公开(公告)号：US20130193947A1

公开(公告)日：2013-08-01

申请号：US13361736

申请日：2012-01-30

申请人： John W. Poore ,  Gene A. Bornzin

发明人： John W. Poore ,  Gene A. Bornzin

IPC分类号： G05F3/02

CPC分类号： H02M3/145 ,  H02J17/00 ,  H02J50/12 ,  H02M7/5383 ,  H02M2003/1557 ,  H03F3/2176

摘要： A high voltage resonant step-up convertor converts a lower voltage signal to a higher voltage signal. The converter may be used, for example, to supply power via electromagnetic coupling to an implantable medical device. In some embodiments, a power converter comprises a driver circuit and a resonant circuit. The resonant circuit generates a high voltage output signal at a selected frequency. The driver circuit is controlled by a low voltage signal and periodically generates a higher frequency signal (e.g., approximately twice the selected frequency) to drive the resonant circuit. In some embodiments, the driver circuit comprises another resonant circuit and a switching circuit. The switching circuit periodically pumps current to the other resonant circuit and isolates the two resonant circuits. The other resonant circuit periodically pumps current to the output resonant circuit.

摘要翻译： 高压谐振升压转换器将较低电压信号转换为较高电压信号。 转换器可以用于例如通过电磁耦合向可植入医疗装置供电。 在一些实施例中，功率转换器包括驱动器电路和谐振电路。 谐振电路以选定的频率产生高电压输出信号。 驱动器电路由低电压信号控制，并且周期性地产生较高频率信号（例如，大约是所选频率的两倍）以驱动谐振电路。 在一些实施例中，驱动器电路包括另一个谐振电路和开关电路。 开关电路周期性地将电流泵送到另一个谐振电路并隔离两个谐振电路。 另一个谐振电路周期性地将电流泵送到输出谐振电路。

公开(公告)号：US08391980B2

公开(公告)日：2013-03-05

申请号：US12498982

申请日：2009-07-07

申请人： Gene A. Bornzin ,  John W. Poore ,  Richard Williamson ,  Gabriel A. Mouchawar ,  Eric S. Fain

发明人： Gene A. Bornzin ,  John W. Poore ,  Richard Williamson ,  Gabriel A. Mouchawar ,  Eric S. Fain

IPC分类号： A61N1/00

CPC分类号： A61N1/3706 ,  A61N1/37 ,  A61N1/371 ,  A61N2001/083 ,  G01R31/026

摘要： A method for detecting potential failures by a lead of an implantable medical device is provided. The method includes sensing a first signal over a first channel between a first combination of electrodes on the lead and sensing a second signal from a second channel between a second combination of electrodes on the lead. The method determines whether at least one of the first and second signals is representative of a potential failure in the lead and identifies a failure and the electrode associated with the failure based on which of the first and second sensed signals is representative of the potential failure. Optionally, when the first and second sensed signals are both representative of the potential failure, the method further includes determining whether the first and second sensed signals are correlated with one another. When the first and second sensed signals are correlated, the method declares an electrode common to both of the first and second combinations to be associated with the failure.

摘要翻译： 提供了一种用于检测可植入医疗装置的引线的潜在故障的方法。 该方法包括在引线上的第一电极组合之间的第一通道上感测第一信号，并且感测来自引线上的第二电极组合之间的第二通道的第二信号。 该方法基于第一和第二感测信号中的哪一个代表潜在故障，确定第一和第二信号中的至少一个是否代表引线中的潜在故障，并且识别故障和与故障相关联的电极。 可选地，当第一和第二感测信号都代表潜在故障时，该方法还包括确定第一和第二感测信号是否彼此相关。 当第一和第二感测信号相关时，该方法声明与故障相关联的第一和第二组合两者共同的电极。

公开(公告)号：US08175668B1

公开(公告)日：2012-05-08

申请号：US11877056

申请日：2007-10-23

申请人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Taraneh Ghaffari Farazi ,  John W. Poore

发明人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Taraneh Ghaffari Farazi ,  John W. Poore

IPC分类号： A61B5/1455

CPC分类号： A61B5/14552 ,  A61B5/1459 ,  A61N1/36557

摘要： An intravenous implantable optical sensor assesses the relative absorbance of multiple wavelengths of light in order to determine oxygen saturation. The calculation of oxygen saturation is enhanced by use of a function of hematocrit which is derived from the relative absorbance of light of an isobestic wavelength along two different length paths through the blood. The use of the hematocrit-dependent term and multiple wavelengths of light to calculate oxygen saturation provides results that are less susceptible to noise and variation in hematocrit and thus provides a more accurate measure of oxygen saturation over a wider range of conditions than previously possible. The optical sensor may form part of an implantable system which performs the calculation of oxygen saturation and uses the results for a diagnostic or therapeutic purpose.

