45 antigen expressed on various forms of lymphomas is useful as a radio-therapeutic and diagnostic agent in the treatment of human malignancies of hematopoietic origin, including lymphomas.
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![Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds](/abs-image/US/2010/02/02/US07655658B2/abs.jpg.150x150.jpg)
47.发明授权公开(公告)号：US07655658B2
公开(公告)日：2010-02-02
申请号：US11040838
申请日：2005-01-21
申请人： Shubh D. Sharma , Yiqun Shi
发明人： Shubh D. Sharma , Yiqun Shi
IPC分类号： A61K31/497 , C07D241/36
CPC分类号： C07D495/04
摘要： A thienopyrimidine compound of the formula: wherein R1, R2, R3, and R4 are as defined herein, and methods of use of such compounds for the treatment of melanocortin receptor-associated disorders.
摘要翻译： 下式的噻吩并嘧啶化合物：其中R1，R2，R3和R4如本文所定义，以及使用这些化合物治疗黑皮质素受体相关疾病的方法。
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公开(公告)号：US07235625B2
公开(公告)日：2007-06-26
申请号：US11139730
申请日：2005-05-26
CPC分类号： C07K14/685 , A61K31/519 , A61K33/24 , A61K38/12 , A61K45/06 , Y10S436/811 , A61K2300/00
摘要： Multiple agent therapy for treatment of sexual dysfunction, including male erectile dysfunction, with sequential administration a type V phosphodiesterase inhibitor (PDE-5), such as sildenafil, preferably wherein the PDE-5 inhibitor is administered by oral dose means, and a melanocortin 3 and/or 4 receptor agonist, such as Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH (PT-141) preferably wherein the PT-141 is formulated for and administered by intranasal means, and further preferably wherein the PDE-5 inhibitor is administered prior to PT-141.
摘要翻译： 用于治疗性功能障碍（包括男性勃起功能障碍）的多药物治疗，连续施用V型磷酸二酯酶抑制剂（PDE-5），例如西地那非，其中PDE-5抑制剂通过口服剂量方式施用，黑皮质素3 和/或4受体激动剂，例如Ac-Nle-cyclo（-Asp-His-D-Phe-Arg-Trp-Lys）-OH（PT-141），优选其中PT-141配制用于鼻内给药 是指，进一步优选其中PDE-5抑制剂在PT-141之前施用。
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公开(公告)号：US5683981A
公开(公告)日：1997-11-04
申请号：US470343
申请日：1995-06-06
申请人： Mac E. Hadley , Victor J. Hruby , Shubh D. Sharma
发明人： Mac E. Hadley , Victor J. Hruby , Shubh D. Sharma
IPC分类号： A61K38/00 , C07K14/685 , A61K38/02 , C07K5/00 , C07K7/00
CPC分类号： C07K14/685 , A61K38/00
摘要： A novel class of cyclic bridged analogs of .alpha.-MSH are described herein. With the described analogs, when administered in pharmaceutical compositions, it is now possible to achieve normalization of hypopigmentation dysfunctions and to achieve darkening of the skin in the total absence of sun or UV light irradiation.
摘要翻译： 本文描述了一类新型α-MSH的环状桥连类似物。 使用所描述的类似物，当以药物组合物施用时，现在可以实现色素沉着功能障碍的正常化，并且在完全没有阳光或UV光照射下实现皮肤变暗。
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公开(公告)号：US07754691B1
公开(公告)日：2010-07-13
申请号：US11428749
申请日：2006-07-05
申请人： Shubh D. Sharma
发明人： Shubh D. Sharma
CPC分类号： C07K5/1002 , A61K38/00 , C07K5/1024 , C07K7/06 , C07K14/68
摘要： Linear peptides with a C-terminus —OH group that are specific for one or more melanocortin receptors, and which may be used in the treatment of melanocortin receptor-mediated disorders, including a variety of body weight disorders including cachexia, and for treatment of inflammation, immune disorders and other conditions, diseases and syndromes, and pharmaceutical compositions including such linear peptides.
摘要翻译： 具有一个或多个黑皮质素受体特异性的C末端-OH基团的线性肽，其可用于治疗黑皮质素受体介导的病症，包括各种体重紊乱（包括恶病质）和治疗炎症 ，免疫疾病和其他病症，疾病和综合征，以及包括这种线性肽的药物组合物。
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