公开(公告)号：US20040204736A1

公开(公告)日：2004-10-14

申请号：US10411087

申请日：2003-04-11

申请人： Medtronic AVE, Inc.

发明人： Noel Coyle ,  Patrick Duane

IPC分类号： A61M029/00

CPC分类号： A61M25/0172 ,  A61M25/0169 ,  A61M25/104 ,  A61M2025/0177 ,  A61M2025/0183 ,  A61M2029/025

摘要： A balloon catheter includes an inflation shaft and an elongated guidewire shaft. A relatively short, distal portion of the guidewire shaft is attached to, or enveloped within, a distal portion of the inflation shaft. A proximal portion of the guidewire shaft is detached from and independent of a proximal portion of the inflation shaft. The detached portion of the guidewire shaft contains perforations at pre-determined points along its length that define removable segments thereof. The removable segments remain attached to the guidewire shaft under normal conditions, but may be torn away from the guidewire shaft to provide access to a guidewire within a guidewire lumen thereof.

摘要翻译： 球囊导管包括充气轴和细长的导丝轴。 导丝轴的相对较短的远端部分附接到膨胀轴的远端部分或者包围在膨胀轴的远侧部分内。 导丝轴的近端部分与膨胀轴的近端部分分离并独立于膨胀轴的近端部分。 导丝轴的分离部分沿着其长度的预定点处包含穿孔，其限定其可拆卸部分。 可移动部分在正常条件下保持连接到导丝轴，但是可以从导丝线轴撕开以提供对其导丝管腔内的导丝的接近。

公开(公告)号：US20040176790A1

公开(公告)日：2004-09-09

申请号：US10376288

申请日：2003-03-03

申请人： Medtronic AVE, Inc.

发明人： James Alexus Coyle

IPC分类号： A61M029/00

CPC分类号： A61M25/0032 ,  A61M25/0023 ,  A61M25/104 ,  A61M2025/107

摘要： A balloon catheter includes a one-piece shaft and a guidewire track for use of a guidewire that runs along an outer surface of the one-piece shaft adjacent to a longitudinal central axis of the one-piece shaft. The one-piece shaft has an inflation lumen formed therein. The one-piece shaft is formed to include a substantially C-shaped cross section, which has two endpoints and forms the guidewire track. The dimensions of the wall thicknesses between the inflation lumen and the guidewire track may be varied to help maintain the guidewire track and the gap between the endpoints of the C-shaped cross section such that a guidewire is maintained on the guidewire track and does not traverse the gap. In addition, a reinforcement may be included in the single lumen shaft to maintain the integrity of the guidewire track.

摘要翻译： 气囊导管包括单件轴和导丝轨道，用于沿着一体式轴的外表面延伸的导丝，该导丝与单件轴的纵向中心轴线相邻。 一体式轴具有形成在其中的充气腔。 单件轴形成为包括基本上C形的横截面，其具有两个端点并形成导丝轨道。 膨胀腔和导丝轨道之间的壁厚的尺寸可以变化以帮助维持导丝轨道和C形横截面的端点之间的间隙，使得导丝保持在导丝轨道上并且不穿过 差距。 此外，可以在单腔轴中包括加强件以保持导丝轨道的完整性。

公开(公告)号：US20030187498A1

公开(公告)日：2003-10-02

申请号：US10107473

申请日：2002-03-28

申请人： Medtronic AVE, Inc.

发明人： Gordon B. Bishop

IPC分类号： A61F002/06

CPC分类号： A61F2/86 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/3011 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2220/0008 ,  A61F2220/0058 ,  A61F2230/0002

摘要： A prosthesis for implantation in a blood vessel includes struts with a cross-section having a flat base with angled edges on the inner surface and chamfered edges on the outer or exterior surface. The base angled edge is substantially a right angle, while the outer or exterior surface has edges that are chamfered with either round or angled chamfers. The chamfers could be manufactured by either machining the chamfer into the stock material, or by tumbling the stent in a tumbler to abrasively wear the edges to form a chamfer.

摘要翻译： 用于植入血管的假体包括具有平坦基部的横截面的支柱，在内表面上具有成角度的边缘并且在外表面或外表面上具有倒角边缘。 基本成角度的边缘基本上是直角，而外表面或外表面具有用圆形或斜角倒角倒角的边缘。 倒角可以通过将倒角加工到原料中，或者通过在转筒中翻转支架以磨擦边缘以形成倒角来制造。

公开(公告)号：US20030012340A1

公开(公告)日：2003-01-16

申请号：US09905267

申请日：2001-07-13

申请人： Medtronic AVE, Inc.