摘要翻译： 静脉注射光学传感器评估多个波长的光的相对吸光度以确定氧饱和度。 通过使用血细胞比容的功能来提高氧饱和度的计算，血细胞比容的功能来源于通过血液的两条不同长度路径的异质波长的光的相对吸光度。 使用血细胞比容相关术语和多个波长的光来计算氧饱和度提供的结果不太容易受噪声和血细胞比容的变化，因此在比以前可能的更宽的条件下提供更准确的氧饱和度测量。 光学传感器可以形成可执行氧饱和度的计算的可植入系统的一部分，并将结果用于诊断或治疗目的。

公开(公告)号：US20110098546A1

公开(公告)日：2011-04-28

申请号：US12976493

申请日：2010-12-22

申请人： Taraneh Ghaffari Farazi ,  Gene A. Bornzin ,  Yelena Nabutovsky ,  Kyungmoo Ryu ,  Keith Victorine ,  Xiaoyi Min ,  John W. Poore

发明人： Taraneh Ghaffari Farazi ,  Gene A. Bornzin ,  Yelena Nabutovsky ,  Kyungmoo Ryu ,  Keith Victorine ,  Xiaoyi Min ,  John W. Poore

IPC分类号： A61B5/1459

CPC分类号： A61B5/1459 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/029 ,  A61B5/04001 ,  A61B5/0464 ,  A61B5/0816 ,  A61B5/14535 ,  A61B5/14539 ,  A61B5/7285 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36585

摘要： Methods for assessing, diagnosing and treating medical conditions using SvO2 and hematocrit measurements alone, or in combination with other measurements related to cardiac activity are provided. These includes methods for distinguishing true anemia from diluted anemia, methods for anemia detection, methods for measuring disease progression based on anemia trending, methods for managing therapy delivery, methods for managing heart failure drug therapies, methods for cardiac output optimization based on SvO2, methods for cardiac resynchronization therapy lead placement, method for detection of heart failure decompensation, and methods to monitor and treat systolic versus diastolic heart failure are provided.

摘要翻译： 提供了使用SvO2和血细胞比容测量单独评估，诊断和治疗医疗条件或与心脏活动相关的其他测量结合的方法。 这些包括区分真正贫血与稀释性贫血的方法，贫血检测方法，基于贫血趋势测量疾病进展的方法，管理治疗递送的方法，管理心力衰竭药物治疗的方法，基于SvO2的心输出优化方法 用于心脏再同步治疗铅放置，心脏失代偿失代偿检测方法以及监测和治疗心脏收缩期与舒张性心力衰竭的方法。

公开(公告)号：US20110009918A1

公开(公告)日：2011-01-13

申请号：US12498982

申请日：2009-07-07

申请人： Gene A. Bornzin ,  John W. Poore ,  Richard Williamson ,  Gabriel A. Mouchawar ,  Eric S. Fain

发明人： Gene A. Bornzin ,  John W. Poore ,  Richard Williamson ,  Gabriel A. Mouchawar ,  Eric S. Fain

IPC分类号： A61N1/37

CPC分类号： A61N1/3706 ,  A61N1/37 ,  A61N1/371 ,  A61N2001/083 ,  G01R31/026

摘要： A method for detecting potential failures by a lead of an implantable medical device is provided. The method includes sensing a first signal over a first channel between a first combination of electrodes on the lead and sensing a second signal from a second channel between a second combination of electrodes on the lead. The method determines whether at least one of the first and second signals is representative of a potential failure in the lead and identifies a failure and the electrode associated with the failure based on which of the first and second sensed signals is representative of the potential failure. Optionally, when the first and second sensed signals are both representative of the potential failure, the method further includes determining whether the first and second sensed signals are correlated with one another. When the first and second sensed signals are correlated, the method declares an electrode common to both of the first and second combinations to be associated with the failure.

摘要翻译： 提供了一种用于检测可植入医疗装置的引线的潜在故障的方法。 该方法包括在引线上的第一电极组合之间的第一通道上感测第一信号，并且感测来自引线上的第二电极组合之间的第二通道的第二信号。 该方法基于第一和第二感测信号中的哪一个代表潜在故障，确定第一和第二信号中的至少一个是否代表引线中的潜在故障，并且识别故障和与故障相关联的电极。 可选地，当第一和第二感测信号都代表潜在故障时，该方法还包括确定第一和第二感测信号是否彼此相关。 当第一和第二感测信号相关时，该方法声明与故障相关联的第一和第二组合两者共同的电极。

