公开(公告)号：US11903992B2

公开(公告)日：2024-02-20

申请号：US17650664

申请日：2022-02-10

申请人： Cellix Bio Private Limited

发明人： Mahesh Kandula

IPC分类号： A61K38/05 ,  A61K31/167 ,  A61K31/164 ,  A61K31/728 ,  A61K47/12 ,  A61K9/00 ,  A61K47/18 ,  A61K47/02 ,  A61K47/32 ,  A61K47/10 ,  A61K47/26

CPC分类号： A61K38/05 ,  A61K9/006 ,  A61K31/164 ,  A61K31/167 ,  A61K31/728 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/186 ,  A61K47/26 ,  A61K47/32

摘要： The present disclosure provides a composition comprising Lidocaine or salt or hydrate or solvate thereof, L-Carnosine or salt or hydrate or solvate thereof and dexpanthenol or salt or hydrate or solvate thereof. The composition may further comprise one or more other active agents. In an embodiment, the composition is formulated as an oral formulation. The compositions of the present disclosure may find utility in treatment of oral mucositis, ulcers, ulcer mediated pain and the like conditions. Aspects of the present disclosure also relates to method of treating oral, pharyngeal, oropharyngeal and esophageal diseases or conditions using the advantageous compositions of the present disclosure.

公开(公告)号：US20240050724A1

公开(公告)日：2024-02-15

申请号：US18088131

申请日：2022-12-23

申请人： Annadurai Dharmarajan

发明人： Annadurai Dharmarajan

IPC分类号： A61M35/00 ,  A61K31/045 ,  A61K31/125 ,  A61K31/618 ,  A61K31/522 ,  A61K31/455 ,  A61K33/14 ,  A61K33/00 ,  A61K31/4045 ,  A61K31/198 ,  A61K31/167

CPC分类号： A61M35/10 ,  A61K31/045 ,  A61K31/125 ,  A61K31/618 ,  A61K31/522 ,  A61K31/455 ,  A61K33/14 ,  A61K33/00 ,  A61K31/4045 ,  A61K31/198 ,  A61K31/167 ,  A61M2205/6081 ,  A61M2205/6063

摘要： The disclosure relates to a topical workout muscle recovery composition that includes a pain reliever, water for hydration, an amino acid and inorganic salts, method of use along with a adhesive bandage pod (Appod™). Muscle recovery and the pain often present after a workout are traditionally constituted treated by sitting into an ice bath and/or by taking nutritional supplements along with minerals as a drink or an energy bar by mouth or oral route. When taken orally, the supplements and minerals are provided to whole body, but during a workout, certain muscles will be used and go through fatigue and pain. The invention relates to topical workout muscle recovery compositions that includes a hands-free applicator along with Appod™ on to the skin that can be applied to specific part of the body and provide pain relief. In some embodiments, the amino acid and mineral supplement can be required for muscle recovery.

公开(公告)号：US20240050422A1

公开(公告)日：2024-02-15

申请号：US18379449

申请日：2023-10-12

申请人： GLYCOSBIO, INC.

发明人： Daniel J. MONTICELLO ,  Nathaniel Scott SCHOCKER ,  David Michael STEVENS

IPC分类号： A61K31/445 ,  A61K31/167 ,  A61K31/573 ,  A61K9/06 ,  A61K47/44

CPC分类号： A61K31/445 ,  A61K31/167 ,  A61K31/573 ,  A61K9/06 ,  A61K47/44

摘要： Compositions and methods for the preparation of nanoemulsion from oils are disclosure. These nanoemulsions can be produced without the addition of exogenous surfactants or emulsifiers and can be useful as carriers for active ingredients.

公开(公告)号：US20240050361A1

公开(公告)日：2024-02-15

申请号：US17885163

申请日：2022-08-10

申请人： Annadurai Dharmarajan

发明人： Annadurai Dharmarajan

IPC分类号： A61K9/00 ,  A61K9/70

CPC分类号： A61K9/0014 ,  A61K9/7092 ,  A61K31/167

摘要： The invention is directed to a method of treating one or more topical diseases and enhancing patient compliance using a topical drug delivery system, applicator, composition and adhesive bandage pod (APPOD™).

公开(公告)号：US20240041812A1

公开(公告)日：2024-02-08

申请号：US18235533

申请日：2023-08-18

申请人： SOCIÉTÉ DES PRODUITS NESTLÉ S.A. ,  BAYLOR COLLEGE OF MEDICINE

发明人： Stephen Kirnon ,  Eric Freedland ,  Rajagopal V. Sekhar

IPC分类号： A61K31/198 ,  A61K38/05 ,  A61K31/167 ,  A61K31/223 ,  A61K31/341 ,  A61K38/21 ,  A61K31/683 ,  A61K31/27 ,  A61K45/06 ,  A61K31/381 ,  A61K31/205 ,  A61P39/06 ,  A23K20/142 ,  A23K50/50 ,  A61P21/00 ,  A61P39/00 ,  A61P31/18 ,  A61P29/00 ,  A61K38/02

CPC分类号： A61K31/198 ,  A61K38/05 ,  A61K31/167 ,  A61K31/223 ,  A61K31/341 ,  A61K38/21 ,  A61K31/683 ,  A61K31/27 ,  A61K45/06 ,  A61K31/381 ,  A61K31/205 ,  A61P39/06 ,  A23K20/142 ,  A23K50/50 ,  A61P21/00 ,  A61P39/00 ,  A61P31/18 ,  A61P29/00 ,  A61K38/02

摘要： Compositions and methods are related to utilizing glycine and N-acetylcysteine for a variety of medical conditions related to reduced levels of glycine, N-acetylcysteine, and/or glutathione, for example, muscle loss such as sarcopenia, HIV infection and other infections, organ damage such as those from diabetes and insulin resistance and diabetic nephropathy, cardiac function and failure such as preventing or improving heart failure, fatty liver, cancer prevention, and other conditions.