发明人： Victor Chornenky

IPC分类号： H01J035/32

CPC分类号： A61N5/1001 ,  H05G1/46

摘要： An x-ray emitting system and method for administering a predetermined x-ray dose rate are provided. The system includes an x-ray emitter, a controller operably connected to the x-ray emitter, a current sensor operably connected to the controller, and a voltage sensor operably connected to the controller. The controller determines an actual dose rate based on a received current sensor signal and a received voltage sensor signal and adjusts a supplied voltage to allow the actual dose rate to match a predetermined dose rate. The method of operating a device for emitting x-rays includes: applying a voltage from a voltage source to the device, measuring current and voltage within the device, determining an actual dose rate based on the measured current and voltage, comparing a desired dose rate to the actual dose rate, adjusting the applied voltage, and matching the actual dose rate to the desired dose rate.

摘要翻译： 提供了用于施用预定x射线剂量率的x射线发射系统和方法。 该系统包括x射线发射器，可操作地连接到x射线发射器的控制器，可操作地连接到控制器的电流传感器和可操作地连接到控制器的电压传感器。 控制器基于接收到的电流传感器信号和接收到的电压传感器信号来确定实际剂量率，并且调整所提供的电压以允许实际剂量率与预定剂量率匹配。 操作用于发射x射线的装置的方法包括：将来自电压源的电压施加到装置，测量装置内的电流和电压，基于测量的电流和电压确定实际剂量率，将期望的剂量率 到实际剂量率，调整施加的电压，并将实际剂量率与期望的剂量率相匹配。

公开(公告)号：US20030012339A1

公开(公告)日：2003-01-16

申请号：US09902659

申请日：2001-07-12

申请人： Medtronic AVE, Inc

发明人： Graham S. Kerslick ,  Victor I Chornenky ,  Ali Jaafar

IPC分类号： H05H001/00 ,  G21G004/00 ,  H01J035/00

CPC分类号： A61N5/1001 ,  A61N5/1002 ,  H01J35/32 ,  H01J2235/062 ,  H01J2235/164

摘要： A cathode for a miniature X-ray device includes an insulating shell, a cathode and an anode. The cathode includes a focusing cup formed into an end. The focusing cup can include a thin metal layer that conforms to an inner surface of the cathode. An emitting material having a low work function, such as diamond, is deposited directly onto the internal surface of the focusing cup. The anode has a flat receiving surface for collecting electrons emitted from the anode. An interior coating is applied as a circumferential belt on the interior surface of the insulating shell. The interior coating, formed of a negative secondary emission yield material, extends lengthwise in the region of the cathode to an anode gap, covering the region of the insulating shell most likely to be subject to stray electrons emitted from the cathode.

摘要翻译： 用于微型X射线装置的阴极包括绝缘壳，阴极和阳极。 阴极包括形成在一端的聚焦杯。 聚焦杯可以包括符合阴极内表面的薄金属层。 具有低功函数的发射材料（例如金刚石）直接沉积在聚焦杯的内表面上。 阳极具有用于收集从阳极发射的电子的平坦的接收表面。 内部涂层作为周向带施加在绝缘壳体的内表面上。 由负二次发射产生材料形成的内部涂层在阴极的区域中纵向延伸到阳极间隙，覆盖最可能经受从阴极发射的杂散电子的绝缘壳体的区域。

公开(公告)号：US6160032A

公开(公告)日：2000-12-12

申请号：US163240

申请日：1998-09-30

申请人： Chirag B. Shah ,  John A. Hudson ,  Eugene Tedeschi

发明人： Chirag B. Shah ,  John A. Hudson ,  Eugene Tedeschi

IPC分类号： A61L29/08 ,  C08G18/64 ,  C08G18/80 ,  C09D5/00 ,  C09D175/00 ,  A01N1/00

CPC分类号： C09D175/00 ,  A61L29/085 ,  C08G18/6484 ,  C08G18/8061 ,  C09D5/00 ,  Y10S623/926 ,  Y10T428/31551 ,  C08L5/08

摘要： A coating composition is provided comprising hyaluronic acid or a salt thereof and a blocked polyisocyanate in a solvent comprising water. A method is provided for preparing the coating on a substrate comprising forming a coating mixture of hyaluronic acid or a salt thereof and a blocked polyisocyanate in a solvent comprising water; applying the coating mixture to the substrate; and curing the coating.