公开(公告)号：US07797059B1

公开(公告)日：2010-09-14

申请号：US11560297

申请日：2006-11-15

申请人： Gene A. Bornzin ,  Yougandh Chitre ,  John W. Poore

发明人： Gene A. Bornzin ,  Yougandh Chitre ,  John W. Poore

IPC分类号： A61N1/05

CPC分类号： A61N1/0587

摘要： A system for pericardial lead implantation is disclosed herein. The system includes an implantation tool and a stimulation lead. The implantation tool includes a tubular body, a first lumen, a second lumen, a stylet or guidewire, a first port, and a second port. The first and second lumens longitudinally extend through tubular body. The first port is in communication with the first lumen, and the second port is in communication with the second lumen. The stylet or guidewire is longitudinally displaceable in the first lumen and across the first port. A tissue adhesive is selectively administrable through the second port via the second lumen. The stimulation lead includes a distal end and an engagement feature. Placing the engagement feature in the first port and causing the stylet or guidewire to displace in a first direction across the first port causes the lead to attach to the implantation tool. Displacing the stylet or guidewire in a second direction opposite the first direction allows the lead to detach from the implantation tool.

摘要翻译： 本文公开了用于心包线植入的系统。 该系统包括植入工具和刺激引线。 植入工具包括管状体，第一腔，第二腔，探针或导丝，第一端口和第二端口。 第一和第二管腔纵向延伸穿过管状体。 第一端口与第一管腔连通，第二端口与第二管腔连通。 探针或导丝可在第一管腔中纵向移动并穿过第一端口。 组织粘合剂可经由第二内腔通过第二端口选择性地施用。 刺激引线包括远端和接合特征。 将接合特征放置在第一端口中并且导致探针或导丝沿第一方向跨越第一端口移位导致引线附着到植入工具。 在与第一方向相反的第二方向上置换探针或导丝允许引线从植入工具脱离。

公开(公告)号：US07536227B1

公开(公告)日：2009-05-19

申请号：US11045626

申请日：2005-01-26

申请人： John W. Poore ,  Gene A. Bornzin

发明人： John W. Poore ,  Gene A. Bornzin

IPC分类号： A61N1/05 ,  A61N5/04

CPC分类号： A61N1/0556 ,  A61B5/04001 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/6885 ,  A61B2562/182

摘要： A shielded electrode assembly for nerve sensing is disclosed. The electrode assembly is a flexible and generally tubular structure that can be wrapped around and secured to the outer surface of a nerve so as to establish and maintain electrical contact therewith. The assembly includes an electrically conductive shield with conductive reference electrodes positioned at opposite ends thereof to define an isopotential reference. A sense electrode is placed within the isopotential reference and senses signals either with respect to the isopotential reference or to a sense reference electrode also positioned within the isopotential reference to a sensing device. The isopotential reference provides a region along which nerve activity propagating along the nerve can be sensed with a large attenuation of any external noise which may be present adjacent the sensing region of the nerve. The shielded electrode assembly facilitates direct, long-term nerve sensing with reduced need for filtering or signal processing.

摘要翻译： 公开了一种用于神经感测的屏蔽电极组件。 电极组件是柔性且通常为管状的结构，其可以缠绕并固定到神经的外表面，以便建立并保持与其的电接触。 该组件包括导电屏蔽，导电参考电极位于其相对端，以限定等电位参考。 感测电极放置在等电位参考中，并且相对于等电位参考信号或感测参考电极也感测信号，该感测参考电极也位于感测装置的等位基准之内。 等势参考提供了沿着神经活动传播的神经活动可以被感测到的区域，其中可能存在与神经感觉区域相邻的任何外部噪声的大衰减。 屏蔽电极组件有助于直接，长期的神经感测，减少对滤波或信号处理的需要。

公开(公告)号：US07418868B1

公开(公告)日：2008-09-02

申请号：US11359952

申请日：2006-02-21

申请人： Annapurna Karicherla ,  Sheldon Williams ,  Gene A. Bornzin ,  John W. Poore ,  Dion F. Davis

发明人： Annapurna Karicherla ,  Sheldon Williams ,  Gene A. Bornzin ,  John W. Poore ,  Dion F. Davis

IPC分类号： G01L7/00

CPC分类号： G01L19/142 ,  G01L19/0046 ,  G01L19/0061 ,  G01L19/0645

摘要： A body fluid pressure sensor module according to the invention comprises a housing having a first end and a second end and enclosing a pressure sensor. The pressure sensor is electrically coupled to a plurality of electrical conductors extending into the housing through a feedthrough disposed within, and hermetically sealing, the first end of the housing. The housing defines a chamber disposed between the feedthrough and the second end of the housing. The chamber contains a material in communication with the pressure sensor, the material being capable of transmitting pressure variations to the pressure sensor. The plurality of electrical conductors have ends within the housing, and the pressure sensor is mounted on the end of at least one of the conductors. Also disclosed are medical leads incorporating the pressure sensor module, and methods for fabricating the modules. The pressure sensor module is compact, and particularly so where cable conductors are utilized and the sensor is directly mounted on at least one of the cable conductors. The compactness of a pressure sensor module pursuant to the invention facilitates its incorporation into a small diameter, flexible medical lead enhancing its placement within a patient's body, for example, within the left atrium of the heart.