公开(公告)号：US11890331B2

公开(公告)日：2024-02-06

申请号：US17394804

申请日：2021-08-05

申请人： Med Progress, LLC

发明人： Steve Yoelin

IPC分类号： A61K38/47 ,  A61K31/245 ,  A61K31/445 ,  A61K31/167 ,  A61K31/381 ,  A61K31/47 ,  A61K31/196 ,  A61K31/5375 ,  A61K31/46 ,  A61K9/00 ,  A61P27/02 ,  A61P9/10

CPC分类号： A61K38/47 ,  A61K9/0048 ,  A61K31/167 ,  A61K31/196 ,  A61K31/245 ,  A61K31/381 ,  A61K31/445 ,  A61K31/46 ,  A61K31/47 ,  A61K31/5375 ,  A61P9/10 ,  A61P27/02

摘要： The present disclosure discloses compositions comprising a hyaluronidase, devices comprising such compositions, as well as methods and uses employing such compositions and devices to reduce or eliminate a hyaluronic acid-induced blockage of one or more blood vessels supplying an eye of an individual; methods and uses for employing such compositions and devices to reduce or inhibit a vascular occlusion in an eye of an individual; and methods and uses for employing such compositions and devices to reduce or inhibit a hyaluronic acid-induced loss of vision of an individual.

公开(公告)号：US11883393B2

公开(公告)日：2024-01-30

申请号：US17126501

申请日：2020-12-18

申请人： Arvinas Operations, Inc.

发明人： Lawrence B. Snyder ,  Hanqing Dong

IPC分类号： A61K31/496 ,  A61K47/54 ,  A61K31/167 ,  A61K31/277 ,  A61K31/4523 ,  A61K31/4545 ,  C07D401/14 ,  A61K31/337 ,  A61K31/417 ,  A61K31/497 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/57 ,  A61K31/661 ,  A61K31/663 ,  A61K31/675 ,  A61K38/09 ,  C07D401/12 ,  A61K31/506 ,  C07D413/12 ,  C07D413/14 ,  C07D498/10

CPC分类号： A61K31/496 ,  A61K31/167 ,  A61K31/277 ,  A61K31/337 ,  A61K31/417 ,  A61K31/4523 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/57 ,  A61K31/661 ,  A61K31/663 ,  A61K31/675 ,  A61K38/09 ,  A61K47/545 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D413/14 ,  C07D498/10

摘要： This disclosure pertains to compounds, the preparation thereof, and the use of these compounds in the treatment of prostate cancer, including metastatic and/or castrate-resistant prostate cancer, in subjects in need thereof.

公开(公告)号：US20240024374A1

公开(公告)日：2024-01-25

申请号：US18327278

申请日：2023-06-01

申请人： Omeza Holdings, Inc.

发明人： Griscom BETTLE, III ,  John HARLIN ,  Thomas GARDNER

IPC分类号： A61K35/60 ,  A61K9/00 ,  A61K31/14 ,  A61K31/167 ,  A61K36/185 ,  A61K47/14 ,  A61K47/22 ,  A61K47/38 ,  A61K47/44

CPC分类号： A61K35/60 ,  A61K9/0014 ,  A61K31/14 ,  A61K31/167 ,  A61K47/44 ,  A61K47/14 ,  A61K47/22 ,  A61K47/38 ,  A61K36/185

摘要： Disclosed is a topical anhydrous, homogenous pharmaceutical composition for treating skin disorder and wounds comprising cod liver oil, hempseed oil, monolaurin, medium chain triglycerides (“MCT”), free fatty acids, sea salt, and vegetable oil selected from the group consisting of red palm concentrate, coconut oil, and red palm oil and combination thereof and optionally fish collagen, ascorbyl palmitate, thickening agent, such as beeswax, red palm concentrate and cetyl ester.

公开(公告)号：US20240024229A1

公开(公告)日：2024-01-25

申请号：US18188899

申请日：2023-03-23

申请人： Pearl Therapeutics, Inc.

发明人： Reinhard Vehring ,  Michael Steven Hartman ,  David Lechuga-Ballesteros ,  Adrian Edward Smith ,  Vidya B. Joshi ,  Sarvajna Kumar Dwivedi

IPC分类号： A61K9/00 ,  A61K31/167 ,  A61K45/06 ,  A61M15/00 ,  A61K31/40 ,  A61K9/12 ,  A61K31/138 ,  A61K31/46 ,  A61K31/56 ,  A61K31/58

CPC分类号： A61K9/008 ,  A61K31/167 ,  A61K45/06 ,  A61M15/0065 ,  A61K31/40 ,  A61K9/124 ,  A61K31/138 ,  A61K31/46 ,  A61K31/56 ,  A61K31/58

摘要： Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.

公开(公告)号：US20240016767A1

公开(公告)日：2024-01-18

申请号：US18355802

申请日：2023-07-20

申请人： Monash University

发明人： Johanna Elisabeth FRASER ,  David Andrew JANS ,  Kylie Michelle WAGSTAFF

IPC分类号： A61K31/167 ,  A61K31/203

CPC分类号： A61K31/167 ,  A61K31/203 ,  Y02A50/30

摘要： This invention relates to methods of treating or preventing viral infections caused by flaviviruses, such as dengue virus, yellow fever virus, West Nile virus or Japanese encephalitis virus or infections caused by Chikungunya virus (CHIKV). The methods involve the administration of retinoic acid analogues to subjects who have, are suspected of having a flavivirus infection or infection with CHIKV, or to those who are at risk of becoming infected with a flavivirus or becoming infected with CHIKV.