摘要翻译： 在包含水的溶剂中提供包含透明质酸或其盐和封端多异氰酸酯的涂料组合物。 提供了一种在基材上制备涂层的方法，包括在包含水的溶剂中形成透明质酸或其盐和封端多异氰酸酯的涂层混合物; 将涂料混合物施加到基材上; 并固化涂层。

公开(公告)号：US6159229A

公开(公告)日：2000-12-12

申请号：US189743

申请日：1998-11-10

申请人： Bradly A. Jendersee ,  Robert D. Lashinski

发明人： Bradly A. Jendersee ,  Robert D. Lashinski

IPC分类号： A61F2/82 ,  A61F2/06 ,  A61F2/84 ,  A61M29/00

CPC分类号： A61F2/958 ,  A61F2002/9583

摘要： A encapsulated stent device for implantation within the vascular system includes a balloon of a balloon catheter formed around and adhered to a wire-like stent so that the outer surface of the device is more regular for delivery through the vascular system without an exterior sheath. The encapsulation securely anchors the stent to the balloon and maintains a low profile for negotiation of tortuous and narrowed vessels. Encapsulation requires placement of the stent over the balloon, placement of a sheath over the stent on the balloon, heating and preferably pressurization of the balloon to cause it to expand around the stent within the sheath, and cooling while preferably maintaining pressure to cause the balloon to adhere to the stent and to set the shape of the expanded balloon. Retainers may be placed at the distal and/or proximal ends of the stent during the encapsulation process, or the balloon material may expand to form retainers. The balloon defines at least three folded wings for symmetrical expansion of the stent, and one or more connected or non-connected stents may be encapsulated depending upon the area to be treated.

摘要翻译： 用于植入血管系统中的胶囊化支架装置包括气囊导管的球囊，其围绕并附着到线状支架上，使得该装置的外表面更规则地用于通过血管系统输送而无外部护套。 封装将支架固定在气囊上，并保持低调，用于谈判曲折和变窄的血管。 封装需要将支架放置在气囊上，将护套放置在球囊上的支架上，加热并优选地对气囊进行加压以使其在护套内围绕支架扩张，并且冷却，同时优选保持压力以引起气囊 粘附到支架上并设定膨胀气囊的形状。 保持器可以在包封过程期间放置在支架的远端和/或近端处，或者球囊材料可以膨胀以形成保持器。 气囊限定至少三个折叠的翼，用于支架的对称膨胀，并且根据待治疗的区域，可以封装一个或多个连接或未连接的支架。

公开(公告)号：US6129738A

公开(公告)日：2000-10-10

申请号：US100416

申请日：1998-06-20

申请人： Randall T. Lashinski ,  Philip J. Haarstad ,  Matthew J. Birdsall

发明人： Randall T. Lashinski ,  Philip J. Haarstad ,  Matthew J. Birdsall

IPC分类号： A61F2/06 ,  A61F2/86 ,  A61M29/02 ,  A61M29/00

CPC分类号： A61M25/104 ,  A61F2/954 ,  A61F2/958 ,  A61F2/86 ,  A61F2002/065 ,  A61M2025/1045 ,  A61M2025/1093

摘要： A method and apparatus for treating stenoses at bifurcated regions of body lumens is disclosed. A balloon catheter system is disclosed comprising two balloon catheters, or a balloon catheter having a bifurcated distal end, with a linking guide wire lumen at the distal end of one balloon catheter, or one branch of the bifurcated catheter, for linking the two balloons or branches such that the device can be tracked to a treatment site. Once at the treatment site, the balloon catheters or branches of the bifurcated distal end can be unlinked and separately positioned within the branches of the bifurcated body lumen. The apparatus can also serve as a delivery system for multiple prostheses or a bifurcated endoluminal prosthesis.