摘要翻译： 根据本发明的体液压力传感器模块包括具有第一端和第二端并且包围压力传感器的壳体。 压力传感器电耦合到通过设置在壳体的第一端内并且密封地密封壳体中的馈通部延伸到壳体中的多个电导体。 壳体限定设置在馈通和壳体的第二端之间的室。 该室包含与压力传感器连通的材料，该材料能够将压力变化传递到压力传感器。 多个电导体具有在壳体内的端部，并且压力传感器安装在至少一个导体的端部上。 还公开了结合压力传感器模块的医疗引线以及用于制造模块的方法。 压力传感器模块是紧凑的，特别是在使用电缆导体并且传感器直接安装在至少一个电缆导体上的情况下。 根据本发明的压力传感器模块的紧凑性便于其结合到小直径的柔性医疗引线中，从而增强其在患者身体内的放置，例如在心脏的左心房内。

公开(公告)号：US07294108B1

公开(公告)日：2007-11-13

申请号：US11046270

申请日：2005-01-27

申请人： Gene A. Bornzin ,  John W. Poore

发明人： Gene A. Bornzin ,  John W. Poore

IPC分类号： A61B5/00

CPC分类号： A61B5/042 ,  G06F19/00

摘要： A cardiac event microrecorder comprising a hermetically sealed housing is shaped and dimensioned to facilitate the subcutaneous implantation of the microrecorder in a human patient by injection through the lumen of a hypodermic needle. The housing comprises a tubular central section of an electrically insulating material, the central section having spaced apart extremities. An electrically conductive sense electrode is secured to and seals each extremity. The housing may have an interior enclosing (1) electrical circuitry for processing, storing and telemetering data representing physiologic information detected by the sense electrodes; (2) a primary cell or rechargeable battery for electrically powering the electrical circuitry; and (3) an inductively couplable charger where a rechargeable battery is used. Also disclosed are a method of subcutaneously implanting a cardiac event recorder in a patient's thoracic region, and a handheld mapping device for determining an optimum location and orientation for the cardiac event microrecorder to be implanted.

摘要翻译： 包括密封壳体的心脏事件微量记录器的形状和尺寸被设计成便于通过注射通过皮下注射针管的内腔将微量记录器皮下植入人类患者。 壳体包括电绝缘材料的管状中心部分，中心部分具有间隔开的末端。 导电感测电极固定到每个末端并密封。 壳体可以具有内部封闭（1）电路，用于处理，存储和遥测表示由感测电极检测的生理信息的数据; （2）用于为电路供电的主电池或可再充电电池; 和（3）使用可充电电池的感应式可耦合充电器。 还公开了一种在患者胸部区域皮下植入心脏事件记录器的方法，以及用于确定要植入的心脏事件微距离记录器的最佳位置和方向的手持式测绘装置。

公开(公告)号：US07103414B1

公开(公告)日：2006-09-05

申请号：US10829907

申请日：2004-04-21

申请人： John W. Poore ,  Eric Falkenberg ,  Gene A. Bornzin

发明人： John W. Poore ,  Eric Falkenberg ,  Gene A. Bornzin

IPC分类号： A61N1/18 ,  A61N1/372

CPC分类号： A61N1/37235

摘要： A combined programming wand and PSA for physician programmers. A programmer/PSA wand can be connected to known programmers and PSA application software can be installed on the programmer to provide a system with the functionality of a PSA and a programmer in a single piece of clinical equipment. The programmer/PSA wand includes electronics to sense, pace, and shock to facilitate evaluation of indwelling leads during implantation of the implantable device and leads to facilitate programming of the device. The system includes one or more displays and control inputs that can provide information to a clinician at a single point that is typically provided with separate programmer and PSA equipment. The system provides increased efficiency, reduced opportunities for errors and/or equipment malfunction, and integrated data collection.

摘要翻译： 用于医师程序员的组合编程棒和PSA。 程序员/ PSA棒可以连接到已知的程序员，PSA应用软件可以安装在程序员上，以便在单个临床设备中为系统提供PSA和程序员的功能。 编程器/ PSA棒包括用于感测，速度和冲击的电子装置，以便在植入可植入装置期间评估留置线，并且促进装置的编程。 该系统包括一个或多个显示器和控制输入，其可以在通常具有单独的编程器和PSA设备的单个点向临床医生提供信息。 该系统提供更高的效率，减少错误和/或设备故障的机会以及集成的数据收集。