公开(公告)号：US20220409895A1

公开(公告)日：2022-12-29

申请号：US17872432

申请日：2022-07-25

Applicant: Galvani Bioelectronics Limited

Inventor： Margarita J. Vervoordeldonk ,  Eric Irwin ,  Daniel John Chew ,  Matteo Donega ,  Cindy Cleypool ,  Isha Gupta

IPC: A61N1/36 ,  A61N1/05

Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.

公开(公告)号：US20220409887A1

公开(公告)日：2022-12-29

申请号：US17619205

申请日：2020-06-17

Applicant: Galvani Bioelectronics Limited

Inventor： Isha Gupta ,  Matteo Donega

IPC: A61N1/05 ,  A61N1/36

Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is associated with a neurovascular bundle, can re-programme immune cells in the spleen, modulate pro- and anti-inflammatory molecules levels, and induce disease-resolution pathways system-ically thereby reducing inflammation and providing ways of treating inflammatory disorders. The invention provides improved ways of treating inflammatory disorders which minimize off-target effects.

公开(公告)号：US20220241590A1

公开(公告)日：2022-08-04

申请号：US17619223

申请日：2020-06-17

Applicant: Galvani Bioelectronics Limited

Inventor： Isha Gupta ,  Matteo Donega

IPC: A61N1/36 ,  A61N1/05

Abstract: Modulation of the neural activity of a nerve adjacent to the left gastro epiploic artery (LGEA) and/or a nerve adjacent to a short gastric artery (SGA) can modulate the neural activity of the sympathetic nerves that impact splenic function. This is useful for reducing inflammation and providing ways of treating inflammatory disorders.

公开(公告)号：US11331501B2

公开(公告)日：2022-05-17

申请号：US16446681

申请日：2019-06-20

Applicant: Greatbatch Ltd. ,  Galvani Bioelectronics Limited

Inventor： Ignacio A. Armesto ,  Luis Daniel Villamil ,  Refet Firat Yazicioglu ,  Kristina Schlegel ,  Kent Leyde

IPC: A61N1/37 ,  A61N1/375 ,  A61N1/05

Abstract: A device that is implantable in body tissue of a human or animal. The device is comprised of a header comprising at least one terminal adapted for removable connection to a lead and an open ended case closed by a plate to form a housing. The housing is comprised of a surrounding edge wall joined to a first side wall and a second side wall opposed to the first side wall. At least a first suture port extends through the edge wall and the second side wall but not the first side wall at an upper edge region of the housing. A second suture port may extend through the surrounding edge wall and the second side wall but not the first side wall in a similar manner. A third suture port may extend through the header. The three suture ports may define a triangular attachment configuration.

公开(公告)号：US20210138238A1

公开(公告)日：2021-05-13

申请号：US16622679

申请日：2018-06-22

Applicant: GALVANI BIOELECTRONICS LIMITED ,  UCL BUSINESS LTD

Inventor： David Holder ,  Kirill ARISTOVICH ,  Daniel CHEW ,  Matteo DONEGA

IPC: A61N1/05 ,  A61N1/36

Abstract: There is provided a nerve interface device including (1, 3) comprising: at least one cuff portion; and a first pair of electrodes mounted on the at least one cuff portion. The cuff portion has an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a cuff axis passing through the passageway. The electrodes of the first pair are spaced apart from one another in the direction of the cuff axis.

公开(公告)号：US20200368531A1

公开(公告)日：2020-11-26

申请号：US16634252

申请日：2018-07-27

Applicant: GALVANI BIOELECTRONICS LIMITED ,  UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Arun SRIDHAR ,  Andrew C WEITZ ,  Victor Eugene PIKOV ,  Alessandra GIAROLA ,  Mark HUMAYUN

IPC: A61N1/36 ,  A61N1/05

Abstract: Modulation of neural signaling of an eye-related sympathetic nerve can decrease the levels of pro-inflammatory cytokines in the eye, and this provides a way of treating eye disorders, such as ocular neovascular diseases.

公开(公告)号：US20190262613A1

公开(公告)日：2019-08-29

申请号：US16348924

申请日：2017-11-10

Applicant: Galvani Bioelectronics Limited ,  Tokyo Metropolitan Institute of Gerontology

Inventor： Hans Jakob Kristoffer FAMM ,  Harumi HOTTA ,  Arun SRIDHAR

IPC: A61N1/36 ,  A61N5/06 ,  A61N7/02 ,  A61N1/05

Abstract: Modulation of neural activity in the superior laryngeal nerve (SLN) or cervical sympathetic trunk (CST) is effective in treating diseases and conditions mediated by thyroid and parathyroid hormones, in particular diseases associated with calcitonin secretion (e.g. osteoporosis) or diseases associated with thyroxine secretion (e.g. hypothyroid syndrome).

公开(公告)号：US20180117319A1

公开(公告)日：2018-05-03

申请号：US15568964

申请日：2016-04-22

Applicant: GALVANI BIOELECTRONICS LIMITED ,  ACADEMISCH MEDISCH CENTRUM

Inventor： Daniel John CHEW ,  Wouter Jacob DE JONGE ,  Hans Jakob Kristoffer FAMM ,  Sonal PATEL ,  Olaf WELTING

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/3606 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36007 ,  A61N1/3605 ,  A61N1/36135

Abstract: The invention provides devices, apparatuses, systems and methods for treating and ameliorating inflammation of the gut. In particular, the invention provides devices, apparatuses and methods in which a neuromodulatory signal is delivered a splenic nerve and/or superior mesenteric plexus (SMP). The signal is able to treat inflammatory disorders, e.g., colitis, for example in Inflammatory Bowel Disease.

公开(公告)号：US20180043155A1

公开(公告)日：2018-02-15

申请号：US15551592

申请日：2016-02-19

Applicant: GALVANI BIOELECTRONICS LIMITED ,  HUNTINGTON MEDICAL RESEARCH INSTITUTES ,  UNIVERSITY OF CHILI

Inventor： Hans Jakob Kristoffer FAMM ,  Hernan E. LARA ,  Victor Eugene PIKOV ,  Arun SRIDHAR

IPC: A61N1/36 ,  A61F7/12 ,  A61N5/06 ,  A61N7/00 ,  A61N1/05 ,  A61N1/20

CPC classification number: A61N1/3606 ,  A61F7/12 ,  A61F2007/126 ,  A61N1/0551 ,  A61N1/20 ,  A61N1/36007 ,  A61N1/36135 ,  A61N5/0622 ,  A61N7/00 ,  A61N2005/063 ,  A61N2007/0026

Abstract: The present invention relates to medical devices and, more particularly, to medical devices that deliver neuromodulating therapy.

公开(公告)号：US20250099762A1

公开(公告)日：2025-03-27

申请号：US18924183

申请日：2024-10-23

Applicant: Galvani Bioelectronics Limited

Inventor： Gerald Edwin Hunsberger ,  Arun Sridhar

IPC: A61N1/36 ,  A61N1/05

Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.