摘要翻译： 公开了一种用于在体腔的分叉区域处理狭窄的方法和装置。 公开了一种气囊导管系统，其包括两个球囊导管或具有分叉远端的球囊导管，其中一个球囊导管的远端处的连接导丝管腔或分叉导管的一个分支用于连接两个气囊或 分支，使得设备可以跟踪到治疗部位。 一旦在治疗部位，分叉的远端的气囊导管或分支可以被取消连接并且分开地定位在分叉的体腔的分支内。 该装置还可以用作多个假体或分叉的腔内假体的递送系统。

公开(公告)号：US6129708A

公开(公告)日：2000-10-10

申请号：US255732

申请日：1999-02-23

申请人： Christine D. Enger

发明人： Christine D. Enger

IPC分类号： A61M25/00 ,  A61M25/01 ,  A61M29/02 ,  A61M29/00

CPC分类号： A61M25/104 ,  A61M25/0054 ,  A61M2025/0183 ,  A61M2025/1079

摘要： A rapidly exchangeable catheter for use in the coronary arteries includes an elongate relatively stiff proximal segment that defines an inflation lumen, an intermediate, shorter segment formed from a more flexible plastic material and having two lumens, and a third, single lumen distal segment. A balloon or other instrumentality adapted to operate in a coronary artery is mounted to the distal region of the catheter. The intermediate and distal segments include a guidewire lumen by which the catheter may be advanced along a guidewire. The proximal segment may include an inflation lumen when the operating instrumentality at the distal end of the catheter is a balloon. The intermediate and distal segments of the catheter are of a length of between about 35 to 45 cm such that when the catheter is advanced into the most remote distal portions of the coronary anatomy, the flexible plastic intermediate and distal segments will extend over the aortic arch of the patient thereby containing the guidewire over the aortic arch and maintaining the juncture of the relatively stiff proximal segment and the more flexible intermediate segment proximally of the aortic arch. The relatively stiff proximal section thus extends generally along a straight line from the femoral artery into the descending aorta but not so far as into the aortic arch. Buckling of the catheter is avoided so that the catheter is more easily manipulated.

摘要翻译： 用于冠状动脉的可快速更换的导管包括细长的相对刚性的近端段，其限定充气腔，由更柔性的塑料材料形成并具有两个腔的中间较短区段，以及第三单腔远端区段。 适于在冠状动脉中操作的球囊或其它器械被安装到导管的远端区域。 中间部分和远端部分包括导丝管腔，导管可以沿着导丝线前进。 当导管远端的操作手段是气球时，近端段可以包括充气腔。 导管的中间部分和远端部分的长度为约35至45厘米，使得当导管进入冠状动脉解剖结构的最远端远端部分时，柔性塑料中间部分和远端部分将延伸超过主动脉弓 从而在主动脉弓上包含导丝，并且保持相对刚性的近端段的接合点和主动脉弓近端更柔韧的中间段。 相对刚性的近端部分大致沿着从股动脉到降主动脉的直线延伸，但不能延伸到主动脉弓。 避免导管的屈曲，使导管更容易操作。

公开(公告)号：US6108402A

公开(公告)日：2000-08-22

申请号：US8202

申请日：1998-01-16

申请人： Victor I. Chornenky

发明人： Victor I. Chornenky

IPC分类号： A61N5/10 ,  H01J35/06 ,  H01J35/16 ,  H01J35/32 ,  H61J35/32

CPC分类号： A61N5/1001 ,  H01J35/065 ,  H01J35/32

摘要： A device suitable for insertion into a body and for delivery of x-ray radiation, comprising a connector, a diamond vacuum housing coupled to a distal portion of the connector, an anode and cathode, disposed within the vacuum housing and arranged to enable the production of x-ray radiation. Also, a device suitable for insertion into a body and for delivery of x-ray radiation including a vacuum housing coupled to a distal portion of a connector where the vacuum housing has a diameter of less than 2.5 mm. A method of fabricating a miniature x-ray emitter by constructing a structure of diamond that defines a vacuum chamber and encases a cathode and an anode.

摘要翻译： 适于插入体内和用于X射线辐射传送的装置，包括连接器，联接到连接器的远端部分的金刚石真空壳体，阳极和阴极，设置在真空壳体内并且被布置成使得能够生产 的X射线辐射。 而且，适用于插入体内并用于输送x射线辐射的装置，包括联接到真空壳体的直径小于2.5mm的连接器的远端部分的真空壳体。 一种通过构造金刚石结构来制造微型X射线发射器的方法，所述金刚石的结构限定了真空室并且包住阴极和阳极。