公开(公告)号：US5560902A

公开(公告)日：1996-10-01

申请号：US419800

申请日：1995-04-11

Applicant: William P. Cacheris ,  Linda Meeh

Inventor： William P. Cacheris ,  Linda Meeh

IPC: A61B19/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61K51/00

CPC classification number: A61K49/225 ,  A61K47/48861 ,  A61K49/1818 ,  A61K49/1842 ,  A61K49/1881 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61B90/39 ,  Y10S977/773 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

Abstract: Methods of preparing solid apatite particles using a microfluidizer, for use in medical diagnostic imaging such as magnetic resonance imaging, X-ray, and ultrasound. The desired apatite particles are synthesized, passed through a microfluidizer, and purified to remove excess base, salts, and other materials used to synthesize the particles. The microfluidizer causes two high pressure streams to interact at ultra high velocities in a precisely defined microchannel. Microfluidization of preparations causes small (

Abstract translation: 使用微流化器制备固体磷灰石颗粒的方法，用于诸如磁共振成像，X射线和超声的医学诊断成像。 合成所需的磷灰石颗粒，通过微流化器，并纯化以除去用于合成颗粒的过量碱，盐和其它材料。 微流化器引起两个高压流在精确限定的微通道中以超高速度相互作用。 制剂的微流化导致小（<5μm）和均匀的颗粒形成。 涂层和净化（特别是通过切向流过滤），颗粒改善了颗粒的稳定性。

公开(公告)号：US5419892A

公开(公告)日：1995-05-30

申请号：US249776

申请日：1994-07-26

Applicant: William P. Cacheris ,  Linda Meeh

Inventor： William P. Cacheris ,  Linda Meeh

IPC: A61B5/055 ,  A61B19/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  C01B25/32 ,  C01G28/00 ,  C01G31/00 ,  C01G45/00 ,  C07F9/38 ,  A61K33/32 ,  A61K33/42

CPC classification number: A61K47/48861 ,  A61K47/48884 ,  A61K49/1818 ,  A61K49/1827 ,  A61K49/183 ,  A61K49/1842 ,  A61K49/1878 ,  A61K49/1881 ,  A61K49/225 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61B90/39 ,  Y10S977/847 ,  Y10S977/896 ,  Y10S977/90 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93 ,  Y10T436/24

Abstract: Methods of preparing solid apatite particles using a microfluidizer, for use in medical diagnostic imaging such as magnetic resonance imaging, X-ray, and ultrasound. The desired apatite particles are synthesized, passed through a microfluidizer, and purified to remove excess base, salts, and other materials used to synthesize the particles. The microfluidizer causes two high pressure streams to interact at ultra high velocities in a precisely defined microchannel. Microfluidization of preparations causes small (

Abstract translation: 使用微流化器制备固体磷灰石颗粒的方法，用于诸如磁共振成像，X射线和超声的医学诊断成像。 合成所需的磷灰石颗粒，通过微流化器，并纯化以除去用于合成颗粒的过量碱，盐和其它材料。 微流化器引起两个高压流在精确限定的微通道中以超高速度相互作用。 制剂的微流化导致小（<5μm）和均匀的颗粒形成。 涂层和净化（特别是通过切向流过滤），颗粒改善了颗粒的稳定性。

公开(公告)号：US5407659A

公开(公告)日：1995-04-18

申请号：US47129

申请日：1993-04-13

Applicant: Edward A. Deutsch ,  Karen F. Deutsch ,  Dennis L. Nosco ,  William H. Ralston ,  David H. White ,  Janet B. Wilking ,  Robert G. Wolfangel ,  Steven R. Woulfe

Inventor： Edward A. Deutsch ,  Karen F. Deutsch ,  Dennis L. Nosco ,  William H. Ralston ,  David H. White ,  Janet B. Wilking ,  Robert G. Wolfangel ,  Steven R. Woulfe

IPC: A61B5/055 ,  A61B8/00 ,  A61B19/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  A61K51/00 ,  A61K51/12 ,  C01B25/32 ,  C01G28/00 ,  C01G31/00 ,  C01G45/00 ,  C07F9/38 ,  G01R33/28

CPC classification number: A61K51/1241 ,  A61K47/48861 ,  A61K49/0414 ,  A61K49/1818 ,  A61K49/1842 ,  A61K49/1878 ,  A61K49/1881 ,  A61K49/225 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61B90/39 ,  G01R33/281 ,  Y10S977/722 ,  Y10S977/881 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93 ,  Y10T436/24

Abstract: Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.

Abstract translation: 公开了用于增强医学诊断成像例如磁共振成像（“MRI”），磁共振光谱（“MRS”），磁共振光谱成像（“MRSI”），X射线诊断成像， 和超声成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏或组织疾病状态的器官特异性成像的组合物。 根据诊断成像技术，含钙/含氧阴离子的颗粒被处理为顺磁性，不透射线的或回声的。 还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述颗粒，然后进行医学诊断程序。

公开(公告)号：US4810401A

公开(公告)日：1989-03-07

申请号：US55066

申请日：1987-05-28

Applicant: Gunther Mair ,  Werner Steck

Inventor： Gunther Mair ,  Werner Steck

IPC: C01G53/00 ,  A61K49/18 ,  C01G49/00 ,  C01G51/00 ,  C09K9/00 ,  H01F1/36 ,  H01F1/44 ,  C04B35/26

CPC classification number: H01F1/44 ,  A61K49/1806 ,  A61K49/1818 ,  A61K49/1842

Abstract: Superparamagnetic solid particles of the general formula IM.sub.v Mn.sub.w Zn.sub.x Fe.sub.y O.sub.z (I)where M is Co and/or Ni, v and w are each from 0 to 0.998, x is from 0.001 to 0.998, y is from 2.001 to 2.998, z is from 3.001 to 4, v+w+x is from 0.002 to 0.999, v+w+x+y is 3, v.noteq.0 if w=0 and w.noteq.0 or v=0, polar and nonpolar superparamagnetic liquids which contain the surfactant-coated superparamagnetic solid particles I in the form of a colloidal dispersion in polar or nonpolar liquid media, and processes for the preparation of polar and nonpolar superparamagnetic liquids.

Abstract translation: 其中M为Co和/或Ni，v和w的通式I MvMnwZnxFeyOz（I）的超顺磁固体颗粒各自为0至0.998，x为0.001至0.998，y为2.001至2.998，z为3.001至 4，v + w + x为0.002〜0.999，v + w + x + y为3，v如果w = 0，则注释0，w NOTEQUAL 0或v = 0，极性和非极性超顺磁性液体含有表面活性剂 极性或非极性液体介质中胶体分散体形式的超顺磁性固体颗粒I，以及制备极性和非极性超顺磁性液体的方法。